ADP compounds hydrolase nudE (P45799)

Identification
Name:ADP compounds hydrolase nudE
Synonyms:Not Available
Gene Name:nudE
Enzyme Class:Not Available
Biological Properties
General Function:Involved in hydrolase activity
Specific Function:Active on adenosine(5')triphospho(5')adenosine (Ap3A), ADP-ribose, NADH, adenosine(5')diphospho(5')adenosine (Ap2A)
Cellular Location:Cytoplasmic
SMPDB Pathways:Not Available
KEGG Pathways:
KEGG Reactions:
1.0Thumb+1.0Thumb ↔ 1.0Thumb+2.0Thumb+1.0Thumb
1.0Adenosine diphosphate ribose + 1.0Water ↔ 1.0Adenosine monophosphate + 2.0Hydrogen ion + 1.0D-Ribose-5-phosphate
ReactionCard
1.0Thumb+1.0Thumb ↔ 1.0Thumb+1.0Thumb
1.0Adenosine diphosphate ribose + 1.0Water ↔ 1.0Adenosine monophosphate + 1.0D-Ribose-5-phosphate
ReactionCard
EcoCyc Reactions:
1.0Thumb+1.0Thumb ↔ 1.0Thumb+2.0Thumb+1.0Thumb
1.0Adenosine diphosphate ribose + 1.0Water ↔ 1.0Adenosine monophosphate + 2.0Hydrogen ion + 1.0D-Ribose-5-phosphate
ReactionCard
Metabolites:
ECMDB IDNameView
ECMDB01178Adenosine diphosphate riboseMetaboCard
ECMDB00045Adenosine monophosphateMetaboCard
ECMDB02033D-Ribose-5-phosphateMetaboCard
ECMDB21225Hydrogen ionMetaboCard
ECMDB00494WaterMetaboCard
GO Classification:
Function
catalytic activity
hydrolase activity
Gene Properties
Blattner:b3397
Gene OrientationCounterclockwise
Centisome Percentage:75.95
Left Sequence End3523611
Right Sequence End3524171
Gene Sequence:
>561 bp
ATGAACGTGAGTAAATATGTCGCTATCTTTTCCTTTGTTTTTATTCAGTTAATCAGCGTT
GGTAAAGTTTTTGCTAACGCAGATGAGTGGATGACAACGTTTAGAGAAAATATTGCACAA
ACCTGGCAACAGCCTGAACATTATGATTTATATATTCCTGCCATCACCTGGCATGCACGT
TTCGCTTACGACAAAGAAAAAACCGATCGCTATAACGAGCGACCGTGGGGTGGCGGTTTT
GGCCTGTCGCGTTGGGATGAAAAAGGAAACTGGCATGGCCTGTATGCCATGGCATTTAAG
GACTCGTGGAACAAATGGGAACCGATTGCCGGATACGGATGGGAAAGTACCTGGCGACCG
CTGGCGGATGAAAATTTTCATTTAGGTCTGGGATTCACCGCTGGCGTAACGGCACGCGAT
AACTGGAATTACATCCCTCTCCCGGTTCTACTGCCATTGGCCTCCGTGGGTTATGGCCCA
GTGACTTTTCAGATGACCTACATTCCGGGTACCTACAACAATGGCAATGTGTACTTTGCC
TGGATGCGCTTTCAGTTTTGA
Protein Properties
Pfam Domain Function:
Protein Residues:186
Protein Molecular Weight:21153
Protein Theoretical pI:5
PDB File:1VHZ
Signaling Regions:
  • None
Transmembrane Regions:
  • None
Protein Sequence:
>ADP compounds hydrolase nudE
MSKSLQKPTILNVETVARSRLFTVESVDLEFSNGVRRVYERMRPTNREAVMIVPIVDDHL
ILIREYAVGTESYELGFSKGLIDPGESVYEAANRELKEEVGFGANDLTFLKKLSMAPSYF
SSKMNIVVAQDLYPESLEGDEPEPLPQVRWPLAHMMDLLEDPDFNEARNVSALFLVREWL
KGQGRV
References
External Links:
ResourceLink
Uniprot ID:P45799
Uniprot Name:NUDE_ECOLI
GenBank Gene ID:AP009048
Genebank Protein ID:85674727
PDB ID:1VHZ
Ecogene ID:EG12926
Ecocyc:EG12926
ColiBase:b3397
Kegg Gene:b3397
EchoBASE ID:EB2762
CCDB:NUDE_ECOLI
BacMap:16131274
General Reference:
  • Badger, J., Sauder, J. M., Adams, J. M., Antonysamy, S., Bain, K., Bergseid, M. G., Buchanan, S. G., Buchanan, M. D., Batiyenko, Y., Christopher, J. A., Emtage, S., Eroshkina, A., Feil, I., Furlong, E. B., Gajiwala, K. S., Gao, X., He, D., Hendle, J., Huber, A., Hoda, K., Kearins, P., Kissinger, C., Laubert, B., Lewis, H. A., Lin, J., Loomis, K., Lorimer, D., Louie, G., Maletic, M., Marsh, C. D., Miller, I., Molinari, J., Muller-Dieckmann, H. J., Newman, J. M., Noland, B. W., Pagarigan, B., Park, F., Peat, T. S., Post, K. W., Radojicic, S., Ramos, A., Romero, R., Rutter, M. E., Sanderson, W. E., Schwinn, K. D., Tresser, J., Winhoven, J., Wright, T. A., Wu, L., Xu, J., Harris, T. J. (2005). "Structural analysis of a set of proteins resulting from a bacterial genomics project." Proteins 60:787-796. Pubmed: 16021622
  • Blattner, F. R., Plunkett, G. 3rd, Bloch, C. A., Perna, N. T., Burland, V., Riley, M., Collado-Vides, J., Glasner, J. D., Rode, C. K., Mayhew, G. F., Gregor, J., Davis, N. W., Kirkpatrick, H. A., Goeden, M. A., Rose, D. J., Mau, B., Shao, Y. (1997). "The complete genome sequence of Escherichia coli K-12." Science 277:1453-1462. Pubmed: 9278503
  • Hayashi, K., Morooka, N., Yamamoto, Y., Fujita, K., Isono, K., Choi, S., Ohtsubo, E., Baba, T., Wanner, B. L., Mori, H., Horiuchi, T. (2006). "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Mol Syst Biol 2:2006.0007. Pubmed: 16738553
  • O'Handley, S. F., Frick, D. N., Dunn, C. A., Bessman, M. J. (1998). "Orf186 represents a new member of the Nudix hydrolases, active on adenosine(5')triphospho(5')adenosine, ADP-ribose, and NADH." J Biol Chem 273:3192-3197. Pubmed: 9452430