High-affinity zinc uptake system membrane protein znuB (P39832)

Identification
Name:High-affinity zinc uptake system membrane protein znuB
Synonyms:Not Available
Gene Name:znuB
Enzyme Class:Not Available
Biological Properties
General Function:Involved in ATP binding
Specific Function:Involved in the high-affinity zinc uptake transport system
Cellular Location:Cell inner membrane; Multi-pass membrane protein
SMPDB Pathways:
  • Collection of Reactions without pathways PW001891
KEGG Pathways:
Transports:
    Transport References:Not Available
    EcoCyc Reactions:
    1.0Thumb+1.0Thumb+1.0Thumb → 1.0Thumb+1.0Thumb+1.0Thumb+1.0Thumb
    1.0Adenosine triphosphate + 1.0Water + 1.0Zinc → 1.0ADP + 1.0Hydrogen ion + 1.0Phosphate + 1.0Zinc
    ReactionCard
    Metabolites:
    ECMDB IDNameView
    ECMDB00538Adenosine triphosphateMetaboCard
    ECMDB01341ADPMetaboCard
    ECMDB21225Hydrogen ionMetaboCard
    ECMDB01429PhosphateMetaboCard
    ECMDB00494WaterMetaboCard
    ECMDB01303ZincMetaboCard
    GO Classification:
    Component
    cell part
    membrane
    Function
    active transmembrane transporter activity
    adenyl nucleotide binding
    adenyl ribonucleotide binding
    ATP binding
    ATPase activity, coupled to transmembrane movement of substances
    binding
    nucleoside binding
    P-P-bond-hydrolysis-driven transmembrane transporter activity
    primary active transmembrane transporter activity
    purine nucleoside binding
    transmembrane transporter activity
    transporter activity
    Process
    establishment of localization
    transport
    Gene Properties
    Blattner:b1859
    Gene OrientationClockwise
    Centisome Percentage:41.84
    Left Sequence End1941438
    Right Sequence End1942223
    Gene Sequence:
    >786 bp
ATGAATTCAAAAAAGCTTTGTTGCATATGTGTGTTATTCTCGCTGCTTGCAGGATGTGCC
TCTGAATCTTCTATTGATGAAAAGAAGAAAAAAGCTCAAGTCACACAAAGTAATATTAAT
AAAAACACTCCCCAGCAACTGACAGACAAAGATTTATTCGGTAATGAAACCACTCTGGCC
GTATCCGAAGAGGATATTCAAGCTGCGCTTGATGGAGATGAGTTCCGCGTTCCCCTTAAT
TCTCCTGTAATACTTGTTCAATCCGGCAACCGCGCACCGGAAACCATTATGCAGGAGGAG
ATGCGAAAATATTATACTGTTTCCACATTCTCTGGTATCCCGGACAGGCAAAAGCCTCTG
ACTTGTAACAAAAACAAAGATAAAAATGAGAACGAGGATGTTGCCAGTGCTGAGAATATG
AACTGGATGCAGGCACTGCGTTTTGTGGCTGCAAAAGGACATCAGAAAGCGATTATTGTT
TACCAGGATATGTTGCAGACAGGAAAATATGACTCTGCGCTGAAATCAACAGTATGGTCC
GACTATAAAAATGACAAACTCACTGACGCTATCTCCCTGCGCTACCTGGTACGTTTCACG
CTGGTGGATGTGGCAACAGGTGAGTGGGCTACCTGGTCGCCGGTGAATTATGAATATAAA
GTGCTTCCACCATTGCCCGACAAGAATGAAGCCAGTACGACTGATATGACAGAGCAGCAA
ATCATGCAACTTAAGCAAAAGACCTATAAAGCGATGGTAAAAGATTTGGTTAACCGCTAT
CAATAA
    Protein Properties
    Pfam Domain Function:
    Protein Residues:261
    Protein Molecular Weight:27728
    Protein Theoretical pI:9
    Signaling Regions:
    • None
    Transmembrane Regions:
    • 8-28
    • 54-74
    • 84-104
    • 122-142
    • 178-198
    • 214-234
    • 236-256
    Protein Sequence:
    >High-affinity zinc uptake system membrane protein znuB
MIELLFPGWLAGIMLACAAGPLGSFVVWRRMSYFGDTLAHASLLGVAFGLLLDVNPFYAV
IAVTLLLAGGLVWLEKRPQLAIDTLLGIMAHSALSLGLVVVSLMSNIRVDLMAYLFGDLL
AVTPEDLISIAIGVVIVVAILFWQWRNLLSMTISPDLAFVDGVKLQRVKLLLMLVTALTI
GVAMKFVGALIITSLLIIPAATARRFARTPEQMAGVAVLVGMVAVTGGLTFSAVYDTPAG
PSVVLCAALLFILSMMKKQAS
    References
    External Links:
    ResourceLink
    Uniprot ID:P39832
    Uniprot Name:ZNUB_ECOLI
    GenBank Gene ID:AP009048
    Genebank Protein ID:4902953
    Ecogene ID:EG12368
    Ecocyc:EG12368
    ColiBase:b1859
    Kegg Gene:b1859
    EchoBASE ID:EB2271
    CCDB:ZNUB_ECOLI
    BacMap:16129812
    General Reference:
    • Blattner, F. R., Plunkett, G. 3rd, Bloch, C. A., Perna, N. T., Burland, V., Riley, M., Collado-Vides, J., Glasner, J. D., Rode, C. K., Mayhew, G. F., Gregor, J., Davis, N. W., Kirkpatrick, H. A., Goeden, M. A., Rose, D. J., Mau, B., Shao, Y. (1997). "The complete genome sequence of Escherichia coli K-12." Science 277:1453-1462. Pubmed: 9278503
    • Borodovsky, M., Rudd, K. E., Koonin, E. V. (1994). "Intrinsic and extrinsic approaches for detecting genes in a bacterial genome." Nucleic Acids Res 22:4756-4767. Pubmed: 7984428
    • Daley, D. O., Rapp, M., Granseth, E., Melen, K., Drew, D., von Heijne, G. (2005). "Global topology analysis of the Escherichia coli inner membrane proteome." Science 308:1321-1323. Pubmed: 15919996
    • Hayashi, K., Morooka, N., Yamamoto, Y., Fujita, K., Isono, K., Choi, S., Ohtsubo, E., Baba, T., Wanner, B. L., Mori, H., Horiuchi, T. (2006). "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Mol Syst Biol 2:2006.0007. Pubmed: 16738553
    • Itoh, T., Aiba, H., Baba, T., Hayashi, K., Inada, T., Isono, K., Kasai, H., Kimura, S., Kitakawa, M., Kitagawa, M., Makino, K., Miki, T., Mizobuchi, K., Mori, H., Mori, T., Motomura, K., Nakade, S., Nakamura, Y., Nashimoto, H., Nishio, Y., Oshima, T., Saito, N., Sampei, G., Seki, Y., Horiuchi, T., et, a. l. .. (1996). "A 460-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 40.1-50.0 min region on the linkage map." DNA Res 3:379-392. Pubmed: 9097040
    • Patzer, S. I., Hantke, K. (1998). "The ZnuABC high-affinity zinc uptake system and its regulator Zur in Escherichia coli." Mol Microbiol 28:1199-1210. Pubmed: 9680209
    • Shinagawa, H., Makino, K., Amemura, M., Kimura, S., Iwasaki, H., Nakata, A. (1988). "Structure and regulation of the Escherichia coli ruv operon involved in DNA repair and recombination." J Bacteriol 170:4322-4329. Pubmed: 2842314