L-Aspartic acid (ECMDB00191) (M2MDB000080)

General function:

Involved in transferase activity

Specific function:

L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate

Gene Name:

aspC

Uniprot ID:

P00509

Molecular weight:

43573

Reactions

General function:

Involved in amino acid binding

Specific function:

L-homoserine + NAD(P)(+) = L-aspartate 4- semialdehyde + NAD(P)H

Gene Name:

thrA

Uniprot ID:

P00561

Molecular weight:

89119

Reactions

General function:

Involved in cellular amino acid biosynthetic process

Specific function:

L-homoserine + NAD(P)(+) = L-aspartate 4- semialdehyde + NAD(P)H

Gene Name:

metL

Uniprot ID:

P00562

Molecular weight:

88887

Reactions

General function:

Involved in asparaginase activity

Specific function:

L-asparagine + H(2)O = L-aspartate + NH(3)

Gene Name:

ansB

Uniprot ID:

P00805

Molecular weight:

36851

Reactions

General function:

Involved in nucleotide binding

Specific function:

ATP + L-aspartate + NH(3) = AMP + diphosphate + L-asparagine

Gene Name:

asnA

Uniprot ID:

P00963

Molecular weight:

36650

Reactions

General function:

Involved in transferase activity

Specific function:

An aromatic amino acid + 2-oxoglutarate = an aromatic oxo acid + L-glutamate

Gene Name:

tyrB

Uniprot ID:

P04693

Molecular weight:

43537

Reactions

General function:

Involved in amino acid binding

Specific function:

ATP + L-aspartate = ADP + 4-phospho-L- aspartate

Gene Name:

lysC

Uniprot ID:

P08660

Molecular weight:

48531

Reactions

General function:

Involved in argininosuccinate synthase activity

Specific function:

ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate

Gene Name:

argG

Uniprot ID:

P0A6E4

Molecular weight:

49898

Reactions

General function:

Involved in carboxyl- or carbamoyltransferase activity

Specific function:

Carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate

Gene Name:

pyrB

Uniprot ID:

P0A786

Molecular weight:

34427

Reactions

General function:

Involved in aspartate 1-decarboxylase activity

Specific function:

Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine

Gene Name:

panD

Uniprot ID:

P0A790

Molecular weight:

13834

Reactions

General function:

Involved in adenylosuccinate synthase activity

Specific function:

Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP

Gene Name:

purA

Uniprot ID:

P0A7D4

Molecular weight:

47345

Reactions

General function:

Involved in ATP binding

Specific function:

ATP + 5-amino-1-(5-phospho-D- ribosyl)imidazole-4-carboxylate + L-aspartate = ADP + phosphate + (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate

Gene Name:

purC

Uniprot ID:

P0A7D7

Molecular weight:

26995

Reactions

General function:

Involved in 'de novo' pyrimidine base biosynthetic process

Specific function:

Involved in allosteric regulation of aspartate carbamoyltransferase

Gene Name:

pyrI

Uniprot ID:

P0A7F3

Molecular weight:

17121

General function:

Involved in asparaginase activity

Specific function:

L-asparagine + H(2)O = L-aspartate + NH(3)

Gene Name:

ansA

Uniprot ID:

P0A962

Molecular weight:

37127

Reactions

General function:

Involved in aspartate ammonia-lyase activity

Specific function:

L-aspartate = fumarate + NH(3)

Gene Name:

aspA

Uniprot ID:

P0AC38

Molecular weight:

52356

Reactions

General function:

Involved in electron carrier activity

Specific function:

Catalyzes the oxidation of L-aspartate to iminoaspartate

Gene Name:

nadB

Uniprot ID:

P10902

Molecular weight:

60337

Reactions

General function:

Involved in nucleotide binding

Specific function:

ATP + L-aspartate + tRNA(Asp) = AMP + diphosphate + L-aspartyl-tRNA(Asp)

Gene Name:

aspS

Uniprot ID:

P21889

Molecular weight:

65913

Reactions

General function:

Involved in asparagine synthase (glutamine-hydrolyzing) activity

Specific function:

ATP + L-aspartate + L-glutamine + H(2)O = AMP + diphosphate + L-asparagine + L-glutamate

Gene Name:

asnB

Uniprot ID:

P22106

Molecular weight:

62659

Reactions

General function:

Involved in hydrolase activity

Specific function:

May be involved in glutathione, and possibly other peptide, transport, although these results could also be due to polar effects of disruption

Gene Name:

iaaA

Uniprot ID:

P37595

Molecular weight:

33394

Reactions

General function:

Involved in glutamate decarboxylase activity

Specific function:

Converts glutamate to gamma-aminobutyrate (GABA), consuming one intracellular proton in the reaction. The gad system helps to maintain a near-neutral intracellular pH when cells are exposed to extremely acidic conditions. The ability to survive transit through the acidic conditions of the stomach is essential for successful colonization of the mammalian host by commensal and pathogenic bacteria

Gene Name:

gadA

Uniprot ID:

P69908

Molecular weight:

52685

Reactions

General function:

Involved in glutamate decarboxylase activity

Specific function:

Converts glutamate to gamma-aminobutyrate (GABA), consuming one intracellular proton in the reaction. The gad system helps to maintain a near-neutral intracellular pH when cells are exposed to extremely acidic conditions. The ability to survive transit through the acidic conditions of the stomach is essential for successful colonization of the mammalian host by commensal and pathogenic bacteria

Gene Name:

gadB

Uniprot ID:

P69910

Molecular weight:

52668

Reactions

General function:

Involved in transporter activity

Specific function:

Part of the binding-protein-dependent transport system for aspartate/glutamate; probably responsible for the translocation of the substrate across the membrane

Gene Name:

gltJ

Uniprot ID:

P0AER3

Molecular weight:

27502

General function:

Involved in transporter activity

Specific function:

Part of the binding-protein-dependent transport system for aspartate/glutamate; probably responsible for the translocation of the substrate across the membrane

Gene Name:

gltK

Uniprot ID:

P0AER5

Molecular weight:

24914

General function:

Involved in nucleotide binding

Specific function:

Part of the binding-protein-dependent transport system for glutamate and aspartate. Probably responsible for energy coupling to the transport system

Gene Name:

gltL

Uniprot ID:

P0AAG3

Molecular weight:

26661

General function:

Involved in transporter activity

Specific function:

Part of the binding-protein-dependent transport system for glutamate and aspartate. Binds to both aspartate and glutamate

Gene Name:

gltI

Uniprot ID:

P37902

Molecular weight:

33420