Glycerate kinase 2 (P23524)

Identification
Name:Glycerate kinase 2
Synonyms:Not Available
Gene Name:garK
Enzyme Class:
Biological Properties
General Function:Involved in glycerate kinase activity
Specific Function:ATP + (R)-glycerate = ADP + 3-phospho-(R)- glycerate
Cellular Location:Not Available
SMPDB Pathways:
  • 2-O-alpha-mannosyl-D-glycerate degradation PW002096
  • glycolate and glyoxylate degradation PW000827
  • glycolate and glyoxylate degradation II PW002021
  • superpathway of D-glucarate and D-galactarate degradation PW000795
KEGG Pathways:
KEGG Reactions:
1.0Thumb+1.0Thumb ↔ 1.0Thumb+1.0Thumb
1.0Adenosine triphosphate + 1.0Glyceric acid ↔ 1.0ADP + 1.03-Phospho-D-glycerate
ReactionCard
1.0Thumb+1.0Thumb → 1.0Thumb+1.0Thumb
1.0Adenosine triphosphate + 1.0Glyceric acid → 1.0ADP + 1.03-Phospho-D-glycerate
ReactionCard
SMPDB Reactions:
1.0Thumb+1.0Thumb → 1.0Thumb+1.0Adenosine diphosphate+1.02-Phosphoglyceric acid+1.0Thumb+1.0Thumb
1.0Glyceric acid + 1.0Adenosine triphosphate → 1.0Hydrogen ion + 1.0Adenosine diphosphate + 1.02-Phosphoglyceric acid + 1.0ADP + 1.02-Phosphoglyceric acid
ReactionCard
1.0Thumb+1.0Thumb → 1.0Adenosine diphosphate+1.0Thumb+1.03-Phosphoglyceric acid+1.0Thumb+1.0Thumb
1.0Glyceric acid + 1.0Adenosine triphosphate → 1.0Adenosine diphosphate + 1.0Hydrogen ion + 1.03-Phosphoglyceric acid + 1.0ADP + 1.03-Phosphoglycerate
ReactionCard
EcoCyc Reactions:
1.0Thumb+1.0Thumb → 1.0Thumb+1.0Thumb+1.0Thumb
1.0Adenosine triphosphate + 1.0Glyceric acid → 1.02-Phospho-D-glyceric acid + 1.0ADP + 1.0Hydrogen ion
ReactionCard
Complex Reactions:
1.0Thumb+1.0Thumb → 1.0Thumb+1.0Thumb
1.0Adenosine triphosphate + 1.0Glyceric acid → 1.0ADP + 1.02-Phospho-D-glyceric acid
ReactionCard
Metabolites:
ECMDB IDNameView
ECMDB041292-Phospho-D-glyceric acidMetaboCard
ECMDB214192-Phosphoglyceric acidMetaboCard
ECMDB216453-Phospho-D-glycerateMetaboCard
ECMDB041313-PhosphoglycerateMetaboCard
ECMDB00538Adenosine triphosphateMetaboCard
ECMDB01341ADPMetaboCard
ECMDB04077Glyceric acidMetaboCard
ECMDB21225Hydrogen ionMetaboCard
GO Classification:
Function
catalytic activity
glycerate kinase activity
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
Process
cellular metabolic process
metabolic process
organic acid metabolic process
organic acid phosphorylation
Gene Properties
Blattner:b3124
Gene OrientationCounterclockwise
Centisome Percentage:70.45
Left Sequence End3268647
Right Sequence End3269792
Gene Sequence:
>1146 bp
TTGATAATCAGCGAAATGCAACGCAAGCTTGCCACATGGGCAGCCACCGATCCGTCCCTA
CGGATTCAACGGCTGCTGCGTCTGATAACACAACCAGAATGGCTGGCTGAAGCGGCGCGG
ATCACGCTTTCATCAAAGGGGGCCCATACCCCCGGCGTTGATGGCGTGAACAAAACAATG
