Fructose-bisphosphate aldolase class 1 (P0A991)

Identification
Name:Fructose-bisphosphate aldolase class 1
Synonyms:
  • Fructose-biphosphate aldolase class I
  • FBP aldolase
Gene Name:fbaB
Enzyme Class:
Biological Properties
General Function:Involved in catalytic activity
Specific Function:D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate
Cellular Location:Cytoplasm (Probable)
SMPDB Pathways:
KEGG Pathways:
KEGG Reactions:
1.0Thumb ↔ 1.0Thumb+1.0Thumb
1.0Fructose 1,6-bisphosphate ↔ 1.0Dihydroxyacetone phosphate + 1.0D-Glyceraldehyde 3-phosphate
ReactionCard
1.0Thumb ↔ 1.0Thumb+1.0Thumb
1.0Sedoheptulose 1,7-bisphosphate ↔ 1.0Dihydroxyacetone phosphate + 1.0D-Erythrose 4-phosphate
ReactionCard
1.0Thumb ↔ 1.0Thumb+1.0Thumb
1.0beta-D-Fructose 1,6-bisphosphate ↔ 1.0Dihydroxyacetone phosphate + 1.0D-Glyceraldehyde 3-phosphate
ReactionCard
1.0Thumb ↔ 1.0Thumb+1.0D-Glyceraldehyde
1.0Fructose 1-phosphate ↔ 1.0Dihydroxyacetone phosphate + 1.0D-Glyceraldehyde
ReactionCard
SMPDB Reactions:
1.0Fructose 1,6-bisphosphate+1.0Thumb ↔ 1.0D-Glyceraldehyde 3-phosphate+1.0Thumb+1.0Thumb
1.0Fructose 1,6-bisphosphate + 1.0Fructose 1,6-bisphosphate ↔ 1.0D-Glyceraldehyde 3-phosphate + 1.0Dihydroxyacetone phosphate + 1.0D-Glyceraldehyde 3-phosphate
ReactionCard
1.0D-Glyceraldehyde 3-phosphate+1.0Thumb+1.0Thumb → 1.0Fructose 1,6-bisphosphate+1.0Thumb
1.0D-Glyceraldehyde 3-phosphate + 1.0Dihydroxyacetone phosphate + 1.0D-Glyceraldehyde 3-phosphate → 1.0Fructose 1,6-bisphosphate + 1.0Fructose 1,6-bisphosphate
ReactionCard
1.0Fructose 1,6-bisphosphate+1.0Thumb → 1.0Thumb+1.0D-Glyceraldehyde 3-phosphate+1.0Thumb
1.0Fructose 1,6-bisphosphate + 1.0Fructose 1,6-bisphosphate → 1.0Dihydroxyacetone phosphate + 1.0D-Glyceraldehyde 3-phosphate + 1.0D-Glyceraldehyde 3-phosphate
ReactionCard
EcoCyc Reactions:
1.0Thumb ↔ 1.0Thumb+1.0Thumb
1.0Fructose 1,6-bisphosphate ↔ 1.0Dihydroxyacetone phosphate + 1.0D-Glyceraldehyde 3-phosphate
ReactionCard
1.0Thumb ↔ 1.0Thumb+1.0Thumb
1.0Sedoheptulose 1,7-bisphosphate ↔ 1.0Dihydroxyacetone phosphate + 1.0D-Erythrose 4-phosphate
ReactionCard
Complex Reactions:
1.0Thumb → 1.0Thumb+1.0Thumb
1.0Fructose 1,6-bisphosphate → 1.0Dihydroxyacetone phosphate + 1.0D-Glyceraldehyde 3-phosphate
ReactionCard
Metabolites:
ECMDB IDNameView
ECMDB20123beta-D-Fructose 1,6-bisphosphateMetaboCard
ECMDB02649D-Erythrose 4-phosphateMetaboCard
ECMDB01051D-GlyceraldehydeMetaboCard
ECMDB01112D-Glyceraldehyde 3-phosphateMetaboCard
ECMDB01473Dihydroxyacetone phosphateMetaboCard
