Identification
Name:Pantothenate kinase
Synonyms:
  • Pantothenic acid kinase
  • Rts protein
Gene Name:coaA
Enzyme Class:
Biological Properties
General Function:Involved in pantothenate kinase activity
Specific Function:ATP + (R)-pantothenate = ADP + (R)-4'- phosphopantothenate
Cellular Location:Cytoplasm (Probable)
SMPDB Pathways:
KEGG Pathways:
KEGG Reactions:
1.0Thumb+1.0Thumb1.0Thumb+1.0Thumb+1.0Thumb
1.0Thumb+1.0Thumb1.0Thumb+1.0Thumb
1.0Thumb+1.0Thumb1.0Thumb+1.0Thumb
1.0Thumb+1.0Thumb1.0Thumb+1.0Thumb
SMPDB Reactions:
1.0Pantothenic acid+1.0Thumb+1.0Thumb1.0Adenosine diphosphate+1.0Thumb+1.0D-4'-Phosphopantothenate+1.0Thumb+1.0Thumb
1.0Pantothenic acid + 1.0Adenosine triphosphate + 1.0Pantothenic acid → 1.0Adenosine diphosphate + 1.0Hydrogen ion + 1.0D-4'-Phosphopantothenate + 1.0ADP + 1.0D-4'-Phosphopantothenate
ReactionCard
EcoCyc Reactions:
1.0Thumb+1.0Thumb1.0Thumb+1.0Thumb+1.0Thumb
1.0Thumb+1.0Thumb1.0Thumb+1.0Thumb
Metabolites:
ECMDB IDNameView
ECMDB011174-PhosphopantothenoylcysteineMetaboCard
ECMDB00538Adenosine triphosphateMetaboCard
ECMDB01341ADPMetaboCard
ECMDB01016D-4'-PhosphopantothenateMetaboCard
ECMDB06834D-Pantothenoyl-L-cysteineMetaboCard
ECMDB21225Hydrogen ionMetaboCard
ECMDB03426PantetheineMetaboCard
ECMDB01416Pantetheine 4'-phosphateMetaboCard
ECMDB00210Pantothenic acidMetaboCard
GO Classification:
Component
cell part
cytoplasm
intracellular part
Function
adenyl nucleotide binding
adenyl ribonucleotide binding
ATP binding
binding
catalytic activity
kinase activity
nucleoside binding
pantothenate kinase activity
purine nucleoside binding
transferase activity
transferase activity, transferring phosphorus-containing groups
Process
cellular metabolic process
coenzyme A biosynthetic process
coenzyme biosynthetic process
coenzyme metabolic process
cofactor metabolic process
metabolic process
Gene Properties
Blattner:b3974
Gene OrientationCounterclockwise
Centisome Percentage:89.92
Left Sequence End4172099
Right Sequence End4173049
Gene Sequence:
>951 bp
ATGCAGATCCTGTTGGCCAACCCGCGTGGTTTTTGTGCCGGGGTAGACCGCGCTATCAGC
ATTGTTGAAAACGCGCTGGCCATTTACGGCGCACCGATATATGTCCGTCACGAAGTGGTA
CATAACCGCTATGTGGTCGATAGCTTGCGTGAGCGTGGGGCTATCTTTATTGAGCAGATT
AGCGAAGTACCGGACGGCGCGATCCTGATTTTCTCCGCACACGGTGTTTCTCAGGCGGTA
CGTAACGAAGCAAAAAGTCGCGATTTGACGGTGTTTGATGCCACCTGTCCGCTGGTGACC
AAAGTGCATATGGAAGTCGCCCGCGCCAGTCGCCGTGGCGAAGAATCTATTCTCATCGGT
CACGCCGGGCACCCGGAAGTGGAAGGGACAATGGGCCAGTACAGTAACCCGGAAGGGGGA
ATGTATCTGGTCGAATCGCCGGACGATGTGTGGAAACTGACGGTCAAAAACGAAGAGAAG
CTCTCCTTTATGACCCAGACCACGCTGTCGGTGGATGACACGTCTGATGTGATCGACGCG
