Stress response kinase A (P0C0K3)

Identification
Name:Stress response kinase A
Synonyms:Not Available
Gene Name:srkA
Enzyme Class:
Biological Properties
General Function:protein phosphorylation
Specific Function:A protein kinase that (auto)phosphorylates on Ser and Thr residues (PubMed:17302814). Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Protects cells from stress by antagonizing the MazE-MazF TA module, probably indirectly as it has not been seen to phosphorylate MazE, MazF or MazG (PubMed:23416055). Probably involved in the extracytoplasmic stress response (PubMed:9159398).
Cellular Location:Not Available
SMPDB Pathways:
KEGG Pathways:Not Available
KEGG Reactions:
1.0Thumb+1.0Protein ↔ 1.0Thumb+1.0Thumb
1.0Adenosine triphosphate + 1.0Protein ↔ 1.0ADP + 1.0Phosphoprotein
ReactionCard
SMPDB Reactions:
1.0a [protein]-(L-serine/L-threonine) +1.0Thumb → 1.0a [protein]-(L-serine/L-threonine) phosphate+1.0Adenosine diphosphate+1.0Thumb+1.0Thumb
1.0a [protein]-(L-serine/L-threonine) + 1.0Adenosine triphosphate → 1.0a [protein]-(L-serine/L-threonine) phosphate + 1.0Adenosine diphosphate + 1.0Hydrogen ion + 1.0ADP
ReactionCard
Metabolites:
ECMDB IDNameView
ECMDB00538Adenosine triphosphateMetaboCard
ECMDB01341ADPMetaboCard
ECMDB21225Hydrogen ionMetaboCard
GO Classification:
Function
cytoplasm
protein phosphorylation
protein serine/threonine kinase activity
Gene Properties
Blattner:Not Available
Gene OrientationNot Available
Centisome Percentage:Not Available
Left Sequence EndNot Available
Right Sequence EndNot Available
Gene Sequence:
>987
atgaataacagcgcttttactttccagacactacacccggataccatcatggacgctctg
tttgagcatgggatccgggtggattccggtcttaccccgcttaacagctatgaaaaccgt
gtctatcaatttcaggacgaagatcgtcgacgttttgtcgtcaaattttatcgccctgaa
cgttggacagccgatcaaatcctcgaagaacatcaatttgcgttgcagctggtaaatgat
gaagttccggtcgcagcacctgtggcctttaacggtcagactttattgaatcatcaggga
ttttatttcgctgtttttccaagcgtcggtggtcgccagttcgaagctgataatatcgat
cagatggaagcggttgggcgttatttagggcgtatgcaccagacggggcgcaaacagctt
tttatccatcgcccgaccatcggtttgaacgaatatctcattgagccacgcaagctgttt
gaggacgctacactgataccttccgggttgaaagcggcattcctgaaagcgacagatgag
ctgattgccgccgttacagcacactggcgggaagatttcaccgttctgcggctacatgga
gactgccacgccgggaatattctctggcgcgatggtccaatgtttgttgatctggatgat
gcacgtaatggtccagccgttcaggatttgtggatgttgctcaatggcgataaagccgag
cagcggatgcaactggaaactattattgaagcttatgaagaatttagcgagttcgacacc
gctgaaatcggactgattgaacctttacgcgccatgcgtttggtttattatcttgcctgg
ctaatgcggcgttgggctgatcccgcgttcccgaaaaatttcccgtggttaaccggggaa
gattactggctgcgacagacggcgacttttatagaacaggcaaaagttctacaagaaccc
cctttgcaattaacacctatgtattaa
Protein Properties
Pfam Domain Function:Not Available
Protein Residues:328
Protein Molecular Weight:38120
Protein Theoretical pI:Not Available
PDB File:1ZYL
Signaling Regions:Not Available
Transmembrane Regions:Not Available
Protein Sequence:
>Stress response kinase A
MNNSAFTFQTLHPDTIMDALFEHGIRVDSGLTPLNSYENRVYQFQDEDRRRFVVKFYRPE
RWTADQILEEHQFALQLVNDEVPVAAPVAFNGQTLLNHQGFYFAVFPSVGGRQFEADNID
QMEAVGRYLGRMHQTGRKQLFIHRPTIGLNEYLIEPRKLFEDATLIPSGLKAAFLKATDE
LIAAVTAHWREDFTVLRLHGDCHAGNILWRDGPMFVDLDDARNGPAVQDLWMLLNGDKAE
QRMQLETIIEAYEEFSEFDTAEIGLIEPLRAMRLVYYLAWLMRRWADPAFPKNFPWLTGE
DYWLRQTATFIEQAKVLQEPPLQLTPMY
References
External Links:
ResourceLink
Uniprot ID:P0C0K3
Uniprot Name:SRKA_ECOLI
PDB ID:1ZYL
CCDB:SRKA_ECOLI
General Reference:Not Available