Lactaldehyde dehydrogenase (P25553)

Identification
Name:Lactaldehyde dehydrogenase
Synonyms:
  • Aldehyde dehydrogenase A
  • Glycolaldehyde dehydrogenase
Gene Name:aldA
Enzyme Class:
Biological Properties
General Function:Involved in oxidoreductase activity
Specific Function:Acts on lactaldehyde as well as other aldehydes
Cellular Location:Not Available
SMPDB Pathways:
KEGG Pathways:
  • Microbial metabolism in diverse environments ec01120
  • Pyruvate metabolism ec00620
KEGG Reactions:
1.0Thumb+1.0Thumb+1.0Thumb+1.0Thumb ↔ 2.0Thumb+1.0Thumb+1.0Thumb
1.0Water + 1.0Lactaldehyde + 1.0NAD + 1.0(S)-Lactaldehyde ↔ 2.0Hydrogen ion + 1.0L-Lactic acid + 1.0NADH
ReactionCard
1.0Thumb+1.0Thumb+1.0Thumb → 1.0Thumb+2.0Thumb+1.0Thumb
1.0Glycolaldehyde + 1.0Water + 1.0NAD → 1.0Glycolic acid + 2.0Hydrogen ion + 1.0NADH
ReactionCard
1.0Thumb+1.0Thumb+1.0Thumb ↔ 1.0Thumb+1.0Thumb+1.0Thumb
1.0Pyruvaldehyde + 1.0NAD + 1.0Water ↔ 1.0Pyruvic acid + 1.0NADH + 1.0Hydrogen ion
ReactionCard
1.0Thumb+1.0Thumb+1.0Thumb ↔ 1.0Thumb+1.0Thumb+1.0Thumb
1.0Glycolaldehyde + 1.0NAD + 1.0Water ↔ 1.0Glycolic acid + 1.0NADH + 1.0Hydrogen ion
ReactionCard
1.0Thumb+1.0Thumb+1.0Thumb ↔ 1.0Thumb+1.0Thumb+1.0Thumb
1.0Lactaldehyde + 1.0NAD + 1.0Water ↔ 1.0L-Lactic acid + 1.0NADH + 1.0Hydrogen ion
ReactionCard
1.0Thumb+1.0Thumb+1.0Thumb → 1.0Thumb+1.0Thumb+1.0Thumb
1.0Water + 1.0NAD + 1.0Lactaldehyde → 1.0Hydrogen ion + 1.0NADH + 1.0L-Lactic acid
ReactionCard
SMPDB Reactions:
1.0Thumb+1.0Thumb+1.0(S)-lactaldehyde+1.0Thumb → 1.0Thumb+2.0Thumb+1.0L-Lactic acid+1.0Thumb
1.0NAD + 1.0Water + 1.0(S)-lactaldehyde + 1.0Lactaldehyde → 1.0NADH + 2.0Hydrogen ion + 1.0L-Lactic acid + 1.0L-Lactic acid
ReactionCard
EcoCyc Reactions:
1.0Thumb+1.0Thumb+1.0Thumb+1.0Thumb ↔ 2.0Thumb+1.0Thumb+1.0Thumb
1.0Water + 1.0Lactaldehyde + 1.0NAD + 1.0(S)-Lactaldehyde ↔ 2.0Hydrogen ion + 1.0L-Lactic acid + 1.0NADH
ReactionCard
1.0Thumb+1.0Thumb+1.0Thumb → 1.0Thumb+2.0Thumb+1.0Thumb
1.0Glycolaldehyde + 1.0Water + 1.0NAD → 1.0Glycolic acid + 2.0Hydrogen ion + 1.0NADH
ReactionCard
1.0Thumb+1.0Thumb+1.0Thumb ↔ 1.0Thumb+1.0Thumb+1.0Thumb
1.0Glycolaldehyde + 1.0NAD + 1.0Water ↔ 1.0Glycolic acid + 1.0NADH + 1.0Hydrogen ion
ReactionCard
1.0Thumb+1.0Thumb+1.0Thumb → 1.0Thumb+1.0Thumb+1.0Thumb
1.0Water + 1.0NAD + 1.0Lactaldehyde → 1.0Hydrogen ion + 1.0NADH + 1.0L-Lactic acid
ReactionCard
Complex Reactions:
1.0Thumb+1.0Thumb+1.0Thumb → 1.0Thumb+1.0Thumb
1.0Lactaldehyde + 1.0NAD + 1.0Water → 1.0L-Lactic acid + 1.0NADH
ReactionCard
1.0Thumb+1.0Thumb+1.0Thumb → 1.0Thumb+1.0Thumb
