| Identification |
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| Name: | Acyl carrier protein phosphodiesterase |
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| Synonyms: | |
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| Gene Name: | acpH |
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| Enzyme Class: | |
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| Biological Properties |
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| General Function: | Involved in [acyl-carrier-protein] phosphodiesterase activity |
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| Specific Function: | Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP |
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| Cellular Location: | Cytoplasmic |
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| SMPDB Pathways: | - Pantothenate and CoA biosynthesis PW000828
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| KEGG Pathways: | - Pantothenate and CoA biosynthesis ec00770
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| KEGG Reactions: | |
1.0Acyl-carrier protein | + | 1.0 | + | 1.0Acyl-carrier protein | ↔ | 1.0 | + | 1.0Apo-[acyl-carrier-protein] |
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| Complex Reactions: | |
1.0Decanoyl-ACP (n-C10:0ACP) | + | 1.0 | → | 1.0acyl carrier protein | + | 1.0 | + | 1.0 |
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1.0Dodecanoyl-ACP (n-C12:0ACP) | + | 1.0 | → | 1.0acyl carrier protein | + | 1.0 | + | 1.0 |
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1.0 | + | 1.0cis-tetradec-7-enoyl-[acyl-carrier protein] (n-C14:1) | → | 1.0acyl carrier protein | + | 1.0 | + | 1.0 |
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1.0 | + | 1.0Myristoyl-ACP (n-C14:0ACP) | → | 1.0acyl carrier protein | + | 1.0 | + | 1.0 |
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1.0 | + | 1.0Octanoyl-ACP (n-C8:0ACP) | → | 1.0acyl carrier protein | + | 1.0 | + | 1.0 |
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1.0 | + | 1.0Palmitoyl-ACP (n-C16:0ACP) | → | 1.0acyl carrier protein | + | 1.0 | + | 1.0 |
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1.0Holo-[acyl-carrier-protein] | + | 1.0 | → | 1.0 | + | 1.0apo-[acyl-carrier-protein] |
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| Metabolites: | |
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| GO Classification: | | Function |
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| catalytic activity | | hydrolase activity | | hydrolase activity, acting on ester bonds | | phosphoric diester hydrolase activity | | phosphoric ester hydrolase activity | | [acyl-carrier-protein] phosphodiesterase activity | | Process |
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| carboxylic acid metabolic process | | cellular metabolic process | | fatty acid biosynthetic process | | fatty acid metabolic process | | metabolic process | | monocarboxylic acid metabolic process | | organic acid metabolic process | | oxoacid metabolic process |
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| Gene Properties |
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| Blattner: | b0404 |
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| Gene Orientation | Counterclockwise |
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| Centisome Percentage: | 9.13 |
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| Left Sequence End | 423561 |
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| Right Sequence End | 424142 |
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| Gene Sequence: | >582 bp
ATGAATTTTTTAGCTCACCTGCATTTAGCCCATCTCGCGGAAAGCTCGCTTTCCGGCAAT
TTACTGGCTGATTTCGTACGCGGAAATCCTGAAGAAAGTTTTCCGCCCGACGTCGTGGCT
GGCATTCATATGCATCGACGTATCGACGTATTGACTGACAATCTGCCGGAAGTCCGCGAA
GCACGGGAGTGGTTTCGTAGTGAAACGCGCCGCGTTGCGCCTATTACGCTGGATGTCATG
TGGGATCACTTTCTTTCCCGCCACTGGTCGCAGCTGTCGCCGGACTTTCCGCTACAGGAA
TTTGTCTGTTATGCCCGCGAGCAAGTGATGACGATTTTGCCGGACTCACCGCCACGTTTT
ATCAATCTGAACAATTACTTGTGGTCAGAGCAGTGGCTGGTGCGCTATCGCGATATGGAT
TTCATCCAGAACGTGTTAAACGGCATGGCAAGCCGCCGCCCACGTCTGGATGCCCTGCGT
GACTCCTGGTACGATTTAGACGCTCATTATGACGCCCTCGAAACCCGCTTCTGGCAGTTT
TATCCGCGGATGATGGCGCAGGCGTCACGCAAGGCGTTATAA |
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| Protein Properties |
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| Pfam Domain Function: | |
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| Protein Residues: | 193 |
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| Protein Molecular Weight: | 22961 |
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| Protein Theoretical pI: | 6 |
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| Signaling Regions: | |
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| Transmembrane Regions: | |
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| Protein Sequence: | >Acyl carrier protein phosphodiesterase
MNFLAHLHLAHLAESSLSGNLLADFVRGNPEESFPPDVVAGIHMHRRIDVLTDNLPEVRE
AREWFRSETRRVAPITLDVMWDHFLSRHWSQLSPDFPLQEFVCYAREQVMTILPDSPPRF
INLNNYLWSEQWLVRYRDMDFIQNVLNGMASRRPRLDALRDSWYDLDAHYDALETRFWQF
YPRMMAQASRKAL |
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| References |
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| External Links: | |
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| General Reference: | - Blattner, F. R., Plunkett, G. 3rd, Bloch, C. A., Perna, N. T., Burland, V., Riley, M., Collado-Vides, J., Glasner, J. D., Rode, C. K., Mayhew, G. F., Gregor, J., Davis, N. W., Kirkpatrick, H. A., Goeden, M. A., Rose, D. J., Mau, B., Shao, Y. (1997). "The complete genome sequence of Escherichia coli K-12." Science 277:1453-1462. Pubmed: 9278503
- Hayashi, K., Morooka, N., Yamamoto, Y., Fujita, K., Isono, K., Choi, S., Ohtsubo, E., Baba, T., Wanner, B. L., Mori, H., Horiuchi, T. (2006). "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Mol Syst Biol 2:2006.0007. Pubmed: 16738553
- Reuter, K., Slany, R., Ullrich, F., Kersten, H. (1991). "Structure and organization of Escherichia coli genes involved in biosynthesis of the deazaguanine derivative queuine, a nutrient factor for eukaryotes." J Bacteriol 173:2256-2264. Pubmed: 1706703
- Thomas, J., Cronan, J. E. (2005). "The enigmatic acyl carrier protein phosphodiesterase of Escherichia coli: genetic and enzymological characterization." J Biol Chem 280:34675-34683. Pubmed: 16107329
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