| Identification |
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| Name: | Galactose/methyl galactoside import ATP-binding protein MglA |
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| Synonyms: | Not Available |
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| Gene Name: | mglA |
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| Enzyme Class: | |
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| Biological Properties |
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| General Function: | Involved in nucleotide binding |
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| Specific Function: | Part of the ABC transporter complex MglABC involved in galactose/methyl galactoside import. Responsible for energy coupling to the transport system (Probable) |
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| Cellular Location: | Cell inner membrane; Peripheral membrane protein (Probable) |
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| SMPDB Pathways: | Not Available |
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| KEGG Pathways: | |
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| EcoCyc Reactions: | |
1.0 | + | 1.0 | + | 1.0 | → | 1.0 | + | 1.0 | + | 1.0 | + | 1.0 |
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| Complex Reactions: | |
1.0 | + | 1.0 | + | 1.0 | → | 1.0 | + | 1.0 | + | 1.0 | + | 1.0 |
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| Metabolites: | |
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| GO Classification: | | Component |
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| cell part | | membrane | | Function |
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| adenyl nucleotide binding | | adenyl ribonucleotide binding | | ATP binding | | ATPase activity | | binding | | carbohydrate transmembrane transporter activity | | carbohydrate-transporting ATPase activity | | catalytic activity | | hydrolase activity | | hydrolase activity, acting on acid anhydrides | | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | | nucleoside binding | | nucleoside-triphosphatase activity | | nucleotide binding | | purine nucleoside binding | | pyrophosphatase activity | | substrate-specific transmembrane transporter activity | | transmembrane transporter activity | | transporter activity | | Process |
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| carbohydrate transport | | establishment of localization | | transport |
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| Gene Properties |
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| Blattner: | b2149 |
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| Gene Orientation | Counterclockwise |
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| Centisome Percentage: | 48.19 |
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| Left Sequence End | 2235791 |
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| Right Sequence End | 2237311 |
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| Gene Sequence: | >1521 bp
ATGGTCAGCTCAACGACTCCGTCCTCCGGGGAATACTTGTTGGAAATGAGCGGTATCAAC
AAGTCCTTTCCTGGTGTTAAGGCACTTGATAACGTTAATTTAAAAGTCCGGCCACATTCT
ATCCATGCATTAATGGGGGAAAACGGTGCAGGAAAATCGACATTATTAAAATGCCTGTTT
GGTATTTATCAAAAAGACTCCGGCACCATTTTATTCCAGGGTAAAGAGATCGATTTCCAT
TCTGCAAAAGAAGCCCTGGAAAATGGTATTTCGATGGTACACCAGGAGTTAAACCTGGTA
TTACAACGTTCGGTGATGGATAACATGTGGCTGGGGCGATATCCCACCAAAGGCATGTTT
GTCGATCAGGACAAAATGTACCGCGAAACCAAAGCGATTTTTGACGAACTGGATATTGAT
ATCGATCCGCGTGCGCGCGTCGGCACATTATCCGTTTCGCAAATGCAGATGATCGAAATC
GCCAAAGCGTTTTCCTATAACGCGAAAATTGTGATTATGGATGAACCGACTTCTTCGTTA
ACCGAAAAAGAGGTCAATCATCTGTTCACTATTATTCGTAAATTAAAAGAGCGCGGCTGC
GGTATTGTTTATATCTCGCATAAAATGGAAGAAATCTTCCAGTTATGTGATGAAGTTACC
GTATTGCGCGACGGTCAGTGGATCGCCACCGAACCGCTGGCAGGACTGACGATGGACAAG
ATCATCGCCATGATGGTTGGGCGTTCTCTTAACCAGCGTTTCCCTGACAAAGAAAACAAA
