Ferrienterobactin-binding periplasmic protein (P0AEL6)

Identification
Name:Ferrienterobactin-binding periplasmic protein
Synonyms:Not Available
Gene Name:fepB
Enzyme Class:Not Available
Biological Properties
General Function:Involved in binding
Specific Function:Binds ferrienterobactin; part of the binding-protein- dependent transport system for uptake of ferrienterobactin
Cellular Location:Periplasm
SMPDB Pathways:
  • Biosynthesis of siderophore group nonribosomal peptides PW000760
  • inner membrane transport PW000786
KEGG Pathways:
  • ABC transporters ec02010
  • Biosynthesis of siderophore group nonribosomal peptides ec01053
Transports:
Transport References:Not Available
SMPDB Reactions:
1.0Thumb+1.0Thumb+1.0Thumb ? 1.0Thumb+1.0Adenosine diphosphate+1.0Thumb+1.0Thumb
1.0Ferric enterobactin + 1.0Adenosine triphosphate + 1.0Water ? 1.0Ferric enterobactin + 1.0Adenosine diphosphate + 1.0Hydrogen ion + 1.0ADP
ReactionCard
EcoCyc Reactions:
1.0Thumb+1.0Thumb+1.0Thumb → 1.0Thumb+1.0Thumb+1.0Thumb+1.0Thumb
1.0Adenosine triphosphate + 1.0Water + 1.0Ferric enterobactin → 1.0ADP + 1.0Ferric enterobactin + 1.0Hydrogen ion + 1.0Phosphate
ReactionCard
Complex Reactions:
1.0Thumb+1.0Thumb+1.0Thumb → 1.0Thumb+1.0Thumb+1.0Thumb+1.0Thumb
1.0Adenosine triphosphate + 1.0Water + 1.0ferric 2,3-dihydroxybenzoylserine → 1.0ADP + 1.0ferric 2,3-dihydroxybenzoylserine + 1.0Hydrogen ion + 1.0Phosphate
ReactionCard
Metabolites:
ECMDB IDNameView
ECMDB00538Adenosine triphosphateMetaboCard
ECMDB01341ADPMetaboCard
ECMDB21331ferric 2,3-dihydroxybenzoylserineMetaboCard
ECMDB21372Ferric enterobactinMetaboCard
ECMDB21225Hydrogen ionMetaboCard
ECMDB01429PhosphateMetaboCard
ECMDB00494WaterMetaboCard
GO Classification:
Function
cation transmembrane transporter activity
di-, tri-valent inorganic cation transmembrane transporter activity
inorganic cation transmembrane transporter activity
ion transmembrane transporter activity
iron ion transmembrane transporter activity
substrate-specific transmembrane transporter activity
transmembrane transporter activity
transporter activity
Process
cation transport
establishment of localization
high-affinity iron ion transport
ion transport
iron ion transmembrane transport
iron ion transport
metal ion transport
transition metal ion transport
transport
Gene Properties
Blattner:b0592
Gene OrientationCounterclockwise
Centisome Percentage:13.42
Left Sequence End622777
Right Sequence End623733
Gene Sequence:
>957 bp
GTGAGACTCGCCCCGCTCTACCGCAACGCCCTTCTATTAACAGGACTTTTGCTTTCAGGA
ATAGCCGCAGTTCAGGCCGCTGACTGGCCGCGTCAGATTACTGACAGCCGTGGCACACAT
ACACTGGAAAGCCAGCCGCAGCGTATTGTTTCCACCAGCGTCACCCTGACCGGCTCACTG
CTGGCGATTGATGCTCCGGTGATCGCCAGCGGCGCGACCACGCCGAATAACCGCGTCGCG
