Ferrous iron transport protein B (P33650)

Identification
Name:Ferrous iron transport protein B
Synonyms:Not Available
Gene Name:feoB
Enzyme Class:Not Available
Biological Properties
General Function:Involved in GTP binding
Specific Function:GTP-driven Fe(2+) uptake system
Cellular Location:Cell inner membrane; Multi-pass membrane protein
SMPDB Pathways:Not Available
KEGG Pathways:Not Available
Transports:
Transport References:Not Available
Complex Reactions:
1.0Thumb+1.0Thumb+1.0Thumb → 1.0Thumb+1.0Thumb+1.0Thumb+1.0Thumb
1.0Adenosine triphosphate + 1.0Water + 1.0Iron → 1.0ADP + 1.0Iron + 1.0Hydrogen ion + 1.0Phosphate
ReactionCard
Metabolites:
ECMDB IDNameView
ECMDB00538Adenosine triphosphateMetaboCard
ECMDB01341ADPMetaboCard
ECMDB21225Hydrogen ionMetaboCard
ECMDB00692IronMetaboCard
ECMDB01429PhosphateMetaboCard
ECMDB00494WaterMetaboCard
GO Classification:
Component
cell part
integral to membrane
intrinsic to membrane
membrane part
Function
binding
cation transmembrane transporter activity
di-, tri-valent inorganic cation transmembrane transporter activity
ferrous iron transmembrane transporter activity
GTP binding
guanyl nucleotide binding
guanyl ribonucleotide binding
inorganic cation transmembrane transporter activity
ion transmembrane transporter activity
iron ion transmembrane transporter activity
nucleoside binding
nucleotide binding
purine nucleotide binding
substrate-specific transmembrane transporter activity
transmembrane transporter activity
transporter activity
Process
cation transport
establishment of localization
ferrous iron transport
ion transport
iron ion transport
metal ion transport
transition metal ion transport
transport
Gene Properties
Blattner:b3409
Gene OrientationClockwise
Centisome Percentage:76.26
Left Sequence End3538429
Right Sequence End3540750
Gene Sequence:
>2322 bp
ATGAAAAAATTAACCATTGGCTTAATTGGTAATCCAAATTCTGGCAAGACAACGTTATTT
AACCAGCTCACTGGCTCACGTCAGCGTGTAGGTAACTGGGCTGGCGTTACCGTCGAACGT
AAAGAAGGGCAATTCTCCACCACCGATCATCAGGTCACGCTGGTGGACCTGCCCGGCACC
TATTCTCTGACCACCATCTCATCGCAGACCTCGCTCGATGAGCAAATCGCCTGTCACTAC
ATTTTGAGTGGCGACGCCGACCTGCTGATTAACGTGGTGGATGCGTCTAACCTTGAGCGT
AACCTGTACCTGACGCTACAACTGCTGGAACTCGGCATTCCCTGCATTGTGGCACTGAAC
ATGCTCGACATTGCCGAGAAGCAAAATATTCGTATTGAAATTGATGCTCTGTCGGCGCGT
CTGGGCTGTCCGGTGATCCCGCTGGTTTCAACCCGTGGTCGCGGTATTGAAGCGCTCAAG
