Adenosine monophosphate (ECMDB00045) (M2MDB000014)

General function:

Involved in catalytic activity

Specific function:

A phosphate monoester + H(2)O = an alcohol + phosphate

Gene Name:

phoA

Uniprot ID:

P00634

Molecular weight:

49438

Reactions

General function:

Involved in nucleotide binding

Specific function:

ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp)

Gene Name:

trpS

Uniprot ID:

P00954

Molecular weight:

37438

Reactions

General function:

Involved in nucleotide binding

Specific function:

Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)

Gene Name:

ileS

Uniprot ID:

P00956

Molecular weight:

104296

Reactions

General function:

Involved in nucleotide binding

Specific function:

Edits incorrectly charged Ser-tRNA(Ala) and Gly- tRNA(Ala) but not incorrectly charged Ser-tRNA(Thr)

Gene Name:

alaS

Uniprot ID:

P00957

Molecular weight:

96032

Reactions

General function:

Involved in nucleotide binding

Specific function:

Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation

Gene Name:

metG

Uniprot ID:

P00959

Molecular weight:

76254

Reactions

General function:

Involved in nucleotide binding

Specific function:

ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly)

Gene Name:

glyQ

Uniprot ID:

P00960

Molecular weight:

34774

Reactions

General function:

Involved in arginine-tRNA ligase activity

Specific function:

ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly)

Gene Name:

glyS

Uniprot ID:

P00961

Molecular weight:

76812

Reactions

General function:

Involved in nucleotide binding

Specific function:

ATP + L-glutamine + tRNA(Gln) = AMP + diphosphate + L-glutaminyl-tRNA(Gln)

Gene Name:

glnS

Uniprot ID:

P00962

Molecular weight:

63477

Reactions

General function:

Involved in nucleotide binding

Specific function:

ATP + L-aspartate + NH(3) = AMP + diphosphate + L-asparagine

Gene Name:

asnA

Uniprot ID:

P00963

Molecular weight:

36650

Reactions

General function:

Involved in GMP synthase (glutamine-hydrolyzing) activity

Specific function:

Catalyzes the synthesis of GMP from XMP

Gene Name:

guaA

Uniprot ID:

P04079

Molecular weight:

58679

Reactions

General function:

Involved in nucleotide binding

Specific function:

Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction:glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)

Gene Name:

gltX

Uniprot ID:

P04805

Molecular weight:

53815

Reactions

General function:

Involved in biotin-[acetyl-CoA-carboxylase] ligase activity

Specific function:

BirA acts both as a biotin-operon repressor and as the enzyme that synthesizes the corepressor, acetyl-CoA:carbon-dioxide ligase. This protein also activates biotin to form biotinyl-5'- adenylate and transfers the biotin moiety to biotin-accepting proteins

Gene Name:

birA

Uniprot ID:

P06709

Molecular weight:

35312

Reactions

General function:

Involved in hydrolase activity

Specific function:

Degradation of external UDP-glucose to uridine monophosphate and glucose-1-phosphate, which can then be used by the cell

Gene Name:

ushA

Uniprot ID:

P07024

Molecular weight:

60824

Reactions

General function:

Involved in nucleotide binding

Specific function:

Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a "posttransfer" editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner

Gene Name:

valS

Uniprot ID:

P07118

Molecular weight:

108192

Reactions

General function:

Involved in RNA binding

Specific function:

ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe)

Gene Name:

pheT

Uniprot ID:

P07395

Molecular weight:

87377

Reactions

General function:

Involved in nucleotide binding

Specific function:

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu)

Gene Name:

leuS

Uniprot ID:

P07813

Molecular weight:

97233

Reactions

General function:

Involved in nucleotide binding

Specific function:

ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe)

Gene Name:

pheS

Uniprot ID:

P08312

Molecular weight:

36832

Reactions

General function:

Involved in metabolic process

Specific function:

Catalyzes the removal of elemental sulfur and selenium atoms from cysteine and selenocysteine to produce alanine. Functions as a sulfur delivery protein for NAD, biotin and Fe-S cluster synthesis. Transfers sulfur on 'Cys-456' of thiI in a transpersulfidation reaction. Transfers sulfur on 'Cys-19' of tusA in a transpersulfidation reaction. Functions also as a selenium delivery protein in the pathway for the biosynthesis of selenophosphate

Gene Name:

iscS

Uniprot ID:

P0A6B7

Molecular weight:

45089

Reactions

General function:

Involved in argininosuccinate synthase activity

Specific function:

ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate

Gene Name:

argG

Uniprot ID:

P0A6E4

Molecular weight:

49898

Reactions

General function:

Involved in magnesium ion binding

Specific function:

ATP + D-ribose 5-phosphate = AMP + 5-phospho- alpha-D-ribose 1-diphosphate

Gene Name:

prs

Uniprot ID:

P0A717

Molecular weight:

34218

Reactions

General function:

Involved in hydrolase activity

Specific function:

Nucleotidase with a broad substrate specificity as it can dephosphorylate various ribo- and deoxyribonucleoside 5'- monophosphates and ribonucleoside 3'-monophosphates with highest affinity to 3'-AMP. Also hydrolyzes polyphosphate (exopolyphosphatase activity) with the preference for short-chain- length substrates (P20-25). Might be involved in the regulation of dNTP and NTP pools, and in the turnover of 3'-mononucleotides produced by numerous intracellular RNases (T1, T2, and F) during the degradation of various RNAs. Also plays a significant physiological role in stress-response and is required for the survival of E.coli in stationary growth phase

Gene Name:

surE

Uniprot ID:

P0A840

Molecular weight:

26900

Reactions

General function:

Involved in nucleotide binding

Specific function:

Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)

Gene Name:

serS

Uniprot ID:

P0A8L1

Molecular weight:

48414

Reactions

General function:

Involved in nucleotide binding

Specific function:

ATP + L-asparagine + tRNA(Asn) = AMP + diphosphate + L-asparaginyl-tRNA(Asn)

Gene Name:

asnS

Uniprot ID:

P0A8M0

Molecular weight:

52570

Reactions

General function:

Involved in nucleotide binding

Specific function:

ThrS is also a translational repressor protein, it controls the translation of its own gene by binding to its mRNA

Gene Name:

thrS

Uniprot ID:

P0A8M3

Molecular weight:

74014

Reactions

General function:

Involved in nucleotide binding

Specific function:

ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys)

Gene Name:

lysS

Uniprot ID:

P0A8N3

Molecular weight:

57603

Reactions

General function:

Involved in nucleotide binding

Specific function:

Also can synthesize a number of adenyl dinucleotides (in particular AppppA). These dinucleotides have been proposed to act as modulators of the heat-shock response and stress response

Gene Name:

lysU

Uniprot ID:

P0A8N5

Molecular weight:

57826

Reactions

General function:

Involved in nucleotide binding

Specific function:

With YjeK might be involved in the post-translational modification of elongation factor P (EF-P)

Gene Name:

poxA

Uniprot ID:

P0A8N7

Molecular weight:

36976

General function:

Involved in catalytic activity

Specific function:

Nucleotidase that shows high phosphatase activity toward three nucleoside 5'-monophosphates, UMP, dUMP, and dTMP, and very low activity against TDP, IMP, UDP, GMP, dGMP, AMP, dAMP, and 6- phosphogluconate. Is strictly specific to substrates with 5'- phosphates and shows no activity against nucleoside 2'- or 3'- monophosphates. Might be involved in the pyrimidine nucleotide substrate cycles

Gene Name:

yjjG

Uniprot ID:

P0A8Y1

Molecular weight:

25300

Reactions

General function:

Involved in hypoxanthine phosphoribosyltransferase activity

Specific function:

This enzyme acts exclusively on hypoxanthine; it does not act on guanine

Gene Name:

hpt

Uniprot ID:

P0A9M2

Molecular weight:

20115

Reactions

General function:

Involved in N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity

Specific function:

N(6)-(1,2-dicarboxyethyl)AMP = fumarate + AMP

Gene Name:

purB

Uniprot ID:

P0AB89

Molecular weight:

51542

Reactions

General function:

Involved in phosphopantothenate--cysteine ligase activity

Specific function:

Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine

Gene Name:

coaBC

Uniprot ID:

P0ABQ0

Molecular weight:

43438

Reactions

General function:

Involved in isochorismatase activity

Specific function:

Required for production of 2,3-DHB. Also serves as an aryl carrier protein and plays a role in enterobactin assembly

Gene Name:

entB

Uniprot ID:

P0ADI4

Molecular weight:

32554

Reactions

General function:

Involved in catalytic activity

Specific function:

Involved in regulation of AMP concentrations

Gene Name:

amn

Uniprot ID:

P0AE12

Molecular weight:

53994

Reactions

General function:

Involved in acid phosphatase activity

Specific function:

Dephosphorylates several organic phosphomonoesters and catalyzes the transfer of low-energy phosphate groups from phosphomonoesters to hydroxyl groups of various organic compounds. Preferentially acts on aryl phosphoesters. Might function as a broad-spectrum dephosphorylating enzyme able to scavenge both 3'- and 5'-nucleotides and also additional organic phosphomonoesters

Gene Name:

aphA

Uniprot ID:

P0AE22

Molecular weight:

26103

Reactions

General function:

Involved in nucleoside-triphosphate diphosphatase activity

Specific function:

Specific function unknown

Gene Name:

mazG

Uniprot ID:

P0AEY3

Molecular weight:

30412

Reactions

General function:

Involved in amino acid binding

Specific function:

In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which is then hydrolyzed to form ppGpp

Gene Name:

relA

Uniprot ID:

P0AG20

Molecular weight:

83875

Reactions

General function:

Involved in catalytic activity

Specific function:

In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes both the synthesis and degradation of ppGpp. The second messengers ppGpp and c-di-GMP together control biofilm formation in response to translational stress; ppGpp represses biofilm formation while c- di-GMP induces it

Gene Name:

spoT

Uniprot ID:

P0AG24

Molecular weight:

79342

Reactions

General function:

Involved in nucleotide binding

Specific function:

Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction:tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)

Gene Name:

tyrS

Uniprot ID:

P0AGJ9

Molecular weight:

47527

Reactions

General function:

Involved in catalytic activity

Specific function:

Activates the carboxylate group of 2,3-dihydroxy- benzoate (2,3-DHB), via ATP-dependent PPi exchange reactions, to the acyladenylate. Then, catalyzes the acylation of holo-entB with 2,3-DHB adenylate, preparing that molecule for amide bond formation with L-serine

Gene Name:

entE

Uniprot ID:

P10378

Molecular weight:

59112

Reactions

General function:

Involved in ligase activity

Specific function:

Activates the carboxylate group of L-serine via ATP- dependent PPi exchange reactions to the aminoacyladenylate, preparing that molecule for the final stages of enterobactin synthesis. Holo-entF acts as the catalyst for the formation of the three amide and three ester bonds present in the cyclic (2,3- dihydroxybenzoyl)serine trimer enterobactin, using seryladenylate and acyl-holo-entB (acylated with 2,3-dihydroxybenzoate by entE)

Gene Name:

entF

Uniprot ID:

P11454

Molecular weight:

141990

Reactions

General function:

Involved in phosphotransferase activity, alcohol group as acceptor

Specific function:

ATP + L-fuculose = ADP + L-fuculose 1- phosphate

Gene Name:

fucK

Uniprot ID:

P11553

Molecular weight:

53235

Reactions

General function:

Involved in nucleotide binding

Specific function:

ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg)

Gene Name:

argS

Uniprot ID:

P11875

Molecular weight:

64682

Reactions

General function:

Involved in DNA ligase (NAD+) activity

Specific function:

DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA

Gene Name:

ligA

Uniprot ID:

P15042

Molecular weight:

73605

Reactions

General function:

Involved in catalytic activity

Specific function:

Synthesizes selenophosphate from selenide and ATP

Gene Name:

selD

Uniprot ID:

P16456

Molecular weight:

36687

Reactions

General function:

Involved in nucleotide binding

Specific function:

Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction:proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). Misacylated Cys-tRNA(Pro) is not edited by ProRS, but instead may be edited in trans by ybaK

Gene Name:

proS

Uniprot ID:

P16659

Molecular weight:

63692

Reactions

General function:

Involved in NAD+ synthase (glutamine-hydrolyzing) activity

Specific function:

Catalyzes a key step in NAD biosynthesis, transforming deamido-NAD into NAD by a two-step reaction

Gene Name:

nadE

Uniprot ID:

P18843

Molecular weight:

30637

Reactions

General function:

Involved in magnesium ion binding

Specific function:

Catalyzes the transfer of the 4'-phosphopantetheine moiety from coenzyme A to apo-domains of both entB (an ArCP domain) and entF (a PCP domain). Plays an essential role in the assembly of the enterobactin

Gene Name:

entD

Uniprot ID:

P19925

Molecular weight:

23604

Reactions

General function:

Involved in cysteine-tRNA ligase activity

Specific function:

ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys)

Gene Name:

cysS

Uniprot ID:

P21888

Molecular weight:

52202

Reactions

General function:

Involved in nucleotide binding

Specific function:

ATP + L-aspartate + tRNA(Asp) = AMP + diphosphate + L-aspartyl-tRNA(Asp)

Gene Name:

aspS

Uniprot ID:

P21889

Molecular weight:

65913

Reactions

General function:

Involved in asparagine synthase (glutamine-hydrolyzing) activity

Specific function:

ATP + L-aspartate + L-glutamine + H(2)O = AMP + diphosphate + L-asparagine + L-glutamate

Gene Name:

asnB

Uniprot ID:

P22106

Molecular weight:

62659

Reactions

General function:

Involved in magnesium ion binding

Specific function:

Converts 3'(2')-phosphoadenosine 5'-phosphate (PAP) to AMP. May also convert adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS). Has 10000-fold lower activity towards inositol 1,4-bisphosphate (Ins(1,4)P2)

Gene Name:

cysQ

Uniprot ID:

P22255

Molecular weight:

27176

Reactions

General function:

Involved in catalytic activity

Specific function:

Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate

Gene Name:

ppsA

Uniprot ID:

P23538

Molecular weight:

87434

Reactions

General function:

Involved in sulfurtransferase activity

Specific function:

Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA(Lys), tRNA(Glu) and tRNA(Gln), leading to the formation of s(2)U34, the first step of tRNA-mnm(5)s(2)U34 synthesis. Sulfur is provided by iscS, via a sulfur-relay system. Binds ATP and its substrate tRNAs

Gene Name:

mnmA

Uniprot ID:

P25745

Molecular weight:

40959

General function:

Involved in DNA ligase (NAD+) activity

Specific function:

Catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction

Gene Name:

ligB

Uniprot ID:

P25772

Molecular weight:

63179

Reactions

General function:

Involved in 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity

Specific function:

ATP + 2-amino-4-hydroxy-6-hydroxymethyl-7,8- dihydropteridine = AMP + (2-amino-4-hydroxy-7,8-dihydropteridin-6- yl)methyl diphosphate

Gene Name:

folK

Uniprot ID:

P26281

Molecular weight:

18079

Reactions

General function:

Involved in acetate-CoA ligase activity

Specific function:

Enables the cell to use acetate during aerobic growth to generate energy via the TCA cycle, and biosynthetic compounds via the glyoxylate shunt. Acetylates CheY, the response regulator involved in flagellar movement and chemotaxis

Gene Name:

acs

Uniprot ID:

P27550

Molecular weight:

72093

Reactions

General function:

