| Identification |
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| Name: | tRNA N6-adenosine threonylcarbamoyltransferase |
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| Synonyms: | Not Available |
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| Gene Name: | tsaD |
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| Enzyme Class: | |
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| Biological Properties |
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| General Function: | threonylcarbamoyladenosine biosynthetic process |
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| Specific Function: | Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction. May also be involved in the metabolism of glycated proteins, but does not show sialoglycoprotease activity against glycophorin A. |
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| Cellular Location: | Not Available |
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| SMPDB Pathways: | Not Available |
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| KEGG Pathways: | Not Available |
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| KEGG Reactions: | |
1.0 | ↔ | 1.0 |
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| Metabolites: | | ECMDB ID | Name | View |
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| ECMDB00045 | Adenosine monophosphate | MetaboCard | | ECMDB23796 | L-Threonylcarbamoyladenylate | MetaboCard |
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| GO Classification: | | Function |
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| cytosol | | glycoprotein binding | | identical protein binding | | iron ion binding | | metalloendopeptidase activity | | peptidase activity | | proteolysis | | threonylcarbamoyladenosine biosynthetic process | | transferase activity, transferring acyl groups other than amino-acyl groups |
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| Gene Properties |
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| Blattner: | Not Available |
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| Gene Orientation | Not Available |
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| Centisome Percentage: | Not Available |
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| Left Sequence End | Not Available |
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| Right Sequence End | Not Available |
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| Gene Sequence: | >1014
atgcgtgtactgggtattgaaacttcctgcgatgaaaccggcatcgccatttacgacgat
gaaaaaggtttgttagccaaccaattgtatagtcaggtgaaattgcacgctgactacggc
ggcgtcgtgcctgaactggcctcccgcgatcatgtgcgtaaaaccgtaccgttgatccag
gcggcgctaaaggagtctggtttaacggcaaaagacattgatgctgtggcctataccgca
ggccctggattagtcggcgcgctactggttggcgcgaccgtggggcgttctctggcgttt
gcctgggacgttccggcgatccctgtacaccatatggaagggcatctgttagcgccgatg
ctggaagataacccgccggaatttccgtttgttgcgctgcttgtttccggcggtcatacg
cagttaatcagcgtgactggcattggtcagtacgagctgctcggcgagtctatcgatgat
gccgccggggaagcgtttgataaaaccgcgaagctgctggggctggattatcctggcggg
ccgttactgtcgaaaatggcggctcagggtactgccgggcgctttgtcttcccgcgtccg
atgaccgaccgtccggggctggatttcagcttctccggcctgaaaaccttcgcggcaaat
accattcgtgacaacggcaccgacgaccagacgcgtgctgatatcgcccgcgcctttgaa
gatgcggtggtcgatacgctgatgattaagtgcaagcgggcgctggatcagacgggcttt
aagcgactggtcatggcgggcggcgtgagtgctaaccgtacgttacgggcgaagctggct
gaaatgatgaaaaaacgccgcggcgaagtgttctacgcgcgtccggaattttgtactgat
aacggcgcgatgatcgcctatgccggaatggtgcggtttaaagcaggcgcgacggcggat
ctcggcgttagcgtgcgtccgcgctggccgctggcggagttaccggctgcgtaa |
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| Protein Properties |
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| Pfam Domain Function: | Not Available |
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| Protein Residues: | 337 |
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| Protein Molecular Weight: | 36008 |
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| Protein Theoretical pI: | Not Available |
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| PDB File: | 4WQ4 |
| Signaling Regions: | Not Available |
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| Transmembrane Regions: | Not Available |
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| Protein Sequence: | >tRNA N6-adenosine threonylcarbamoyltransferase
MRVLGIETSCDETGIAIYDDEKGLLANQLYSQVKLHADYGGVVPELASRDHVRKTVPLIQ
AALKESGLTAKDIDAVAYTAGPGLVGALLVGATVGRSLAFAWDVPAIPVHHMEGHLLAPM
LEDNPPEFPFVALLVSGGHTQLISVTGIGQYELLGESIDDAAGEAFDKTAKLLGLDYPGG
PLLSKMAAQGTAGRFVFPRPMTDRPGLDFSFSGLKTFAANTIRDNGTDDQTRADIARAFE
DAVVDTLMIKCKRALDQTGFKRLVMAGGVSANRTLRAKLAEMMKKRRGEVFYARPEFCTD
NGAMIAYAGMVRFKAGATADLGVSVRPRWPLAELPAA |
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| References |
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| External Links: | |
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| General Reference: | Not Available |
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