L-Aspartic acid (ECMDB00191) (M2MDB000080)
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Version | 2.0 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Creation Date | 2012-05-31 10:23:25 -0600 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Update Date | 2015-09-13 12:56:06 -0600 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Secondary Accession Numbers |
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Identification | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Name: | L-Aspartic acid | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Description | Aspartic acid (Asp, D), also known as aspartate (the name of its anion), is one of the 20 natural proteinogenic amino acids which are the building blocks of proteins. Aspartic acid has 2 enantiomeric forms: D and L. L-aspartic acid is the isomer with more biological roles and is the form used in constructing proteins. (Wikipedia) In E. coli, L-aspartate can be produced from L-glutamate, and interconversion can occur between L-asparagine and L-aspartate. L-aspartate is also involved in the biosynthesis pathways of many compounds, including adenosine nucleotides, beta-alanine, and homoserine. (EcoCyc) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Structure | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Synonyms: |
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Chemical Formula: | C4H7NO4 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Weight: | Average: 133.1027 Monoisotopic: 133.037507717 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
InChI Key: | CKLJMWTZIZZHCS-REOHCLBHSA-N | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
InChI: | InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/t2-/m0/s1 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
CAS number: | 56-84-8 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
IUPAC Name: | (2S)-2-aminobutanedioic acid | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Traditional IUPAC Name: | L-aspartic acid | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
SMILES: | N[C@@H](CC(O)=O)C(O)=O | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Chemical Taxonomy | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Description | belongs to the class of organic compounds known as aspartic acid and derivatives. Aspartic acid and derivatives are compounds containing an aspartic acid or a derivative thereof resulting from reaction of aspartic acid at the amino group or the carboxy group, or from the replacement of any hydrogen of glycine by a heteroatom. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Kingdom | Organic compounds | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Super Class | Organic acids and derivatives | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Class | Carboxylic acids and derivatives | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sub Class | Amino acids, peptides, and analogues | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Direct Parent | Aspartic acid and derivatives | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Alternative Parents | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Substituents |
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Molecular Framework | Aliphatic acyclic compounds | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
External Descriptors |
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Physical Properties | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
State: | Solid | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Charge: | -1 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Melting point: | 270 °C | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Experimental Properties: |
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Predicted Properties |
