D-methionine transport system permease protein metI (P31547)

Identification
Name:D-methionine transport system permease protein metI
Synonyms:Not Available
Gene Name:metI
Enzyme Class:Not Available
Biological Properties
General Function:Involved in transporter activity
Specific Function:Part of the binding-protein-dependent transport system for D-methionine and the toxic methionine analog alpha-methyl- methionine. Probably responsible for the translocation of the substrate across the membrane
Cellular Location:Cell inner membrane; Multi-pass membrane protein
SMPDB Pathways:
KEGG Pathways:
Transports:
Transport References:
  • Uniprot Consortium (2012). "Reorganizing the protein space at the Universal Protein Resource (UniProt)." Nucleic Acids Res 40:D71-D75. Pubmed: 22102590
SMPDB Reactions:
1.0Thumb+1.0Thumb+1.0Thumb → 1.0Adenosine diphosphate+1.0Thumb+1.0Thumb+1.0Thumb+1.0Thumb
1.0L-Methionine + 1.0Adenosine triphosphate + 1.0Water → 1.0Adenosine diphosphate + 1.0Phosphate + 1.0Hydrogen ion + 1.0L-Methionine + 1.0ADP
ReactionCard
1.0Thumb+1.0Thumb+1.0Thumb → 1.0Adenosine diphosphate+1.0Pyrophosphate+1.0Thumb+1.0Thumb+1.0Thumb
1.0L-Methionine + 1.0Adenosine triphosphate + 1.0Water → 1.0Adenosine diphosphate + 1.0Pyrophosphate + 1.0Hydrogen ion + 1.0L-Methionine + 1.0ADP
ReactionCard
EcoCyc Reactions:
1.0Thumb+1.0Thumb+1.0Thumb → 1.0Thumb+1.0Thumb+1.0Thumb+1.0Thumb
1.0Adenosine triphosphate + 1.0Water + 1.0L-Methionine → 1.0ADP + 1.0Hydrogen ion + 1.0L-Methionine + 1.0Phosphate
ReactionCard
1.0Thumb+1.0Thumb+1.0Thumb → 1.0Thumb+1.0Thumb+1.0Thumb+1.0Thumb
1.0Adenosine triphosphate + 1.0Water + 1.0D-Methionine → 1.0ADP + 1.0Hydrogen ion + 1.0D-Methionine + 1.0Phosphate
ReactionCard
Metabolites:
ECMDB IDNameView
ECMDB00538Adenosine triphosphateMetaboCard
ECMDB01341ADPMetaboCard
ECMDB21203D-MethionineMetaboCard
ECMDB21225Hydrogen ionMetaboCard
ECMDB00696L-MethionineMetaboCard
ECMDB01429PhosphateMetaboCard
ECMDB00494WaterMetaboCard
GO Classification:
Component
cell part
membrane
Function
transporter activity
Process
establishment of localization
transport
Gene Properties
Blattner:b0198
Gene OrientationCounterclockwise
Centisome Percentage:4.76
Left Sequence End220968
Right Sequence End221621
Gene Sequence:
>654 bp
ATGTCTGAGCCGATGATGTGGCTGCTGGTTCGTGGCGTATGGGAAACGCTGGCAATGACC
TTCGTATCCGGTTTTTTTGGCTTTGTGATTGGTCTGCCGGTTGGCGTTCTGCTTTATGTC
ACGCGTCCGGGGCAAATTATTGCTAACGCGAAGCTGTATCGTACCGTTTCTGCGATTGTG
AACATTTTCCGTTCCATCCCGTTCATTATCTTGCTTGTATGGATGATTCCGTTTACCCGC
GTTATTGTCGGTACATCGATTGGTTTGCAGGCAGCGATTGTTCCGTTAACCGTTGGTGCA
GCACCGTTTATTGCCCGTATGGTCGAGAACGCTCTGCTGGAGATCCCAACCGGGTTAATT
GAAGCTTCCCGCGCAATGGGTGCCACGCCGATGCAGATCGTCCGTAAGGTGCTGTTACCG
GAAGCGCTGCCGGGTCTGGTGAATGCGGCAACTATCACCCTGATTACCCTGGTCGGTTAT
TCCGCGATGGGTGGTGCAGTCGGTGCCGGTGGTTTAGGTCAGATTGGCTATCAGTATGGC
TACATCGGCTATAACGCGACGGTGATGAATACGGTACTGGTATTGCTGGTCATTCTGGTT
TATTTAATTCAGTTCGCAGGCGACCGCATCGTCCGGGCTGTCACTCGCAAGTAA
Protein Properties
Pfam Domain Function:
Protein Residues:217
Protein Molecular Weight:23256
Protein Theoretical pI:10
Signaling Regions:
  • None
Transmembrane Regions:
  • 20-40
  • 58-78
  • 81-101
  • 152-172
  • 186-206
Protein Sequence:
>D-methionine transport system permease protein metI
MSEPMMWLLVRGVWETLAMTFVSGFFGFVIGLPVGVLLYVTRPGQIIANAKLYRTVSAIV
NIFRSIPFIILLVWMIPFTRVIVGTSIGLQAAIVPLTVGAAPFIARMVENALLEIPTGLI
EASRAMGATPMQIVRKVLLPEALPGLVNAATITLITLVGYSAMGGAVGAGGLGQIGYQYG
YIGYNATVMNTVLVLLVILVYLIQFAGDRIVRAVTRK
References
External Links:
ResourceLink
Uniprot ID:P31547
Uniprot Name:METI_ECOLI
GenBank Gene ID:AP009048
Genebank Protein ID:4902941
Ecogene ID:EG11737
Ecocyc:EG11737
ColiBase:b0198
Kegg Gene:b0198
EchoBASE ID:EB1688
CCDB:METI_ECOLI
BacMap:16128191
General Reference:
  • Blattner, F. R., Plunkett, G. 3rd, Bloch, C. A., Perna, N. T., Burland, V., Riley, M., Collado-Vides, J., Glasner, J. D., Rode, C. K., Mayhew, G. F., Gregor, J., Davis, N. W., Kirkpatrick, H. A., Goeden, M. A., Rose, D. J., Mau, B., Shao, Y. (1997). "The complete genome sequence of Escherichia coli K-12." Science 277:1453-1462. Pubmed: 9278503
  • Daley, D. O., Rapp, M., Granseth, E., Melen, K., Drew, D., von Heijne, G. (2005). "Global topology analysis of the Escherichia coli inner membrane proteome." Science 308:1321-1323. Pubmed: 15919996
  • Gal, J., Szvetnik, A., Schnell, R., Kalman, M. (2002). "The metD D-methionine transporter locus of Escherichia coli is an ABC transporter gene cluster." J Bacteriol 184:4930-4932. Pubmed: 12169620
  • Hayashi, K., Morooka, N., Yamamoto, Y., Fujita, K., Isono, K., Choi, S., Ohtsubo, E., Baba, T., Wanner, B. L., Mori, H., Horiuchi, T. (2006). "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Mol Syst Biol 2:2006.0007. Pubmed: 16738553