Involved in Mo-molybdopterin cofactor biosynthetic process

Specific function:

Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin

Gene Name:

moaD

Uniprot ID:

P30748

Molecular weight:

8758

General function:

Involved in transferase activity, transferring acyl groups

Specific function:

Plays a role in lysophospholipid acylation. Transfers fatty acids to the 1-position via an enzyme-bound acyl-ACP intermediate in the presence of ATP and magnesium. Its physiological function is to regenerate phosphatidylethanolamine from 2-acyl-glycero-3-phosphoethanolamine (2-acyl-GPE) formed by transacylation reactions or degradation by phospholipase A1

Gene Name:

aas

Uniprot ID:

P31119

Molecular weight:

80699

Reactions

General function:

Involved in catalytic activity

Specific function:

Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate

Gene Name:

panC

Uniprot ID:

P31663

Molecular weight:

31597

Reactions

General function:

Involved in catalytic activity

Specific function:

Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes. Is also able to catalyze very poorly the transfer of lipoyl and octanoyl moiety from their acyl carrier protein

Gene Name:

lplA

Uniprot ID:

P32099

Molecular weight:

37926

Reactions

General function:

Involved in hydrolase activity

Specific function:

NAD(+) + H(2)O = AMP + NMN

Gene Name:

nudC

Uniprot ID:

P32664

Molecular weight:

29689

Reactions

General function:

Involved in catalytic activity

Specific function:

Converts 2-succinylbenzoate (OSB) to 2-succinylbenzoyl- CoA (OSB-CoA)

Gene Name:

menE

Uniprot ID:

P37353

Molecular weight:

50184

Reactions

General function:

Involved in RNA processing

Specific function:

Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps:(A) adenylation of the enzyme by ATP; (B) the enzyme acts on RNA-N3'P to produce RNA-N3'PP5'A; (C) a non catalytic nucleophilic attack by the adjacent 2'hydroxyl on the phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing

Gene Name:

rtcA

Uniprot ID:

P46849

Molecular weight:

35903

Reactions

General function:

Involved in nucleotide binding

Specific function:

ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His)

Gene Name:

hisS

Uniprot ID:

P60906

Molecular weight:

47029

Reactions

General function:

Involved in ATP binding

Specific function:

Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth

Gene Name:

adk

Uniprot ID:

P69441

Molecular weight:

23586

Reactions

General function:

Involved in catalytic activity

Specific function:

Catalyzes the esterification, concomitant with transport, of exogenous long-chain fatty acids into metabolically active CoA thioesters for subsequent degradation or incorporation into phospholipids

Gene Name:

fadD

Uniprot ID:

P69451

Molecular weight:

62332

Reactions

General function:

Involved in adenine phosphoribosyltransferase activity

Specific function:

Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis

Gene Name:

apt

Uniprot ID:

P69503

Molecular weight:

19859

Reactions

General function:

Involved in catalytic activity

Specific function:

Catalyzes the activation of phenylacetic acid to phenylacetyl-CoA

Gene Name:

paaK

Uniprot ID:

P76085

Molecular weight:

48953

Reactions

General function:

Involved in phosphorus-oxygen lyase activity

Specific function:

In association with DosC is involved in the production and removal of the second messenger c-di-GMP in response to changing O(2) levels. Has phosphodiesterase (PDE) activity with c- di-GMP (PubMed:15995192), very poor activity on cAMP (PubMed:15995192) but not with cGMP, bis(p-nitrophenyl) phosphate or p-nitrophenyl phosphate (PubMed:11970957). Cyclic-di-GMP is a second messenger which controls cell surface-associated traits in bacteria

Gene Name:

dosP

Uniprot ID:

P76129

Molecular weight:

90260

Reactions

General function:

Involved in catalytic activity

Specific function:

Nucleotidase that shows strict specificity toward deoxyribonucleoside 5'-monophosphates and does not dephosphorylate 5'-ribonucleotides or ribonucleoside 3'-monophosphates. Might be involved in the regulation of all dNTP pools in E.coli