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Biological Properties | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Cellular Locations: | Cytoplasm | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Reactions: | L-Aspartic acid + Carbamoylphosphate <> Ureidosuccinic acid + Hydrogen ion + Phosphate L-Aspartic acid + Adenosine triphosphate <> L-Aspartyl-4-phosphate + ADP Adenosine triphosphate + Water + L-Aspartic acid > ADP + L-Aspartic acid + Hydrogen ion + Phosphate Adenosine triphosphate + Water + L-Aspartic acid > ADP + L-Aspartic acid + Hydrogen ion + Phosphate L-Asparagine + Water > L-Aspartic acid + Ammonium L-Aspartic acid + Hydrogen ion <> beta-Alanine + Carbon dioxide L-Aspartic acid + Adenosine triphosphate + L-Glutamine + Water > Adenosine monophosphate + L-Asparagine + L-Glutamate + Hydrogen ion + Pyrophosphate alpha-Ketoglutarate + L-Aspartic acid <> L-Glutamate + Oxalacetic acid L-Aspartic acid + Adenosine triphosphate + tRNA(Asp) + tRNA(Asp) <> Adenosine monophosphate + L-Aspartyl-tRNA(Asp) + Pyrophosphate + L-Aspartyl-tRNA(Asp) 5-Amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-Aspartic acid + Adenosine triphosphate <> SAICAR + ADP + Hydrogen ion + Phosphate L-Aspartic acid + Fumaric acid > Hydrogen ion + Iminoaspartic acid + Succinic acid L-Aspartic acid + Oxygen <> Hydrogen ion + Hydrogen peroxide + Iminoaspartic acid L-Aspartic acid + Ubiquinone-8 > Hydrogen ion + Iminoaspartic acid + Ubiquinol-8 L-Aspartic acid + Menaquinone 8 > Hydrogen ion + Iminoaspartic acid + Menaquinol 8 L-Aspartic acid + Adenosine triphosphate + Citrulline <> Adenosine monophosphate + Argininosuccinic acid + Hydrogen ion + Pyrophosphate L-Aspartic acid + Adenosine triphosphate + Ammonium > Adenosine monophosphate + L-Asparagine + Hydrogen ion + Pyrophosphate L-Aspartic acid > Fumaric acid + Ammonium L-Aspartic acid + Guanosine triphosphate + Inosinic acid <> Adenylsuccinic acid + Guanosine diphosphate +2 Hydrogen ion + Phosphate L-Aspartic acid + Water + Oxygen <> Oxalacetic acid + Ammonia + Hydrogen peroxide L-Aspartic acid + Oxygen <> Iminoaspartic acid + Hydrogen peroxide Adenosine triphosphate + L-Aspartic acid + Ammonia <> Adenosine monophosphate + Pyrophosphate + L-Asparagine L-Asparagine + Water <> L-Aspartic acid + Ammonia L-Aspartic acid <> beta-Alanine + Carbon dioxide L-Aspartic acid <> Fumaric acid + Ammonia Adenosine triphosphate + L-Aspartic acid + L-Glutamine + Water <> Adenosine monophosphate + Pyrophosphate + L-Asparagine + L-Glutamate Guanosine triphosphate + Inosinic acid + L-Aspartic acid <> Guanosine diphosphate + Phosphate + Adenylsuccinic acid More...Carbamoylphosphate + L-Aspartic acid <> Phosphate + Ureidosuccinic acid Oxalacetic acid + L-Arogenate <> L-Aspartic acid + Prephenate Adenosine triphosphate + Citrulline + L-Aspartic acid <> Adenosine monophosphate + Pyrophosphate + Argininosuccinic acid Adenosine triphosphate + 5-Amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-Aspartic acid <> ADP + Phosphate + SAICAR tRNA(Asp) + L-Aspartic acid + Adenosine triphosphate <> L-Aspartyl-tRNA(Asp) + Pyrophosphate + Adenosine monophosphate a dipetide with aspartate at N-terminal + Water L-Aspartic acid + a standard α amino acid L-Aspartic acid + Inosinic acid + Guanosine triphosphate > Hydrogen ion + adenylo-succinate + Phosphate + Guanosine diphosphate L-Aspartic acid + Citrulline + Adenosine triphosphate > Hydrogen ion + L-arginino-succinate + Pyrophosphate + Adenosine monophosphate Ammonia + L-Aspartic acid + Adenosine triphosphate > L-Asparagine + Pyrophosphate + Adenosine monophosphate L-Aspartic acid + Oxoglutaric acid <> Oxalacetic acid + L-Glutamate L-Asparagine + Water > Hydrogen ion + L-Aspartic acid + Ammonia L-Aspartic acid <> Hydrogen ion + Fumaric acid + Ammonia L-Aspartic acid + Adenosine triphosphate > L-Aspartyl-4-phosphate + ADP L-Aspartic acid + Carbamoylphosphate > Hydrogen ion + Ureidosuccinic acid + Phosphate Hydrogen ion + L-Aspartic