Zinc import ATP-binding protein ZnuC (P0A9X1)

Identification
Name:Zinc import ATP-binding protein ZnuC
Synonyms:Not Available
Gene Name:znuC
Enzyme Class:Not Available
Biological Properties
General Function:Involved in nucleotide binding
Specific Function:Part of the ABC transporter complex ZnuABC involved in zinc import. Responsible for energy coupling to the transport system
Cellular Location:Cell inner membrane; Peripheral membrane protein
SMPDB Pathways:
  • Collection of Reactions without pathways PW001891
KEGG Pathways:
Transports:
    Transport References:Not Available
    EcoCyc Reactions:
    1.0Thumb+1.0Thumb+1.0Thumb → 1.0Thumb+1.0Thumb+1.0Thumb+1.0Thumb
    1.0Adenosine triphosphate + 1.0Water + 1.0Zinc → 1.0ADP + 1.0Hydrogen ion + 1.0Phosphate + 1.0Zinc
    ReactionCard
    Metabolites:
    ECMDB IDNameView
    ECMDB00538Adenosine triphosphateMetaboCard
    ECMDB01341ADPMetaboCard
    ECMDB21225Hydrogen ionMetaboCard
    ECMDB01429PhosphateMetaboCard
    ECMDB00494WaterMetaboCard
    ECMDB01303ZincMetaboCard
    GO Classification:
    Component
    cell part
    membrane
    plasma membrane
    Function
    adenyl nucleotide binding
    adenyl ribonucleotide binding
    ATP binding
    ATPase activity
    binding
    catalytic activity
    cation transmembrane transporter activity
    di-, tri-valent inorganic cation transmembrane transporter activity
    hydrolase activity
    hydrolase activity, acting on acid anhydrides
    hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    inorganic cation transmembrane transporter activity
    ion transmembrane transporter activity
    nucleoside binding
    nucleoside-triphosphatase activity
    nucleotide binding
    purine nucleoside binding
    pyrophosphatase activity
    substrate-specific transmembrane transporter activity
    transmembrane transporter activity
    transporter activity
    zinc ion transmembrane transporter activity
    zinc transporting ATPase activity
    Process
    cation transport
    establishment of localization
    ion transport
    metal ion transport
    transition metal ion transport
    transport
    zinc ion transport
    Gene Properties
    Blattner:b1858
    Gene OrientationClockwise
    Centisome Percentage:41.83
    Left Sequence End1940686
    Right Sequence End1941441
    Gene Sequence:
    >756 bp
ATGGCAACGGTTAATAAACAAGCCATTGCAGCGGCATTTGGTCGGGCAGCCGCACACTAT
GAGCAACATGCAGATCTACAGCGCCAGAGTGCTGACGCCTTACTGGCAATGCTTCCACAG
CGTAAATACACCCACGTACTGGACGCGGGTTGTGGACCTGGCTGGATGAGCCGCCACTGG
CGGGAACGTCACGCGCAGGTGACGGCCTTAGATCTCTCGCCGCCAATGCTTGTTCAGGCA
CGCCAGAAGGATGCCGCAGACCATTATCTGGCGGGAGATATCGAATCCCTGCCGTTAGCG
ACTGCGACGTTCGATCTTGCATGGAGCAATCTCGCAGTGCAGTGGTGCGGTAATTTATCC
ACGGCACTCCGCGAGCTGTATCGGGTGGTGCGCCCCAAAGGCGTGGTCGCGTTTACCACG
CTGGTGCAGGGATCGTTACCCGAACTGCATCAGGCGTGGCAGGCGGTGGACGAGCGTCCG
CATGCTAATCGCTTTTTACCGCCAGATGAAATCGAACAGTCGCTGAACGGCGTGCATTAT
CAACATCATATTCAGCCCATCACGCTGTGGTTTGATGATGCGCTCAGTGCCATGCGTTCG
CTGAAAGGCATCGGTGCCACGCATCTTCATGAAGGGCGCGACCCGCGAATATTAACGCGT
TCGCAGTTGCAGCGATTGCAACTGGCCTGGCCGCAACAGCAGGGGCGATATCCTCTGACG
TATCATCTTTTTTTGGGAGTGATTGCTCGTGAGTAA
    Protein Properties
    Pfam Domain Function:
    Protein Residues:251
    Protein Molecular Weight:27867
    Protein Theoretical pI:10
    Signaling Regions:
    • None
    Transmembrane Regions:
    • None
    Protein Sequence:
    >Zinc import ATP-binding protein ZnuC
MTSLVSLENVSVSFGQRRVLSDVSLELKPGKILTLLGPNGAGKSTLVRVVLGLVTPDEGV
IKRNGKLRIGYVPQKLYLDTTLPLTVNRFLRLRPGTHKEDILPALKRVQAGHLINAPMQK
LSGGETQRVLLARALLNRPQLLVLDEPTQGVDVNGQVALYDLIDQLRRELDCGVLMVSHD
LHLVMAKTDEVLCLNHHICCSGTPEVVSLHPEFISMFGPRGAEQLGIYRHHHNHRHDLQG
RIVLRRGNDRS
    References
    External Links:
    ResourceLink
    Uniprot ID:P0A9X1
    Uniprot Name:ZNUC_ECOLI
    GenBank Gene ID:AP009048
    Genebank Protein ID:85674760
    Ecogene ID:EG13132
    Ecocyc:EG13132
    ColiBase:b1858
    Kegg Gene:b1858
    EchoBASE ID:EB2931
    CCDB:ZNUC_ECOLI
    BacMap:16129811
    General Reference:
    • Blattner, F. R., Plunkett, G. 3rd, Bloch, C. A., Perna, N. T., Burland, V., Riley, M., Collado-Vides, J., Glasner, J. D., Rode, C. K., Mayhew, G. F., Gregor, J., Davis, N. W., Kirkpatrick, H. A., Goeden, M. A., Rose, D. J., Mau, B., Shao, Y. (1997). "The complete genome sequence of Escherichia coli K-12." Science 277:1453-1462. Pubmed: 9278503
    • Hayashi, K., Morooka, N., Yamamoto, Y., Fujita, K., Isono, K., Choi, S., Ohtsubo, E., Baba, T., Wanner, B. L., Mori, H., Horiuchi, T. (2006). "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Mol Syst Biol 2:2006.0007. Pubmed: 16738553
    • Itoh, T., Aiba, H., Baba, T., Hayashi, K., Inada, T., Isono, K., Kasai, H., Kimura, S., Kitakawa, M., Kitagawa, M., Makino, K., Miki, T., Mizobuchi, K., Mori, H., Mori, T., Motomura, K., Nakade, S., Nakamura, Y., Nashimoto, H., Nishio, Y., Oshima, T., Saito, N., Sampei, G., Seki, Y., Horiuchi, T., et, a. l. .. (1996). "A 460-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 40.1-50.0 min region on the linkage map." DNA Res 3:379-392. Pubmed: 9097040
    • Patzer, S. I., Hantke, K. (1998). "The ZnuABC high-affinity zinc uptake system and its regulator Zur in Escherichia coli." Mol Microbiol 28:1199-1210. Pubmed: 9680209
    • Yamamoto, K., Ishihama, A. (2005). "Transcriptional response of Escherichia coli to external zinc." J Bacteriol 187:6333-6340. Pubmed: 16159766