ECMDB

Identification

Name:

Putative aliphatic sulfonates transport permease protein ssuC

Synonyms:

Not Available

Gene Name:

ssuC

Enzyme Class:

Not Available

Biological Properties

General Function:

Involved in transporter activity

Specific Function:

Part of a binding-protein-dependent transport system for aliphatic sulfonates. Probably responsible for the translocation of the substrate across the membrane

Cellular Location:

Cell inner membrane; Multi-pass membrane protein

SMPDB Pathways:

Sulfur metabolism PW000922
sulfur metabolism (butanesulfonate) PW000923
sulfur metabolism (ethanesulfonate) PW000925
sulfur metabolism (isethionate) PW000926
sulfur metabolism (methanesulfonate) PW000927
sulfur metabolism (propanesulfonate) PW000924

KEGG Pathways:

Sulfur metabolism ec00920

Transports:

Transport References:

Uniprot Consortium (2012). "Reorganizing the protein space at the Universal Protein Resource (UniProt)." Nucleic Acids Res 40:D71-D75. Pubmed: 22102590

SMPDB Reactions:

1.0Alkyl Sulfate

1.0

→

1.0Adenosine diphosphate

1.0

1.0Alkyl Sulfate

1.0

1.0Alkyl Sulfate + 1.0Adenosine triphosphate + 1.0Water → 1.0Adenosine diphosphate + 1.0Phosphate + 1.0Hydrogen ion + 1.0Alkyl Sulfate + 1.0ADP
ReactionCard

1.0

→

1.0Adenosine diphosphate

1.0

1.0Adenosine triphosphate + 1.0Water + 1.0Butanesulfonate → 1.0Adenosine diphosphate + 1.0Phosphate + 1.0Hydrogen ion + 1.0Butanesulfonate + 1.0ADP
ReactionCard

1.0

→

1.0

1.0Adenosine diphosphate

1.0

1.0Adenosine triphosphate + 1.0Water + 1.03-(N-morpholino)propanesulfonate → 1.0Phosphate + 1.0Hydrogen ion + 1.0Adenosine diphosphate + 1.03-(N-morpholino)propanesulfonate + 1.0ADP
ReactionCard

1.0

→

1.0

1.0Adenosine diphosphate

1.0

1.0Adenosine triphosphate + 1.0Water + 1.0 ethanesulfonate → 1.0Hydrogen ion + 1.0Phosphate + 1.0Adenosine diphosphate + 1.0 ethanesulfonate + 1.0ADP
ReactionCard

1.0

→

1.0Adenosine diphosphate

1.0

1.0Adenosine triphosphate + 1.0Water + 1.0 isethionate → 1.0Adenosine diphosphate + 1.0Hydrogen ion + 1.0Phosphate + 1.0 isethionate + 1.0ADP
ReactionCard

1.0

1.0methanesulfonate

1.0

→

1.0Adenosine diphosphate

1.0

1.0methanesulfonate

1.0

1.0Adenosine triphosphate + 1.0Water + 1.0methanesulfonate + 1.0Methanesulfonate → 1.0Adenosine diphosphate + 1.0Phosphate + 1.0Hydrogen ion + 1.0methanesulfonate + 1.0ADP
ReactionCard

1.0

→

1.0

1.0Adenosine diphosphate

1.0

1.0Cysteine-S-sulfate + 1.0Adenosine triphosphate + 1.0Water → 1.0Cysteine-S-sulfate + 1.0Adenosine diphosphate + 1.0Phosphate + 1.0Hydrogen ion + 1.0ADP
ReactionCard

Complex Reactions:

1.0

→

1.0

1.0Adenosine triphosphate + 1.0Water + 1.0Isethionic acid → 1.0ADP + 1.0Hydrogen ion + 1.0Isethionic acid + 1.0Phosphate
ReactionCard

1.0

→

1.0

1.0Adenosine triphosphate + 1.0Water + 1.0Butanesulfonate → 1.0ADP + 1.0Butanesulfonate + 1.0Hydrogen ion + 1.0Phosphate
ReactionCard

