ADP (ECMDB01341) (M2MDB000345)

General function:

Involved in oxidation-reduction process

Specific function:

Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. R1 contains the binding sites for both substrates and allosteric effectors and carries out the actual reduction of the ribonucleotide. It also provides redox- active cysteines

Gene Name:

nrdA

Uniprot ID:

P00452

Molecular weight:

85774

Reactions

General function:

Involved in ATP binding

Specific function:

Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate. Is also able to phosphorylate the hydroxy group on gamma-carbon of L-homoserine analogs when the functional group at the alpha-position is a carboxyl, an ester, or even a hydroxymethyl group. Neither L- threonine nor L-serine are substrates of the enzyme

Gene Name:

thrB

Uniprot ID:

P00547

Molecular weight:

33623

Reactions

General function:

Involved in amino acid binding

Specific function:

L-homoserine + NAD(P)(+) = L-aspartate 4- semialdehyde + NAD(P)H

Gene Name:

thrA

Uniprot ID:

P00561

Molecular weight:

89119

Reactions

General function:

Involved in cellular amino acid biosynthetic process

Specific function:

L-homoserine + NAD(P)(+) = L-aspartate 4- semialdehyde + NAD(P)H

Gene Name:

metL

Uniprot ID:

P00562

Molecular weight:

88887

Reactions

General function:

Involved in nucleotide binding

Specific function:

ATP + L-glutamine + tRNA(Gln) = AMP + diphosphate + L-glutaminyl-tRNA(Gln)

Gene Name:

glnS

Uniprot ID:

P00962

Molecular weight:

63477

Reactions

General function:

Involved in ATP binding

Specific function:

2 ATP + L-glutamine + HCO(3)(-) + H(2)O = 2 ADP + phosphate + L-glutamate + carbamoyl phosphate

Gene Name:

carB

Uniprot ID:

P00968

Molecular weight:

117841

Reactions

General function:

Involved in potassium-transporting ATPase activity

Specific function:

One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions

Gene Name:

kdpA

Uniprot ID:

P03959

Molecular weight:

59189

Reactions

General function:

Involved in nucleotide binding

Specific function:

One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions

Gene Name:

kdpB

Uniprot ID:

P03960

Molecular weight:

72198

Reactions

General function:

Involved in potassium-transporting ATPase activity

Specific function:

One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex

Gene Name:

kdpC

Uniprot ID:

P03961

Molecular weight:

20267

Reactions

General function:

Involved in ATP binding

Specific function:

ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + phosphate + glutathione

Gene Name:

gshB

Uniprot ID:

P04425

Molecular weight:

35561

Reactions

General function:

Involved in nucleotide binding

Specific function:

Part of the ABC transporter complex RbsABCD involved in ribose import. Responsible for energy coupling to the transport system

Gene Name:

rbsA

Uniprot ID:

P04983

Molecular weight:

55041

Reactions

General function:

Involved in RNA binding

Specific function:

Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction

Gene Name:

pnp

Uniprot ID:

P05055

Molecular weight:

77100

Reactions

General function:

Involved in bis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity

Specific function:

Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP

Gene Name:

apaH

Uniprot ID:

P05637

Molecular weight:

31296

Reactions

General function:

Involved in nucleotide binding

Specific function:

Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system

Gene Name:

btuD

Uniprot ID:

P06611

Molecular weight:

27081

Reactions

General function:

Involved in phosphotransferase activity, alcohol group as acceptor

Specific function:

ATP + D-fructose 6-phosphate = ADP + D- fructose 1,6-bisphosphate

Gene Name:

pfkB

Uniprot ID:

P06999

Molecular weight:

32456

Reactions

General function:

Involved in nucleotide binding

Specific function:

Part of the binding-protein-dependent transport system for histidine. Probably responsible for energy coupling to the transport system

Gene Name:

hisP

Uniprot ID:

P07109

Molecular weight:

