Thiamine-monophosphate kinase (P0AGG0)

Identification
Name:Thiamine-monophosphate kinase
Synonyms:
  • Thiamine-phosphate kinase
Gene Name:thiL
Enzyme Class:
Biological Properties
General Function:Involved in catalytic activity
Specific Function:ATP + thiamine phosphate = ADP + thiamine diphosphate
Cellular Location:Not Available
SMPDB Pathways:
KEGG Pathways:
KEGG Reactions:
1.0Thumb+1.0Thumb ↔ 1.0Thumb+1.0Thumb
1.0Adenosine triphosphate + 1.0Thiamine monophosphate ↔ 1.0ADP + 1.0Thiamine pyrophosphate
ReactionCard
SMPDB Reactions:
1.0Thiamine monophosphate+1.0Thumb+1.0Thumb → 1.0Thumb+1.0Adenosine diphosphate+1.0Thumb
1.0Thiamine monophosphate + 1.0Adenosine triphosphate + 1.0Thiamine monophosphate → 1.0Thiamine pyrophosphate + 1.0Adenosine diphosphate + 1.0ADP
ReactionCard
EcoCyc Reactions:
1.0Thumb+1.0Thumb ↔ 1.0Thumb+1.0Thumb
1.0Adenosine triphosphate + 1.0Thiamine monophosphate ↔ 1.0ADP + 1.0Thiamine pyrophosphate
ReactionCard
1.0Thumb+1.0Thumb → 1.0Thumb+1.0Thumb
1.0Thiamine monophosphate + 1.0Adenosine triphosphate → 1.0Thiamine pyrophosphate + 1.0ADP
ReactionCard
Metabolites:
ECMDB IDNameView
ECMDB00538Adenosine triphosphateMetaboCard
ECMDB01341ADPMetaboCard
ECMDB02666Thiamine monophosphateMetaboCard
ECMDB01372Thiamine pyrophosphateMetaboCard
GO Classification:
Function
catalytic activity
kinase activity
thiamin phosphate kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
Process
cellular aromatic compound metabolic process
cellular metabolic process
metabolic process
thiamin and derivative metabolic process
thiamin biosynthetic process
thiamin metabolic process
Gene Properties
Blattner:b0417
Gene OrientationClockwise
Centisome Percentage:9.37
Left Sequence End434858
Right Sequence End435835
Gene Sequence:
>978 bp
ATGGCATGTGGCGAGTTCTCCCTGATTGCCCGTTATTTTGACCGTGTAAGAAGTTCTCGT
CTTGATGTCGAACTGGGCATCGGCGACGATTGCGCACTTCTCAATATCCCCGAGAAACAG
ACCCTGGCGATCAGCACTGATACGCTGGTGGCGGGTAACCATTTCCTCCCTGATATCGAT
CCTGCTGATCTGGCTTATAAAGCACTGGCGGTGAACCTAAGCGATCTGGCAGCGATGGGG
GCCGATCCGGCCTGGCTGACGCTGGCATTAACCTTACCGGACGTAGACGAAGCGTGGCTT
GAGTCCTTCAGCGACAGTTTGTTTGATCTTCTCAATTATTACGATATGCAACTCATTGGC
GGCGATACCACGCGTGGGCCATTATCAATGACGTTGGGTATCCACGGCTTTGTTCCGATG
GGACGAGCCTTAACGCGCTCTGGGGCGAAACCGGGTGACTGGATCTATGTGACCGGTACA
CCGGGCGATAGCGCCGCCGGGCTGGCGATTTTGCAAAACCGTTTGCAGGTTGCCGATGCT
AAAGATGCGGACTACTTGATCAAACGTCATCTCCGTCCATCGCCGCGTATTTTACAGGGG
CAGGCACTGCGCGATCTGGCAAATTCAGCCATCGATCTCTCTGACGGTTTGATTTCCGAT
CTCGGGCATATCGTGAAAGCCAGCGACTGCGGCGCACGTATTGACCTGGCATTGCTGCCG
TTTTCTGATGCGCTTTCTCGCCATGTTGAACCGGAACAGGCGCTGCGCTGGGCGCTCTCT
GGCGGTGAAGATTACGAGTTGTGTTTCACTGTGCCGGAACTGAACCGTGGCGCGCTGGAT
GTGGCTCTCGGACACCTGGGCGTACCGTTTACCTGTATCGGGCAAATGACCGCCGATATC
GAAGGGCTTTGTTTTATTCGTGACGGCGAACCTGTTACATTAGACTGGAAAGGATATGAC
CATTTTGCCACGCCATAA
Protein Properties
Pfam Domain Function:
Protein Residues:325
Protein Molecular Weight:35070
Protein Theoretical pI:4
Signaling Regions:
  • None
Transmembrane Regions:
  • None
Protein Sequence:
>Thiamine-monophosphate kinase
MACGEFSLIARYFDRVRSSRLDVELGIGDDCALLNIPEKQTLAISTDTLVAGNHFLPDID
PADLAYKALAVNLSDLAAMGADPAWLTLALTLPDVDEAWLESFSDSLFDLLNYYDMQLIG
GDTTRGPLSMTLGIHGFVPMGRALTRSGAKPGDWIYVTGTPGDSAAGLAILQNRLQVADA
KDADYLIKRHLRPSPRILQGQALRDLANSAIDLSDGLISDLGHIVKASDCGARIDLALLP
FSDALSRHVEPEQALRWALSGGEDYELCFTVPELNRGALDVALGHLGVPFTCIGQMTADI
EGLCFIRDGEPVTLDWKGYDHFATP
References
External Links:
ResourceLink
Uniprot ID:P0AGG0
Uniprot Name:THIL_ECOLI
GenBank Gene ID:AP009048
Genebank Protein ID:85674557
Ecogene ID:EG20227
Ecocyc:EG20227
ColiBase:b0417
Kegg Gene:b0417
EchoBASE ID:EB4149
CCDB:THIL_ECOLI
BacMap:16128402
General Reference:
  • Blattner, F. R., Plunkett, G. 3rd, Bloch, C. A., Perna, N. T., Burland, V., Riley, M., Collado-Vides, J., Glasner, J. D., Rode, C. K., Mayhew, G. F., Gregor, J., Davis, N. W., Kirkpatrick, H. A., Goeden, M. A., Rose, D. J., Mau, B., Shao, Y. (1997). "The complete genome sequence of Escherichia coli K-12." Science 277:1453-1462. Pubmed: 9278503
  • Hayashi, K., Morooka, N., Yamamoto, Y., Fujita, K., Isono, K., Choi, S., Ohtsubo, E., Baba, T., Wanner, B. L., Mori, H., Horiuchi, T. (2006). "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Mol Syst Biol 2:2006.0007. Pubmed: 16738553