CTGGCGATTGATCGCTATAAAGCTAACGAGAATGTGGAACTGGTGCATTACGCACAGCCG
CTGCTCAACGAAGCAGATTCACTGGCAAAAGTGATGCCTTCCGACATCCCGCTGAAACAA
CGTCGCTGGCTGGGCCTGCAAATGCTGGAAGGCGATATCTACAGCCGCGCCTACGCCGGT
GAAGCGTCGCAGCATCTGGATGCCGCCCTCGCCCGTCTGCGTAATGAGATGGACGATCCG
GCGCTGCACATTGCCGATGCGCGTTACCAGTGCATTGCTGCCATCTGTGATGTGGTAAGC
AACACCCTGACGGCAGAACCCAGCCGTTTCACCACTGCGGTAGATAAAATCGTGCTCAAC
CGTTTCCTCGGTCTGCCGATTTTCCTCTTTGTGATGTACCTGATGTTCCTGCTGGCTATC
AACATCGGCGGGGCGTTACAGCCGCTGTTTGACGTCGGCTCCGTGGCGCTATTTGTGCAT
GGTATTCAATGGATTGGCTACACGCTCCACTTCCCGGACTGGCTGACTATCTTCCTCGCC
CAGGGCCTGGGTGGCGGCATTAACACCGTGCTGCCACTGGTGCCGCAGATTGGCATGATG
TACCTGTTCCTCTCCTTCCTTGAGGACTCCGGGTATATGGCGCGTGCGGCGTTTGTGATG
GACCGTCTGATGCAGGCGCTGGGCTTGCCGGGGAAATCCTTTGTGCCGCTGATCGTCGGT
TTCGGTTGTAACGTACCGTCGGTAATGGGTGCACGTACGCTTGATGCACCGCGTGAACGT
CTGATGACCATCATGATGGCACCGTTTATGTCCTGCGGCGCGCGTCTGGCTATCTTCGCA
GTATTCGCGGCTGCCTTCTTCGGGCAGAACGGTGCGCTGGCGGTCTTCTCGCTGTATATG
CTGGGTATTGTGATGGCGGTGCTGACTGGCCTGATGCTCAAGTACACCATCATGCGCGGT
GAAGCGACGCCGTTTGTCATGGAGTTGCCGGTCTATCATGTACCACACGTTAAAAGCCTG
ATTATCCAGACCTGGCAGCGTCTGAAAGGCTTCGTTCTGCGTGCTGGTAAAGTGATCATC
ATCGTCAGCATTTTCCTGAGCGCTTTCAACAGCTTCTCGCTGAGCGGGAAAATCGTCGAT
AACATCAACGACTCGGCGCTGGCGTCCGTCAGCCGGGTGATCACCCCGGTCTTCAAGCCA
ATTGGCGTGCATGAAGATAACTGGCAGGCAACGGTTGGCCTGTTTACAGGTGCCATGGCG
AAAGAAGTGGTAGTGGGTACGCTCAACACCCTCTACACCGCAGAAAATATTCAGGACGAA
GAGTTCAATCCGGCAGAATTTAACCTCGGTGAAGAGCTGTTCAGTGCGATAGATGAAACC
TGGCAGAGCCTGAAAGACACCTTCAGCCTTAGCGTACTGATGAACCCCATTGAAGCCAGC
AAAGGCGACGGCGAAATGGGTACCGGGGCGATGGGCGTGATGGATCAGAAATTCGGTAGC
GCAGCAGCAGCTTACAGCTACCTGATTTTCGTCCTGCTGTATGTACCATGTATCTCGGTG
ATGGGGGCTATCGCCCGTGAATCAAGCCGTGGCTGGATGGGCTTCTCCATCCTGTGGGGG
CTGAATATCGCTTACTCACTGGCAACATTGTTCTATCAGGTCGCCAGCTACAGTCAGCAT
CCAACTTACAGCCTGGTGTGCATTCTGGCGGTTATCCTGTTTAACATCGTGGTTATCGGT
CTGCTGCGCCGCGCGCGTAGCCGGGTGGATATCGAACTGCTGGCAACCCGCAAGTCGGTA
AGCAGTTGCTGCGCAGCCAGCACCACCGGTGATTGCCATTAA
Protein Properties
Pfam Domain Function:
Protein Residues:773
Protein Molecular Weight:84473
Protein Theoretical pI:6
Signaling Regions:
  • None
Transmembrane Regions:
  • 102-122
  • 282-302
  • 309-329
  • 334-354
  • 383-403
  • 427-447
  • 453-473
  • 482-502
  • 518-538
  • 568-588
  • 664-684
  • 691-711
  • 722-742
Protein Sequence:
>Ferrous iron transport protein B
MKKLTIGLIGNPNSGKTTLFNQLTGSRQRVGNWAGVTVERKEGQFSTTDHQVTLVDLPGT
YSLTTISSQTSLDEQIACHYILSGDADLLINVVDASNLERNLYLTLQLLELGIPCIVALN
