Ferric enterobactin transport system permease protein fepG (P23877)

Identification
Name:Ferric enterobactin transport system permease protein fepG
Synonyms:Not Available
Gene Name:fepG
Enzyme Class:Not Available
Biological Properties
General Function:Involved in transporter activity
Specific Function:Part of the binding-protein-dependent transport system for ferric enterobactin. Probably responsible for the translocation of the substrate across the membrane
Cellular Location:Cell inner membrane; Multi-pass membrane protein
SMPDB Pathways:
  • Biosynthesis of siderophore group nonribosomal peptides PW000760
  • inner membrane transport PW000786
KEGG Pathways:
  • ABC transporters ec02010
  • Biosynthesis of siderophore group nonribosomal peptides ec01053
Transports:
Transport References:
  • Uniprot Consortium (2012). "Reorganizing the protein space at the Universal Protein Resource (UniProt)." Nucleic Acids Res 40:D71-D75. Pubmed: 22102590
SMPDB Reactions:
1.0Thumb+1.0Thumb+1.0Thumb ? 1.0Thumb+1.0Adenosine diphosphate+1.0Thumb+1.0Thumb
1.0Ferric enterobactin + 1.0Adenosine triphosphate + 1.0Water ? 1.0Ferric enterobactin + 1.0Adenosine diphosphate + 1.0Hydrogen ion + 1.0ADP
ReactionCard
EcoCyc Reactions:
1.0Thumb+1.0Thumb+1.0Thumb → 1.0Thumb+1.0Thumb+1.0Thumb+1.0Thumb
1.0Adenosine triphosphate + 1.0Water + 1.0Ferric enterobactin → 1.0ADP + 1.0Ferric enterobactin + 1.0Hydrogen ion + 1.0Phosphate
ReactionCard
Complex Reactions:
1.0Thumb+1.0Thumb+1.0Thumb → 1.0Thumb+1.0Thumb+1.0Thumb+1.0Thumb
1.0Adenosine triphosphate + 1.0Water + 1.0ferric 2,3-dihydroxybenzoylserine → 1.0ADP + 1.0ferric 2,3-dihydroxybenzoylserine + 1.0Hydrogen ion + 1.0Phosphate
ReactionCard
Metabolites:
ECMDB IDNameView
ECMDB00538Adenosine triphosphateMetaboCard
ECMDB01341ADPMetaboCard
ECMDB21331ferric 2,3-dihydroxybenzoylserineMetaboCard
ECMDB21372Ferric enterobactinMetaboCard
ECMDB21225Hydrogen ionMetaboCard
ECMDB01429PhosphateMetaboCard
ECMDB00494WaterMetaboCard
GO Classification:
Component
cell part
membrane
Function
transporter activity
Process
establishment of localization
transport
Gene Properties
Blattner:b0589
Gene OrientationCounterclockwise
Centisome Percentage:13.35
Left Sequence End619419
Right Sequence End620411
Gene Sequence:
>993 bp
ATGATTTACGTCTCTCGCCGATTACTCATCACCTGTTTGCTGCTGGTTTCCGCCTGTGTG
GTTGCAGGTATCTGGGGATTACGCAGCGGTGCCGTCACGCTGGAAACCTCGCAGGTATTC
GCCGCGCTGATGGGCGATGCGCCGCGCAGTATGACGATGGTGGTCACCGAATGGCGTTTA
CCACGCGTGCTGATGGCGCTGTTGATTGGCGCAGCACTGGGCGTCAGTGGCGCGATTTTT
CAGTCGCTGATGCGTAACCCGCTCGGCAGCCCTGACGTAATGGGCTTTAACACCGGGGCG
TGGAGCGGCGTGCTGGTGGCGATGGTGCTGTTTGGTCAGGACCTGACGGCTATCGCGCTG