28653

General function:

Involved in nucleotide binding

Specific function:

Part of the ABC transporter complex fhuCDB involved in iron(3+)-hydroxamate import. Responsible for energy coupling to the transport system

Gene Name:

fhuC

Uniprot ID:

P07821

Molecular weight:

28886

Reactions

General function:

Involved in ATP binding

Specific function:

Cell wall formation

Gene Name:

ddlB

Uniprot ID:

P07862

Molecular weight:

32839

Reactions

General function:

Involved in catalytic activity

Specific function:

ATP + 2-(formamido)-N(1)-(5-phospho-D- ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D- ribosyl)imidazole

Gene Name:

purM

Uniprot ID:

P08178

Molecular weight:

36854

Reactions

General function:

Involved in tetrahydrofolylpolyglutamate synthase activity

Specific function:

Conversion of folates to polyglutamate derivatives

Gene Name:

folC

Uniprot ID:

P08192

Molecular weight:

45405

Reactions

General function:

Involved in phosphotransferase activity, alcohol group as acceptor

Specific function:

ATP + L(or D)-ribulose = ADP + L(or D)- ribulose 5-phosphate

Gene Name:

araB

Uniprot ID:

P08204

Molecular weight:

61089

Reactions

General function:

Involved in amino acid binding

Specific function:

ATP + L-aspartate = ADP + 4-phospho-L- aspartate

Gene Name:

lysC

Uniprot ID:

P08660

Molecular weight:

48531

Reactions

General function:

Involved in phosphoribosylaminoimidazole carboxylase activity

Specific function:

Possesses an ATPase activity that is dependent on the presence of AIR (aminoimidazole ribonucleotide). The association of purK and purE produces an enzyme complex capable of converting AIR to CAIR efficiently under physiological condition

Gene Name:

purK

Uniprot ID:

P09029

Molecular weight:

39461

Reactions

General function:

Involved in phosphotransferase activity, alcohol group as acceptor

Specific function:

ATP + D-xylulose = ADP + D-xylulose 5- phosphate

Gene Name:

xylB

Uniprot ID:

P09099

Molecular weight:

52618

Reactions

General function:

Involved in kinase activity

Specific function:

Involved in the activation of acetate to acetyl CoA and the secretion of acetate. During anaerobic growth of the organism, this enzyme is also involved in the synthesis of most of the ATP formed catabolically

Gene Name:

ackA

Uniprot ID:

P0A6A3

Molecular weight:

43290

Reactions

General function:

Involved in acetylglutamate kinase activity

Specific function:

ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L- glutamate 5-phosphate

Gene Name:

argB

Uniprot ID:

P0A6C8

Molecular weight:

27159

Reactions

General function:

Involved in shikimate kinase activity

Specific function:

Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate

Gene Name:

aroK

Uniprot ID:

P0A6D7

Molecular weight:

19538

Reactions

General function:

Involved in shikimate kinase activity

Specific function:

Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate

Gene Name:

aroL

Uniprot ID:

P0A6E1

Molecular weight:

19151

Reactions

General function:

Involved in hydrogen ion transporting ATP synthase activity, rotational mechanism

Specific function:

Produces ATP from ADP in the presence of a proton gradient across the membrane

Gene Name:

atpC

Uniprot ID:

P0A6E6

Molecular weight:

15068

General function:

Involved in magnesium ion binding

Specific function:

ATP + 7,8-diaminononanoate + CO(2) = ADP + phosphate + dethiobiotin

Gene Name:

ynfK

Uniprot ID:

P0A6E9

Molecular weight:

24981

Reactions

General function:

Involved in glutamine catabolic process

Specific function:

2 ATP + L-glutamine + HCO(3)(-) + H(2)O = 2 ADP + phosphate + L-glutamate + carbamoyl phosphate

Gene Name:

carA

Uniprot ID:

P0A6F1

Molecular weight:

41431

Reactions

General function:

Involved in phosphotransferase activity, alcohol group as acceptor

Specific function:

Key enzyme in the regulation of glycerol uptake and metabolism

Gene Name:

glpK

Uniprot ID:

P0A6F3

Molecular weight:

56230

Reactions

General function:

Involved in cytidylate kinase activity

Specific function:

ATP, dATP, and GTP are equally effective as phosphate donors. CMP and dCMP are the best phosphate acceptors

Gene Name:

cmk

Uniprot ID:

P0A6I0

Molecular weight:

24746

Reactions

General function:

Involved in pantothenate kinase activity

Specific function:

ATP + (R)-pantothenate = ADP + (R)-4'- phosphopantothenate

Gene Name:

coaA

Uniprot ID:

P0A6I3

Molecular weight:

36359

Reactions

General function:

Involved in dephospho-CoA kinase activity

Specific function:

Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A

Gene Name:

coaE

Uniprot ID:

P0A6I9

Molecular weight:

22622

Reactions

General function:

Involved in adenylylsulfate kinase activity

Specific function:

Catalyzes the synthesis of activated sulfate

Gene Name:

cysC

Uniprot ID:

P0A6J1

Molecular weight:

22321

Reactions

General function:

Involved in ATP binding

Specific function:

Cell wall formation

Gene Name:

ddlA

Uniprot ID:

P0A6J8

Molecular weight:

39315

Reactions

General function:

Involved in galactokinase activity

Specific function:

ATP + D-galactose = ADP + alpha-D-galactose 1- phosphate

Gene Name:

galK

Uniprot ID:

P0A6T3

Molecular weight:

41442

Reactions

General function:

Involved in biosynthetic process

Specific function:

Synthesizes alpha-1,4-glucan chains using ADP-glucose

Gene Name:

glgA

Uniprot ID:

P0A6U8

Molecular weight:

52822

Reactions

General function:

Involved in glucokinase activity

Specific function:

Not highly important in E.coli as glucose is transported into the cell by the PTS system already as glucose 6-phosphate

Gene Name:

glk

Uniprot ID:

P0A6V8

Molecular weight:

34723

Reactions

General function:

Involved in glutamate-cysteine ligase activity

Specific function:

ATP + L-glutamate + L-cysteine = ADP + phosphate + gamma-L-glutamyl-L-cysteine

Gene Name:

gshA

Uniprot ID:

P0A6W9

Molecular weight:

58269

Reactions

General function:

Involved in thymidylate kinase activity

Specific function:

Catalyzes the reversible phosphorylation of deoxythymidine monophosphate (dTMP) to deoxythymidine diphosphate (dTDP), using ATP as its preferred phosphoryl donor. Situated at the junction of both de novo and salvage pathways of deoxythymidine triphosphate (dTTP) synthesis, is essential for DNA synthesis and cellular growth

Gene Name:

tmk

Uniprot ID:

P0A720

Molecular weight:

23783

Reactions

General function:

Involved in nucleoside diphosphate kinase activity

Specific function:

Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate

Gene Name:

ndk

Uniprot ID:

P0A763

Molecular weight:

15463

Reactions

General function:

Involved in ATP binding

Specific function:

ATP + D-fructose 6-phosphate = ADP + D- fructose 1,6-bisphosphate

Gene Name:

pfkA

Uniprot ID:

P0A796

Molecular weight:

34842

Reactions

General function:

Involved in phosphoglycerate kinase activity

Specific function:

ATP + 3-phospho-D-glycerate = ADP + 3-phospho- D-glyceroyl phosphate

Gene Name:

pgk

Uniprot ID:

P0A799

Molecular weight:

41118

Reactions

General function:

Involved in catalytic activity

Specific function:

Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP). Can form linear polymers of orthophosphate with chain lengths up to 1000 or more. Can also act in the reverse direction to form ATP in the presence of excess ADP. Can also use GTP instead of ATP; but the efficiency of GTP is 5% that of ATP