1.0Glycolaldehyde + 1.0NAD + 1.0Water → 1.0Glycolic acid + 1.0NADH
ReactionCard
Metabolites:
ECMDB IDNameView
ECMDB23841(S)-LactaldehydeMetaboCard
ECMDB02165GlycolaldehydeMetaboCard
ECMDB23741GlycolateMetaboCard
ECMDB03035Glycolic acidMetaboCard
ECMDB21225Hydrogen ionMetaboCard
ECMDB00190L-Lactic acidMetaboCard
ECMDB03052LactaldehydeMetaboCard
ECMDB00902NADMetaboCard
ECMDB01487NADHMetaboCard
ECMDB01167PyruvaldehydeMetaboCard
ECMDB00243Pyruvic acidMetaboCard
ECMDB00494WaterMetaboCard
GO Classification:
Function
catalytic activity
oxidoreductase activity
Process
metabolic process
oxidation reduction
Gene Properties
Blattner:b1415
Gene OrientationClockwise
Centisome Percentage:32.03
Left Sequence End1486256
Right Sequence End1487695
Gene Sequence:
>1440 bp
ATGTCAGTACCCGTTCAACATCCTATGTATATCGATGGACAGTTTGTTACCTGGCGTGGA
GACGCATGGATTGATGTGGTAAACCCTGCTACAGAGGCTGTCATTTCCCGCATACCCGAT
GGTCAGGCCGAGGATGCCCGTAAGGCAATCGATGCAGCAGAACGTGCACAACCAGAATGG
GAAGCGTTGCCTGCTATTGAACGCGCCAGTTGGTTGCGCAAAATCTCCGCCGGGATCCGC
GAACGCGCCAGTGAAATCAGTGCGCTGATTGTTGAAGAAGGGGGCAAGATCCAGCAGCTG
GCTGAAGTCGAAGTGGCTTTTACTGCCGACTATATCGATTACATGGCGGAGTGGGCACGG
CGTTACGAGGGCGAGATTATTCAAAGCGATCGTCCAGGAGAAAATATTCTTTTGTTTAAA
CGTGCGCTTGGTGTGACTACCGGCATTCTGCCGTGGAACTTCCCGTTCTTCCTCATTGCC
CGCAAAATGGCTCCCGCTCTTTTGACCGGTAATACCATCGTCATTAAACCTAGTGAATTT
ACGCCAAACAATGCGATTGCATTCGCCAAAATCGTCGATGAAATAGGCCTTCCGCGCGGC
GTGTTTAACCTTGTACTGGGGCGTGGTGAAACCGTTGGGCAAGAACTGGCGGGTAACCCA
AAGGTCGCAATGGTCAGTATGACAGGCAGCGTCTCTGCAGGTGAGAAGATCATGGCGACT
GCGGCGAAAAACATCACCAAAGTGTGTCTGGAATTGGGGGGTAAAGCACCAGCTATCGTA
ATGGACGATGCCGATCTTGAACTGGCAGTCAAAGCCATCGTTGATTCACGCGTCATTAAT
AGTGGGCAAGTGTGTAACTGTGCAGAACGTGTTTATGTACAGAAAGGCATTTATGATCAG
TTCGTCAATCGGCTGGGTGAAGCGATGCAGGCGGTTCAATTTGGTAACCCCGCTGAACGC
AACGACATTGCGATGGGGCCGTTGATTAACGCCGCGGCGCTGGAAAGGGTCGAGCAAAAA
GTGGCGCGCGCAGTAGAAGAAGGGGCGAGAGTGGCGTTCGGTGGCAAAGCGGTAGAGGGG
AAAGGATATTATTATCCGCCGACATTGCTGCTGGATGTTCGCCAGGAAATGTCGATTATG
CATGAGGAAACCTTTGGCCCGGTGCTGCCAGTTGTCGCATTTGACACGCTGGAAGATGCT
ATCTCAATGGCTAATGACAGTGATTACGGCCTGACCTCATCAATCTATACCCAAAATCTG
AACGTCGCGATGAAAGCCATTAAAGGGCTGAAGTTTGGTGAAACTTACATCAACCGTGAA
AACTTCGAAGCTATGCAAGGCTTCCACGCCGGATGGCGTAAATCCGGTATTGGCGGCGCA
GATGGTAAACATGGCTTGCATGAATATCTGCAGACCCAGGTGGTTTATTTACAGTCTTAA
Protein Properties
Pfam Domain Function:
Protein Residues:479
Protein Molecular Weight:52272
Protein Theoretical pI:5
Signaling Regions:
  • None
Transmembrane Regions:
  • None
Protein Sequence:
>Lactaldehyde dehydrogenase
MSVPVQHPMYIDGQFVTWRGDAWIDVVNPATEAVISRIPDGQAEDARKAIDAAERAQPEW
EALPAIERASWLRKISAGIRERASEISALIVEEGGKIQQLAEVEVAFTADYIDYMAEWAR
