Glycogen synthase (P0A6U8)

Identification
Name:Glycogen synthase
Synonyms:
  • Starch [bacterial glycogen] synthase
Gene Name:glgA
Enzyme Class:
Biological Properties
General Function:Involved in biosynthetic process
Specific Function:Synthesizes alpha-1,4-glucan chains using ADP-glucose
Cellular Location:Not Available
SMPDB Pathways:
  • Secondary metabolites: Trehalose Biosynthesis and Metabolism PW000968
  • Starch and sucrose metabolism PW000941
KEGG Pathways:
KEGG Reactions:
1.0Thumb+1.0Thumb ↔ 1.0Thumb+1.0Thumb
1.0ADP-Glucose + 1.01,4-alpha-D-glucan ↔ 1.0ADP + 1.01,4-alpha-D-glucan
ReactionCard
SMPDB Reactions:
1.0Thumb+1.0Thumb ↔ 1.0Thumb+1.0Adenosine diphosphate+1.0Thumb
1.0ADP-Glucose + 1.0Amylose ↔ 1.0Amylose + 1.0Adenosine diphosphate + 1.0ADP
ReactionCard
EcoCyc Reactions:
1.0a 1,4-α-D-glucan+1.0Thumb ↔ 1.0Thumb+1.0a 1,4-α-D-glucan
1.0a 1,4-α-D-glucan + 1.0ADP-Glucose ↔ 1.0ADP + 1.0a 1,4-α-D-glucan
ReactionCard
Complex Reactions:
1.0Thumb → 1.0Thumb+1.0Thumb+1.0Thumb
1.0ADP-Glucose → 1.0ADP + 1.0Glycogen + 1.0Hydrogen ion
ReactionCard
1.0Thumb+1.0(1,4-alpha-D-glucosyl)(n) → 1.0Thumb+1.0(1,4-alpha-D-glucosyl)(n+1)
1.0ADP-Glucose + 1.0(1,4-alpha-D-glucosyl)(n) → 1.0ADP + 1.0(1,4-alpha-D-glucosyl)(n+1)
ReactionCard
Metabolites:
ECMDB IDNameView
ECMDB211101,4-alpha-D-glucanMetaboCard
ECMDB01341ADPMetaboCard
ECMDB06557ADP-GlucoseMetaboCard
ECMDB24082AmyloseMetaboCard
ECMDB21341GlycogenMetaboCard
ECMDB21225Hydrogen ionMetaboCard
GO Classification:
Function
catalytic activity
glucosyltransferase activity
starch synthase activity
transferase activity
transferase activity, transferring glycosyl groups
transferase activity, transferring hexosyl groups
Process
biosynthetic process
carbohydrate metabolic process
cellular glucan metabolic process
glucan biosynthetic process
glucan metabolic process
metabolic process
polysaccharide metabolic process
primary metabolic process
Gene Properties
Blattner:b3429
Gene OrientationCounterclockwise
Centisome Percentage:76.83
Left Sequence End3564623
Right Sequence End3566056
Gene Sequence:
>1434 bp
ATGTGGCCGGATAACCGTATCGCCCGTGACGCGCACTATCTTTACCGGTATGACCGTCAC
GGCAGGCTGACGGAGAAAACCGACCTCATCCCGGAAGGGGTTATCCGCACGGATGATGAG
CGCACCCACCGGTACCATTACGACAGTCAGCACCGGCTGGTGCACTACACGCGGACACAA
TATGCAGAGCCGCTGGTCGAAAGCCGCTATCTTTACGACCCGCTGGGCCGCAGGGTGGCA
AAACGGGTGTGGCGACGTGAACGGGACCTGACGGGCTGGATGTCGCTGTCACGGAAACCG
CAAGTGACCTGGTACGGCTGGGACGGCGACCGCCTGACCACGATACAGAACGACAGAACC
CGCATCCAGACGATTTATCAGCCGGGGAGCTTCACGCCACTCATCAGGGTTGAAACCGCC
ACCGGTGAGCTGGCGAAAACGCAGCGCCGCAGCCTGGCGGATACCCTTCAGCAGTCCGGC
GGCGAAGACGGTGGCAGTGTGGTGTTCCCGCCGGTGCTGGTGCAGATGCTCGACCGGCTG
GAAAGTGAAATCCTGGCTGACCGGGTGAGTGAGGAAAGCCGCCGCTGGCTGGCATCGTGC
GGCCTGACGGTGGAGCAGATGCAAAACCAGATGGACCCGGTGTACACGCCGGCGCGAAAA
ATCCACCTGTACCACTGCGACCATCGCGGCCTGCCGCTGGCGCTTGTCAGCACGGAAGGG
GCAACAGAATGGTGCGCAGAATACGATGAATGGGGCAACCTGCTGAATGAAGAGAACCCG
CATCAGCTGCAGCAGCTTATCCGCCTGCCGGGGCAGCAGTATGATGAGGAGTCCGGCCTG
