ECMDB

Identification

Name:

Autoinducer 2-binding protein LsrB

Synonyms:

Not Available

Gene Name:

lsrB

Enzyme Class:

Not Available

Biological Properties

General Function:

periplasmic space

Specific Function:

Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Binds AI-2 and delivers it to the LsrC and LsrD permeases (Probable).

Cellular Location:

Not Available

SMPDB Pathways:

Quorum Sensing PW000836

KEGG Pathways:

ABC transporters ec02010

Transports:

Transport References:

Not Available

SMPDB Reactions:

1.0(2R,4S)-2-methyl-2,3,3,4-tetrahydroxytetrahydrofuran

1.0Phosphoribosyl-ATP

1.0

→

1.0(2R,4S)-2-methyl-2,3,3,4-tetrahydroxytetrahydrofuran

1.0Adenosine diphosphate

1.0

1.0Pyrophosphate

1.0

1.0(2R,4S)-2-methyl-2,3,3,4-tetrahydroxytetrahydrofuran + 1.0Phosphoribosyl-ATP + 1.0Water + 1.0(2R,4S)-2-Methyl-2,3,3,4-tetrahydroxytetrahydrofuran + 1.0Phosphoribosyl-ATP → 1.0(2R,4S)-2-methyl-2,3,3,4-tetrahydroxytetrahydrofuran + 1.0Adenosine diphosphate + 1.0Hydrogen ion + 1.0Pyrophosphate + 1.0ADP
ReactionCard

Metabolites:

ECMDB ID	Name	View
ECMDB21368	(2R,4S)-2-Methyl-2,3,3,4-tetrahydroxytetrahydrofuran	MetaboCard
ECMDB01341	ADP	MetaboCard
ECMDB21225	Hydrogen ion	MetaboCard
ECMDB04138	Phosphoribosyl-ATP	MetaboCard
ECMDB00494	Water	MetaboCard

GO Classification:

Function
ATP-binding cassette (ABC) transporter complex
periplasmic space

Gene Properties

Blattner:

Not Available

Gene Orientation

Not Available

Centisome Percentage:

Not Available

Left Sequence End

Not Available

Right Sequence End

Not Available

Gene Sequence:

>1023
atgacacttcatcgctttaagaaaatcgccttacttagcgctcttggcattgccgcaatc
tctatgaatgtgcaggccgcagagcgtattgcatttattcccaaactggttggcgtggga
ttttttaccagcggtggcaacggcgcacaacaagcgggtaaagagctgggcgttgatgtg
acctacgacgggccgacagaacccagtgtttctggtcaggtacagttgattaataacttc
gtcaatcaaggttataacgccattatcgtttctgcggtttcgcctgatggcttgtgtccg
gcactgaaacgcgccatgcaacgtggtgtgagagtgctgacctgggactctgatactaaa
ccggagtgccgctcttactacattaatcagggaacgcccgcccagttaggaggtatgttg
gtggatatggcggcgcgtcaggtgaataaagacaaagccaaagtcgcgtttttctactca
agccccaccgttacggaccaaaaccagtgggtgaaagaagcgaaagcgaaaatcgccaaa
gagcatccaggctgggaaattgtcactacgcagtttggctataacgatgccactaaatcg
ttacaaaccgcagaaggaatattaaaagcgtatagcgatctcgacgccattatcgccccc
gatgccaacgccctgcccgctgccgcacaagccgcagaaaacttgaaaaatgacaaagta
gcgattgtcggattcagtacgccaaatgtgatgcgcccgtatgtagagcgcggcacggtg
aaagaatttggcctgtgggatgtggttcagcaaggcaaaatttcagtgtatgtcgcggat
gcattattgaaaaaaggatcaatgaaaacgggcgacaagctggatatcaagggcgtaggt
caggttgaagtctcgccaaacagcgttcagggctatgactacgaagcggatggtaatggc
atcgtactgttaccggagcgcgtgatattcaacaaagagaatatcggcaaatacgatttc
tga

Protein Properties

Pfam Domain Function:

Not Available

Protein Residues:

340

Protein Molecular Weight:

36684

Protein Theoretical pI:

Not Available

Signaling Regions:

1-26

Transmembrane Regions:

Not Available

Protein Sequence:

>Autoinducer 2-binding protein LsrB
MTLHRFKKIALLSALGIAAISMNVQAAERIAFIPKLVGVGFFTSGGNGAQQAGKELGVDV
TYDGPTEPSVSGQVQLINNFVNQGYNAIIVSAVSPDGLCPALKRAMQRGVRVLTWDSDTK
PECRSYYINQGTPAQLGGMLVDMAARQVNKDKAKVAFFYSSPTVTDQNQWVKEAKAKIAK
EHPGWEIVTTQFGYNDATKSLQTAEGILKAYSDLDAIIAPDANALPAAAQAAENLKNDKV
AIVGFSTPNVMRPYVERGTVKEFGLWDVVQQGKISVYVADALLKKGSMKTGDKLDIKGVG
QVEVSPNSVQGYDYEADGNGIVLLPERVIFNKENIGKYDF

References

External Links:

Resource	Link
Uniprot ID:	P76142
Uniprot Name:	LSRB_ECOLI
CCDB:	LSRB_ECOLI

General Reference:

Not Available

Autoinducer 2-binding protein LsrB (P76142)