1.0

→

1.0

1.0Adenosine triphosphate + 1.0Water + 1.0Ethanesulfonate → 1.0ADP + 1.0Ethanesulfonate + 1.0Hydrogen ion + 1.0Phosphate
ReactionCard

1.0

→

1.0

1.0Adenosine triphosphate + 1.0Water + 1.0Methanesulfonate → 1.0ADP + 1.0Hydrogen ion + 1.0Methanesulfonate + 1.0Phosphate
ReactionCard

1.0

→

1.0

1.0Adenosine triphosphate + 1.0Water + 1.0Sulfoacetate → 1.0ADP + 1.0Hydrogen ion + 1.0Phosphate + 1.0Sulfoacetate
ReactionCard

Metabolites:

ECMDB ID	Name	View
ECMDB24254	ethanesulfonate	MetaboCard
ECMDB24255	isethionate	MetaboCard
ECMDB24253	3-(N-morpholino)propanesulfonate	MetaboCard
ECMDB21002	3-Sulfopyruvic acid	MetaboCard
ECMDB04195	5-L-Glutamyl-taurine	MetaboCard
ECMDB00538	Adenosine triphosphate	MetaboCard
ECMDB01341	ADP	MetaboCard
ECMDB21313	Butanesulfonate	MetaboCard
ECMDB02757	Cysteic acid	MetaboCard
ECMDB00731	Cysteine-S-sulfate	MetaboCard
ECMDB21330	Ethanesulfonate	MetaboCard
ECMDB21225	Hydrogen ion	MetaboCard
ECMDB21233	Isethionic acid	MetaboCard
ECMDB21344	Methanesulfonate	MetaboCard
ECMDB01429	Phosphate	MetaboCard
ECMDB01134	Phosphoadenosine phosphosulfate	MetaboCard
ECMDB01448	Sulfate	MetaboCard
ECMDB00240	Sulfite	MetaboCard
ECMDB21358	Sulfoacetate	MetaboCard
ECMDB00494	Water	MetaboCard

GO Classification:

Component
cell part
membrane
Function
transporter activity
Process
establishment of localization
transport

Gene Properties

Blattner:

b0934

Gene Orientation

Counterclockwise

Centisome Percentage:

21.41

Left Sequence End

993264

Right Sequence End

994055

Gene Sequence:

>792 bp
ATGGCAACGCCAGTGAAGAAGTGGTTATTGCGCGTTGCCCCCTGGTTTTTACCGGTGGGC
ATCGTGGCGGTGTGGCAACTGGCCTCCTCGGTTGGCTGGCTGTCGACGCGTATTTTGCCT
TCACCGGAAGGAGTGGTGACGGCGTTCTGGACGCTCTCCGCCAGCGGCGAACTGTGGCAG
CATCTGGCGATCAGCTCCTGGCGGGCGCTGATTGGCTTTTCAATTGGCGGATCGCTGGGG
TTGATTTTGGGACTGATTAGCGGGCTATCTCGCTGGGGAGAACGGCTGCTGGATACCTCA
ATTCAGATGTTGCGCAACGTGCCGCATCTGGCGCTGATCCCGCTGGTGATTTTGTGGTTT
GGCATTGATGAATCCGCAAAAATCTTTCTGGTGGCGCTCGGTACGCTATTCCCCATTTAT
ATCAACACCTGGCATGGCATCCGTAATATCGATCGCGGGTTGGTGGAGATGGCGCGTAGC
TATGGATTATCCGGCATACCGCTGTTTATCCATGTGATCCTGCCTGGTGCCCTGCCCTCA
ATTATGGTCGGCGTGCGTTTTGCGTTGGGCCTGATGTGGCTGACGCTGATTGTTGCCGAA
ACCATTTCTGCCAATTCAGGCATTGGTTATCTGGCGATGAATGCGCGGGAGTTTTTGCAA
ACGGACGTGGTGGTAGTCGCTATTATTCTTTACGCCCTGCTCGGCAAACTGGCTGACGTC
AGCGCGCAGCTGTTAGAGCGCCTCTGGTTGCGCTGGAACCCGGCTTATCATTTGAAGGAG
GCCACGGTATGA