TATTACAACCGCCACCGCTATTATGACCCGCTGCAGGGGAGGTATATCACTCAGGATCCG
ATTGGGCTGAAGGGGGGATGGAATTTTTATCAGTATCCGCTGAATCCGGTTCAGTATATA
GATTCAATGGGACTGGCATCAAAATATGGACACTTAAATAATGGCGGATATGGAGCGAGA
CCCAACAAACCGCCTACGCCCGATCCAAGTAAATTGCCGGACATAGCGAAACAATTAAGA
CTGCCATATCCTATTGACCAGGCCAGTAGTGCGCCTAATGTTTTCAAAACATTCTTCAGA
GCATTAAGCCCTTACGACTACACACTGTATTGCAGGAAGTGGGTAAAACCAAATCTGACT
TGTACGCCACAGGATGATTCCCAGTATCCAGGGATGGATACAAAGACAGCAAGTGATTAC
CTGCCACAGACAAATTGGCCAACAACTCAATTACCACCAGGATATACTTGTGCAGAACCC
TATTTATTCCCAGACATTAATAAACCCGATGGGCCAGCAACAGCAGGGATAGATGATTTG
GGTGAAATTTTAGCTAAGATGAAACAGAGAACATCGAGAGGAATAAGAAAATGA
Protein Properties
Pfam Domain Function:
Protein Residues:477
Protein Molecular Weight:52822
Protein Theoretical pI:7
Signaling Regions:
  • None
Transmembrane Regions:
  • None
Protein Sequence:
>Glycogen synthase
MQVLHVCSEMFPLLKTGGLADVIGALPAAQIADGVDARVLLPAFPDIRRGVTDAQVVSRR
DTFAGHITLLFGHYNGVGIYLIDAPHLYDRPGSPYHDTNLFAYTDNVLRFALLGWVGAEM
ASGLDPFWRPDVVHAHDWHAGLAPAYLAARGRPAKSVFTVHNLAYQGMFYAHHMNDIQLP
WSFFNIHGLEFNGQISFLKAGLYYADHITAVSPTYAREITEPQFAYGMEGLLQQRHREGR
LSGVLNGVDEKIWSPETDLLLASRYTRDTLEDKAENKRQLQIAMGLKVDDKVPLFAVVSR
LTSQKGLDLVLEALPGLLEQGGQLALLGAGDPVLQEGFLAAAAEYPGQVGVQIGYHEAFS
HRIMGGADVILVPSRFEPCGLTQLYGLKYGTLPLVRRTGGLADTVSDCSLENLADGVASG
FVFEDSNAWSLLRAIRRAFVLWSRPSLWRFVQRQAMAMDFSWQVAAKSYRELYYRLK
References
External Links:
ResourceLink
Uniprot ID:P0A6U8
Uniprot Name:GLGA_ECOLI
GenBank Gene ID:AP009048
Genebank Protein ID:1651310
Ecogene ID:EG10377
Ecocyc:EG10377
ColiBase:b3429
Kegg Gene:b3429
EchoBASE ID:EB0372
CCDB:GLGA_ECOLI
BacMap:16131303
General Reference:
  • Baecker, P. A., Furlong, C. E., Preiss, J. (1983). "Biosynthesis of bacterial glycogen. Primary structure of Escherichia coli ADP-glucose synthetase as deduced from the nucleotide sequence of the glg C gene." J Biol Chem 258:5084-5088. Pubmed: 6300111
  • Blattner, F. R., Plunkett, G. 3rd, Bloch, C. A., Perna, N. T., Burland, V., Riley, M., Collado-Vides, J., Glasner, J. D., Rode, C. K., Mayhew, G. F., Gregor, J., Davis, N. W., Kirkpatrick, H. A., Goeden, M. A., Rose, D. J., Mau, B., Shao, Y. (1997). "The complete genome sequence of Escherichia coli K-12." Science 277:1453-1462. Pubmed: 9278503
  • Hayashi, K., Morooka, N., Yamamoto, Y., Fujita, K., Isono, K., Choi, S., Ohtsubo, E., Baba, T., Wanner, B. L., Mori, H., Horiuchi, T. (2006). "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Mol Syst Biol 2:2006.0007. Pubmed: 16738553
  • Kaidow, A., Kataoka, T., Wachi, M., Takada, A., Yamasaki, M., Nagai, K. (1992). "The 55-kilodalton protein in an oriC complex fraction is glycogen synthase." J Bacteriol 174:5454-5456. Pubmed: 1644773
  • Kumar, A., Larsen, C. E., Preiss, J. (1986). "Biosynthesis of bacterial glycogen. Primary structure of Escherichia coli ADP-glucose:alpha-1,4-glucan, 4-glucosyltransferase as deduced from the nucleotide sequence of the glgA gene." J Biol Chem 261:16256-16259. Pubmed: 3097003