ECMDB

Identification

Name:

Autoinducer 2 import ATP-binding protein LsrA

Synonyms:

Not Available

Gene Name:

lsrA

Enzyme Class:

Not Available

Biological Properties

General Function:

ATPase activity, coupled to transmembrane movement of substances

Specific Function:

Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Responsible for energy coupling to the transport system (Probable). This protein is essential for aerobic growth.

Cellular Location:

Not Available

SMPDB Pathways:

Quorum Sensing PW000836

KEGG Pathways:

ABC transporters ec02010

Transports:

Transport References:

Not Available

SMPDB Reactions:

1.0(2R,4S)-2-methyl-2,3,3,4-tetrahydroxytetrahydrofuran

1.0Phosphoribosyl-ATP

1.0

→

1.0(2R,4S)-2-methyl-2,3,3,4-tetrahydroxytetrahydrofuran

1.0Adenosine diphosphate

1.0

1.0Pyrophosphate

1.0

1.0(2R,4S)-2-methyl-2,3,3,4-tetrahydroxytetrahydrofuran + 1.0Phosphoribosyl-ATP + 1.0Water + 1.0(2R,4S)-2-Methyl-2,3,3,4-tetrahydroxytetrahydrofuran + 1.0Phosphoribosyl-ATP → 1.0(2R,4S)-2-methyl-2,3,3,4-tetrahydroxytetrahydrofuran + 1.0Adenosine diphosphate + 1.0Hydrogen ion + 1.0Pyrophosphate + 1.0ADP
ReactionCard

Metabolites:

ECMDB ID	Name	View
ECMDB21368	(2R,4S)-2-Methyl-2,3,3,4-tetrahydroxytetrahydrofuran	MetaboCard
ECMDB01341	ADP	MetaboCard
ECMDB21225	Hydrogen ion	MetaboCard
ECMDB04138	Phosphoribosyl-ATP	MetaboCard
ECMDB00494	Water	MetaboCard

GO Classification:

Function
ATP binding
ATPase activity, coupled to transmembrane movement of substances
integral component of membrane
plasma membrane

Gene Properties

Blattner:

Not Available

Gene Orientation

Not Available

Centisome Percentage:

Not Available

Left Sequence End

Not Available

Right Sequence End

Not Available

Gene Sequence:

>1536
atgcaaacgagtgatacccgcgcgttaccgctactttgcgcccgctcggtttataaacag
tattcaggggtcaatgtcctgaaaggcatcgattttacgttgcatcagggggaggtccac
gccctgctcggcggcaatggtgccggtaaatcgacgttaatgaagattattgccggtatt
acccctgctgatagcggtacgctggagattgagggcaacaactacgtcagattaacgcca
gttcatgctcatcagctgggtatttatctcgttccccaggaaccgctgcttttcccaagc
ctgtcgataaaagaaaacatcctgtttgggctggcaaaaaaacagctctccatgcagaaa
atgaagaacttgctggcggcgctgggctgccagtttgatctgcatagtctggcaggatcg
ctggatgtcgccgatcgccaaatggtggaaatcctccgcgggctgatgcgcgactcgcgg
attctgatcctcgatgaacctaccgcctcgcttacccctgcggaaaccgaacgcttgttt
agtcgcttgcaagagctgcttgctactggcgtgggtattgtttttatctcgcataagctg
ccggaaattcgccagattgccgatcgaattagcgtgatgcgcgacggaaccatcgcctta
agcggcaaaaccagcgaactgtctaccgacgacattattcaggccatcaccccagcggta
cgggaaaaatcgctctctgccagccaaaaattatggctggagttacctggtaaccgccca
caacatgccgccggaacgccggtgctgacactggaaaatctgaccggcgaaggtttcagg
aatgtcagcctgacgctcaatgccggagaaattctgggcctggctgggctggtgggggcc
ggacgcacagaactggccgagacgctctatggtctgcgtactttgcgtggcggacgcatt
atgctgaatggtaaagagatcaataaattatccactggagaacgtttactgcgcggtctg
gtttatctgccggaagatcgccagtcatccggactgaatctcgatgcttcgctggcctgg
aacgtctgcgcccttactcataaccttcgtggattctgggcgaaaaccgcgaaagataat
gccaccctggaacgttatcgtcgggcgctgaatattaaattcaaccaaccggaacaagct
gcacggacattatccggtggcaaccagcaaaaaatcctcattgccaaatgcttggaagct
tcgccgcaagtattgattgtcgatgagccgacgcgcggcgtggatgtctcggcccgtaat
gatatctaccagctgttgcgcagcatcgccgcacaaaatgtggctgtgctgcttatctcc
tccgacctggaagagatcgaactgatggcagatcgtgtgtatgtgatgcatcagggcgaa
attacccactctgcactgaccgagcgcgatattaatgtcgagactattatgcgcgttgcc
ttcggcgatagtcagcgtcaggaggcgtcatgctga

Protein Properties

Pfam Domain Function:

Not Available

Protein Residues:

511

Protein Molecular Weight:

55820

Protein Theoretical pI:

Not Available

Signaling Regions:

Not Available

Transmembrane Regions:

Not Available

Protein Sequence:

>Autoinducer 2 import ATP-binding protein LsrA
MQTSDTRALPLLCARSVYKQYSGVNVLKGIDFTLHQGEVHALLGGNGAGKSTLMKIIAGI
TPADSGTLEIEGNNYVRLTPVHAHQLGIYLVPQEPLLFPSLSIKENILFGLAKKQLSMQK
MKNLLAALGCQFDLHSLAGSLDVADRQMVEILRGLMRDSRILILDEPTASLTPAETERLF
SRLQELLATGVGIVFISHKLPEIRQIADRISVMRDGTIALSGKTSELSTDDIIQAITPAV
REKSLSASQKLWLELPGNRPQHAAGTPVLTLENLTGEGFRNVSLTLNAGEILGLAGLVGA
GRTELAETLYGLRTLRGGRIMLNGKEINKLSTGERLLRGLVYLPEDRQSSGLNLDASLAW
NVCALTHNLRGFWAKTAKDNATLERYRRALNIKFNQPEQAARTLSGGNQQKILIAKCLEA
SPQVLIVDEPTRGVDVSARNDIYQLLRSIAAQNVAVLLISSDLEEIELMADRVYVMHQGE
ITHSALTERDINVETIMRVAFGDSQRQEASC

References

External Links:

Resource	Link
Uniprot ID:	P77257
Uniprot Name:	LSRA_ECOLI
CCDB:	LSRA_ECOLI

General Reference:

Not Available

Autoinducer 2 import ATP-binding protein LsrA (P77257)