CCGGGCGAAGTCATCCTCGAGGTACGTAACCTGACGTCACTGCGCCAGCCGTCGATTCGC
GATGTCTCGTTTGATCTGCATAAAGGGGAGATCCTCGGTATTGCCGGTCTGGTGGGGGCG
AAACGTACCGATATTGTTGAGACGTTATTTGGTATTCGCGAGAAATCGGCTGGCACCATA
ACGTTGCACGGCAAACAGATCAATAACCATAATGCCAACGAAGCCATAAACCATGGATTT
GCACTGGTAACTGAGGAGCGCCGCTCAACGGGAATTTATGCCTATCTGGATATTGGTTTT
AACTCGTTAATTTCCAATATTCGCAACTACAAAAATAAAGTTGGTTTACTGGATAACTCG
CGGATGAAAAGCGATACCCAGTGGGTGATTGATTCGATGCGGGTAAAAACGCCGGGTCAT
CGGACGCAAATTGGTTCGCTCTCCGGTGGTAATCAGCAAAAGGTGATTATTGGTCGCTGG
CTACTAACGCAACCAGAAATATTAATGCTCGATGAACCGACGCGCGGTATTGATGTCGGG
GCGAAGTTTGAAATTTATCAGTTAATTGCCGAACTGGCGAAGAAAGGCAAGGGGATTATT
ATTATCTCCTCTGAAATGCCTGAGTTGTTAGGGATAACAGACCGTATTCTGGTCATGAGC
AATGGTCTCGTTTCCGGAATTGTCGATACAAAAACAACAACGCAAAACGAAATTCTGCGT
CTTGCGTCTTTGCACCTTTAA |
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| Protein Properties |
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| Pfam Domain Function: | |
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| Protein Residues: | 506 |
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| Protein Molecular Weight: | 56415 |
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| Protein Theoretical pI: | 8 |
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| Signaling Regions: | |
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| Transmembrane Regions: | |
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| Protein Sequence: | >Galactose/methyl galactoside import ATP-binding protein MglA
MVSSTTPSSGEYLLEMSGINKSFPGVKALDNVNLKVRPHSIHALMGENGAGKSTLLKCLF
GIYQKDSGTILFQGKEIDFHSAKEALENGISMVHQELNLVLQRSVMDNMWLGRYPTKGMF
VDQDKMYRETKAIFDELDIDIDPRARVGTLSVSQMQMIEIAKAFSYNAKIVIMDEPTSSL
TEKEVNHLFTIIRKLKERGCGIVYISHKMEEIFQLCDEVTVLRDGQWIATEPLAGLTMDK
IIAMMVGRSLNQRFPDKENKPGEVILEVRNLTSLRQPSIRDVSFDLHKGEILGIAGLVGA
KRTDIVETLFGIREKSAGTITLHGKQINNHNANEAINHGFALVTEERRSTGIYAYLDIGF
NSLISNIRNYKNKVGLLDNSRMKSDTQWVIDSMRVKTPGHRTQIGSLSGGNQQKVIIGRW
LLTQPEILMLDEPTRGIDVGAKFEIYQLIAELAKKGKGIIIISSEMPELLGITDRILVMS
NGLVSGIVDTKTTTQNEILRLASLHL |
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| References |
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| External Links: | |
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| General Reference: | - Blattner, F. R., Plunkett, G. 3rd, Bloch, C. A., Perna, N. T., Burland, V., Riley, M., Collado-Vides, J., Glasner, J. D., Rode, C. K., Mayhew, G. F., Gregor, J., Davis, N. W., Kirkpatrick, H. A., Goeden, M. A., Rose, D. J., Mau, B., Shao, Y. (1997). "The complete genome sequence of Escherichia coli K-12." Science 277:1453-1462. Pubmed: 9278503
- Boos, W., Sarvas, M. O. (1970). "Close linkage between a galactose binding protein and the beta-methylgalactoside permease in Escherichia coli." Eur J Biochem 13:526-533. Pubmed: 4910389
- Harayama, S., Bollinger, J., Iino, T., Hazelbauer, G. L. (1983). "Characterization of the mgl operon of Escherichia coli by transposon mutagenesis and molecular cloning." J Bacteriol 153:408-415. Pubmed: 6294056
- Hayashi, K., Morooka, N., Yamamoto, Y., Fujita, K., Isono, K., Choi, S., Ohtsubo, E., Baba, T., Wanner, B. L., Mori, H., Horiuchi, T. (2006). "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Mol Syst Biol 2:2006.0007. Pubmed: 16738553
- Hogg, R. W., Voelker, C., Von Carlowitz, I. (1991). "Nucleotide sequence and analysis of the mgl operon of Escherichia coli K12." Mol Gen Genet 229:453-459. Pubmed: 1719366
- Rotman, B., Guzman, R. (1982). "Identification of the mglA gene product in the beta-methylgalactoside transport system of Escherichia coli using plasmid DNA deletions generated in vitro." J Biol Chem 257:9030-9034. Pubmed: 6807987
- Scholle, A., Vreemann, J., Blank, V., Nold, A., Boos, W., Manson, M. D. (1987). "Sequence of the mglB gene from Escherichia coli K12: comparison of wild-type and mutant galactose chemoreceptors." Mol Gen Genet 208:247-253. Pubmed: 3302609
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