Identification
Name:Sugar efflux transporter C
Synonyms:Not Available
Gene Name:setC
Enzyme Class:Not Available
Biological Properties
General Function:Involved in transmembrane transport
Specific Function:Involved in the efflux of sugars. The physiological role may be the detoxification of non-metabolizable sugar analogs
Cellular Location:Cell inner membrane; Multi-pass membrane protein
SMPDB Pathways:Not Available
KEGG Pathways:Not Available
Transports:
Transport References:
  • Uniprot Consortium (2012). "Reorganizing the protein space at the Universal Protein Resource (UniProt)." Nucleic Acids Res 40:D71-D75. Pubmed: 22102590
Metabolites:
ECMDB IDNameView
ECMDB202191-DeoxyxylonojirimycinMetaboCard
ECMDB204072-AminogalactopyranoseMetaboCard
ECMDB211755'-DeoxyriboseMetaboCard
ECMDB04007AllolactoseMetaboCard
ECMDB03345alpha-D-GlucoseMetaboCard
ECMDB20264alpha-L-FucoseMetaboCard
ECMDB00849alpha-L-RhamnoseMetaboCard
ECMDB00186alpha-LactoseMetaboCard
ECMDB00516b-D-GlucoseMetaboCard
ECMDB04025beta-D-GalactoseMetaboCard
ECMDB20343beta-D-ribofuranoseMetaboCard
ECMDB20344beta-D-RibopyranoseMetaboCard
ECMDB00055CellobioseMetaboCard
ECMDB03556ChitobioseMetaboCard
ECMDB01151D-AlloseMetaboCard
ECMDB00660D-FructoseMetaboCard
ECMDB00143D-GalactoseMetaboCard
ECMDB01051D-GlyceraldehydeMetaboCard
ECMDB00621D-RibuloseMetaboCard
ECMDB00654D-XyluloseMetaboCard
ECMDB03224DeoxyriboseMetaboCard
ECMDB00646L-ArabinoseMetaboCard
ECMDB00174L-FucoseMetaboCard
ECMDB04069L-FuculoseMetaboCard
ECMDB20580L-GlyceraldehydeMetaboCard
ECMDB04144L-RhamnuloseMetaboCard
ECMDB20282L-RiboseMetaboCard
ECMDB04149L-RibuloseMetaboCard
ECMDB01266L-SorboseMetaboCard
ECMDB00048MelibioseMetaboCard
ECMDB20176N-Acetyl-D-muramoateMetaboCard
ECMDB00258SucroseMetaboCard
ECMDB00975TrehaloseMetaboCard
GO Classification:
Component
cell part
integral to membrane
intrinsic to membrane
membrane part
Function
cation transmembrane transporter activity
cation:sugar symporter activity
ion transmembrane transporter activity
solute:cation symporter activity
substrate-specific transmembrane transporter activity
sugar efflux transmembrane transporter activity
sugar:hydrogen symporter activity
transmembrane transporter activity
transporter activity
Process
carbohydrate transport
establishment of localization
transmembrane transport
transport
Gene Properties
Blattner:b3659
Gene OrientationClockwise
Centisome Percentage:82.66
Left Sequence End3834976
Right Sequence End3836160
Gene Sequence:
>1185 bp
ATGAAAAATTGTGTCATCGTCAGTGCGGTACGTACTGCTATCGGTAGTTTTAACGGTTCA
CTCGCTTCCACCAGCGCCATCGACCTGGGGGCGACAGTAATTAAAGCCGCCATTGAACGT
GCAAAAATCGATTCACAACACGTTGATGAAGTGATTATGGGTAACGTGTTACAAGCCGGG
CTGGGGCAAAATCCGGCGCGTCAGGCACTGTTAAAAAGCGGGCTGGCAGAAACGGTGTGC
GGATTCACGGTCAATAAAGTATGTGGTTCGGGTCTTAAAAGTGTGGCGCTTGCCGCCCAG
GCCATTCAGGCAGGTCAGGCGCAGAGCATTGTGGCGGGGGGTATGGAAAATATGAGTTTA
GCCCCCTACTTACTCGATGCAAAAGCACGCTCTGGTTATCGTCTTGGAGACGGACAGGTT
TATGACGTAATCCTGCGCGATGGCCTGATGTGCGCCACCCATGGTTATCATATGGGGATT
ACCGCCGAAAACGTGGCTAAAGAGTACGGAATTACCCGTGAAATGCAGGATGAACTGGCG
CTACATTCACAGCGTAAAGCGGCAGCCGCAATTGAGTCCGGTGCTTTTACAGCCGAAATC
