| Identification |
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| Name: | Sensor protein uhpB |
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| Synonyms: | Not Available |
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| Gene Name: | uhpB |
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| Enzyme Class: | |
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| Biological Properties |
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| General Function: | Signal transduction mechanisms |
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| Specific Function: | Member of the two-component regulatory system uhpB/uhpA involved in the regulation of the uptake of hexose phosphates. UhpB functions as a membrane-associated protein kinase that phosphorylates uhpA in response to environmental signals |
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| Cellular Location: | Cell inner membrane; Multi-pass membrane protein |
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| SMPDB Pathways: | Not Available |
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| KEGG Pathways: | |
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| Metabolites: | |
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| GO Classification: | | Component |
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| cell part | | integral to membrane | | intrinsic to membrane | | membrane part | | Function |
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| adenyl nucleotide binding | | adenyl ribonucleotide binding | | ATP binding | | binding | | catalytic activity | | kinase activity | | nucleoside binding | | protein binding | | protein dimerization activity | | protein histidine kinase activity | | protein kinase activity | | purine nucleoside binding | | transferase activity | | transferase activity, transferring phosphorus-containing groups | | two-component sensor activity | | Process |
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| biological regulation | | cellular metabolic process | | metabolic process | | peptidyl-histidine phosphorylation | | phosphate metabolic process | | phosphorus metabolic process | | phosphorylation | | protein amino acid phosphorylation | | regulation of biological process | | regulation of cellular process | | signal transduction | | signal transmission | | signaling process | | two-component signal transduction system (phosphorelay) |
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| Gene Properties |
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| Blattner: | Not Available |
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| Gene Orientation | Not Available |
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| Centisome Percentage: | Not Available |
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| Left Sequence End | Not Available |
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| Right Sequence End | Not Available |
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| Gene Sequence: | >1503 bp
ATGAAGACGTTGTTCTCCCGCTTAATTACCGTTATTGCCTGCTTTTTTATCTTCTCTGCC
GCATGGTTTTGCCTGTGGAGTATCAGCCTGCATCTGGTTGAGCGCCCTGATATGGCGGTG
CTGTTATTTCCGTTTGGTCTGCGTCTGGGGCTAATGCTGCAATGCCCGCGCGGATACTGG
CCCGTATTGCTGGGCGCGGAGTGGCTGCTGATTTACTGGCTAACGCAGGCGGTCGGTTTA
ACCCATTTTCCGTTATTGATGATCGGTAGTTTACTGACGTTACTGCCCGTAGCGCTGATC
TCGCGCTATCGCCATCAGCGTGACTGGCGCACCTTGCTGTTACAGGGGGCGGCGTTAACG
GCGGCGGCGTTGTTGCAGTCGCTGCCCTGGCTTTGGCACGGCAAAGAGTCGTGGAATGCG
CTGTTGCTGACTTTAACTGGCGGCCTGACGCTGGCCCCGATATGTCTGGTGTTCTGGCAC
TATCTCGCCAATAACACCTGGCTGCCGCTCGGTCCGTCACTGGTTTCTCAGCCAATCAAC
TGGCGCGGGCGACATCTGGTCTGGTACTTGCTGCTGTTTGTTATCAGTCTCTGGCTCCAG
TTGGGATTGCCGGACGAACTGTCGCGCTTTACGCCATTCTGTCTGGCGCTGCCGATTATC
GCGCTGGCCTGGCACTATGGTTGGCAAGGGGCGCTGATTGCGACGTTGATGAACGCCATC
