ATP-binding/permease protein cydC (P23886)

Identification
Name:ATP-binding/permease protein cydC
Synonyms:Not Available
Gene Name:cydC
Enzyme Class:Not Available
Biological Properties
General Function:Involved in nucleotide binding
Specific Function:Somehow involved in the cytochrome D branch of aerobic respiration. Seems to be a component of a transport system
Cellular Location:Cell inner membrane; Multi-pass membrane protein
SMPDB Pathways:Not Available
KEGG Pathways:
EcoCyc Reactions:
1.0Thumb+1.0Thumb+1.0Thumb → 1.0Thumb+1.0Thumb+1.0Thumb+1.0Thumb
1.0Adenosine triphosphate + 1.0Water + 1.0Glutathione → 1.0ADP + 1.0Glutathione + 1.0Hydrogen ion + 1.0Phosphate
ReactionCard
1.0Thumb+1.0Thumb+1.0Thumb → 1.0Thumb+1.0Thumb+1.0Thumb+1.0Thumb
1.0Adenosine triphosphate + 1.0L-Cysteine + 1.0Water → 1.0ADP + 1.0Hydrogen ion + 1.0Phosphate + 1.0L-Cysteine
ReactionCard
Metabolites:
ECMDB IDNameView
ECMDB00538Adenosine triphosphateMetaboCard
ECMDB01341ADPMetaboCard
ECMDB00125GlutathioneMetaboCard
ECMDB21225Hydrogen ionMetaboCard
ECMDB00574L-CysteineMetaboCard
ECMDB01429PhosphateMetaboCard
ECMDB00494WaterMetaboCard
GO Classification:
Component
cell part
integral to membrane
intrinsic to membrane
membrane part
Function
active transmembrane transporter activity
adenyl nucleotide binding
adenyl ribonucleotide binding
ATP binding
ATPase activity
ATPase activity, coupled to transmembrane movement of substances
binding
catalytic activity
hydrolase activity
hydrolase activity, acting on acid anhydrides
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
nucleoside binding
nucleoside-triphosphatase activity
nucleotide binding
P-P-bond-hydrolysis-driven transmembrane transporter activity
primary active transmembrane transporter activity
purine nucleoside binding
pyrophosphatase activity
transmembrane transporter activity
transporter activity
Process
establishment of localization
transmembrane transport
transport
Gene Properties
Blattner:b0886
Gene OrientationCounterclockwise
Centisome Percentage:19.97
Left Sequence End926697
Right Sequence End928418
Gene Sequence:
>1722 bp
ATGCGCGCTTTGCTACCCTATCTGGCACTGTATAAACGTCATAAATGGATGTTAAGTCTT
GGTATTGTGCTGGCAATTGTGACGCTGCTCGCCAGTATCGGTCTGTTGACACTTTCCGGC
TGGTTCCTCTCGGCCTCAGCGGTTGCGGGGGTTGCCGGACTGTACAGCTTCAACTATATG
CTACCCGCTGCGGGCGTGCGTGGCGCAGCAATCACCCGTACTGCCGGGCGCTATTTTGAA
CGTCTGGTAAGTCACGACGCGACTTTCCGCGTGTTGCAGCATCTGCGCATTTACACCTTC
AGCAAATTGCTGCCCCTCTCCCCTGCCGGACTGGCGCGCTATCGTCAGGGCGAATTGCTC
AATCGCGTGGTGGCGGATGTTGATACGCTCGATCATCTTTACCTGCGCGTTATCTCGCCG
CTGGTGGGCGCTTTTGTGGTGATTATGGTGGTGACAATCGGGTTAAGTTTCCTTGATTTC
ACCCTCGCCTTTACGCTGGGCGGCATTATGTTACTGACGCTTTTCCTGATGCCACCGCTG
TTTTATCGTGCGGGAAAAAGCACCGGGCAAAATCTGACTCATCTTCGCGGACAGTATCGC
CAACAACTGACGGCCTGGCTGCAAGGGCAAGCTGAGCTGACCATTTTTGGTGCCAGCGAT
CGTTATCGCACGCAACTAGAGAATACAGAAATTCAATGGCTGGAAGCGCAACGCCGTCAA
TCTGAACTGACCGCATTGTCGCAAGCGATAATGCTGCTCATTGGCGCGTTAGCGGTGATC
CTGATGCTGTGGATGGCGTCTGGCGGCGTTGGCGGCAATGCTCAACCCGGCGCGTTAATT
GCCCTGTTTGTCTTCTGCGCGTTAGCCGCGTTTGAAGCACTGGCACCAGTAACGGGTGCA
TTTCAGCATCTGGGGCAAGTCATTGCCTCTGCCGTACGTATCTCTGACTTAACGGATCAA
AAACCGGAGGTCACCTTTCCTGATACCCAAACTCGTGTTGCCGATCGCGTTTCGCTGACG
TTACGGGATGTTCAGTTCACTTATCCGGAGCAATCTCAACAGGCACTTAAAGGGATTTCT
CTTCAGGTAAACGCCGGGGAACATATAGCGATTCTCGGGCGAACCGGATGCGGCAAATCA
ACACTGTTACAACAGCTGACCCGCGCATGGGACCCGCAACAGGGCGAGATTTTGCTTAAC
GATAGCCCCATAGCCAGCCTGAATGAAGCGGCTCTACGACAGACCATCAGCGTTGTTCCT
CAGCGAGTGCATCTGTTTAGCGCCACGCTGCGTGATAATCTTTTACTCGCCTCGCCTGGC
AGTAGTGATGAGGCTCTGTCGGAGATCTTGCGTCGCGTTGGCCTGGAAAAGCTGCTCGAG
GATGCAGGTCTCAACAGTTGGTTAGGTGAAGGCGGACGCCAGCTCTCCGGTGGTGAACTG
CGCCGTCTGGCTATCGCCCGTGCGCTGTTACATGATGCGCCACTGGTGTTGCTGGATGAA
