Ribose import ATP-binding protein RbsA (P04983)

Identification
Name:Ribose import ATP-binding protein RbsA
Synonyms:Not Available
Gene Name:rbsA
Enzyme Class:
Biological Properties
General Function:Involved in nucleotide binding
Specific Function:Part of the ABC transporter complex RbsABCD involved in ribose import. Responsible for energy coupling to the transport system
Cellular Location:Cell inner membrane; Peripheral membrane protein
SMPDB Pathways:
KEGG Pathways:
SMPDB Reactions:
1.0Thumb+1.0Thumb+1.0Thumb → 1.0Thumb+1.0Thumb+1.0Thumb
1.0beta-D-Ribopyranose + 1.0Adenosine triphosphate + 1.0Water → 1.0ADP + 1.0Phosphate + 1.0Hydrogen ion
ReactionCard
Complex Reactions:
1.0Thumb+1.0Thumb+1.0Thumb → 1.0Thumb+1.0Thumb+1.0Thumb+1.0Thumb
1.0Adenosine triphosphate + 1.0Water + 1.0Ribose → 1.0ADP + 1.0Hydrogen ion + 1.0Phosphate + 1.0Ribose
ReactionCard
Metabolites:
ECMDB IDNameView
ECMDB00538Adenosine triphosphateMetaboCard
ECMDB01341ADPMetaboCard
ECMDB20344beta-D-RibopyranoseMetaboCard
ECMDB21225Hydrogen ionMetaboCard
ECMDB21380Inorganic phosphateMetaboCard
ECMDB01429PhosphateMetaboCard
ECMDB00283RiboseMetaboCard
ECMDB00494WaterMetaboCard
GO Classification:
Component
cell part
membrane
Function
adenyl nucleotide binding
adenyl ribonucleotide binding
ATP binding
ATPase activity
binding
carbohydrate transmembrane transporter activity
carbohydrate-transporting ATPase activity
catalytic activity
hydrolase activity
hydrolase activity, acting on acid anhydrides
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
nucleoside binding
nucleoside-triphosphatase activity
nucleotide binding
purine nucleoside binding
pyrophosphatase activity
substrate-specific transmembrane transporter activity
transmembrane transporter activity
transporter activity
Process
carbohydrate transport
establishment of localization
transport
Gene Properties
Blattner:b3749
Gene OrientationClockwise
Centisome Percentage:84.74
Left Sequence End3931801
Right Sequence End3933306
Gene Sequence:
>1506 bp
ATGGAAGCATTACTTCAGCTTAAAGGCATCGATAAAGCCTTCCCGGGCGTAAAAGCCCTC
TCGGGCGCAGCGTTAAATGTCTATCCGGGCCGCGTGATGGCGCTGGTGGGCGAAAACGGC
GCGGGTAAATCCACCATGATGAAAGTGCTTACTGGCATCTATACTCGCGATGCCGGTACG
CTTTTATGGCTGGGGAAAGAAACGACATTTACCGGGCCAAAATCTTCCCAGGAAGCCGGG
ATTGGGATTATCCATCAGGAACTGAACCTGATCCCGCAGTTGACCATTGCCGAAAACATT
TTCCTCGGTCGTGAGTTTGTTAATCGCTTTGGCAAAATTGACTGGAAAACCATGTATGCC
GAAGCGGATAAATTGCTGGCTAAACTTAACCTGCGCTTTAAAAGCGACAAGCTGGTGGGC
GATCTTTCCATCGGTGACCAGCAAATGGTTGAAATCGCCAAAGTGCTGAGCTTTGAGTCG
AAAGTCATCATTATGGATGAACCGACCGATGCGCTGACCGATACCGAAACCGAATCCCTG
TTCCGCGTCATCCGCGAGCTGAAATCGCAAGGCCGCGGTATTGTCTATATCTCCCACCGC
ATGAAAGAAATCTTCGAGATTTGCGATGACGTTACCGTTTTTCGTGATGGGCAATTTATT
GCTGAGCGCGAAGTGGCATCACTGACCGAAGATTCGCTGATTGAGATGATGGTGGGTCGC
AAGCTGGAAGATCAATATCCGCACCTGGACAAAGCGCCGGGAGATATCCGCCTGAAAGTC
GATAATCTCTGCGGACCTGGCGTTAACGATGTCTCTTTTACTTTACGCAAAGGCGAAATT
CTTGGCGTCTCTGGTTTGATGGGCGCAGGTCGTACCGAACTGATGAAAGTGCTCTACGGC
GCACTACCGCGCACCAGCGGTTACGTCACCCTGGATGGGCATGAAGTCGTTACCCGTTCA
CCGCAGGATGGCCTGGCAAACGGCATTGTGTATATCTCCGAAGACCGTAAACGTGACGGT