Gene Name:

yfbR

Uniprot ID:

P76491

Molecular weight:

22708

Reactions

General function:

Involved in [citrate (pro-3S)-lyase] ligase activity

Specific function:

Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase

Gene Name:

citC

Uniprot ID:

P77390

Molecular weight:

40077

Reactions

General function:

Involved in catalytic activity

Specific function:

Catalyzes the synthesis of propionyl-CoA from propionate and CoA. Also converts acetate to acetyl-CoA but with a lower specific activity

Gene Name:

prpE

Uniprot ID:

P77495

Molecular weight:

69350

Reactions

General function:

Involved in hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides

Specific function:

Acts on ADP-mannose and ADP-glucose as well as ADP- ribose. Prevents glycogen biosynthesis. The reaction catalyzed by this enzyme is a limiting step of the gluconeogenic process

Gene Name:

nudF

Uniprot ID:

Q93K97

Molecular weight:

23667

Reactions

General function:

Involved in Mo-molybdopterin cofactor biosynthetic process

Specific function:

Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP

Gene Name:

moeA

Uniprot ID:

P12281

Molecular weight:

44067

Reactions

General function:

Involved in hydrolase activity

Specific function:

Active on adenosine(5')triphospho(5')adenosine (Ap3A), ADP-ribose, NADH, adenosine(5')diphospho(5')adenosine (Ap2A)

Gene Name:

nudE

Uniprot ID:

P45799

Molecular weight:

21153

Reactions

General function:

Involved in nucleotide binding

Specific function:

Catalyzes the adenylation by ATP of the carboxyl group of the C-terminal glycine of sulfur carrier protein ThiS

Gene Name:

thiF

Uniprot ID:

P30138

Molecular weight:

26970

Reactions

General function:

Involved in catalytic activity

Specific function:

Could catalyze the transfer of CoA to carnitine, generating the initial carnitinyl-CoA needed for the CaiB reaction cycle

Gene Name:

caiC

Uniprot ID:

P31552

Molecular weight:

58559

General function:

Involved in RNA binding

Specific function:

Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by iscS

Gene Name:

thiI

Uniprot ID:

P77718

Molecular weight:

54973

Reactions

General function:

Coenzyme transport and metabolism

Specific function:

Is the sulfur donor in the synthesis of the thiazole phosphate moiety of thiamine phosphate

Gene Name:

thiS

Uniprot ID:

O32583

Molecular weight:

7311

General function:

Involved in catalytic activity

Specific function:

Catalyzes the radical-mediated cleavage of tyrosine to dehydroglycine and p-cresol

Gene Name:

thiH

Uniprot ID:

P30140

Molecular weight:

43320

Reactions

General function:

Involved in catalytic activity

Specific function:

Catalyzes the esterification, concomitant with transport, of exogenous fatty acids into metabolically active CoA thioesters for subsequent degradation or incorporation into phospholipids. It has a low activity on medium or long chain fatty acids and is maximally active on C6 and C8 substrates

Gene Name:

fadK

Uniprot ID:

P38135

Molecular weight:

60773

Reactions

General function:

Involved in fatty acid biosynthetic process

Specific function:

Carrier of the growing fatty acid chain in fatty acid biosynthesis

Gene Name:

acpP

Uniprot ID:

P0A6A8

Molecular weight:

8640

General function:

Not Available

Specific function:

Not Available

Gene Name:

tilS

Uniprot ID:

P52097

Molecular weight:

Not Available

General function:

Carbohydrate transport and metabolism

Specific function:

Not Available

Gene Name:

yjeF

Uniprot ID:

P31806

Molecular weight:

54650

Reactions

General function:

threonylcarbamoyladenosine biosynthetic process

Specific function:

Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction. May also be involved in the metabolism of glycated proteins, but does not show sialoglycoprotease activity against glycophorin A.

Gene Name:

tsaD

Uniprot ID:

P05852

Molecular weight:

36008

Reactions