Gene Name:

ppk

Uniprot ID:

P0A7B1

Molecular weight:

80431

Reactions

General function:

Involved in NAD+ kinase activity

Specific function:

Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus

Gene Name:

ppnK

Uniprot ID:

P0A7B3

Molecular weight:

32566

Reactions

General function:

Involved in cellular amino acid biosynthetic process

Specific function:

Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline

Gene Name:

proB

Uniprot ID:

P0A7B5

Molecular weight:

39056

Reactions

General function:

Involved in ATP binding

Specific function:

ATP + 5-amino-1-(5-phospho-D- ribosyl)imidazole-4-carboxylate + L-aspartate = ADP + phosphate + (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate

Gene Name:

purC

Uniprot ID:

P0A7D7

Molecular weight:

26995

Reactions

General function:

Involved in CTP synthase activity

Specific function:

Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen

Gene Name:

pyrG

Uniprot ID:

P0A7E5

Molecular weight:

60374

Reactions

General function:

Involved in cellular amino acid biosynthetic process

Specific function:

Catalyzes the reversible phosphorylation of UMP to UDP, with ATP as the most efficient phosphate donor

Gene Name:

pyrH

Uniprot ID:

P0A7E9

Molecular weight:

25970

Reactions

General function:

Involved in ATP binding

Specific function:

ATP + succinate + CoA = ADP + phosphate + succinyl-CoA

Gene Name:

sucC

Uniprot ID:

P0A836

Molecular weight:

41392

Reactions

General function:

Involved in ATP binding

Specific function:

ATP + uridine = ADP + UMP

Gene Name:

udk

Uniprot ID:

P0A8F4

Molecular weight:

24353

Reactions

General function:

Involved in glutamate-ammonia ligase activity

Specific function:

ATP + L-glutamate + NH(3) = ADP + phosphate + L-glutamine

Gene Name:

glnA

Uniprot ID:

P0A9C5

Molecular weight:

51903

Reactions

General function:

Involved in phosphotransferase activity, alcohol group as acceptor

Specific function:

ATP + D-ribose = ADP + D-ribose 5-phosphate

Gene Name:

rbsK

Uniprot ID:

P0A9J6

Molecular weight:

32290

Reactions

General function:

Involved in acetyl-CoA carboxylase activity

Specific function:

Controls translation of mRNA for both itself and the alpha-subunit (accA) by binding to a probable hairpin in the 5' of the mRNA. Binding to mRNA inhibits translation; this is partially relieved by acetyl-CoA. Increasing amounts of mRNA also inhibit enzyme activity

Gene Name:

accD

Uniprot ID:

P0A9Q5

Molecular weight:

33322

Reactions

General function:

Involved in nucleotide binding

Specific function:

Part of the ABC transporter complex AraFGH involved in arabinose import. Responsible for energy coupling to the transport system (Probable)

Gene Name:

araG

Uniprot ID:

P0AAF3

Molecular weight:

55018

Reactions

General function:

Involved in nucleotide binding

Specific function:

Part of the ABC transporter complex MglABC involved in galactose/methyl galactoside import. Responsible for energy coupling to the transport system (Probable)

Gene Name:

mglA

Uniprot ID:

P0AAG8

Molecular weight:

56415

Reactions

General function:

Involved in nucleotide binding

Specific function:

Part of the ABC transporter complex pstSACB involved in phosphate import. Responsible for energy coupling to the transport system

Gene Name:

pstB

Uniprot ID:

P0AAH0

Molecular weight:

29027

Reactions

General function:

Involved in hydrogen ion transmembrane transporter activity

Specific function:

Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane

Gene Name:

atpB

Uniprot ID:

P0AB98

Molecular weight:

30303

General function:

Involved in hydrogen ion transmembrane transporter activity

Specific function:

Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)

Gene Name:

atpF

Uniprot ID:

P0ABA0

Molecular weight:

17264

General function:

Involved in hydrogen ion transporting ATP synthase activity, rotational mechanism

Specific function:

This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction

Gene Name:

atpH

Uniprot ID:

P0ABA4

Molecular weight:

19332

General function:

Involved in hydrogen ion transporting ATP synthase activity, rotational mechanism

Specific function:

Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex

Gene Name:

atpG

Uniprot ID:

P0ABA6

Molecular weight:

31577

General function:

Involved in ATP binding

Specific function:

Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit

Gene Name:

atpA

Uniprot ID:

P0ABB0

Molecular weight:

55222

Reactions

General function:

Involved in nucleotide binding

Specific function:

Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits

Gene Name:

atpD

Uniprot ID:

P0ABB4

Molecular weight:

50325

Reactions

General function:

Involved in hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances

Specific function:

Mediates magnesium influx to the cytosol

Gene Name:

mgtA

Uniprot ID:

P0ABB8

Molecular weight:

99466

Reactions

General function:

Involved in acetyl-CoA carboxylase activity

Specific function:

Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA

Gene Name:

accA

Uniprot ID:

P0ABD5

Molecular weight:

35241

Reactions

General function:

Involved in acetyl-CoA carboxylase activity

Specific function:

This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA

Gene Name:

accB

Uniprot ID:

P0ABD8

Molecular weight:

16687

General function:

Involved in diacylglycerol kinase activity

Specific function:

Recycling of diacylglycerol produced during the turnover of membrane phospholipid

Gene Name:

dgkA

Uniprot ID:

P0ABN1

Molecular weight:

13245

Reactions

General function:

Involved in magnesium ion binding

Specific function:

ATP + pyruvate = ADP + phosphoenolpyruvate

Gene Name:

pykF

Uniprot ID:

P0AD61

Molecular weight:

50729

Reactions

General function:

Involved in nucleotide binding

Specific function:

ATP-dependent phosphorylation of adenosylcobinamide and adds GMP to adenosylcobinamide phosphate

Gene Name:

cobU

Uniprot ID:

P0AE76

Molecular weight:

20164

Reactions

General function:

Amino acid transport and metabolism

Specific function:

Catalyzes the formation of an amide bond between glutathione and spermidine coupled with hydrolysis of ATP; also catalyzes the hydrolysis of glutathionylspermidine to glutathione and spermidine

Gene Name:

gsp

Uniprot ID:

P0AES0

Molecular weight:

70531

Reactions

General function:

Involved in phosphotransferase activity, alcohol group as acceptor

Specific function:

ATP + inosine = ADP + IMP

Gene Name:

gsk

Uniprot ID:

P0AEW6

Molecular weight:

48448

Reactions

General function:

Involved in 1-phosphofructokinase activity

Specific function:

ATP + D-fructose 1-phosphate = ADP + D- fructose 1,6-bisphosphate

Gene Name:

fruK

Uniprot ID:

P0AEW9

Molecular weight:

33755

Reactions

General function:

Involved in ATP binding

Specific function:

ATP + D-ribulose 5-phosphate = ADP + D- ribulose 1,5-bisphosphate

Gene Name:

prkB

Uniprot ID:

P0AEX5

Molecular weight:

32344

Reactions

General function:

Involved in nucleoside-triphosphate diphosphatase activity

Specific function:

Specific function unknown

Gene Name:

mazG

Uniprot ID:

P0AEY3

Molecular weight:

30412

Reactions

General function:

Involved in FMN adenylyltransferase activity

Specific function:

ATP + riboflavin = ADP + FMN

Gene Name:

ribF

Uniprot ID:

P0AG40

Molecular weight:

34734

Reactions

General function:

Involved in catalytic activity

Specific function:

ATP + succinate + CoA = ADP + phosphate + succinyl-CoA

Gene Name:

sucD

Uniprot ID:

P0AGE9

Molecular weight:

29777

Reactions

General function:

Involved in catalytic activity

Specific function:

ATP + thiamine phosphate = ADP + thiamine diphosphate

Gene Name:

thiL

Uniprot ID:

P0AGG0

Molecular weight:

35070

Reactions

General function:

Involved in electron carrier activity

Specific function:

Efficient electron donor for the essential enzyme ribonucleotide reductase. Is also able to reduce the interchain disulfide bridges of insulin

Gene Name:

trxC

Uniprot ID:

P0AGG4

Molecular weight:

15555

Reactions

General function:

Involved in catalytic activity

Specific function:

Component of the tagatose-1,6-bisphosphate aldolase gatYZ that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of gatY. When expressed alone, gatZ does not show any aldolase activity. Is involved in the catabolism of galactitol

Gene Name:

gatZ

Uniprot ID:

P0C8J8

Molecular weight:

47108

General function:

Involved in catalytic activity

Specific function:

Component of the tagatose-1,6-bisphosphate aldolase kbaYZ that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of kbaY. When expressed alone, kbaZ does not show any aldolase activity

Gene Name:

kbaZ

Uniprot ID:

P0C8K0

Molecular weight:

47192

General function:

Involved in nucleotide binding

Specific function:

Part of the ABC transporter complex UgpABCE involved in sn-glycerol-3-phosphate import. Responsible for energy coupling to the transport system (Probable). Can also transport glycerophosphoryl diesters

Gene Name:

ugpC

Uniprot ID:

P10907

Molecular weight:

39524

Reactions

General function:

Involved in [isocitrate dehydrogenase (NADP+)] kinase activity

Specific function:

Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation

Gene Name:

aceK

Uniprot ID:

P11071

Molecular weight:

67698

Reactions

General function:

Involved in phosphotransferase activity, alcohol group as acceptor

Specific function:

ATP + L-fuculose = ADP + L-fuculose 1- phosphate

Gene Name:

fucK

Uniprot ID:

P11553

Molecular weight:

53235

Reactions

General function:

Involved in kinase activity

Specific function:

ATP + propanoate = ADP + propanoyl phosphate

Gene Name:

tdcD

Uniprot ID:

P11868

Molecular weight:

43384

Reactions

General function:

Involved in ATP binding

Specific function:

Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein

Gene Name:

murF

Uniprot ID:

P11880

Molecular weight:

47447

Reactions

General function:

Involved in magnesium ion binding

Specific function:

ATP + 7,8-diaminononanoate + CO(2) = ADP + phosphate + dethiobiotin

Gene Name:

bioD

Uniprot ID:

P13000

Molecular weight:

24139

Reactions

General function:

Involved in nucleotide binding

Specific function:

Involved in a multicomponent binding-protein-dependent transport system for glycine betaine/L-proline

Gene Name:

proV

Uniprot ID:

P14175

Molecular weight:

44162

General function:

Involved in ATP binding

Specific function:

Member of the two-component regulatory system zraS/zraR. May function as a membrane-associated protein kinase that phosphorylates zraR in response to high concentrations of zinc or lead in the medium

Gene Name:

zraS

Uniprot ID:

P14377

Molecular weight:

51031

Reactions

General function:

Involved in ATP binding

Specific function:

Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)

Gene Name:

murD

Uniprot ID:

P14900

Molecular weight:

46973

Reactions

General function:

Involved in nucleotide binding

Specific function:

Part of the binding-protein-dependent transport system for citrate-dependent Fe(3+). Probably responsible for energy coupling to the transport system

Gene Name:

fecE

Uniprot ID:

P15031

Molecular weight:

28191

General function:

Involved in catalytic activity

Specific function:

ATP + N(2)-formyl-N(1)-(5-phospho-D- ribosyl)glycinamide + L-glutamine + H(2)O = ADP + phosphate + 2- (formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + L-glutamate

Gene Name:

purL

Uniprot ID:

P15254

Molecular weight:

141402

Reactions

General function:

Involved in ATP binding

Specific function:

ATP + 5-phospho-D-ribosylamine + glycine = ADP + phosphate + N(1)-(5-phospho-D-ribosyl)glycinamide

Gene Name:

purD

Uniprot ID:

P15640

Molecular weight:

45940

Reactions

General function:

Involved in nucleotide binding

Specific function:

Part of the ABC transporter complex cysAWTP involved in sulfate/thiosulfate import. Responsible for energy coupling to the transport system

Gene Name:

cysA

Uniprot ID:

P16676

Molecular weight:

41059

Reactions

General function:

Involved in protein binding

Specific function:

Belongs to an operon involved in alkylphosphonate uptake and C-P lyase. Exact function not known

Gene Name:

phnN

Uniprot ID:

P16690

Molecular weight:

20729

Reactions

General function:

Involved in ATP binding

Specific function:

Cell wall formation

Gene Name:

murC

Uniprot ID:

P17952

Molecular weight:

53626

Reactions

General function:

Involved in nicotinate phosphoribosyltransferase activity

Specific function:

Nicotinate D-ribonucleotide + diphosphate = nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate

Gene Name:

pncB

Uniprot ID:

P18133

Molecular weight:

45897

Reactions

General function:

Involved in magnesium ion binding

Specific function:

ATP + pyruvate = ADP + phosphoenolpyruvate

Gene Name:

pykA

Uniprot ID:

P21599

Molecular weight:

51357

Reactions

General function:

Involved in ATP binding

Specific function:

Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Is also able to use many meso-diaminopimelate analogs as substrates, although much less efficiently, but not L-lysine

Gene Name:

murE

Uniprot ID:

P22188

Molecular weight:

53343

Reactions

General function:

Involved in phosphoenolpyruvate carboxykinase (ATP) activity

Specific function:

ATP + oxaloacetate = ADP + phosphoenolpyruvate + CO(2)

Gene Name:

pckA

Uniprot ID:

P22259

Molecular weight:

59643

Reactions

General function:

Involved in thymidine kinase activity

Specific function:

Phosphorylates both thymidine and deoxyuridine

Gene Name:

tdk

Uniprot ID:

P23331

Molecular weight:

23456

Reactions

General function:

Involved in glycerate kinase activity

Specific function:

ATP + (R)-glycerate = ADP + 3-phospho-(R)- glycerate

Gene Name:

garK

Uniprot ID:

P23524

Molecular weight:

39104

Reactions

General function:

Involved in ATP binding

Specific function:

Member of the two-component regulatory system phoQ/phoP involved in adaptation to low Mg(2+) environments and the control of acid resistance genes. In presence of low periplasmic Mg(2+) concentrations, phoQ functions as a membrane-associated protein kinase that undergoes autophosphorylation and subsequently transfers the phosphate to phoP, which results in the expression of phoP-activated genes (PAG) and repression of phoP-repressed genes (PRG). In presence of high periplasmic Mg(2+) concentrations, acts as a protein phosphatase that dephosphorylates phospho-phoP, which results in the repression of phoP-activated genes and may lead to expression of some phoP- repressed genes. Mediates magnesium influx to the cytosol by activation of mgtA. Promotes expression of the two- component regulatory system rstA/rstB and transcription of the hemL, mgrB, nagA, slyB, vboR and yrbL genes

Gene Name:

phoQ

Uniprot ID:

P23837

Molecular weight:

55299

Reactions

General function:

Involved in nucleotide binding

Specific function:

Part of the binding-protein-dependent transport system for ferric enterobactin. Probably responsible for energy coupling to the transport system

Gene Name:

fepC

Uniprot ID:

P23878

Molecular weight:

29784

General function:

Transcription

Specific function:

Catalyzes the phosphorylation of fructose to fructose-6- P. Has also low level glucokinase activity in vitro. Is not able to phosphorylate D-ribose, D-mannitol, D-sorbitol, inositol, and L-threonine