MLDIAEKQNIRIEIDALSARLGCPVIPLVSTRGRGIEALKLAIDRYKANENVELVHYAQP
LLNEADSLAKVMPSDIPLKQRRWLGLQMLEGDIYSRAYAGEASQHLDAALARLRNEMDDP
ALHIADARYQCIAAICDVVSNTLTAEPSRFTTAVDKIVLNRFLGLPIFLFVMYLMFLLAI
NIGGALQPLFDVGSVALFVHGIQWIGYTLHFPDWLTIFLAQGLGGGINTVLPLVPQIGMM
YLFLSFLEDSGYMARAAFVMDRLMQALGLPGKSFVPLIVGFGCNVPSVMGARTLDAPRER
LMTIMMAPFMSCGARLAIFAVFAAAFFGQNGALAVFSLYMLGIVMAVLTGLMLKYTIMRG
EATPFVMELPVYHVPHVKSLIIQTWQRLKGFVLRAGKVIIIVSIFLSAFNSFSLSGKIVD
NINDSALASVSRVITPVFKPIGVHEDNWQATVGLFTGAMAKEVVVGTLNTLYTAENIQDE
EFNPAEFNLGEELFSAIDETWQSLKDTFSLSVLMNPIEASKGDGEMGTGAMGVMDQKFGS
AAAAYSYLIFVLLYVPCISVMGAIARESSRGWMGFSILWGLNIAYSLATLFYQVASYSQH
PTYSLVCILAVILFNIVVIGLLRRARSRVDIELLATRKSVSSCCAASTTGDCH
References
External Links:
ResourceLink
Uniprot ID:P33650
Uniprot Name:FEOB_ECOLI
GenBank Gene ID:AP009048
Genebank Protein ID:85676632
Ecogene ID:EG12102
Ecocyc:EG12102
ColiBase:b3409
Kegg Gene:b3409
EchoBASE ID:EB2026
CCDB:FEOB_ECOLI
BacMap:16131285
General Reference:
  • Blattner, F. R., Plunkett, G. 3rd, Bloch, C. A., Perna, N. T., Burland, V., Riley, M., Collado-Vides, J., Glasner, J. D., Rode, C. K., Mayhew, G. F., Gregor, J., Davis, N. W., Kirkpatrick, H. A., Goeden, M. A., Rose, D. J., Mau, B., Shao, Y. (1997). "The complete genome sequence of Escherichia coli K-12." Science 277:1453-1462. Pubmed: 9278503
  • Daley, D. O., Rapp, M., Granseth, E., Melen, K., Drew, D., von Heijne, G. (2005). "Global topology analysis of the Escherichia coli inner membrane proteome." Science 308:1321-1323. Pubmed: 15919996
  • Hayashi, K., Morooka, N., Yamamoto, Y., Fujita, K., Isono, K., Choi, S., Ohtsubo, E., Baba, T., Wanner, B. L., Mori, H., Horiuchi, T. (2006). "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Mol Syst Biol 2:2006.0007. Pubmed: 16738553
  • Kammler, M., Schon, C., Hantke, K. (1993). "Characterization of the ferrous iron uptake system of Escherichia coli." J Bacteriol 175:6212-6219. Pubmed: 8407793
  • Lenski, R. E., Winkworth, C. L., Riley, M. A. (2003). "Rates of DNA sequence evolution in experimental populations of Escherichia coli during 20,000 generations." J Mol Evol 56:498-508. Pubmed: 12664169
  • Marlovits, T. C., Haase, W., Herrmann, C., Aller, S. G., Unger, V. M. (2002). "The membrane protein FeoB contains an intramolecular G protein essential for Fe(II) uptake in bacteria." Proc Natl Acad Sci U S A 99:16243-16248. Pubmed: 12446835