ECMDB: Glutamate/aspartate transport ATP-binding protein gltL (P0AAG3)

Identification

Name:

Glutamate/aspartate transport ATP-binding protein gltL

Synonyms:

Not Available

Gene Name:

gltL

Enzyme Class:

Not Available

Biological Properties

General Function:

Involved in nucleotide binding

Specific Function:

Part of the binding-protein-dependent transport system for glutamate and aspartate. Probably responsible for energy coupling to the transport system

Cellular Location:

Cell inner membrane; Peripheral membrane protein (Potential)

SMPDB Pathways:

D-Glutamine and D-glutamate metabolism PW000769
Glutathione metabolism PW000833
L-glutamate metabolism PW000789
Lysine biosynthesis PW000771
Porphyrin metabolism PW000936
glutathione metabolism II PW001927
glutathione metabolism III PW002018
proline metabolism PW000794
tRNA charging PW000799

KEGG Pathways:

ABC transporters ec02010
D-Glutamine and D-glutamate metabolism ec00471
Glutathione metabolism ec00480
Lysine biosynthesis ec00300

SMPDB Reactions:

1.0L-Glutamic acid

1.0

→

1.0Adenosine diphosphate

1.0

1.0L-Glutamic acid

1.0

1.0L-Glutamic acid + 1.0Adenosine triphosphate + 1.0Water + 1.0L-Glutamate → 1.0Adenosine diphosphate + 1.0Phosphate + 1.0Hydrogen ion + 1.0L-Glutamic acid + 1.0ADP
ReactionCard

1.0L-Aspartic acid

1.0

→

1.0Adenosine diphosphate

1.0

1.0L-Aspartic acid

1.0

1.0L-Aspartic acid + 1.0Adenosine triphosphate + 1.0Water + 1.0L-Aspartic acid → 1.0Adenosine diphosphate + 1.0Phosphate + 1.0Hydrogen ion + 1.0L-Aspartic acid + 1.0ADP
ReactionCard

EcoCyc Reactions:

1.0

→

1.0

1.0Adenosine triphosphate + 1.0Water + 1.0L-Glutamate → 1.0ADP + 1.0L-Glutamate + 1.0Hydrogen ion + 1.0Phosphate
ReactionCard

1.0

→

1.0

1.0Adenosine triphosphate + 1.0Water + 1.0L-Aspartic acid → 1.0ADP + 1.0L-Aspartic acid + 1.0Hydrogen ion + 1.0Phosphate
ReactionCard

Metabolites:

ECMDB ID	Name	View
ECMDB00538	Adenosine triphosphate	MetaboCard
ECMDB01341	ADP	MetaboCard
ECMDB21225	Hydrogen ion	MetaboCard
ECMDB00191	L-Aspartic acid	MetaboCard
ECMDB00148	L-Glutamate	MetaboCard
ECMDB01429	Phosphate	MetaboCard
ECMDB00494	Water	MetaboCard

GO Classification:

Function
adenyl nucleotide binding
adenyl ribonucleotide binding
ATP binding
ATPase activity
binding
catalytic activity
hydrolase activity
hydrolase activity, acting on acid anhydrides
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
nucleoside binding
nucleoside-triphosphatase activity
nucleotide binding
purine nucleoside binding
pyrophosphatase activity

Gene Properties

Blattner:

b0652

Gene Orientation

Counterclockwise

Centisome Percentage:

14.74

Left Sequence End

683753

Right Sequence End

684478

Gene Sequence:

>726 bp
ATGGCAACTGTTTCCATGCGCGACATGCTCAAGGCTGGTGTTCACTTCGGTCACCAGACC
CGTTACTGGAACCCGAAAATGAAGCCGTTCATCTTCGGTGCGCGTAACAAAGTTCACATC
ATCAACCTTGAGAAAACTGTACCGATGTTCAACGAAGCTCTGGCTGAACTGAACAAGATT
GCTTCTCGCAAAGGTAAAATCCTTTTCGTTGGTACTAAACGCGCTGCAAGCGAAGCGGTG
AAAGACGCTGCTCTGAGCTGCGACCAGTTCTTCGTGAACCATCGCTGGCTGGGCGGTATG
CTGACTAACTGGAAAACCGTTCGTCAGTCCATCAAACGTCTGAAAGACCTGGAAACTCAG
TCTCAGGACGGTACTTTCGACAAGCTGACCAAGAAAGAAGCGCTGATGCGCACTCGTGAG
CTGGAGAAACTGGAAAACAGCCTGGGCGGTATCAAAGACATGGGCGGTCTGCCGGACGCT
CTGTTTGTAATCGATGCTGACCACGAACACATTGCTATCAAAGAAGCAAACAACCTGGGT
ATTCCGGTATTTGCTATCGTTGATACCAACTCTGATCCGGACGGTGTTGACTTCGTTATC
CCGGGTAACGACGACGCAATCCGTGCTGTGACCCTGTACCTGGGCGCTGTTGCTGCAACC
GTACGTGAAGGCCGTTCTCAGGATCTGGCTTCCCAGGCGGAAGAAAGCTTCGTAGAAGCT
GAGTAA

Protein Properties

Pfam Domain Function:

ABC_tran (PF00005 )

Protein Residues:

241

Protein Molecular Weight:

26661

Protein Theoretical pI:

Signaling Regions:

None

Transmembrane Regions:

None

Protein Sequence:

>Glutamate/aspartate transport ATP-binding protein gltL
MITLKNVSKWYGHFQVLTDCSTEVKKGEVVVVCGPSGSGKSTLIKTVNGLEPVQQGEITV
DGIVVNDKKTDLAKLRSRVGMVFQHFELFPHLSIIENLTLAQVKVLKRDKAPAREKALKL
LERVGLSAHANKFPAQLSGGQQQRVAIARALCMDPIAMLFDEPTSALDPEMINEVLDVMV
ELANEGMTMMVVTHEMGFARKVANRVIFMDEGKIVEDSPKDAFFDDPKSDRAKDFLAKIL
H

References

External Links:

Resource	Link
Uniprot ID:	P0AAG3
Uniprot Name:	GLTL_ECOLI
GenBank Gene ID:	AP009048
Genebank Protein ID:	21239023
Ecogene ID:	EG12663
Ecocyc:	EG12663
ColiBase:	b0652
Kegg Gene:	b0652
EchoBASE ID:	EB2529
CCDB:	GLTL_ECOLI
BacMap:	16128635

General Reference:

Blattner, F. R., Plunkett, G. 3rd, Bloch, C. A., Perna, N. T., Burland, V., Riley, M., Collado-Vides, J., Glasner, J. D., Rode, C. K., Mayhew, G. F., Gregor, J., Davis, N. W., Kirkpatrick, H. A., Goeden, M. A., Rose, D. J., Mau, B., Shao, Y. (1997). "The complete genome sequence of Escherichia coli K-12." Science 277:1453-1462. Pubmed: 9278503
Hayashi, K., Morooka, N., Yamamoto, Y., Fujita, K., Isono, K., Choi, S., Ohtsubo, E., Baba, T., Wanner, B. L., Mori, H., Horiuchi, T. (2006). "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Mol Syst Biol 2:2006.0007. Pubmed: 16738553
Oshima, T., Aiba, H., Baba, T., Fujita, K., Hayashi, K., Honjo, A., Ikemoto, K., Inada, T., Itoh, T., Kajihara, M., Kanai, K., Kashimoto, K., Kimura, S., Kitagawa, M., Makino, K., Masuda, S., Miki, T., Mizobuchi, K., Mori, H., Motomura, K., Nakamura, Y., Nashimoto, H., Nishio, Y., Saito, N., Horiuchi, T., et, a. l. .. (1996). "A 718-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 12.7-28.0 min region on the linkage map." DNA Res 3:137-155. Pubmed: 8905232