TTAGTGTTGGGCATGTCAGTAAAAGAGAACATGTCGCTGACAGCGCTGCGCTACTTCAGC
CGCGCTGGCGGCAGTTTGAAGCATGCCGATGAACAGCAGGCTGTGAGTGATTTCATTCGT
CTGTTTAATGTGAAAACTCCGTCGATGGAACAGGCAATTGGTCTGCTTTCCGGTGGCAAT
CAGCAAAAAGTGGCGATTGCCCGCGGTCTGATGACACGCCCCAAAGTGTTGATCCTTGAT
GAACCTACCCGTGGCGTAGATGTCGGCGCGAAAAAAGAGATCTATCAACTGATTAACCAG
TTCAAAGCCGATGGCTTGAGCATCATTCTGGTGTCATCGGAGATGCCAGAAGTATTAGGC
ATGAGCGATCGCATCATCGTCATGCATGAAGGGCATCTCAGCGGGGAATTTACTCGTGAG
CAGGCCACCCAGGAAGTGTTAATGGCTGCCGCTGTGGGCAAGCTTAATCGCGTGAATCAG
GAGTAA
Protein Properties
Pfam Domain Function:
Protein Residues:501
Protein Molecular Weight:55041
Protein Theoretical pI:6
Signaling Regions:
  • None
Transmembrane Regions:
  • None
Protein Sequence:
>Ribose import ATP-binding protein RbsA
MEALLQLKGIDKAFPGVKALSGAALNVYPGRVMALVGENGAGKSTMMKVLTGIYTRDAGT
LLWLGKETTFTGPKSSQEAGIGIIHQELNLIPQLTIAENIFLGREFVNRFGKIDWKTMYA
EADKLLAKLNLRFKSDKLVGDLSIGDQQMVEIAKVLSFESKVIIMDEPTDALTDTETESL
FRVIRELKSQGRGIVYISHRMKEIFEICDDVTVFRDGQFIAEREVASLTEDSLIEMMVGR
KLEDQYPHLDKAPGDIRLKVDNLCGPGVNDVSFTLRKGEILGVSGLMGAGRTELMKVLYG
ALPRTSGYVTLDGHEVVTRSPQDGLANGIVYISEDRKRDGLVLGMSVKENMSLTALRYFS
RAGGSLKHADEQQAVSDFIRLFNVKTPSMEQAIGLLSGGNQQKVAIARGLMTRPKVLILD
EPTRGVDVGAKKEIYQLINQFKADGLSIILVSSEMPEVLGMSDRIIVMHEGHLSGEFTRE
QATQEVLMAAAVGKLNRVNQE
References
External Links:
ResourceLink
Uniprot ID:P04983
Uniprot Name:RBSA_ECOLI
GenBank Gene ID:AP009048
Genebank Protein ID:85676289
Ecogene ID:EG10814
Ecocyc:EG10814
ColiBase:b3749
Kegg Gene:b3749
EchoBASE ID:EB0807
CCDB:RBSA_ECOLI
BacMap:16131617
General Reference:
  • Barroga, C. F., Zhang, H., Wajih, N., Bouyer, J. H., Hermodson, M. A. (1996). "The proteins encoded by the rbs operon of Escherichia coli: I. Overproduction, purification, characterization, and functional analysis of RbsA." Protein Sci 5:1093-1099. Pubmed: 8762140
  • Bell, A. W., Buckel, S. D., Groarke, J. M., Hope, J. N., Kingsley, D. H., Hermodson, M. A. (1986). "The nucleotide sequences of the rbsD, rbsA, and rbsC genes of Escherichia coli K12." J Biol Chem 261:7652-7658. Pubmed: 3011793
  • Blattner, F. R., Plunkett, G. 3rd, Bloch, C. A., Perna, N. T., Burland, V., Riley, M., Collado-Vides, J., Glasner, J. D., Rode, C. K., Mayhew, G. F., Gregor, J., Davis, N. W., Kirkpatrick, H. A., Goeden, M. A., Rose, D. J., Mau, B., Shao, Y. (1997). "The complete genome sequence of Escherichia coli K-12." Science 277:1453-1462. Pubmed: 9278503
  • Buckel, S. D., Bell, A. W., Rao, J. K., Hermodson, M. A. (1986). "An analysis of the structure of the product of the rbsA gene of Escherichia coli K12." J Biol Chem 261:7659-7662. Pubmed: 3086314
  • Burland, V., Plunkett, G. 3rd, Daniels, D. L., Blattner, F. R. (1993). "DNA sequence and analysis of 136 kilobases of the Escherichia coli genome: organizational symmetry around the origin of replication." Genomics 16:551-561. Pubmed: 7686882
  • Hayashi, K., Morooka, N., Yamamoto, Y., Fujita, K., Isono, K., Choi, S., Ohtsubo, E., Baba, T., Wanner, B. L., Mori, H., Horiuchi, T. (2006). "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Mol Syst Biol 2:2006.0007. Pubmed: 16738553