Nitrogen regulation protein NR(II) (P0AFB5)

Identification
Name:Nitrogen regulation protein NR(II)
Synonyms:Not Available
Gene Name:glnL
Enzyme Class:
Biological Properties
General Function:Signal transduction mechanisms
Specific Function:NtrB acts as a signal transducer which responds to the nitrogen level of cell and modulates the activity of ntrC. In nitrogen limitation ntrB activates ntrC by phosphorylating it, while in nitrogen excess ntrC is dephosphorylated and consequently inactivated by ntrB
Cellular Location:Not Available
SMPDB Pathways:Not Available
KEGG Pathways:
Metabolites:
ECMDB IDNameView
ECMDB00538Adenosine triphosphateMetaboCard
ECMDB01341ADPMetaboCard
GO Classification:
Component
cell part
membrane
Function
adenyl nucleotide binding
adenyl ribonucleotide binding
ATP binding
binding
catalytic activity
kinase activity
molecular transducer activity
nucleoside binding
protein histidine kinase activity
protein kinase activity
purine nucleoside binding
signal transducer activity
transferase activity
transferase activity, transferring phosphorus-containing groups
two-component sensor activity
Process
biological regulation
cellular metabolic process
metabolic process
peptidyl-histidine phosphorylation
phosphate metabolic process
phosphorus metabolic process
phosphorylation
protein amino acid phosphorylation
regulation of biological process
regulation of cellular process
regulation of gene expression
regulation of macromolecule metabolic process
regulation of metabolic process
regulation of transcription
regulation of transcription, DNA-dependent
signal transduction
Gene Properties
Blattner:Not Available
Gene OrientationNot Available
Centisome Percentage:Not Available
Left Sequence EndNot Available
Right Sequence EndNot Available
Gene Sequence:
>1050 bp
ATGGCAACAGGCACGCAGCCCGATGCTGGGCAGATCCTCAACTCGCTGATTAACAGTATT
TTGTTAATCGATGACAACCTGGCGATCCATTACGCCAACCCTGCCGCGCAACAACTGCTC
GCCCAAAGCTCCCGCAAATTGTTTGGTACACCGTTACCGGAACTGTTGAGCTACTTCTCA
TTAAATATCGAGCTGATGCAAGAAAGTCTGGAGGCGGGGCAAGGTTTTACCGATAACGAA
GTGACGCTGGTCATCGACGGGCGCTCGCATATCCTTTCTGTGACGGCCCAGCGTATGCCG
GACGGCATGATCCTGCTGGAGATGGCTCCGATGGATAACCAGCGCCGCTTAAGTCAGGAA
CAGCTACAGCACGCCCAGCAGGTTGCTGCCCGTGATTTAGTGCGCGGCCTGGCACATGAG
ATTAAAAATCCGCTTGGCGGTTTACGTGGCGCGGCGCAGCTGCTCAGCAAAGCGTTACCT
GACCCATCACTACTCGAATATACCAAAGTGATTATCGAACAGGCGGACCGGCTGCGAAAT
CTGGTCGACCGTCTGTTGGGGCCGCAGCTGCCCGGTACGCGCGTTACCGAAAGTATTCAC
AAAGTGGCTGAACGCGTGGTAACGCTGGTGTCGATGGAACTGCCGGACAACGTGCGGTTG
ATTCGTGATTACGATCCCAGCCTACCGGAACTGGCGCACGACCCGGATCAAATTGAACAG
GTCTTGCTGAATATTGTGCGCAATGCGCTACAGGCGCTGGGGCCGGAAGGCGGTGAAATC
ATTCTGCGTACCCGCACCGCGTTTCAACTGACCTTACACGGCGAGCGCTACCGGCTGGCG
GCGCGGATTGATGTGGAAGATAACGGGCCGGGCATTCCGCCTCATTTGCAGGATACGCTG
TTTTACCCGATGGTCAGCGGCCGCGAAGGTGGCACCGGGCTTGGCTTATCCATCGCTCGT
AATTTGATTGATCAGCATTCAGGCAAAATTGAATTTACCAGTTGGCCAGGGCATACCGAG
TTCTCGGTTTACCTGCCTATCAGGAAATAA
Protein Properties
Pfam Domain Function:
Protein Residues:349
Protein Molecular Weight:38556
Protein Theoretical pI:5
PDB File:1R62
Signaling Regions:
  • None
Transmembrane Regions:
  • None
Protein Sequence:
>Nitrogen regulation protein NR(II)
MATGTQPDAGQILNSLINSILLIDDNLAIHYANPAAQQLLAQSSRKLFGTPLPELLSYFS
LNIELMQESLEAGQGFTDNEVTLVIDGRSHILSVTAQRMPDGMILLEMAPMDNQRRLSQE
QLQHAQQVAARDLVRGLAHEIKNPLGGLRGAAQLLSKALPDPSLLEYTKVIIEQADRLRN
LVDRLLGPQLPGTRVTESIHKVAERVVTLVSMELPDNVRLIRDYDPSLPELAHDPDQIEQ
VLLNIVRNALQALGPEGGEIILRTRTAFQLTLHGERYRLAARIDVEDNGPGIPPHLQDTL
FYPMVSGREGGTGLGLSIARNLIDQHSGKIEFTSWPGHTEFSVYLPIRK
References
External Links:
ResourceLink
Uniprot ID:P0AFB5
Uniprot Name:NTRB_ECOLI
GenBank Gene ID:L19201
Genebank Protein ID:304974
PDB ID:1R62
CCDB:NTRB_ECOLI
General Reference:
  • Blattner, F. R., Plunkett, G. 3rd, Bloch, C. A., Perna, N. T., Burland, V., Riley, M., Collado-Vides, J., Glasner, J. D., Rode, C. K., Mayhew, G. F., Gregor, J., Davis, N. W., Kirkpatrick, H. A., Goeden, M. A., Rose, D. J., Mau, B., Shao, Y. (1997). "The complete genome sequence of Escherichia coli K-12." Science 277:1453-1462. Pubmed: 9278503
  • Hayashi, K., Morooka, N., Yamamoto, Y., Fujita, K., Isono, K., Choi, S., Ohtsubo, E., Baba, T., Wanner, B. L., Mori, H., Horiuchi, T. (2006). "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Mol Syst Biol 2:2006.0007. Pubmed: 16738553
  • Miranda-Rios, J., Sanchez-Pescador, R., Urdea, M., Covarrubias, A. A. (1987). "The complete nucleotide sequence of the glnALG operon of Escherichia coli K12." Nucleic Acids Res 15:2757-2770. Pubmed: 2882477
  • Ninfa, A. J., Bennett, R. L. (1991). "Identification of the site of autophosphorylation of the bacterial protein kinase/phosphatase NRII." J Biol Chem 266:6888-6893. Pubmed: 2016302
  • Plunkett, G. 3rd, Burland, V., Daniels, D. L., Blattner, F. R. (1993). "Analysis of the Escherichia coli genome. III. DNA sequence of the region from 87.2 to 89.2 minutes." Nucleic Acids Res 21:3391-3398. Pubmed: 8346018
  • Rocha, M., Vazquez, M., Garciarrubio, A., Covarrubias, A. A. (1985). "Nucleotide sequence of the glnA-glnL intercistronic region of Escherichia coli." Gene 37:91-99. Pubmed: 2865194
  • Ueno-Nishio, S., Mango, S., Reitzer, L. J., Magasanik, B. (1984). "Identification and regulation of the glnL operator-promoter of the complex glnALG operon of Escherichia coli." J Bacteriol 160:379-384. Pubmed: 6148334