acid > beta-Alanine + Carbon dioxide Oxygen + L-Aspartic acid > Hydrogen ion + Hydrogen peroxide + Iminoaspartic acid Pyridoxamine + Oxalacetic acid <> Pyridoxal + L-Aspartic acid ala-asp + Water > L-Alanine + L-Aspartic acid gly-asp + Water > Glycine + L-Aspartic acid Adenosine triphosphate + 5-Amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-Aspartic acid > Hydrogen ion + ADP + Phosphate + SAICAR Adenosine triphosphate + L-Aspartic acid + Water > L-Aspartic acid + ADP + Phosphate + Hydrogen ion Adenosine triphosphate + L-Aspartic acid + Water > L-Aspartic acid + ADP + Phosphate + Hydrogen ion L-Aspartic acid + Oxoglutaric acid > Oxalacetic acid + L-Glutamate Adenosine triphosphate + L-Aspartic acid > ADP + L-4-aspartyl phosphate Adenosine triphosphate + L-Aspartic acid + L-Glutamine + Water > Adenosine monophosphate + Pyrophosphate + L-Asparagine + L-Glutamate L-Aspartic acid > Fumaric acid + Ammonia L-Asparagine + Water > L-Aspartic acid + Ammonia Adenosine triphosphate + Citrulline + L-Aspartic acid > Adenosine monophosphate + Pyrophosphate + 2-(N(omega)-L-arginino)succinate L-Aspartic acid + Oxygen > Iminoaspartic acid + Hydrogen peroxide L-Aspartic acid > beta-Alanine + Carbon dioxide Adenosine triphosphate + 5-Amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-Aspartic acid > ADP + Inorganic phosphate + SAICAR Guanosine triphosphate + Inosinic acid + L-Aspartic acid > Guanosine diphosphate + Inorganic phosphate + N(6)-(1,2-dicarboxyethyl)AMP Carbamoylphosphate + L-Aspartic acid > Inorganic phosphate + Ureidosuccinic acid Adenosine triphosphate + L-Aspartic acid + tRNA(Asp) > Adenosine monophosphate + Pyrophosphate + L-aspartyl-tRNA(Asp) Adenosine triphosphate + L-Aspartic acid + L-Glutamine + Water + Ammonia <> Adenosine monophosphate + Pyrophosphate + L-Asparagine + L-Glutamate L-Aspartic acid + Adenosine triphosphate + L-Aspartic acid > Adenosine diphosphate + L-Aspartyl-4-phosphate + ADP Adenosine triphosphate + L-Aspartic acid + Ammonia + L-Aspartic acid > Adenosine monophosphate + L-Asparagine + Pyrophosphate + L-Asparagine Adenosine triphosphate + L-Aspartic acid + L-Glutamine + Water + L-Aspartic acid > Adenosine monophosphate + Pyrophosphate + L-Asparagine + L-Glutamic acid + L-Asparagine + L-Glutamate L-Aspartic acid + Oxoglutaric acid + L-Aspartic acid > Oxalacetic acid + L-Glutamic acid + L-Glutamate L-Glutamic acid + Oxalacetic acid + L-Glutamate > L-Aspartic acid + Oxoglutaric acid + L-Aspartic acid L-Aspartic acid + Water + Oxygen + L-Aspartic acid > Oxalacetic acid + Ammonia + Hydrogen peroxide L-Aspartic acid + Oxygen + L-Aspartic acid > Hydrogen peroxide + Hydrogen ion + Iminoaspartic acid L-Aspartic acid + L-Aspartic acid > Fumaric acid + Ammonia L-Aspartic acid + L-Aspartic acid > Fumaric acid + Ammonium Guanosine triphosphate + Inosinic acid + L-Aspartic acid + L-Aspartic acid > Guanosine diphosphate + Phosphate + N(6)-(1,2-dicarboxyethyl)AMP Inosinic acid + L-Aspartic acid + Guanosine triphosphate + L-Aspartic acid > Guanosine diphosphate + Phosphate +2 Hydrogen ion + N(6)-(1,2-dicarboxyethyl)AMP + Adenylsuccinic acid Adenosine triphosphate + Citrulline + L-Aspartic acid + L-Aspartic acid > Pyrophosphate + Adenosine monophosphate + Argininosuccinic acid L-Aspartic acid + L-Aspartic acid > N-carbamoyl-L-aspartate L-Aspartic acid + Adenosine triphosphate + Hydrogen ion + tRNA(Asp) + L-Aspartic acid > Pyrophosphate + Adenosine monophosphate + L-aspartyl-tRNA(Asp) L-Aspartic acid + Water + Adenosine triphosphate + L-Glutamine + L-Aspartic acid > L-Asparagine + Hydrogen ion + Adenosine monophosphate + L-Glutamic acid + Pyrophosphate + L-Asparagine + L-Glutamate L-Aspartic acid + Adenosine triphosphate + Ammonium + L-Aspartic acid > L-Asparagine + Adenosine monophosphate + Pyrophosphate + Hydrogen ion + L-Asparagine L-Aspartic acid + Hydrogen ion + L-Aspartic acid Carbon dioxide + beta-Alanine L-Aspartic acid + Hydrogen ion + L-Aspartic acid > Carbon dioxide + beta-Alanine L-Asparagine + Water + L-Asparagine > L-Aspartic acid + Ammonium + L-Aspartic acid 5-Amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-Aspartic acid + Adenosine triphosphate + L-Aspartic acid > SAICAR + Phosphate + Adenosine diphosphate + Hydrogen ion + SAICAR + ADP Carbamoylphosphate + L-Aspartic acid + L-Aspartic acid > Phosphate + Hydrogen ion + N-carbamoyl-L-aspartate L-Aspartic acid + Adenosine triphosphate + Water + L-Aspartic acid > Adenosine diphosphate + Phosphate + Hydrogen ion + L-Aspartic acid + ADP L-Aspartic acid + Carbamoylphosphate <> Ureidosuccinic acid + Hydrogen ion + Phosphate L-Aspartic acid + Oxygen <> Hydrogen ion + Hydrogen peroxide + Iminoaspartic acid L-Aspartic acid + Adenosine triphosphate <> L-Aspartyl-4-phosphate + ADP L-Aspartic acid + Adenosine triphosphate + tRNA(Asp) <> Adenosine monophosphate + L-Aspartyl-tRNA(Asp) + Pyrophosphate 5 5-Amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-Aspartic acid + Adenosine triphosphate <> SAICAR + ADP + Hydrogen ion + Phosphate L-Asparagine + Water <> L-Aspartic acid + Ammonia L-Aspartic acid + Adenosine triphosphate + Citrulline <> Adenosine monophosphate + Argininosuccinic acid + Hydrogen ion + Pyrophosphate L-Aspartic acid + Hydrogen ion <> beta-Alanine + Carbon dioxide L-Aspartic acid + Guanosine triphosphate + Inosinic acid <> Adenylsuccinic acid + Guanosine diphosphate +2 Hydrogen ion + Phosphate L-Aspartic acid <> Fumaric acid + Ammonia L-Aspartic acid <> Hydrogen ion + Fumaric acid + Ammonia L-Aspartic acid + Carbamoylphosphate <> Ureidosuccinic acid + Hydrogen ion + Phosphate L-Aspartic acid + Oxygen <> Hydrogen ion + Hydrogen peroxide + Iminoaspartic acid 5 5-Amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-Aspartic acid + Adenosine triphosphate <> SAICAR + ADP + Hydrogen ion + Phosphate L-Asparagine + Water > Hydrogen ion + L-Aspartic acid + Ammonia L-Aspartic acid + Adenosine triphosphate + Citrulline <> Adenosine monophosphate + Argininosuccinic acid + Hydrogen ion + Pyrophosphate | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
SMPDB Pathways: |
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KEGG Pathways: |
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EcoCyc Pathways: |
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Concentrations | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Find out more about how we convert literature concentrations. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Spectra | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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References | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
References: |
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Synthesis Reference: | Pamfil, Maria; Lupescu, Irina; Savoiu, Valeria Gabriela. L-aspartic acid production from fumarate using Escherichia coli whole cells. Rom. (2005), 3pp. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Material Safety Data Sheet (MSDS) | Download (PDF) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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External Links: |
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Enzymes
- General function:
- Involved in transferase activity
- Specific function:
- L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate
- Gene Name:
- aspC
- Uniprot ID:
- P00509
- Molecular weight:
- 43573
Reactions
L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate. |
- General function:
- Involved in amino acid binding
- Specific function:
- L-homoserine + NAD(P)(+) = L-aspartate 4- semialdehyde + NAD(P)H
- Gene Name:
- thrA
- Uniprot ID:
- P00561
- Molecular weight:
- 89119
Reactions
L-homoserine + NAD(P)(+) = L-aspartate 4-semialdehyde + NAD(P)H. |
ATP + L-aspartate = ADP + 4-phospho-L-aspartate. |
