Dipeptide transport system permease protein dppB (P0AEF8)

Identification
Name:Dipeptide transport system permease protein dppB
Synonyms:Not Available
Gene Name:dppB
Enzyme Class:Not Available
Biological Properties
General Function:Involved in transporter activity
Specific Function:Part of the binding-protein-dependent transport system for dipeptides; probably responsible for the translocation of the substrate across the membrane
Cellular Location:Cell inner membrane; Multi-pass membrane protein
SMPDB Pathways:
KEGG Pathways:
Transports:
Transport References:
  • Uniprot Consortium (2012). "Reorganizing the protein space at the Universal Protein Resource (UniProt)." Nucleic Acids Res 40:D71-D75. Pubmed: 22102590
SMPDB Reactions:
1.0Homocarnosine+1.0Thumb+1.0Thumb+1.0Thumb → 1.0Homocarnosine+1.0Adenosine diphosphate+1.0Thumb+1.0Thumb+1.0Thumb
1.0Homocarnosine + 1.0Adenosine triphosphate + 1.0Water + 1.0Homocarnosine → 1.0Homocarnosine + 1.0Adenosine diphosphate + 1.0Phosphate + 1.0Hydrogen ion + 1.0ADP
ReactionCard
Complex Reactions:
1.0Thumb+1.0Thumb+1.0Thumb → 1.0Thumb+1.0Thumb+1.0Thumb+1.0Thumb
1.0Adenosine triphosphate + 1.0Water + 1.0D-Alanyl-D-alanine → 1.0ADP + 1.0D-Alanyl-D-alanine + 1.0Hydrogen ion + 1.0Phosphate
ReactionCard
1.0Thumb+1.0Thumb+1.0Thumb → 1.0Thumb+1.0Thumb+1.0Thumb+1.0Thumb
1.0Adenosine triphosphate + 1.0Water + 1.0Cysteinylglycine → 1.0ADP + 1.0Cysteinylglycine + 1.0Hydrogen ion + 1.0Phosphate
ReactionCard
1.0Thumb+1.0Thumb+1.0Thumb → 1.0Thumb+1.0Thumb+1.0Thumb+1.0Thumb
1.0Adenosine triphosphate + 1.0Water + 1.0L-Prolinylglycine → 1.0ADP + 1.0Hydrogen ion + 1.0Phosphate + 1.0L-Prolinylglycine
ReactionCard
Metabolites:
ECMDB IDNameView
ECMDB00538Adenosine triphosphateMetaboCard
ECMDB01341ADPMetaboCard
ECMDB00078CysteinylglycineMetaboCard
ECMDB03459D-Alanyl-D-alanineMetaboCard
ECMDB00745HomocarnosineMetaboCard
ECMDB21225Hydrogen ionMetaboCard
ECMDB20573L-Ala-D-Glu-meso-A2pmMetaboCard
ECMDB00099L-CystathionineMetaboCard
ECMDB21237L-ProlinylglycineMetaboCard
ECMDB01429PhosphateMetaboCard
ECMDB00494WaterMetaboCard
GO Classification:
Component
cell part
membrane
Function
transporter activity
Process
establishment of localization
transport
Gene Properties
Blattner:b3543
Gene OrientationCounterclockwise
Centisome Percentage:79.81
Left Sequence End3702794
Right Sequence End3703813
Gene Sequence:
>1020 bp
ATGCAGCAGGTGTTTTTCCAGGAAACTGAGTTTCTTAATTCAGTTATTGATTATGATCAT
AAAGTAGAAACAGAAAATCTTTGTCTGGACATCGCTTATGGAACTGACAAAAACTTTCTA
TTTGGTTGCGGAATTTCGATTGCTTCAATATTAAAATATAATGAAGGAAGTCGATTGTGT
TTCCATATTTTTACTGATTATTTTGGTGATGATGATCGTAAGTATTTTGATGCCCTGGCG
TTGCAGTATAAAACCAGAATTAAAATATATCTGATTAATGGTGATCGACTGCGCTCATTG
CCTAGCACTAAGAATTGGACTCATGCAATATATTTTCGTTTTGTTATTGCAGATTACTTT
ATTAATAAGGCGCCTAAAGTCCTTTATCTGGATGCAGATATCATTTGTCAGGGGACTATT