GTCCCGGTAAATGTTGTCACTCGAAAGAAAACCTTCGTCTTCAGTCAAGACGAATTCCCG
AAAGCGAATTCAACGGCTGAAGCGTTAGGTGCATTGCGCCCGGCCTTCGATAAAGCAGGA
ACAGTCACCGCTGGGAACGCGTCTGGTATTAACGACGGTGCTGCCGCTCTGGTGATTATG
GAAGAATCTGCGGCGCTGGCAGCAGGCCTTACCCCCCTGGCTCGCATTAAAAGTTATGCC
AGCGGTGGCGTGCCCCCCGCATTGATGGGTATGGGGCCAGTACCTGCCACGCAAAAAGCG
TTACAACTGGCGGGGCTGCAACTGGCGGATATTGATCTCATTGAGGCTAATGAAGCATTT
GCTGCACAGTTCCTTGCCGTTGGGAAAAACCTGGGCTTTGATTCTGAGAAAGTGAATGTC
AACGGCGGGGCCATCGCGCTCGGGCATCCTATCGGTGCCAGTGGTGCTCGTATTCTGGTC
ACACTATTACATGCCATGCAGGCACGCGATAAAACGCTGGGGCTGGCAACACTGTGCATT
GGCGGCGGTCAGGGAATTGCGATGGTGATTGAACGGTTGAATTAA
Protein Properties
Pfam Domain Function:
Protein Residues:394
Protein Molecular Weight:43493
Protein Theoretical pI:8
Signaling Regions:
  • None
Transmembrane Regions:
  • 11-31
  • 50-70
  • 81-101
  • 105-125
  • 151-171
  • 173-193
  • 225-245
  • 254-274
  • 284-304
  • 311-331
  • 371-391
Protein Sequence:
>Sugar efflux transporter C
MQKTATTPSKILDLTAAAFLLVAFLTGIAGALQTPTLSIFLADELKARPIMVGFFFTGSA
IMGILVSQFLARHSDKQGDRKLLILLCCLFGVLACTLFAWNRNYFILLSTGVLLSSFAST
ANPQMFALAREHADRTGRETVMFSTFLRAQISLAWVIGPPLAYELAMGFSFKVMYLTAAI
AFVVCGLIVWLFLPSIQRNIPVVTQPVEILPSTHRKRDTRLLFVVCSMMWAANNLYMINM
PLFIIDELHLTDKLTGEMIGIAAGLEIPMMLIAGYYMKRIGKRLLMLIAIVSGMCFYASV
LMATTPAVELELQILNAIFLGILCGIGMLYFQDLMPEKIGSATTLYANTSRVGWIIAGSV
DGIMVEIWSYHALFWLAIGMLGIAMICLLFIKDI
References
External Links:
ResourceLink
Uniprot ID:P31436
Uniprot Name:SETC_ECOLI
GenBank Gene ID:AP009048
Genebank Protein ID:1736879
Ecogene ID:EG11687
Ecocyc:EG11687
ColiBase:b3659
Kegg Gene:b3659
EchoBASE ID:EB1638
CCDB:SETC_ECOLI
BacMap:16131529
General Reference:
  • Blattner, F. R., Plunkett, G. 3rd, Bloch, C. A., Perna, N. T., Burland, V., Riley, M., Collado-Vides, J., Glasner, J. D., Rode, C. K., Mayhew, G. F., Gregor, J., Davis, N. W., Kirkpatrick, H. A., Goeden, M. A., Rose, D. J., Mau, B., Shao, Y. (1997). "The complete genome sequence of Escherichia coli K-12." Science 277:1453-1462. Pubmed: 9278503
  • Burland, V., Plunkett, G. 3rd, Daniels, D. L., Blattner, F. R. (1993). "DNA sequence and analysis of 136 kilobases of the Escherichia coli genome: organizational symmetry around the origin of replication." Genomics 16:551-561. Pubmed: 7686882
  • Daley, D. O., Rapp, M., Granseth, E., Melen, K., Drew, D., von Heijne, G. (2005). "Global topology analysis of the Escherichia coli inner membrane proteome." Science 308:1321-1323. Pubmed: 15919996
  • Hayashi, K., Morooka, N., Yamamoto, Y., Fujita, K., Isono, K., Choi, S., Ohtsubo, E., Baba, T., Wanner, B. L., Mori, H., Horiuchi, T. (2006). "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Mol Syst Biol 2:2006.0007. Pubmed: 16738553
  • Liu, J. Y., Miller, P. F., Gosink, M., Olson, E. R. (1999). "The identification of a new family of sugar efflux pumps in Escherichia coli." Mol Microbiol 31:1845-1851. Pubmed: 10209755
  • Liu, J. Y., Miller, P. F., Willard, J., Olson, E. R. (1999). "Functional and biochemical characterization of Escherichia coli sugar efflux transporters." J Biol Chem 274:22977-22984. Pubmed: 10438463