Identification |
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Name: | Methionine import ATP-binding protein MetN |
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Synonyms: | Not Available |
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Gene Name: | metN |
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Enzyme Class: | Not Available |
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Biological Properties |
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General Function: | Involved in nucleotide binding |
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Specific Function: | Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (Probable). It has also been shown to be involved in formyl-L-methionine transport |
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Cellular Location: | Cell inner membrane; Peripheral membrane protein |
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SMPDB Pathways: | |
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KEGG Pathways: | |
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SMPDB Reactions: | |
1.0 | + | 1.0 | + | 1.0 | → | 1.0Adenosine diphosphate | + | 1.0 | + | 1.0 | + | 1.0 | + | 1.0 |
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1.0 | + | 1.0 | + | 1.0 | → | 1.0Adenosine diphosphate | + | 1.0Pyrophosphate | + | 1.0 | + | 1.0 | + | 1.0 |
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EcoCyc Reactions: | |
1.0 | + | 1.0 | + | 1.0 | → | 1.0 | + | 1.0 | + | 1.0 | + | 1.0 |
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1.0 | + | 1.0 | + | 1.0 | → | 1.0 | + | 1.0 | + | 1.0 | + | 1.0 |
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Metabolites: | |
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GO Classification: | Component |
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cell part | cell wall | external encapsulating structure | Gram-negative-bacterium-type cell wall | peptidoglycan-based cell wall | Function |
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active transmembrane transporter activity | adenyl nucleotide binding | adenyl ribonucleotide binding | amine transmembrane transporter activity | amino acid transmembrane transporter activity | amino acid-transporting ATPase activity | ATP binding | ATPase activity | binding | catalytic activity | D-methionine transmembrane transporter activity | hydrolase activity | hydrolase activity, acting on acid anhydrides | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | methionine transmembrane transporter activity | nucleoside binding | nucleoside-triphosphatase activity | nucleotide binding | purine nucleoside binding | pyrophosphatase activity | sulfur amino acid transmembrane transporter activity | transmembrane transporter activity | transporter activity | Process |
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amine transport | amino acid transport | D-methionine transport | establishment of localization | methionine transport | sulfur amino acid transport | transport |
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Gene Properties |
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Blattner: | b0199 |
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Gene Orientation | Counterclockwise |
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Centisome Percentage: | 4.78 |
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Left Sequence End | 221614 |
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Right Sequence End | 222645 |
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Gene Sequence: | >1032 bp
ATGATAAAACTTTCGAATATCACCAAAGTGTTCCACCAGGGCACCCGCACCATCCAGGCG
TTGAACAACGTCAGCCTGCATGTGCCAGCTGGACAAATTTATGGCGTTATCGGTGCCTCA
GGCGCGGGTAAGAGTACGCTTATACGTTGTGTAAACCTGCTGGAGCGCCCAACCGAGGGT
AGCGTGCTGGTCGATGGCCAGGAACTGACCACGCTGTCAGAATCCGAGTTGACCAAAGCT
CGCCGCCAGATTGGTATGATTTTCCAGCATTTTAACCTGCTCTCTTCGCGTACTGTTTTT
GGCAACGTGGCTCTGCCGCTGGAGCTGGACAACACACCGAAAGACGAGGTCAAACGTCGC
GTGACGGAATTGCTGTCATTGGTTGGTCTTGGCGATAAGCATGATAGCTACCCGTCGAAT
CTTTCCGGTGGGCAGAAACAACGTGTGGCAATTGCCCGTGCGTTAGCCAGCAATCCCAAA
GTATTGCTGTGTGATGAAGCCACCAGCGCGCTGGACCCGGCAACGACACGTTCTATTCTC
GAACTGCTGAAAGACATCAACCGCCGTCTGGGGTTGACGATTCTGTTGATCACCCACGAA
ATGGACGTTGTGAAGCGCATTTGTGATTGCGTGGCGGTCATCAGCAATGGAGAACTGATC
GAGCAGGACACGGTAAGTGAAGTGTTCTCGCATCCGAAAACGCCGCTGGCGCAGAAGTTT
ATTCAGTCGACCCTGCATCTGGATATCCCGGAAGATTACCAGGAACGTCTGCAAGCGGAG
CCATTTACTGACTGCGTGCCGATGCTGCGTCTGGAGTTTACCGGTCAATCGGTCGATGCC
CCACTGCTTTCTGAAACCGCGCGTCGTTTCAACGTCAACAACAACATTATTAGCGCGCAG
ATGGATTACGCCGGTGGCGTTAAGTTCGGCATCATGCTGACTGAAATGCACGGCACACAA
CAAGATACGCAAGCCGCCATTGCCTGGCTGCAGGAACACCATGTAAAAGTAGAGGTACTG
GGTTATGTCTGA |
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Protein Properties |
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Pfam Domain Function: | |
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Protein Residues: | 343 |
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Protein Molecular Weight: | 37788 |
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Protein Theoretical pI: | 6 |
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Signaling Regions: | |
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Transmembrane Regions: | |
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Protein Sequence: | >Methionine import ATP-binding protein MetN
MIKLSNITKVFHQGTRTIQALNNVSLHVPAGQIYGVIGASGAGKSTLIRCVNLLERPTEG
SVLVDGQELTTLSESELTKARRQIGMIFQHFNLLSSRTVFGNVALPLELDNTPKDEVKRR
VTELLSLVGLGDKHDSYPSNLSGGQKQRVAIARALASNPKVLLCDEATSALDPATTRSIL
ELLKDINRRLGLTILLITHEMDVVKRICDCVAVISNGELIEQDTVSEVFSHPKTPLAQKF
IQSTLHLDIPEDYQERLQAEPFTDCVPMLRLEFTGQSVDAPLLSETARRFNVNNNIISAQ
MDYAGGVKFGIMLTEMHGTQQDTQAAIAWLQEHHVKVEVLGYV |
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References |
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External Links: | |
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General Reference: | - Allikmets, R., Gerrard, B., Court, D., Dean, M. (1993). "Cloning and organization of the abc and mdl genes of Escherichia coli: relationship to eukaryotic multidrug resistance." Gene 136:231-236. Pubmed: 7904973
- Blattner, F. R., Plunkett, G. 3rd, Bloch, C. A., Perna, N. T., Burland, V., Riley, M., Collado-Vides, J., Glasner, J. D., Rode, C. K., Mayhew, G. F., Gregor, J., Davis, N. W., Kirkpatrick, H. A., Goeden, M. A., Rose, D. J., Mau, B., Shao, Y. (1997). "The complete genome sequence of Escherichia coli K-12." Science 277:1453-1462. Pubmed: 9278503
- Gal, J., Szvetnik, A., Schnell, R., Kalman, M. (2002). "The metD D-methionine transporter locus of Escherichia coli is an ABC transporter gene cluster." J Bacteriol 184:4930-4932. Pubmed: 12169620
- Hayashi, K., Morooka, N., Yamamoto, Y., Fujita, K., Isono, K., Choi, S., Ohtsubo, E., Baba, T., Wanner, B. L., Mori, H., Horiuchi, T. (2006). "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Mol Syst Biol 2:2006.0007. Pubmed: 16738553
- Zhang, Z., Feige, J. N., Chang, A. B., Anderson, I. J., Brodianski, V. M., Vitreschak, A. G., Gelfand, M. S., Saier, M. H. Jr (2003). "A transporter of Escherichia coli specific for L- and D-methionine is the prototype for a new family within the ABC superfamily." Arch Microbiol 180:88-100. Pubmed: 12819857
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