Gene Name:

mak

Uniprot ID:

P23917

Molecular weight:

32500

Reactions

General function:

Involved in ligase activity

Specific function:

This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA

Gene Name:

accC

Uniprot ID:

P24182

Molecular weight:

49320

Reactions

General function:

Involved in negative regulation of transcription, DNA-dependent

Specific function:

NadR is bifunctional; it interacts with pnuC at low internal NAD levels, permitting transport of NMN intact into the cell. As NAD levels increase within the cell, the affinity of nadR for the operator regions of nadA, nadB, and pncB increases, repressing the transcription of these genes

Gene Name:

nadR

Uniprot ID:

P27278

Molecular weight:

47346

Reactions

General function:

Involved in ATP binding

Specific function:

Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA)

Gene Name:

lpxK

Uniprot ID:

P27300

Molecular weight:

35589

Reactions

General function:

Involved in acetate-CoA ligase activity

Specific function:

Enables the cell to use acetate during aerobic growth to generate energy via the TCA cycle, and biosynthetic compounds via the glyoxylate shunt. Acetylates CheY, the response regulator involved in flagellar movement and chemotaxis

Gene Name:

acs

Uniprot ID:

P27550

Molecular weight:

72093

Reactions

General function:

Involved in catalytic activity

Specific function:

2'-deoxyribonucleoside triphosphate + thioredoxin disulfide + H(2)O = ribonucleoside triphosphate + thioredoxin

Gene Name:

nrdD

Uniprot ID:

P28903

Molecular weight:

80022

Reactions

General function:

Carbohydrate transport and metabolism

Specific function:

ATP + 2-dehydro-3-deoxy-D-galactonate = ADP + 2-dehydro-3-deoxy-D-galactonate 6-phosphate

Gene Name:

dgoK

Uniprot ID:

P31459

Molecular weight:

31373

Reactions

General function:

Involved in transporter activity

Specific function:

Part of the binding-protein-dependent transport system for D-methionine and the toxic methionine analog alpha-methyl- methionine. Probably responsible for the translocation of the substrate across the membrane

Gene Name:

metI

Uniprot ID:

P31547

Molecular weight:

23256

General function:

Involved in phosphotransferase activity, alcohol group as acceptor

Specific function:

ATP + L-rhamnulose = ADP + L-rhamnulose 1- phosphate

Gene Name:

rhaB

Uniprot ID:

P32171

Molecular weight:

54069

Reactions

General function:

Transcription

Specific function:

Catalyzes the phosphorylation of D-allose to D-allose 6- P. Has also low level glucokinase activity in vitro

Gene Name:

alsK

Uniprot ID:

P32718

Molecular weight:

33821

Reactions

General function:

Involved in nucleotide binding

Specific function:

Part of the ABC transporter complex AlsBAC involved in D-allose import. Probably responsible for energy coupling to the transport system

Gene Name:

alsA

Uniprot ID:

P32721

Molecular weight:

56744

Reactions

General function:

Involved in ATP binding

Specific function:

Catalyzes two reactions:the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR; the second, a side reaction, is the production of acetyl phosphate and ADP from acetate and ATP

Gene Name:

purT

Uniprot ID:

P33221

Molecular weight:

42433

Reactions

General function:

Involved in nucleotide binding

Specific function:

Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system

Gene Name:

ccmA

Uniprot ID:

P33931

Molecular weight:

23053

Reactions

General function:

Involved in nucleotide binding

Specific function:

Part of the ABC transporter complex FbpABC involved in Fe(3+) ions import. Responsible for energy coupling to the transport system

Gene Name:

fbpC

Uniprot ID:

P37009

Molecular weight:

39059

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. R2F contains the tyrosyl radical required for catalysis

Gene Name:

nrdF

Uniprot ID:

P37146

Molecular weight:

36443

Reactions