TCAGCAATGGTGGGCGGCATTGTCACTTCGCTGCTGGTCTGGCTGCTCGCCTGGCGCAAC
GGCATCGACACCTTTCGGTTGATTATTATCGGTATCGGCGTTCGCGCCATGCTGGTGGCC
TTTAATACCTGGCTGTTGCTGAAAGCGTCTTTAGAAACGGCGCTAACAGCAGGTTTGTGG
AATGCCGGATCGCTCAACGGCCTGACGTGGGCAAAAACCTCGCCTTCCGCACCCATCATT
ATATTGATGCTCATTGCCGCCGCCTTACTGGTACGCCGGATGCGCTTGCTGGAAATGGGC
GATGATACCGCGTGTGCGCTGGGCGTCAGCGTCGAACGTTCGCGTCTGTTAATGATGCTG
GTTGCAGTGGTGCTTACCGCTGCGGCAACAGCGCTTGCCGGGCCGATTTCCTTTATTGCT
TTAGTCGCACCGCACATTGCCCGACGCATTAGCGGCACCGCTCGCTGGGGGCTAACCCAG
GCGGCGCTATGCGGGGCGCTGTTACTGCTGGCGGCCGATCTCTGCGCCCAACAACTGTTT
ATGCCGTATCAACTTCCGGTTGGCGTCGTTACCGTCAGCCTCGGCGGTATTTACCTTATC
GTCTTGTTAATTCAGGAGTCTCGCAAAAAATGA
Protein Properties
Pfam Domain Function:
Protein Residues:330
Protein Molecular Weight:34910
Protein Theoretical pI:11
Signaling Regions:
  • None
Transmembrane Regions:
  • 8-28
  • 63-83
  • 93-113
  • 118-138
  • 147-167
  • 191-211
  • 236-256
  • 276-296
  • 304-324
Protein Sequence:
>Ferric enterobactin transport system permease protein fepG
MIYVSRRLLITCLLLVSACVVAGIWGLRSGAVTLETSQVFAALMGDAPRSMTMVVTEWRL
PRVLMALLIGAALGVSGAIFQSLMRNPLGSPDVMGFNTGAWSGVLVAMVLFGQDLTAIAL
SAMVGGIVTSLLVWLLAWRNGIDTFRLIIIGIGVRAMLVAFNTWLLLKASLETALTAGLW
NAGSLNGLTWAKTSPSAPIIILMLIAAALLVRRMRLLEMGDDTACALGVSVERSRLLMML
VAVVLTAAATALAGPISFIALVAPHIARRISGTARWGLTQAALCGALLLLAADLCAQQLF
MPYQLPVGVVTVSLGGIYLIVLLIQESRKK
References
External Links:
ResourceLink
Uniprot ID:P23877
Uniprot Name:FEPG_ECOLI
GenBank Gene ID:AP009048
Genebank Protein ID:85674710
Ecogene ID:EG10298
Ecocyc:EG10298
ColiBase:b0589
Kegg Gene:b0589
EchoBASE ID:EB0294
CCDB:FEPG_ECOLI
BacMap:16128572
General Reference:
  • Blattner, F. R., Plunkett, G. 3rd, Bloch, C. A., Perna, N. T., Burland, V., Riley, M., Collado-Vides, J., Glasner, J. D., Rode, C. K., Mayhew, G. F., Gregor, J., Davis, N. W., Kirkpatrick, H. A., Goeden, M. A., Rose, D. J., Mau, B., Shao, Y. (1997). "The complete genome sequence of Escherichia coli K-12." Science 277:1453-1462. Pubmed: 9278503
  • Daley, D. O., Rapp, M., Granseth, E., Melen, K., Drew, D., von Heijne, G. (2005). "Global topology analysis of the Escherichia coli inner membrane proteome." Science 308:1321-1323. Pubmed: 15919996
  • Hayashi, K., Morooka, N., Yamamoto, Y., Fujita, K., Isono, K., Choi, S., Ohtsubo, E., Baba, T., Wanner, B. L., Mori, H., Horiuchi, T. (2006). "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Mol Syst Biol 2:2006.0007. Pubmed: 16738553
  • Shea, C. M., McIntosh, M. A. (1991). "Nucleotide sequence and genetic organization of the ferric enterobactin transport system: homology to other periplasmic binding protein-dependent systems in Escherichia coli." Mol Microbiol 5:1415-1428. Pubmed: 1838574