GATGACCAGGGCTTTTTACGCCAGTGGAGCAAGGTGGCGAAAGAACGCAAACTGCAACGG
CTCTATATCGGCGAACCGAGCGCCGAAGCCGTTGCCGCGCAAATGCCGGATCTGATTTTA
ATTAGCGCAACCGGCGGGGATTCGGCGCTGGCACTGTATGATCAGCTTTCCACCATCGCC
CCGACATTAATCATCAATTACGACGACAAAAGCTGGCAGTCGCTGTTAACGCAACTTGGC
GAAATTACCGGGCATGAGAAACAAGCGGCAGAGCGGATTGCGCAGTTTGATAAGCAACTG
GCGGCGGCGAAAGAGCAAATCAAATTACCGCCGCAGCCGGTCACTGCCATTGTCTATACT
GCCGCTGCACACAGTGCCAATCTCTGGACGCCAGAATCAGCACAAGGGCAGATGCTGGAA
CAACTCGGCTTTACGCTGGCGAAGTTACCCGCAGGGTTAAATGCCAGCCAAAGTCAGGGT
AAACGCCATGACATCATTCAGCTTGGTGGGGAAAATCTGGCTGCAGGGTTAAATGGCGAG
TCACTATTCCTGTTCGCCGGTGATCAGAAAGATGCCGATGCTATTTATGCTAATCCGCTG
CTCGCGCACCTGCCTGCAGTACAAAACAAGCAGGTTTATGCGCTGGGAACCGAGACGTTC
CGTCTGGATTACTACAGCGCCATGCAAGTGCTGGATAGGCTTAAGGCGCTGTTTTAA
Protein Properties
Pfam Domain Function:
Protein Residues:318
Protein Molecular Weight:34283
Protein Theoretical pI:6
Signaling Regions:
  • 1-26
Transmembrane Regions:
  • None
Protein Sequence:
>Ferrienterobactin-binding periplasmic protein
MRLAPLYRNALLLTGLLLSGIAAVQAADWPRQITDSRGTHTLESQPQRIVSTSVTLTGSL
LAIDAPVIASGATTPNNRVADDQGFLRQWSKVAKERKLQRLYIGEPSAEAVAAQMPDLIL
ISATGGDSALALYDQLSTIAPTLIINYDDKSWQSLLTQLGEITGHEKQAAERIAQFDKQL
AAAKEQIKLPPQPVTAIVYTAAAHSANLWTPESAQGQMLEQLGFTLAKLPAGLNASQSQG
KRHDIIQLGGENLAAGLNGESLFLFAGDQKDADAIYANPLLAHLPAVQNKQVYALGTETF
RLDYYSAMQVLDRLKALF
References
External Links:
ResourceLink
Uniprot ID:P0AEL6
Uniprot Name:FEPB_ECOLI
GenBank Gene ID:AP009048
Genebank Protein ID:85674713
Ecogene ID:EG10294
Ecocyc:EG10294
ColiBase:b0592
Kegg Gene:b0592
EchoBASE ID:EB0290
CCDB:FEPB_ECOLI
BacMap:16128575
General Reference:
  • Blattner, F. R., Plunkett, G. 3rd, Bloch, C. A., Perna, N. T., Burland, V., Riley, M., Collado-Vides, J., Glasner, J. D., Rode, C. K., Mayhew, G. F., Gregor, J., Davis, N. W., Kirkpatrick, H. A., Goeden, M. A., Rose, D. J., Mau, B., Shao, Y. (1997). "The complete genome sequence of Escherichia coli K-12." Science 277:1453-1462. Pubmed: 9278503
  • Brickman, T. J., Ozenberger, B. A., McIntosh, M. A. (1990). "Regulation of divergent transcription from the iron-responsive fepB-entC promoter-operator regions in Escherichia coli." J Mol Biol 212:669-682. Pubmed: 2139473
  • Elkins, M. F., Earhart, C. F. (1989). "Nucleotide sequence and regulation of the Escherichia coli gene for ferrienterobactin transport protein FepB." J Bacteriol 171:5443-5451. Pubmed: 2529253
  • Hayashi, K., Morooka, N., Yamamoto, Y., Fujita, K., Isono, K., Choi, S., Ohtsubo, E., Baba, T., Wanner, B. L., Mori, H., Horiuchi, T. (2006). "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Mol Syst Biol 2:2006.0007. Pubmed: 16738553
  • Stephens, D. L., Choe, M. D., Earhart, C. F. (1995). "Escherichia coli periplasmic protein FepB binds ferrienterobactin." Microbiology 141 ( Pt 7):1647-1654. Pubmed: 7551033