CTGCGTAAACGCTTCCCGAAAATTGTCGGTCCGCGCAAAGATGACATCTGCTACGCCACG
ACTAACCGTCAGGAAGCGGTACGCGCCCTGGCAGAACAGGCGGAAGTTGTGTTGGTGGTC
GGTTCGAAAAACTCCTCCAACTCCAACCGTCTGGCGGAGCTGGCCCAGCGTATGGGCAAA
CGCGCGTTTTTGATTGACGATGCGAAAGACATCCAGGAAGAGTGGGTGAAAGAGGTTAAA
TGCGTCGGCGTGACTGCGGGCGCATCGGCTCCGGATATTCTGGTGCAGAATGTGGTGGCA
CGTTTGCAGCAGCTGGGCGGTGGTGAAGCCATTCCGCTGGAAGGCCGTGAAGAAAACATT
GTTTTCGAAGTGCCGAAAGAGCTGCGTGTCGATATTCGTGAAGTCGATTAA
Protein Properties
Pfam Domain Function:
Protein Residues:316
Protein Molecular Weight:36359
Protein Theoretical pI:7
PDB File:1SQ5
Signaling Regions:
  • None
Transmembrane Regions:
  • None
Protein Sequence:
>Pantothenate kinase
MSIKEQTLMTPYLQFDRNQWAALRDSVPMTLSEDEIARLKGINEDLSLEEVAEIYLPLSR
LLNFYISSNLRRQAVLEQFLGTNGQRIPYIISIAGSVAVGKSTTARVLQALLSRWPEHRR
VELITTDGFLHPNQVLKERGLMKKKGFPESYDMHRLVKFVSDLKSGVPNVTAPVYSHLIY
DVIPDGDKTVVQPDILILEGLNVLQSGMDYPHDPHHVFVSDFVDFSIYVDAPEDLLQTWY
INRFLKFREGAFTDPDSYFHNYAKLTKEEAIKTAMTLWKEINWLNLKQNILPTRERASLI
LTKSANHAVEEVRLRK
References
External Links:
ResourceLink
Uniprot ID:P0A6I3
Uniprot Name:COAA_ECOLI
GenBank Gene ID:AP009048
Genebank Protein ID:21321911
PDB ID:1SQ5
Ecogene ID:EG10922
Ecocyc:EG10922
ColiBase:b3974
Kegg Gene:b3974
EchoBASE ID:EB0915
CCDB:COAA_ECOLI
BacMap:16131808
General Reference:
  • Blattner, F. R., Burland, V., Plunkett, G. 3rd, Sofia, H. J., Daniels, D. L. (1993). "Analysis of the Escherichia coli genome. IV. DNA sequence of the region from 89.2 to 92.8 minutes." Nucleic Acids Res 21:5408-5417. Pubmed: 8265357
  • Blattner, F. R., Plunkett, G. 3rd, Bloch, C. A., Perna, N. T., Burland, V., Riley, M., Collado-Vides, J., Glasner, J. D., Rode, C. K., Mayhew, G. F., Gregor, J., Davis, N. W., Kirkpatrick, H. A., Goeden, M. A., Rose, D. J., Mau, B., Shao, Y. (1997). "The complete genome sequence of Escherichia coli K-12." Science 277:1453-1462. Pubmed: 9278503
  • Flamm, J. A., Friesen, J. D., Otsuka, A. J. (1988). "The nucleotide sequence of the Escherichia coli rts gene." Gene 74:555-558. Pubmed: 3073109
  • Hayashi, K., Morooka, N., Yamamoto, Y., Fujita, K., Isono, K., Choi, S., Ohtsubo, E., Baba, T., Wanner, B. L., Mori, H., Horiuchi, T. (2006). "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Mol Syst Biol 2:2006.0007. Pubmed: 16738553
  • Song, W. J., Jackowski, S. (1992). "Cloning, sequencing, and expression of the pantothenate kinase (coaA) gene of Escherichia coli." J Bacteriol 174:6411-6417. Pubmed: 1328157
  • Song, W. J., Jackowski, S. (1992). "coaA and rts are allelic and located at kilobase 3532 on the Escherichia coli physical map." J Bacteriol 174:1705-1706. Pubmed: 1311303