GAGCCACTAATTAATTTCTCATTTCCTGACGATAAAGTCGCAATGGTTGTTACAGAAGGG
CAAGCTGACTGGTGGGAAAAACGCGCCCATTCGTTAGGTGTTGCGGGAATTGCTAAAGGT
TACTTTAACTCCGGTTTTTTATTGATTAATACTGCCCAATGGGCGGCTCAGCAGGTTTCT
GCACGAGCTATTGCAATGCTAAATGAGCCAGAAATAATCAAAAAAATAACACATCCTGAT
CAGGATGTGTTAAATATGTTGCTGGCGGATAAACTTATTTTCGCTGATATTAAATATAAC
ACCCAGTTCAGCTTAAATTATCAACTCAAAGAAAGCTTTATAAACCCAGTAACCAACGAT
ACTATTTTTATCCATTATATCGGGCCAACCAAGCCCTGGCATGATTGGGCCTGGGATTAT
CCTGTATCACAAGCCTTTATGGAGGCAAAAAATGCTTCGCCATGGAAGAATACGGCGTTG
CTGAAACCGAACAATAGCAATCAATTAAGATATAGCGCAAAACATATGCTTAAAAAGCAT
AGATATCTAAAAGGATTTAGCAACTATCTTTTTTATTTTATTGAAAAGATAAAGCATTAA
Protein Properties
Pfam Domain Function:
Protein Residues:339
Protein Molecular Weight:37497
Protein Theoretical pI:9
Signaling Regions:
  • None
Transmembrane Regions:
  • 10-30
  • 103-123
  • 136-156
  • 172-192
  • 201-221
  • 260-280
  • 310-330
Protein Sequence:
>Dipeptide transport system permease protein dppB
MLQFILRRLGLVIPTFIGITLLTFAFVHMIPGDPVMIMAGERGISPERHAQLLAELGLDK
PMWQQYLHYIWGVMHGDLGISMKSRIPVWEEFVPRFQATLELGVCAMIFATAVGIPVGVL
AAVKRGSIFDHTAVGLALTGYSMPIFWWGMMLIMLVSVHWNLTPVSGRVSDMVFLDDSNP
LTGFMLIDTAIWGEDGNFIDAVAHMILPAIVLGTIPLAVIVRMTRSSMLEVLGEDYIRTA
RAKGLTRMRVIIVHALRNAMLPVVTVIGLQVGTLLAGAILTETIFSWPGLGRWLIDALQR
RDYPVVQGGVLLVATMIILVNLLVDLLYGVVNPRIRHKK
References
External Links:
ResourceLink
Uniprot ID:P0AEF8
Uniprot Name:DPPB_ECOLI
GenBank Gene ID:AP009048
Genebank Protein ID:85676415
Ecogene ID:EG12625
Ecocyc:EG12625
ColiBase:b3543
Kegg Gene:b3543
EchoBASE ID:EB2509
CCDB:DPPB_ECOLI
BacMap:16131415
General Reference:
  • Abouhamad, W. N., Manson, M. D. (1994). "The dipeptide permease of Escherichia coli closely resembles other bacterial transport systems and shows growth-phase-dependent expression." Mol Microbiol 14:1077-1092. Pubmed: 7536291
  • Blattner, F. R., Plunkett, G. 3rd, Bloch, C. A., Perna, N. T., Burland, V., Riley, M., Collado-Vides, J., Glasner, J. D., Rode, C. K., Mayhew, G. F., Gregor, J., Davis, N. W., Kirkpatrick, H. A., Goeden, M. A., Rose, D. J., Mau, B., Shao, Y. (1997). "The complete genome sequence of Escherichia coli K-12." Science 277:1453-1462. Pubmed: 9278503
  • Daley, D. O., Rapp, M., Granseth, E., Melen, K., Drew, D., von Heijne, G. (2005). "Global topology analysis of the Escherichia coli inner membrane proteome." Science 308:1321-1323. Pubmed: 15919996
  • Hayashi, K., Morooka, N., Yamamoto, Y., Fujita, K., Isono, K., Choi, S., Ohtsubo, E., Baba, T., Wanner, B. L., Mori, H., Horiuchi, T. (2006). "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Mol Syst Biol 2:2006.0007. Pubmed: 16738553
  • Sofia, H. J., Burland, V., Daniels, D. L., Plunkett, G. 3rd, Blattner, F. R. (1994). "Analysis of the Escherichia coli genome. V. DNA sequence of the region from 76.0 to 81.5 minutes." Nucleic Acids Res 22:2576-2586. Pubmed: 8041620