High-affinity zinc uptake system membrane protein znuB (P39832)

Identification
Name:High-affinity zinc uptake system membrane protein znuB
Synonyms:Not Available
Gene Name:znuB
Enzyme Class:Not Available
Biological Properties
General Function:Involved in ATP binding
Specific Function:Involved in the high-affinity zinc uptake transport system
Cellular Location:Cell inner membrane; Multi-pass membrane protein
SMPDB Pathways:
  • Collection of Reactions without pathways PW001891
KEGG Pathways:
EcoCyc Reactions:
1.0Thumb+1.0Thumb+1.0Thumb → 1.0Thumb+1.0Thumb+1.0Thumb+1.0Thumb
1.0Adenosine triphosphate + 1.0Water + 1.0Zinc → 1.0ADP + 1.0Hydrogen ion + 1.0Phosphate + 1.0Zinc
ReactionCard
Metabolites:
ECMDB IDNameView
ECMDB00538Adenosine triphosphateMetaboCard
ECMDB01341ADPMetaboCard
ECMDB21225Hydrogen ionMetaboCard
ECMDB01429PhosphateMetaboCard
ECMDB00494WaterMetaboCard
ECMDB01303ZincMetaboCard
GO Classification:
Component
cell part
membrane
Function
active transmembrane transporter activity
adenyl nucleotide binding
adenyl ribonucleotide binding
ATP binding
ATPase activity, coupled to transmembrane movement of substances
binding
nucleoside binding
P-P-bond-hydrolysis-driven transmembrane transporter activity
primary active transmembrane transporter activity
purine nucleoside binding
transmembrane transporter activity
transporter activity
Process
establishment of localization
transport
Gene Properties
Blattner:b1859
Gene OrientationClockwise
Centisome Percentage:41.84
Left Sequence End1941438
Right Sequence End1942223
Gene Sequence:
>786 bp
ATGAATTCAAAAAAGCTTTGTTGCATATGTGTGTTATTCTCGCTGCTTGCAGGATGTGCC
TCTGAATCTTCTATTGATGAAAAGAAGAAAAAAGCTCAAGTCACACAAAGTAATATTAAT
AAAAACACTCCCCAGCAACTGACAGACAAAGATTTATTCGGTAATGAAACCACTCTGGCC
GTATCCGAAGAGGATATTCAAGCTGCGCTTGATGGAGATGAGTTCCGCGTTCCCCTTAAT
TCTCCTGTAATACTTGTTCAATCCGGCAACCGCGCACCGGAAACCATTATGCAGGAGGAG
ATGCGAAAATATTATACTGTTTCCACATTCTCTGGTATCCCGGACAGGCAAAAGCCTCTG
ACTTGTAACAAAAACAAAGATAAAAATGAGAACGAGGATGTTGCCAGTGCTGAGAATATG
AACTGGATGCAGGCACTGCGTTTTGTGGCTGCAAAAGGACATCAGAAAGCGATTATTGTT
TACCAGGATATGTTGCAGACAGGAAAATATGACTCTGCGCTGAAATCAACAGTATGGTCC
GACTATAAAAATGACAAACTCACTGACGCTATCTCCCTGCGCTACCTGGTACGTTTCACG
CTGGTGGATGTGGCAACAGGTGAGTGGGCTACCTGGTCGCCGGTGAATTATGAATATAAA
GTGCTTCCACCATTGCCCGACAAGAATGAAGCCAGTACGACTGATATGACAGAGCAGCAA
ATCATGCAACTTAAGCAAAAGACCTATAAAGCGATGGTAAAAGATTTGGTTAACCGCTAT
CAATAA
Protein Properties
Pfam Domain Function:
Protein Residues:261
Protein Molecular Weight:27728
Protein Theoretical pI:9
Signaling Regions:
  • None
Transmembrane Regions:
  • 8-28
  • 54-74
  • 84-104
  • 122-142
  • 178-198
  • 214-234
  • 236-256
Protein Sequence:
>High-affinity zinc uptake system membrane protein znuB
MIELLFPGWLAGIMLACAAGPLGSFVVWRRMSYFGDTLAHASLLGVAFGLLLDVNPFYAV
IAVTLLLAGGLVWLEKRPQLAIDTLLGIMAHSALSLGLVVVSLMSNIRVDLMAYLFGDLL
AVTPEDLISIAIGVVIVVAILFWQWRNLLSMTISPDLAFVDGVKLQRVKLLLMLVTALTI
GVAMKFVGALIITSLLIIPAATARRFARTPEQMAGVAVLVGMVAVTGGLTFSAVYDTPAG
PSVVLCAALLFILSMMKKQAS
References
External Links:
ResourceLink
Uniprot ID:P39832
Uniprot Name:ZNUB_ECOLI
GenBank Gene ID:AP009048
Genebank Protein ID:4902953
Ecogene ID:EG12368
Ecocyc:EG12368
ColiBase:b1859
Kegg Gene:b1859
EchoBASE ID:EB2271
CCDB:ZNUB_ECOLI
BacMap:16129812
General Reference:
  • Blattner, F. R., Plunkett, G. 3rd, Bloch, C. A., Perna, N. T., Burland, V., Riley, M., Collado-Vides, J., Glasner, J. D., Rode, C. K., Mayhew, G. F., Gregor, J., Davis, N. W., Kirkpatrick, H. A., Goeden, M. A., Rose, D. J., Mau, B., Shao, Y. (1997). "The complete genome sequence of Escherichia coli K-12." Science 277:1453-1462. Pubmed: 9278503
  • Borodovsky, M., Rudd, K. E., Koonin, E. V. (1994). "Intrinsic and extrinsic approaches for detecting genes in a bacterial genome." Nucleic Acids Res 22:4756-4767. Pubmed: 7984428
  • Daley, D. O., Rapp, M., Granseth, E., Melen, K., Drew, D., von Heijne, G. (2005). "Global topology analysis of the Escherichia coli inner membrane proteome." Science 308:1321-1323. Pubmed: 15919996
  • Hayashi, K., Morooka, N., Yamamoto, Y., Fujita, K., Isono, K., Choi, S., Ohtsubo, E., Baba, T., Wanner, B. L., Mori, H., Horiuchi, T. (2006). "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Mol Syst Biol 2:2006.0007. Pubmed: 16738553
  • Itoh, T., Aiba, H., Baba, T., Hayashi, K., Inada, T., Isono, K., Kasai, H., Kimura, S., Kitakawa, M., Kitagawa, M., Makino, K., Miki, T., Mizobuchi, K., Mori, H., Mori, T., Motomura, K., Nakade, S., Nakamura, Y., Nashimoto, H., Nishio, Y., Oshima, T., Saito, N., Sampei, G., Seki, Y., Horiuchi, T., et, a. l. .. (1996). "A 460-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 40.1-50.0 min region on the linkage map." DNA Res 3:379-392. Pubmed: 9097040
  • Patzer, S. I., Hantke, K. (1998). "The ZnuABC high-affinity zinc uptake system and its regulator Zur in Escherichia coli." Mol Microbiol 28:1199-1210. Pubmed: 9680209
  • Shinagawa, H., Makino, K., Amemura, M., Kimura, S., Iwasaki, H., Nakata, A. (1988). "Structure and regulation of the Escherichia coli ruv operon involved in DNA repair and recombination." J Bacteriol 170:4322-4329. Pubmed: 2842314