ECMDB

Identification

Name:

Taurine import ATP-binding protein TauB

Synonyms:

Not Available

Gene Name:

tauB

Enzyme Class:

3.6.3.36

Biological Properties

General Function:

Involved in nucleotide binding

Specific Function:

Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system

Cellular Location:

Cell inner membrane; Peripheral membrane protein

SMPDB Pathways:

Sulfur metabolism PW000922
Taurine Metabolism PW000774
Taurine Metabolism I PW001028
inner membrane transport PW000786
sulfur metabolism (butanesulfonate) PW000923
sulfur metabolism (ethanesulfonate) PW000925
sulfur metabolism (isethionate) PW000926
sulfur metabolism (methanesulfonate) PW000927
sulfur metabolism (propanesulfonate) PW000924

KEGG Pathways:

Sulfur metabolism ec00920

Transports:

Taurine

Transport References:

Not Available

SMPDB Reactions:

1.0

→

1.0

1.0Adenosine diphosphate

1.0

1.0Taurine + 1.0Adenosine triphosphate + 1.0Water → 1.0Taurine + 1.0Adenosine diphosphate + 1.0Phosphate + 1.0Hydrogen ion + 1.0ADP
ReactionCard

EcoCyc Reactions:

1.0

→

1.0

1.0Adenosine triphosphate + 1.0Water + 1.0Taurine → 1.0ADP + 1.0Hydrogen ion + 1.0Phosphate + 1.0Taurine
ReactionCard

Complex Reactions:

1.0

→

1.0

1.0Adenosine triphosphate + 1.0Water + 1.0Isethionic acid → 1.0ADP + 1.0Hydrogen ion + 1.0Isethionic acid + 1.0Phosphate
ReactionCard

1.0

→

1.0

1.0Adenosine triphosphate + 1.0Water + 1.0Butanesulfonate → 1.0ADP + 1.0Butanesulfonate + 1.0Hydrogen ion + 1.0Phosphate
ReactionCard

1.0

→

1.0

1.0Adenosine triphosphate + 1.0Water + 1.0Taurine → 1.0ADP + 1.0Inorganic phosphate + 1.0Taurine
ReactionCard

Metabolites:

ECMDB ID	Name	View
ECMDB00538	Adenosine triphosphate	MetaboCard
ECMDB01341	ADP	MetaboCard
ECMDB21313	Butanesulfonate	MetaboCard
ECMDB21225	Hydrogen ion	MetaboCard
ECMDB21380	Inorganic phosphate	MetaboCard
ECMDB21233	Isethionic acid	MetaboCard
ECMDB01429	Phosphate	MetaboCard
ECMDB00251	Taurine	MetaboCard
ECMDB00494	Water	MetaboCard

GO Classification:

Component
cell part
membrane
Function
active transmembrane transporter activity
adenyl nucleotide binding
adenyl ribonucleotide binding
amine transmembrane transporter activity
ATP binding
ATPase activity
binding
catalytic activity
hydrolase activity
hydrolase activity, acting on acid anhydrides
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
nucleoside binding
nucleoside-triphosphatase activity
nucleotide binding
purine nucleoside binding
pyrophosphatase activity
taurine transmembrane transporter activity
taurine-transporting ATPase activity
transmembrane transporter activity
transporter activity
Process
carboxylic acid transport
establishment of localization
monocarboxylic acid transport
organic acid transport
taurine transport
transport

Gene Properties

Blattner:

b0366

Gene Orientation

Clockwise

Centisome Percentage:

8.31

Left Sequence End

385431

Right Sequence End

386198

Gene Sequence:

>768 bp
ATGTGCGAATTGCTCGGGATGAGCGCCAACGTCCCTACCGATATCTGCTTTAGTTTCACC
GGGCTTGTACAGCGTGGTGGTGGAACCGGGCCACATAAAGATGGCTGGGGCATTACCTTT
TACGAAGGTAAAGGCTGTCGCACATTTAAAGATCCACAACCCAGCTTTAATTCCCCCATC
GCCAAACTTGTCCAGGACTACCCGATAAAATCCTGTTCGGTGGTGGCTCATATTCGCCAG
GCTAATCGGGGCGAGGTGGCGCTGGAAAATACTCACCCATTTACCCGCGAGTTATGGGGG
CGTAACTGGACTTATGCCCATAACGGACAACTGACGGGCTACAAATCACTGGAAACCGGC
AACTTCCGCCCGGTAGGCGAAACCGACAGCGAAAAAGCCTTCTGCTGGCTCCTGCATAAA
TTAACGCAGCGTTACCCGCGCACACCGGGCAACATGGCGGCGGTATTTAAATATATCGCC
TCACTGGCGGATGAACTGCGGCAGAAGGGCGTTTTCAACATGCTGCTTTCGGACGGGCGC
TATGTAATGGCGTATTGCTCGACTAATTTACACTGGATCACCCGCCGCGCGCCGTTTGGC
GTGGCAACGTTGCTGGATCAGGATGTGGAAATCGACTTCAGCTCGCAGACCACACCGAAT
GATGTGGTCACGGTGATTGCAACACAGCCGCTGACGGGCAATGAAACCTGGCAAAAGATT
ATGCCAGGCGAATGGCGCTTATTTTGCCTCGGGGAGCGTGTAGTTTGA

Protein Properties

Pfam Domain Function:

ABC_tran (PF00005 )

Protein Residues:

255

Protein Molecular Weight:

28297

Protein Theoretical pI:

Signaling Regions:

None

Transmembrane Regions:

None

Protein Sequence:

>Taurine import ATP-binding protein TauB
MLQISHLYADYGGKPALEDINLTLESGELLVVLGPSGCGKTTLLNLIAGFVPYQHGSIQL
AGKRIEGPGAERGVVFQNEGLLPWRNVQDNVAFGLQLAGIEKMQRLEIAHQMLKKVGLEG
AEKRYIWQLSGGQRQRVGIARALAANPQLLLLDEPFGALDAFTRDQMQTLLLKLWQETGK
QVLLITHDIEEAVFMATELVLLSSGPGRVLERLPLNFARRFVAGESSRSIKSDPQFIAMR
EYVLSRVFEQREAFS

References

External Links:

Resource	Link
Uniprot ID:	Q47538
Uniprot Name:	TAUB_ECOLI
GenBank Gene ID:	AP009048
Genebank Protein ID:	4902959
Ecogene ID:	EG13299
Ecocyc:	EG13299
ColiBase:	b0366
Kegg Gene:	b0366
EchoBASE ID:	EB3084
CCDB:	TAUB_ECOLI
BacMap:	16128351

General Reference:

Blattner, F. R., Plunkett, G. 3rd, Bloch, C. A., Perna, N. T., Burland, V., Riley, M., Collado-Vides, J., Glasner, J. D., Rode, C. K., Mayhew, G. F., Gregor, J., Davis, N. W., Kirkpatrick, H. A., Goeden, M. A., Rose, D. J., Mau, B., Shao, Y. (1997). "The complete genome sequence of Escherichia coli K-12." Science 277:1453-1462. Pubmed: 9278503
Eichhorn, E., van der Ploeg, J. R., Leisinger, T. (2000). "Deletion analysis of the Escherichia coli taurine and alkanesulfonate transport systems." J Bacteriol 182:2687-2695. Pubmed: 10781534
Hayashi, K., Morooka, N., Yamamoto, Y., Fujita, K., Isono, K., Choi, S., Ohtsubo, E., Baba, T., Wanner, B. L., Mori, H., Horiuchi, T. (2006). "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Mol Syst Biol 2:2006.0007. Pubmed: 16738553
van der Ploeg, J. R., Weiss, M. A., Saller, E., Nashimoto, H., Saito, N., Kertesz, M. A., Leisinger, T. (1996). "Identification of sulfate starvation-regulated genes in Escherichia coli: a gene cluster involved in the utilization of taurine as a sulfur source." J Bacteriol 178:5438-5446. Pubmed: 8808933

Taurine import ATP-binding protein TauB (Q47538)