CCTACCGAAGGCTTAGATGCCACAACCGAAAGCCAGATCCTTGAATTGCTTGCAGAAATG
ATGCGTGAGAAAACGGTGTTAATGGTCACCCATCGACTTCGCGGACTCTCTCGTTTCCAA
CAAATAATAGTGATGGACAACGGGCAAATTATTGAGCAAGGTACTCACGCAGAACTGCTT
GCCAGACAGGGGCGTTATTACCAGTTCAAGCAGGGTTTGTAA
Protein Properties
Pfam Domain Function:
Protein Residues:573
Protein Molecular Weight:62920
Protein Theoretical pI:9
Signaling Regions:
  • None
Transmembrane Regions:
  • 16-36
  • 37-57
  • 137-157
  • 162-182
  • 250-270
  • 277-297
Protein Sequence:
>ATP-binding/permease protein cydC
MRALLPYLALYKRHKWMLSLGIVLAIVTLLASIGLLTLSGWFLSASAVAGVAGLYSFNYM
LPAAGVRGAAITRTAGRYFERLVSHDATFRVLQHLRIYTFSKLLPLSPAGLARYRQGELL
NRVVADVDTLDHLYLRVISPLVGAFVVIMVVTIGLSFLDFTLAFTLGGIMLLTLFLMPPL
FYRAGKSTGQNLTHLRGQYRQQLTAWLQGQAELTIFGASDRYRTQLENTEIQWLEAQRRQ
SELTALSQAIMLLIGALAVILMLWMASGGVGGNAQPGALIALFVFCALAAFEALAPVTGA
FQHLGQVIASAVRISDLTDQKPEVTFPDTQTRVADRVSLTLRDVQFTYPEQSQQALKGIS
LQVNAGEHIAILGRTGCGKSTLLQQLTRAWDPQQGEILLNDSPIASLNEAALRQTISVVP
QRVHLFSATLRDNLLLASPGSSDEALSEILRRVGLEKLLEDAGLNSWLGEGGRQLSGGEL
RRLAIARALLHDAPLVLLDEPTEGLDATTESQILELLAEMMREKTVLMVTHRLRGLSRFQ
QIIVMDNGQIIEQGTHAELLARQGRYYQFKQGL
References
External Links:
ResourceLink
Uniprot ID:P23886
Uniprot Name:CYDC_ECOLI
GenBank Gene ID:AP009048
Genebank Protein ID:1651408
Ecogene ID:EG10012
Ecocyc:EG10012
ColiBase:b0886
Kegg Gene:b0886
EchoBASE ID:EB0012
CCDB:CYDC_ECOLI
BacMap:16128853
General Reference:
  • Blattner, F. R., Plunkett, G. 3rd, Bloch, C. A., Perna, N. T., Burland, V., Riley, M., Collado-Vides, J., Glasner, J. D., Rode, C. K., Mayhew, G. F., Gregor, J., Davis, N. W., Kirkpatrick, H. A., Goeden, M. A., Rose, D. J., Mau, B., Shao, Y. (1997). "The complete genome sequence of Escherichia coli K-12." Science 277:1453-1462. Pubmed: 9278503
  • Cummings, H. S., Sands, J. F., Foreman, P. C., Fraser, J., Hershey, J. W. (1991). "Structure and expression of the infA operon encoding translational initiation factor IF1. Transcriptional control by growth rate." J Biol Chem 266:16491-16498. Pubmed: 1909328
  • Daley, D. O., Rapp, M., Granseth, E., Melen, K., Drew, D., von Heijne, G. (2005). "Global topology analysis of the Escherichia coli inner membrane proteome." Science 308:1321-1323. Pubmed: 15919996
  • Hayashi, K., Morooka, N., Yamamoto, Y., Fujita, K., Isono, K., Choi, S., Ohtsubo, E., Baba, T., Wanner, B. L., Mori, H., Horiuchi, T. (2006). "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Mol Syst Biol 2:2006.0007. Pubmed: 16738553
  • Oshima, T., Aiba, H., Baba, T., Fujita, K., Hayashi, K., Honjo, A., Ikemoto, K., Inada, T., Itoh, T., Kajihara, M., Kanai, K., Kashimoto, K., Kimura, S., Kitagawa, M., Makino, K., Masuda, S., Miki, T., Mizobuchi, K., Mori, H., Motomura, K., Nakamura, Y., Nashimoto, H., Nishio, Y., Saito, N., Horiuchi, T., et, a. l. .. (1996). "A 718-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 12.7-28.0 min region on the linkage map." DNA Res 3:137-155. Pubmed: 8905232
  • Poole, R. K., Hatch, L., Cleeter, M. W., Gibson, F., Cox, G. B., Wu, G. (1993). "Cytochrome bd biosynthesis in Escherichia coli: the sequences of the cydC and cydD genes suggest that they encode the components of an ABC membrane transporter." Mol Microbiol 10:421-430. Pubmed: 7934832
  • Shrader, T. E., Tobias, J. W., Varshavsky, A. (1993). "The N-end rule in Escherichia coli: cloning and analysis of the leucyl, phenylalanyl-tRNA-protein transferase gene aat." J Bacteriol 175:4364-4374. Pubmed: 8331068
  • Siegele, D. A., Kolter, R. (1993). "Isolation and characterization of an Escherichia coli mutant defective in resuming growth after starvation." Genes Dev 7:2629-2640. Pubmed: 8276245