Heme exporter protein B (P0ABL8)

Identification
Name:Heme exporter protein B
Synonyms:
  • Cytochrome c-type biogenesis protein CcmB
Gene Name:ccmB
Enzyme Class:Not Available
Biological Properties
General Function:Involved in heme transporter activity
Specific Function:Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
Cellular Location:Cell inner membrane; Multi-pass membrane protein
SMPDB Pathways:Not Available
KEGG Pathways:
EcoCyc Reactions:
1.0Thumb+1.0Thumb+1.0Thumb → 1.0Thumb+1.0Thumb+1.0Thumb+1.0Thumb
1.0Adenosine triphosphate + 1.0Water + 1.0Heme → 1.0ADP + 1.0Hydrogen ion + 1.0Phosphate + 1.0Heme
ReactionCard
Metabolites:
ECMDB IDNameView
ECMDB00538Adenosine triphosphateMetaboCard
ECMDB01341ADPMetaboCard
ECMDB03178HemeMetaboCard
ECMDB21225Hydrogen ionMetaboCard
ECMDB01429PhosphateMetaboCard
ECMDB00494WaterMetaboCard
GO Classification:
Component
cell part
membrane
Function
cofactor transporter activity
heme transporter activity
transporter activity
Process
cellular component assembly
cellular component organization
cellular component organization or biogenesis
cellular protein complex assembly
cofactor transport
cytochrome complex assembly
establishment of localization
heme transport
macromolecular complex assembly
protein complex assembly
transport
Gene Properties
Blattner:b2200
Gene OrientationCounterclockwise
Centisome Percentage:49.45
Left Sequence End2294384
Right Sequence End2295046
Gene Sequence:
>663 bp
ATGGAACTGTATCTGGATACTTCAGACGTTGTTGCGGTGAAGGCGCTGTCACGTATTTTT
CCGCTGGCGGGTGTGACCACTAACCCAAGCATTATCGCCGCGGGTAAAAAACCGCTGGAT
GTTGTGCTTCCGCAACTTCATGAAGCGATGGGCGGTCAGGGGCGTCTGTTTGCCCAGGTA
ATGGCTACCACTGCCGAAGGGATGGTTAATGACGCGCTTAAGCTGCGTTCTATTATTGCG
GATATCGTGGTGAAAGTTCCGGTGACCGCCGAGGGGCTGGCAGCTATTAAGATGTTAAAA
GCGGAAGGGATTCCGACGCTGGGAACCGCGGTATATGGCGCAGCACAAGGGCTGCTGTCG
GCGCTGGCAGGTGCGGAATATGTTGCGCCTTACGTTAATCGTATTGATGCTCAGGGCGGT
AGCGGCATTCAGACTGTGACCGACTTACACCAGTTATTGAAAATGCATGCGCCGCAGGCG
AAAGTGCTGGCAGCGAGTTTCAAAACCCCGCGTCAGGCGCTGGACTGCTTACTGGCAGGA
TGTGAATCAATTACTCTGCCACTGGATGTGGCACAACAGATGATTAGCTATCCGGCGGTT
GATGCCGCTGTGGCGAAGTTTGAGCAGGACTGGCAGGGAGCGTTTGGCAGAACGTCGATT
TAA
Protein Properties
Pfam Domain Function:
Protein Residues:220
Protein Molecular Weight:23618
Protein Theoretical pI:8
Signaling Regions:
  • None
Transmembrane Regions:
  • 21-41
  • 45-65
  • 101-121
  • 128-148
  • 159-179
  • 193-213
Protein Sequence:
>Heme exporter protein B
MMFWRIFRLELRVAFRHSAEIANPLWFFLIVITLFPLSIGPEPQLLARIAPGIIWVAALL
SSLLALERLFRDDLQDGSLEQLMLLPLPLPAVVLAKVMAHWMVTGLPLLILSPLVAMLLG
MDVYGWQVMALTLLLGTPTLGFLGAPGVALTVGLKRGGVLLSILVLPLTIPLLIFATAAM
DAASMHLPVDGYLAILGALLAGTATLSPFATAAALRISIQ
References
External Links:
ResourceLink
Uniprot ID:P0ABL8
Uniprot Name:CCMB_ECOLI
GenBank Gene ID:AP009048
Genebank Protein ID:85674771
Ecogene ID:EG12058
Ecocyc:EG12058
ColiBase:b2200
Kegg Gene:b2200
EchoBASE ID:EB1988
CCDB:CCMB_ECOLI
BacMap:16130137
General Reference:
  • Blattner, F. R., Plunkett, G. 3rd, Bloch, C. A., Perna, N. T., Burland, V., Riley, M., Collado-Vides, J., Glasner, J. D., Rode, C. K., Mayhew, G. F., Gregor, J., Davis, N. W., Kirkpatrick, H. A., Goeden, M. A., Rose, D. J., Mau, B., Shao, Y. (1997). "The complete genome sequence of Escherichia coli K-12." Science 277:1453-1462. Pubmed: 9278503
  • Daley, D. O., Rapp, M., Granseth, E., Melen, K., Drew, D., von Heijne, G. (2005). "Global topology analysis of the Escherichia coli inner membrane proteome." Science 308:1321-1323. Pubmed: 15919996
  • Hayashi, K., Morooka, N., Yamamoto, Y., Fujita, K., Isono, K., Choi, S., Ohtsubo, E., Baba, T., Wanner, B. L., Mori, H., Horiuchi, T. (2006). "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Mol Syst Biol 2:2006.0007. Pubmed: 16738553
  • Thony-Meyer, L., Fischer, F., Kunzler, P., Ritz, D., Hennecke, H. (1995). "Escherichia coli genes required for cytochrome c maturation." J Bacteriol 177:4321-4326. Pubmed: 7635817