Lysine-arginine-ornithine-binding periplasmic protein (P09551)

Identification
Name:Lysine-arginine-ornithine-binding periplasmic protein
Synonyms:
  • LAO-binding protein
Gene Name:argT
Enzyme Class:Not Available
Biological Properties
General Function:Involved in transporter activity
Specific Function:This periplasmic binding protein is involved in an arginine transport system. ArgT and histidine-binding protein J (hisJ) interact with a common membrane-bound receptor, hisP
Cellular Location:Periplasm
SMPDB Pathways:
KEGG Pathways:
SMPDB Reactions:
1.0L-Lysine+1.0Thumb+1.0Thumb+1.0Thumb → 1.0Adenosine diphosphate+1.0Thumb+1.0Thumb+1.0L-Lysine+1.0Thumb
1.0L-Lysine + 1.0Adenosine triphosphate + 1.0Water + 1.0L-Lysine → 1.0Adenosine diphosphate + 1.0Phosphate + 1.0Hydrogen ion + 1.0L-Lysine + 1.0ADP
ReactionCard
EcoCyc Reactions:
1.0Thumb+1.0Thumb+1.0Thumb → 1.0Thumb+1.0Thumb+1.0Thumb+1.0Thumb
1.0Adenosine triphosphate + 1.0Water + 1.0L-Arginine → 1.0ADP + 1.0L-Arginine + 1.0Hydrogen ion + 1.0Phosphate
ReactionCard
1.0Thumb+1.0Thumb+1.0Thumb → 1.0Thumb+1.0Thumb+1.0Thumb+1.0Thumb
1.0Adenosine triphosphate + 1.0Water + 1.0L-Lysine → 1.0ADP + 1.0Hydrogen ion + 1.0L-Lysine + 1.0Phosphate
ReactionCard
1.0Thumb+1.0Thumb+1.0Thumb → 1.0Thumb+1.0Thumb+1.0Thumb+1.0Thumb
1.0Adenosine triphosphate + 1.0Water + 1.0Ornithine → 1.0ADP + 1.0Hydrogen ion + 1.0Ornithine + 1.0Phosphate
ReactionCard
Metabolites:
ECMDB IDNameView
ECMDB00538Adenosine triphosphateMetaboCard
ECMDB01341ADPMetaboCard
ECMDB21225Hydrogen ionMetaboCard
ECMDB00517L-ArginineMetaboCard
ECMDB00182L-LysineMetaboCard
ECMDB00214OrnithineMetaboCard
ECMDB01429PhosphateMetaboCard
ECMDB00494WaterMetaboCard
GO Classification:
Component
cell part
outer membrane-bounded periplasmic space
periplasmic space
Function
transporter activity
Process
establishment of localization
transport
Gene Properties
Blattner:b2310
Gene OrientationCounterclockwise
Centisome Percentage:52.27
Left Sequence End2425031
Right Sequence End2425813
Gene Sequence:
>783 bp
ATGATCAGTTCATTATGGATCGCCAAAACGGGCCTTGACGCCCAGCAAACCAATATGGAC
GTCATTGCCAACAACCTGGCAAACGTCAGTACTAACGGTTTTAAGCGTCAGCGCGCGGTG
TTTGAAGATCTGCTTTATCAAACCATTCGCCAGCCGGGGGCACAGTCTTCCGAACAAACC
ACCTTACCCTCCGGATTACAAATCGGCACGGGGGTACGCCCGGTCGCCACTGAACGCTTA
CACAGCCAGGGAAACCTGTCGCAGACCAACAACAGCAAAGATGTCGCGATTAAAGGGCAG
GGCTTTTTCCAGGTGATGTTGCCAGATGGTTCATCAGCCTATACCCGTGACGGCTCTTTC
CAGGTGGATCAGAACGGGCAGCTGGTGACGGCTGGTGGTTTTCAGGTGCAGCCAGCGATC
ACCATTCCGGCGAATGCGTTAAGTATCACCATCGGTCGTGATGGCGTGGTCAGCGTAACC
CAACAAGGCCAGGCAGCTCCGGTTCAGGTTGGGCAGCTCAATCTCACCACCTTTATGAAT
GACACCGGGCTGGAGAGCATTGGCGAAAACCTCTACACCGAAACGCAATCCTCTGGTGCA
