Guanylate kinase (P60546)

Identification
Name:Guanylate kinase
Synonyms:
  • GMP kinase
Gene Name:gmk
Enzyme Class:
Biological Properties
General Function:Involved in protein binding
Specific Function:Essential for recycling GMP and indirectly, cGMP
Cellular Location:Cytoplasm
SMPDB Pathways:
  • purine nucleotides de novo biosynthesis PW000910
  • purine nucleotides de novo biosynthesis 1435709748 PW000960
  • purine nucleotides de novo biosynthesis 2 PW002033
KEGG Pathways:
KEGG Reactions:
1.0Thumb+1.0Thumb ↔ 1.0Thumb+1.0Thumb
1.0Adenosine triphosphate + 1.02'-Deoxyguanosine 5'-monophosphate ↔ 1.0ADP + 1.0dGDP
ReactionCard
1.0Thumb+1.0Thumb ↔ 1.0Thumb+1.0Thumb
1.0Adenosine triphosphate + 1.0Guanosine monophosphate ↔ 1.0ADP + 1.0Guanosine diphosphate
ReactionCard
1.0Thumb+1.0Thumb ↔ 1.0Thumb+1.0dGDP
1.0Adenosine triphosphate + 1.02'-Deoxyguanosine 5'-monophosphate ↔ 1.0ADP + 1.0dGDP
ReactionCard
SMPDB Reactions:
1.0Thumb+1.0Thumb → 1.0Adenosine diphosphate+1.0Thumb+1.0Thumb
1.0Guanosine monophosphate + 1.0Adenosine triphosphate → 1.0Adenosine diphosphate + 1.0Guanosine diphosphate + 1.0ADP
ReactionCard
EcoCyc Reactions:
1.0Thumb+1.0Thumb ↔ 1.0Thumb+1.0Thumb
1.0Adenosine triphosphate + 1.02'-Deoxyguanosine 5'-monophosphate ↔ 1.0ADP + 1.0dGDP
ReactionCard
1.0Thumb+1.0Thumb ↔ 1.0Thumb+1.0Thumb
1.0Adenosine triphosphate + 1.0Guanosine monophosphate ↔ 1.0ADP + 1.0Guanosine diphosphate
ReactionCard
Complex Reactions:
1.0Thumb+1.0Thumb → 1.0Thumb+1.0Thumb
1.0Adenosine triphosphate + 1.0Guanosine monophosphate → 1.0ADP + 1.0Guanosine diphosphate
ReactionCard
Metabolites:
ECMDB IDNameView
ECMDB010442'-Deoxyguanosine 5'-monophosphateMetaboCard
ECMDB00538Adenosine triphosphateMetaboCard
ECMDB01341ADPMetaboCard
ECMDB00960dGDPMetaboCard
ECMDB01201Guanosine diphosphateMetaboCard
ECMDB01397Guanosine monophosphateMetaboCard
GO Classification:
Function
catalytic activity
guanylate kinase activity
phosphotransferase activity, phosphate group as acceptor
transferase activity
transferase activity, transferring phosphorus-containing groups
Process
cellular nitrogen compound metabolic process
metabolic process
nitrogen compound metabolic process
nucleobase, nucleoside and nucleotide metabolic process
nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
nucleoside phosphate metabolic process
nucleotide metabolic process
purine nucleotide metabolic process
Gene Properties
Blattner:b3648
Gene OrientationClockwise
Centisome Percentage:82.32
Left Sequence End3819451
Right Sequence End3820074
Gene Sequence:
>624 bp
ATGTCAGGTCTGCCACAGGGCAGACCAACGTTTGGCGCTGCGCAAAACGTGAGCGCGGTG
GTGGCGTATGACTTATCTGCCCACATGCTGGATGTCGTGGCACAAGCTGCCGAAGCCCGG
CAACTGAAAAATATCACCACCCGCCAGGGATATGCCGAAAGTCTGCCATTTGCCGATAAC
GCATTTGATATTGTTATCAGCCGTTATTCTGCCCATCACTGGCATGATGTTGGTGCAGCA
CTGCGAGAAGTGAATAGGATATTGAAACCTGGCGGTAGGCTGATTGTGATGGACGTAATG
TCTCCGGGTCACCCAGTGCGCGACATCTGGTTACAGACGGTAGAAGCATTACGCGATACC
TCTCACGTACGAAACTACGCCAGCGGTGAGTGGTTGACGTTAATCAATGAAGCCAATCTG
ATAGTTGATAATTTAATTACAGATAAGTTACCGCTGGAATTTTCTTCATGGGTCGCGAGA
ATGCGTACGCCAGAAGCGTTAGTAGACGCTATTCGCATTTACCAACAGAGCGCATCGACA
GAGGTGAGAACGTATTTTGCCTTGCAGAATGATGGCTTTTTCACCAGTGATATCATCATG
GTAGATGCACATAAAGCGGCATAA
Protein Properties
Pfam Domain Function:
Protein Residues:207
Protein Molecular Weight:23593
Protein Theoretical pI:7
PDB File:1S96
Signaling Regions:
  • None
Transmembrane Regions:
  • None
Protein Sequence:
>Guanylate kinase
MAQGTLYIVSAPSGAGKSSLIQALLKTQPLYDTQVSVSHTTRQPRPGEVHGEHYFFVNHD
EFKEMISRDAFLEHAEVFGNYYGTSREAIEQVLATGVDVFLDIDWQGAQQIRQKMPHARS
IFILPPSKIELDRRLRGRGQDSEEVIAKRMAQAVAEMSHYAEYDYLIVNDDFDTALTDLK
TIIRAERLRMSRQKQRHDALISKLLAD
References
External Links:
ResourceLink
Uniprot ID:P60546
Uniprot Name:KGUA_ECOLI
GenBank Gene ID:AP009048
Genebank Protein ID:4902947
PDB ID:1S96
Ecogene ID:EG10965
Ecocyc:EG10965
ColiBase:b3648
Kegg Gene:b3648
EchoBASE ID:EB0958
CCDB:KGUA_ECOLI
BacMap:16131519
General Reference:
  • Blattner, F. R., Plunkett, G. 3rd, Bloch, C. A., Perna, N. T., Burland, V., Riley, M., Collado-Vides, J., Glasner, J. D., Rode, C. K., Mayhew, G. F., Gregor, J., Davis, N. W., Kirkpatrick, H. A., Goeden, M. A., Rose, D. J., Mau, B., Shao, Y. (1997). "The complete genome sequence of Escherichia coli K-12." Science 277:1453-1462. Pubmed: 9278503
  • Burland, V., Plunkett, G. 3rd, Daniels, D. L., Blattner, F. R. (1993). "DNA sequence and analysis of 136 kilobases of the Escherichia coli genome: organizational symmetry around the origin of replication." Genomics 16:551-561. Pubmed: 7686882
  • Gentry, D., Bengra, C., Ikehara, K., Cashel, M. (1993). "Guanylate kinase of Escherichia coli K-12." J Biol Chem 268:14316-14321. Pubmed: 8390989
  • Hayashi, K., Morooka, N., Yamamoto, Y., Fujita, K., Isono, K., Choi, S., Ohtsubo, E., Baba, T., Wanner, B. L., Mori, H., Horiuchi, T. (2006). "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Mol Syst Biol 2:2006.0007. Pubmed: 16738553