CTACAGGCCAGACTGGCTGTTGAGCTGCAAATCCTCAGGGATGAATTACTCTCAGGCCAC
TACCAGCCCTTGCCCGCCAGACGGGTTTACATCCCTAAAAGCAACGGCAAACTGCGACCA
CTGGGTATCCCCGCGTTGCGGGATCGTATTGTTCAGCGGGCCATGCTGATGGCGATGGAG
CCGATATGGGAGAGTGATTTTCATACGCTCTCATATGGCTTCCGGCCTGAGCGCAGTGTC
CACCACGCGATCCGCACGGTGAAATTACAGCTCACAGACTGTGGTGAAACCCGGGGACGC
TGGGTGATTGAAGGCGACCTGTCCAGTTACTTCGACACCGTACATCATCGACTGCTGATG
AAGGCTGTACGCCGCAGGATCAGTGACGCACGTTTCATGACTCTGCTGTGGAAAACCATC
AAGGCGGGACATATCGATGTCGGTCTCTTTCGGGCGGCCAGTGAAGGTGTGCCACAGGGC
GGTGTTATATCGCCGCTATTATCGAACATCATGCTGAATGAGTTCGATCAATACCTGCAT
GAGCGCTACCTGAGCGGGAAAGCCAGAAAAGATCGGTGGTACTGGAATAACAGTATCCAA
CGGGGCCGAAGTACGGCGGTCAGAGAAAACTGGCAGTGGAAACCCGCGGTGGCGTACTGC
CGCTATGCCGATGATTTTGTCCTCATCGTCAAAGGCACCAAAGCACAGGTGGAAGCCATC
AGGGAGGAGTGTCGGGGTGTGCTCGAAGGCAGTCTGAAACTCAGGCTGAACATGGATAAG
ACTAAAATCCCCCATGTTAATGACGGCTTTATCTTTCTGGGGCACAGGCTCATTCGCAAA
CGCAGTCGTTATGGCGAGATGCGAGTGGTCTCAACGATCCCGCAGGAGAAAGCCAGAAAC
TTCGCCGCATCGCTGACAGCACTGTTATGGAAGGTGCGAATAAGCGGGGAAATTCTTCTC
GGCTGA
Protein Properties
Pfam Domain Function:
Protein Residues:381
Protein Molecular Weight:39104
Protein Theoretical pI:5
Signaling Regions:
  • None
Transmembrane Regions:
  • None
Protein Sequence:
>Glycerate kinase 2
MKIVIAPDSYKESLSASEVAQAIEKGFREIFPDAQYVSVPVADGGEGTVEAMIAATQGAE
RHAWVTGPLGEKVNASWGISGDGKTAFIEMAAASGLELVPAEKRDPLVTTSRGTGELILQ
ALESGATNIIIGIGGSATNDGGAGMVQALGAKLCDANGNEIGFGGGSLNTLNDIDISGLD
PRLKDCVIRVACDVTNPLVGDNGASRIFGPQKGASEAMIVELDNNLSHYAEVIKKALHVD
VKDVPGAGAAGGMGAALMAFLGAELKSGIEIVTTALNLEEHIHDCTLVITGEGRIDSQSI
HGKVPIGVANVAKKYHKPVIGIAGSLTDDVGVVHQHGIDAVFSVLTSIGTLDEAFRGAYD
NICRASRNIAATLAIGMRNAG
References
External Links:
ResourceLink
Uniprot ID:P23524
Uniprot Name:GLXK2_ECOLI
GenBank Gene ID:AP009048
Genebank Protein ID:85674402
Ecogene ID:EG11175
Ecocyc:EG11175
ColiBase:b3124
Kegg Gene:b3124
EchoBASE ID:EB1162
CCDB:GLXK2_ECOLI
BacMap:145698314
General Reference:
  • Blattner, F. R., Plunkett, G. 3rd, Bloch, C. A., Perna, N. T., Burland, V., Riley, M., Collado-Vides, J., Glasner, J. D., Rode, C. K., Mayhew, G. F., Gregor, J., Davis, N. W., Kirkpatrick, H. A., Goeden, M. A., Rose, D. J., Mau, B., Shao, Y. (1997). "The complete genome sequence of Escherichia coli K-12." Science 277:1453-1462. Pubmed: 9278503
  • Hayashi, K., Morooka, N., Yamamoto, Y., Fujita, K., Isono, K., Choi, S., Ohtsubo, E., Baba, T., Wanner, B. L., Mori, H., Horiuchi, T. (2006). "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Mol Syst Biol 2:2006.0007. Pubmed: 16738553
  • Komine, Y., Inokuchi, H. (1991). "Precise mapping of the rnpB gene encoding the RNA component of RNase P in Escherichia coli K-12." J Bacteriol 173:1813-1816. Pubmed: 1705543