RYEGEIIQSDRPGENILLFKRALGVTTGILPWNFPFFLIARKMAPALLTGNTIVIKPSEF
TPNNAIAFAKIVDEIGLPRGVFNLVLGRGETVGQELAGNPKVAMVSMTGSVSAGEKIMAT
AAKNITKVCLELGGKAPAIVMDDADLELAVKAIVDSRVINSGQVCNCAERVYVQKGIYDQ
FVNRLGEAMQAVQFGNPAERNDIAMGPLINAAALERVEQKVARAVEEGARVAFGGKAVEG
KGYYYPPTLLLDVRQEMSIMHEETFGPVLPVVAFDTLEDAISMANDSDYGLTSSIYTQNL
NVAMKAIKGLKFGETYINRENFEAMQGFHAGWRKSGIGGADGKHGLHEYLQTQVVYLQS
References
External Links:
ResourceLink
Uniprot ID:P25553
Uniprot Name:ALDA_ECOLI
GenBank Gene ID:AP009048
Genebank Protein ID:1742307
Ecogene ID:EG10035
Ecocyc:EG10035
ColiBase:b1415
Kegg Gene:b1415
EchoBASE ID:EB0034
CCDB:ALDA_ECOLI
BacMap:16129376
General Reference:
  • Aiba, H., Baba, T., Hayashi, K., Inada, T., Isono, K., Itoh, T., Kasai, H., Kashimoto, K., Kimura, S., Kitakawa, M., Kitagawa, M., Makino, K., Miki, T., Mizobuchi, K., Mori, H., Mori, T., Motomura, K., Nakade, S., Nakamura, Y., Nashimoto, H., Nishio, Y., Oshima, T., Saito, N., Sampei, G., Horiuchi, T., et, a. l. .. (1996). "A 570-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 28.0-40.1 min region on the linkage map." DNA Res 3:363-377. Pubmed: 9097039
  • Baldoma, L., Aguilar, J. (1987). "Involvement of lactaldehyde dehydrogenase in several metabolic pathways of Escherichia coli K12." J Biol Chem 262:13991-13996. Pubmed: 3308886
  • Blattner, F. R., Plunkett, G. 3rd, Bloch, C. A., Perna, N. T., Burland, V., Riley, M., Collado-Vides, J., Glasner, J. D., Rode, C. K., Mayhew, G. F., Gregor, J., Davis, N. W., Kirkpatrick, H. A., Goeden, M. A., Rose, D. J., Mau, B., Shao, Y. (1997). "The complete genome sequence of Escherichia coli K-12." Science 277:1453-1462. Pubmed: 9278503
  • Caballero, E., Baldoma, L., Ros, J., Boronat, A., Aguilar, J. (1983). "Identification of lactaldehyde dehydrogenase and glycolaldehyde dehydrogenase as functions of the same protein in Escherichia coli." J Biol Chem 258:7788-7792. Pubmed: 6345530
  • Hayashi, K., Morooka, N., Yamamoto, Y., Fujita, K., Isono, K., Choi, S., Ohtsubo, E., Baba, T., Wanner, B. L., Mori, H., Horiuchi, T. (2006). "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Mol Syst Biol 2:2006.0007. Pubmed: 16738553
  • Hidalgo, E., Chen, Y. M., Lin, E. C., Aguilar, J. (1991). "Molecular cloning and DNA sequencing of the Escherichia coli K-12 ald gene encoding aldehyde dehydrogenase." J Bacteriol 173:6118-6123. Pubmed: 1917845
  • Link, A. J., Robison, K., Church, G. M. (1997). "Comparing the predicted and observed properties of proteins encoded in the genome of Escherichia coli K-12." Electrophoresis 18:1259-1313. Pubmed: 9298646