Protein Properties

Pfam Domain Function:

BPD_transp_1 (PF00528 )

Protein Residues:

263

Protein Molecular Weight:

28925

Protein Theoretical pI:

Signaling Regions:

None

Transmembrane Regions:

14-34
44-64
69-89
103-122
126-148
165-185
188-208
218-238

Protein Sequence:

>Putative aliphatic sulfonates transport permease protein ssuC
MATPVKKWLLRVAPWFLPVGIVAVWQLASSVGWLSTRILPSPEGVVTAFWTLSASGELWQ
HLAISSWRALIGFSIGGSLGLILGLISGLSRWGERLLDTSIQMLRNVPHLALIPLVILWF
GIDESAKIFLVALGTLFPIYINTWHGIRNIDRGLVEMARSYGLSGIPLFIHVILPGALPS
IMVGVRFALGLMWLTLIVAETISANSGIGYLAMNAREFLQTDVVVVAIILYALLGKLADV
SAQLLERLWLRWNPAYHLKEATV

References

External Links:

Resource	Link
Uniprot ID:	P75851
Uniprot Name:	SSUC_ECOLI
GenBank Gene ID:	AJ237695
Genebank Protein ID:	4583569
Ecogene ID:	EG13705
Ecocyc:	EG13705
ColiBase:	b0934
Kegg Gene:	b0934
EchoBASE ID:	EB3469
CCDB:	SSUC_ECOLI
BacMap:	90111188

General Reference:

Blattner, F. R., Plunkett, G. 3rd, Bloch, C. A., Perna, N. T., Burland, V., Riley, M., Collado-Vides, J., Glasner, J. D., Rode, C. K., Mayhew, G. F., Gregor, J., Davis, N. W., Kirkpatrick, H. A., Goeden, M. A., Rose, D. J., Mau, B., Shao, Y. (1997). "The complete genome sequence of Escherichia coli K-12." Science 277:1453-1462. Pubmed: 9278503
Daley, D. O., Rapp, M., Granseth, E., Melen, K., Drew, D., von Heijne, G. (2005). "Global topology analysis of the Escherichia coli inner membrane proteome." Science 308:1321-1323. Pubmed: 15919996
Drew, D., Sjostrand, D., Nilsson, J., Urbig, T., Chin, C. N., de Gier, J. W., von Heijne, G. (2002). "Rapid topology mapping of Escherichia coli inner-membrane proteins by prediction and PhoA/GFP fusion analysis." Proc Natl Acad Sci U S A 99:2690-2695. Pubmed: 11867724
Hayashi, K., Morooka, N., Yamamoto, Y., Fujita, K., Isono, K., Choi, S., Ohtsubo, E., Baba, T., Wanner, B. L., Mori, H., Horiuchi, T. (2006). "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Mol Syst Biol 2:2006.0007. Pubmed: 16738553
Oshima, T., Aiba, H., Baba, T., Fujita, K., Hayashi, K., Honjo, A., Ikemoto, K., Inada, T., Itoh, T., Kajihara, M., Kanai, K., Kashimoto, K., Kimura, S., Kitagawa, M., Makino, K., Masuda, S., Miki, T., Mizobuchi, K., Mori, H., Motomura, K., Nakamura, Y., Nashimoto, H., Nishio, Y., Saito, N., Horiuchi, T., et, a. l. .. (1996). "A 718-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 12.7-28.0 min region on the linkage map." DNA Res 3:137-155. Pubmed: 8905232
van Der Ploeg, J. R., Iwanicka-Nowicka, R., Bykowski, T., Hryniewicz, M. M., Leisinger, T. (1999). "The Escherichia coli ssuEADCB gene cluster is required for the utilization of sulfur from aliphatic sulfonates and is regulated by the transcriptional activator Cbl." J Biol Chem 274:29358-29365. Pubmed: 10506196

Putative aliphatic sulfonates transport permease protein ssuC (P75851)