GCGCTGATCGCCAGTCAAACCTGGCGCGATCATCCGGTGGATTTATTGCTCTCGCTGCTG
GTGCAAAGTCTGACAGGGTTGTTGCTTGGCGCTGGCATCCAGCGGTTGCGTGAACTTAAC
CAGTCGCTGCAAAAGGAACTGGCGCGCAATCAGCATCTGGCTGAACGGTTGCTGGAAACC
GAAGAGAGCGTGCGCCGTGATGTGGCGCGTGAGCTGCATGATGATATCGGTCAGACCATC
ACTGCTATTCGTACTCAGGCGGGCATTGTTCAGCGGCTGGCGGCAGATAGACGCCAGCGT
GAAGCAGAGCGGGCAGCTCATCGAACAACTATCGCTGGGCGTTTACGACGGGTGCGCCGT
TTGTTGGGTCGGTTACGTCCGCGCCAGTTGGATGATCTCACCCTGGAGCAGGCCATCCGC
TCACTGATGCGGGAAATGGAGCTGGAAGGGCGCGGTATTGTCAGCCATCTCGAATGGCGA
ATCGATGAATCAGCGTTAAGCGAAAACCAGCGCGTGACGCTGTTTCGTGTCTGCCAGGAA
GGGCTGAACAACATTGTGAAACATGCTGATGCCAGCGCGGTCACCCTGCAAGGCTGGCAG
CAGGATGAACGGTTGATGCTGGTTATTGAAGACGATGGCAGCGGTTTGCCGCCGGGTTCC
GGGCAACAAGGTTTTGGCCTCACCGGAATGCGCGAGCGCGTAACGGCGCTGGGTGGCACA
TTACACATTTCCTGTCTGCACGGCACGCGTGTCAGCGTTTCTCTACCTCAACGCTATGTC
TAA |
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| Protein Properties |
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| Pfam Domain Function: | |
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| Protein Residues: | 500 |
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| Protein Molecular Weight: | 56305 |
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| Protein Theoretical pI: | 8 |
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| Signaling Regions: | |
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| Transmembrane Regions: | - 8-28
- 78-98
- 112-132
- 140-160
- 185-205
- 213-233
- 253-273
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| Protein Sequence: | >Sensor protein uhpB
MKTLFSRLITVIACFFIFSAAWFCLWSISLHLVERPDMAVLLFPFGLRLGLMLQCPRGYW
PVLLGAEWLLIYWLTQAVGLTHFPLLMIGSLLTLLPVALISRYRHQRDWRTLLLQGAALT
AAALLQSLPWLWHGKESWNALLLTLTGGLTLAPICLVFWHYLANNTWLPLGPSLVSQPIN
WRGRHLVWYLLLFVISLWLQLGLPDELSRFTPFCLALPIIALAWHYGWQGALIATLMNAI
ALIASQTWRDHPVDLLLSLLVQSLTGLLLGAGIQRLRELNQSLQKELARNQHLAERLLET
EESVRRDVARELHDDIGQTITAIRTQAGIVQRLAADNASVKQSGQLIEQLSLGVYDAVRR
LLGRLRPRQLDDLTLEQAIRSLMREMELEGRGIVSHLEWRIDESALSENQRVTLFRVCQE
GLNNIVKHADASAVTLQGWQQDERLMLVIEDDGSGLPPGSGQQGFGLTGMRERVTALGGT
LHISCLHGTRVSVSLPQRYV |
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| References |
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| External Links: | |
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| General Reference: | - Blattner, F. R., Plunkett, G. 3rd, Bloch, C. A., Perna, N. T., Burland, V., Riley, M., Collado-Vides, J., Glasner, J. D., Rode, C. K., Mayhew, G. F., Gregor, J., Davis, N. W., Kirkpatrick, H. A., Goeden, M. A., Rose, D. J., Mau, B., Shao, Y. (1997). "The complete genome sequence of Escherichia coli K-12." Science 277:1453-1462. Pubmed: 9278503
- Burland, V., Plunkett, G. 3rd, Daniels, D. L., Blattner, F. R. (1993). "DNA sequence and analysis of 136 kilobases of the Escherichia coli genome: organizational symmetry around the origin of replication." Genomics 16:551-561. Pubmed: 7686882
- Daley, D. O., Rapp, M., Granseth, E., Melen, K., Drew, D., von Heijne, G. (2005). "Global topology analysis of the Escherichia coli inner membrane proteome." Science 308:1321-1323. Pubmed: 15919996
- Friedrich, M. J., Kadner, R. J. (1987). "Nucleotide sequence of the uhp region of Escherichia coli." J Bacteriol 169:3556-3563. Pubmed: 3301805
- Hayashi, K., Morooka, N., Yamamoto, Y., Fujita, K., Isono, K., Choi, S., Ohtsubo, E., Baba, T., Wanner, B. L., Mori, H., Horiuchi, T. (2006). "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Mol Syst Biol 2:2006.0007. Pubmed: 16738553
- Island, M. D., Wei, B. Y., Kadner, R. J. (1992). "Structure and function of the uhp genes for the sugar phosphate transport system in Escherichia coli and Salmonella typhimurium." J Bacteriol 174:2754-2762. Pubmed: 1569007
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