- General function:
- Involved in cellular amino acid biosynthetic process
- Specific function:
- L-homoserine + NAD(P)(+) = L-aspartate 4- semialdehyde + NAD(P)H
- Gene Name:
- metL
- Uniprot ID:
- P00562
- Molecular weight:
- 88887
Reactions
L-homoserine + NAD(P)(+) = L-aspartate 4-semialdehyde + NAD(P)H. |
ATP + L-aspartate = ADP + 4-phospho-L-aspartate. |
- General function:
- Involved in asparaginase activity
- Specific function:
- L-asparagine + H(2)O = L-aspartate + NH(3)
- Gene Name:
- ansB
- Uniprot ID:
- P00805
- Molecular weight:
- 36851
Reactions
L-asparagine + H(2)O = L-aspartate + NH(3). |
- General function:
- Involved in nucleotide binding
- Specific function:
- ATP + L-aspartate + NH(3) = AMP + diphosphate + L-asparagine
- Gene Name:
- asnA
- Uniprot ID:
- P00963
- Molecular weight:
- 36650
Reactions
ATP + L-aspartate + NH(3) = AMP + diphosphate + L-asparagine. |
- General function:
- Involved in transferase activity
- Specific function:
- An aromatic amino acid + 2-oxoglutarate = an aromatic oxo acid + L-glutamate
- Gene Name:
- tyrB
- Uniprot ID:
- P04693
- Molecular weight:
- 43537
Reactions
An aromatic amino acid + 2-oxoglutarate = an aromatic oxo acid + L-glutamate. |
- General function:
- Involved in amino acid binding
- Specific function:
- ATP + L-aspartate = ADP + 4-phospho-L- aspartate
- Gene Name:
- lysC
- Uniprot ID:
- P08660
- Molecular weight:
- 48531
Reactions
ATP + L-aspartate = ADP + 4-phospho-L-aspartate. |
- General function:
- Involved in argininosuccinate synthase activity
- Specific function:
- ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate
- Gene Name:
- argG
- Uniprot ID:
- P0A6E4
- Molecular weight:
- 49898
Reactions
ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate. |
- General function:
- Involved in carboxyl- or carbamoyltransferase activity
- Specific function:
- Carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate
- Gene Name:
- pyrB
- Uniprot ID:
- P0A786
- Molecular weight:
- 34427
Reactions
Carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate. |
- General function:
- Involved in aspartate 1-decarboxylase activity
- Specific function:
- Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
- Gene Name:
- panD
- Uniprot ID:
- P0A790
- Molecular weight:
- 13834
Reactions
L-aspartate = beta-alanine + CO(2). |
- General function:
- Involved in adenylosuccinate synthase activity
- Specific function:
- Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP
- Gene Name:
- purA
- Uniprot ID:
- P0A7D4
- Molecular weight:
- 47345
Reactions
GTP + IMP + L-aspartate = GDP + phosphate + N(6)-(1,2-dicarboxyethyl)-AMP. |
- General function:
- Involved in ATP binding
- Specific function:
- ATP + 5-amino-1-(5-phospho-D- ribosyl)imidazole-4-carboxylate + L-aspartate = ADP + phosphate + (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate
- Gene Name:
- purC
- Uniprot ID:
- P0A7D7
- Molecular weight:
- 26995
Reactions
ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate = ADP + phosphate + (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate. |
- General function:
- Involved in 'de novo' pyrimidine base biosynthetic process
- Specific function:
- Involved in allosteric regulation of aspartate carbamoyltransferase
- Gene Name:
- pyrI
- Uniprot ID:
- P0A7F3
- Molecular weight:
- 17121
- General function:
- Involved in asparaginase activity
- Specific function:
- L-asparagine + H(2)O = L-aspartate + NH(3)
- Gene Name:
- ansA
- Uniprot ID:
- P0A962
- Molecular weight:
- 37127
Reactions
L-asparagine + H(2)O = L-aspartate + NH(3). |
- General function:
- Involved in aspartate ammonia-lyase activity
- Specific function:
- L-aspartate = fumarate + NH(3)
- Gene Name:
- aspA
- Uniprot ID:
- P0AC38
- Molecular weight:
- 52356
Reactions
L-aspartate = fumarate + NH(3). |
- General function:
- Involved in electron carrier activity
- Specific function:
- Catalyzes the oxidation of L-aspartate to iminoaspartate
- Gene Name:
- nadB
- Uniprot ID:
- P10902
- Molecular weight:
- 60337
Reactions
L-aspartate + O(2) = iminosuccinate + H(2)O(2). |
- General function:
- Involved in nucleotide binding
- Specific function:
- ATP + L-aspartate + tRNA(Asp) = AMP + diphosphate + L-aspartyl-tRNA(Asp)
- Gene Name:
- aspS
- Uniprot ID:
- P21889
- Molecular weight:
- 65913
Reactions
ATP + L-aspartate + tRNA(Asp) = AMP + diphosphate + L-aspartyl-tRNA(Asp). |
- General function:
- Involved in asparagine synthase (glutamine-hydrolyzing) activity
- Specific function:
- ATP + L-aspartate + L-glutamine + H(2)O = AMP + diphosphate + L-asparagine + L-glutamate
- Gene Name:
- asnB
- Uniprot ID:
- P22106
- Molecular weight:
- 62659
Reactions
ATP + L-aspartate + L-glutamine + H(2)O = AMP + diphosphate + L-asparagine + L-glutamate. |
- General function:
- Involved in hydrolase activity
- Specific function:
- May be involved in glutathione, and possibly other peptide, transport, although these results could also be due to polar effects of disruption
- Gene Name:
- iaaA
- Uniprot ID:
- P37595
- Molecular weight:
- 33394
Reactions
Cleavage of a beta-linked Asp residue from the N-terminus of a polypeptide. |
- General function:
- Involved in glutamate decarboxylase activity
- Specific function:
- Converts glutamate to gamma-aminobutyrate (GABA), consuming one intracellular proton in the reaction. The gad system helps to maintain a near-neutral intracellular pH when cells are exposed to extremely acidic conditions. The ability to survive transit through the acidic conditions of the stomach is essential for successful colonization of the mammalian host by commensal and pathogenic bacteria
- Gene Name:
- gadA
- Uniprot ID:
- P69908
- Molecular weight:
- 52685
Reactions
L-glutamate = 4-aminobutanoate + CO(2). |
- General function:
- Involved in glutamate decarboxylase activity
- Specific function:
- Converts glutamate to gamma-aminobutyrate (GABA), consuming one intracellular proton in the reaction. The gad system helps to maintain a near-neutral intracellular pH when cells are exposed to extremely acidic conditions. The ability to survive transit through the acidic conditions of the stomach is essential for successful colonization of the mammalian host by commensal and pathogenic bacteria
- Gene Name:
- gadB
- Uniprot ID:
- P69910
- Molecular weight:
- 52668
Reactions
L-glutamate = 4-aminobutanoate + CO(2). |
- General function:
- Involved in transporter activity
- Specific function:
- Part of the binding-protein-dependent transport system for aspartate/glutamate; probably responsible for the translocation of the substrate across the membrane
- Gene Name:
- gltJ
- Uniprot ID:
- P0AER3
- Molecular weight:
- 27502
- General function:
- Involved in transporter activity
- Specific function:
- Part of the binding-protein-dependent transport system for aspartate/glutamate; probably responsible for the translocation of the substrate across the membrane
- Gene Name:
- gltK
- Uniprot ID:
- P0AER5
- Molecular weight:
- 24914
- General function:
- Involved in nucleotide binding
- Specific function:
- Part of the binding-protein-dependent transport system for glutamate and aspartate. Probably responsible for energy coupling to the transport system
- Gene Name:
- gltL
- Uniprot ID:
- P0AAG3
- Molecular weight:
- 26661
- General function:
- Involved in transporter activity
- Specific function:
- Part of the binding-protein-dependent transport system for glutamate and aspartate. Binds to both aspartate and glutamate
- Gene Name:
- gltI
- Uniprot ID:
- P37902
- Molecular weight:
- 33420
Transporters
- General function:
- Involved in nucleotide binding
- Specific function:
- Probably part of a binding-protein-dependent transport system yecCS for an amino acid. Probably responsible for energy coupling to the transport system
- Gene Name:
- yecC
- Uniprot ID:
- P37774
- Molecular weight:
- 27677
- General function:
- Involved in transporter activity
- Specific function:
- Probably part of the binding-protein-dependent transport system yecCS for an amino acid; probably responsible for the translocation of the substrate across the membrane
- Gene Name:
- yecS
- Uniprot ID:
- P0AFT2
- Molecular weight:
- 24801
- General function:
- Involved in C4-dicarboxylate transmembrane transporter activity
- Specific function:
- Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
- Gene Name:
- dcuA
- Uniprot ID:
- P0ABN5
- Molecular weight:
- 45750
- General function:
- Involved in C4-dicarboxylate transmembrane transporter activity
- Specific function:
- Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
- Gene Name:
- dcuB
- Uniprot ID:
- P0ABN9
- Molecular weight:
- 47935
- General function:
- Involved in C4-dicarboxylate transmembrane transporter activity
- Specific function:
- Responsible for the transport of C4-dicarboxylates during anaerobic growth
- Gene Name:
- dcuC
- Uniprot ID:
- P0ABP3
- Molecular weight:
- 48412
- General function:
- Involved in transporter activity
- Specific function:
- Part of the binding-protein-dependent transport system for aspartate/glutamate; probably responsible for the translocation of the substrate across the membrane
- Gene Name:
- gltJ
- Uniprot ID:
- P0AER3
- Molecular weight:
- 27502
- General function:
- Involved in transporter activity
- Specific function:
- Part of the binding-protein-dependent transport system for aspartate/glutamate; probably responsible for the translocation of the substrate across the membrane
- Gene Name:
- gltK
- Uniprot ID:
- P0AER5
- Molecular weight:
- 24914
- General function:
- Involved in sodium:dicarboxylate symporter activity
- Specific function:
- This carrier protein is part of the Na(+)-independent, binding-protein-independent glutamate-aspartate transport system
- Gene Name:
- gltP
- Uniprot ID:
- P21345
- Molecular weight:
- 47159
- General function:
- Involved in transporter activity
- Specific function:
- Non-specific porin
- Gene Name:
- ompN
- Uniprot ID:
- P77747
- Molecular weight:
- 41220
- General function:
- Involved in transporter activity
- Specific function:
- Uptake of inorganic phosphate, phosphorylated compounds, and some other negatively charged solutes
- Gene Name:
- phoE
- Uniprot ID:
- P02932
- Molecular weight:
- 38922
- General function:
- Involved in symporter activity
- Specific function:
- Responsible for the aerobic transport of the dicarboxylates fumarate, L- and D-malate and to a lesser extent succinate, from the periplasm across the inner membrane
- Gene Name:
- dctA
- Uniprot ID:
- P0A830
- Molecular weight:
- 45436
- General function:
- Involved in nucleotide binding
- Specific function:
- Part of the binding-protein-dependent transport system for glutamate and aspartate. Probably responsible for energy coupling to the transport system
- Gene Name:
- gltL
- Uniprot ID:
- P0AAG3
- Molecular weight:
- 26661
- General function:
- Involved in transporter activity
- Specific function:
- OmpF is a porin that forms passive diffusion pores which allow small molecular weight hydrophilic materials across the outer membrane. It is also a receptor for the bacteriophage T2
- Gene Name:
- ompF
- Uniprot ID:
- P02931
- Molecular weight:
- 39333
- General function:
- Involved in transporter activity
- Specific function:
- Forms passive diffusion pores which allow small molecular weight hydrophilic materials across the outer membrane
- Gene Name:
- ompC
- Uniprot ID:
- P06996
- Molecular weight:
- 40368
- General function:
- Involved in transporter activity
- Specific function:
- Part of the binding-protein-dependent transport system for glutamate and aspartate. Binds to both aspartate and glutamate
- Gene Name:
- gltI
- Uniprot ID:
- P37902
- Molecular weight:
- 33420