CCGAACGAAAGCACGCCGGGCCTGAACGGCGCGGGACTGCTGTATCAAGGGTATGTTGAA
ACGTCTAACGTCAACGTGGCGGAAGAACTGGTCAATATGATTCAGGTGCAACGCGCTTAC
GAAATCAACAGTAAAGCGGTGTCCACCACCGATCAGATGCTGCAAAAACTGACGCAACTC
TAA
Protein Properties
Pfam Domain Function:
Protein Residues:260
Protein Molecular Weight:27991
Protein Theoretical pI:5
PDB File:1LAH
Signaling Regions:
  • 1-22
Transmembrane Regions:
  • None
Protein Sequence:
>Lysine-arginine-ornithine-binding periplasmic protein
MKKSILALSLLVGLSTAASSYAALPETVRIGTDTTYAPFSSKDAKGDFVGFDIDLGNEMC
KRMQVKCTWVASDFDALIPSLKAKKIDAIISSLSITDKRQQEIAFSDKLYAADSRLIAAK
GSPIQPTLDSLKGKHVGVLQGSTQEAYANETWRSKGVDVVAYANQDLVYSDLAAGRLDAA
LQDEVAASEGFLKQPAGKDFAFAGSSVKDKKYFGDGTGVGLRKDDAELTAAFNKALGELR
QDGTYDKMAKKYFDFNVYGD
References
External Links:
ResourceLink
Uniprot ID:P09551
Uniprot Name:ARGT_ECOLI
GenBank Gene ID:AP009048
Genebank Protein ID:4062656
PDB ID:1LAH
Ecogene ID:EG10072
Ecocyc:EG10072
ColiBase:b2310
Kegg Gene:b2310
EchoBASE ID:EB0070
CCDB:ARGT_ECOLI
BacMap:16130245
General Reference:
  • Blattner, F. R., Plunkett, G. 3rd, Bloch, C. A., Perna, N. T., Burland, V., Riley, M., Collado-Vides, J., Glasner, J. D., Rode, C. K., Mayhew, G. F., Gregor, J., Davis, N. W., Kirkpatrick, H. A., Goeden, M. A., Rose, D. J., Mau, B., Shao, Y. (1997). "The complete genome sequence of Escherichia coli K-12." Science 277:1453-1462. Pubmed: 9278503
  • Hayashi, K., Morooka, N., Yamamoto, Y., Fujita, K., Isono, K., Choi, S., Ohtsubo, E., Baba, T., Wanner, B. L., Mori, H., Horiuchi, T. (2006). "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Mol Syst Biol 2:2006.0007. Pubmed: 16738553
  • Link, A. J., Robison, K., Church, G. M. (1997). "Comparing the predicted and observed properties of proteins encoded in the genome of Escherichia coli K-12." Electrophoresis 18:1259-1313. Pubmed: 9298646
  • Nonet, M. L., Marvel, C. C., Tolan, D. R. (1987). "The hisT-purF region of the Escherichia coli K-12 chromosome. Identification of additional genes of the hisT and purF operons." J Biol Chem 262:12209-12217. Pubmed: 3040734
  • Yamamoto, Y., Aiba, H., Baba, T., Hayashi, K., Inada, T., Isono, K., Itoh, T., Kimura, S., Kitagawa, M., Makino, K., Miki, T., Mitsuhashi, N., Mizobuchi, K., Mori, H., Nakade, S., Nakamura, Y., Nashimoto, H., Oshima, T., Oyama, S., Saito, N., Sampei, G., Satoh, Y., Sivasundaram, S., Tagami, H., Horiuchi, T., et, a. l. .. (1997). "Construction of a contiguous 874-kb sequence of the Escherichia coli -K12 genome corresponding to 50.0-68.8 min on the linkage map and analysis of its sequence features." DNA Res 4:91-113. Pubmed: 9205837