ECMDB01058Fructose 1,6-bisphosphateMetaboCard
ECMDB01076Fructose 1-phosphateMetaboCard
ECMDB20192Sedoheptulose 1,7-bisphosphateMetaboCard
GO Classification:
Function
catalytic activity
lyase activity
Process
metabolic process
Gene Properties
Blattner:b2097
Gene OrientationCounterclockwise
Centisome Percentage:46.89
Left Sequence End2175534
Right Sequence End2176586
Gene Sequence:
>1053 bp
ATGAATTATCAGAACGACGATTTACGCATCAAAGAAATCAAAGAGTTACTTCCTCCTGTC
GCATTGCTGGAAAAATTCCCCGCTACTGAAAATGCCGCGAATACGGTTGCCCATGCCCGA
AAAGCGATCCATAAGATCCTGAAAGGTAATGATGATCGCCTGTTGGTTGTGATTGGCCCA
TGCTCAATTCATGATCCTGTCGCGGCAAAAGAGTATGCCACTCGCTTGCTGGCGCTGCGT
GAAGAGCTGAAAGATGAGCTGGAAATCGTAATGCGCGTCTATTTTGAAAAGCCGCGTACC
ACGGTGGGCTGGAAAGGGCTGATTAACGATCCGCATATGGATAATAGCTTCCAGATCAAC
GACGGTCTGCGTATAGCCCGTAAATTGCTGCTTGATATTAACGACAGCGGTCTGCCAGCG
GCAGGTGAGTTTCTCGATATGATCACCCCACAATATCTCGCTGACCTGATGAGCTGGGGC
GCAATTGGCGCACGTACCACCGAATCGCAGGTGCACCGCGAACTGGCATCAGGGCTTTCT
TGTCCGGTCGGCTTCAAAAATGGCACCGACGGTACGATTAAAGTGGCTATCGATGCCATT
AATGCCGCCGGTGCGCCGCACTGCTTCCTGTCCGTAACGAAATGGGGGCATTCGGCGATT
GTGAATACCAGCGGTAACGGCGATTGCCATATCATTCTGCGCGGCGGTAAAGAGCCTAAC
TACAGCGCGAAGCACGTTGCTGAAGTGAAAGAAGGGCTGAACAAAGCAGGCCTGCCAGCA
CAGGTGATGATCGATTTCAGCCATGCTAACTCGTCCAAACAATTCAAAAAGCAGATGGAT
GTTTGTGCTGACGTTTGCCAGCAGATTGCCGGTGGCGAAAAGGCCATTATTGGCGTGATG
GTGGAAAGCCATCTGGTGGAAGGCAATCAGAGCCTCGAGAGCGGGGAGCCGCTGGCCTAC
GGTAAGAGCATCACCGATGCCTGCATCGGCTGGGAAGATACCGATGCTCTGTTACGTCAA
CTGGCGAATGCAGTAAAAGCGCGTCGCGGGTAA
Protein Properties
Pfam Domain Function:
Protein Residues:350
Protein Molecular Weight:38109
Protein Theoretical pI:7
Signaling Regions:
  • None
Transmembrane Regions:
  • None
Protein Sequence:
>Fructose-bisphosphate aldolase class 1
MTDIAQLLGKDADNLLQHRCMTIPSDQLYLPGHDYVDRVMIDNNRPPAVLRNMQTLYNTG
RLAGTGYLSILPVDQGVEHSAGASFAANPLYFDPKNIVELAIEAGCNCVASTYGVLASVS
RRYAHRIPFLVKLNHNETLSYPNTYDQTLYASVEQAFNMGAVAVGATIYFGSEESRRQIE
EISAAFERAHELGMVTVLWAYLRNSAFKKDGVDYHVSADLTGQANHLAATIGADIVKQKM
AENNGGYKAINYGYTDDRVYSKLTSENPIDLVRYQLANCYMGRAGLINSGGAAGGETDLS
DAVRTAVINKRAGGMGLILGRKAFKKSMADGVKLINAVQDVYLDSKITIA
References
External Links:
ResourceLink
Uniprot ID:P0A991
Uniprot Name:ALF1_ECOLI
GenBank Gene ID:AP009048
Genebank Protein ID:1651339
Ecogene ID:EG14062
Ecocyc:EG14062
ColiBase:b2097
Kegg Gene:b2097
EchoBASE ID:EB3815
CCDB:ALF1_ECOLI
BacMap:90111385
General Reference:
  • Blattner, F. R., Plunkett, G. 3rd, Bloch, C. A., Perna, N. T., Burland, V., Riley, M., Collado-Vides, J., Glasner, J. D., Rode, C. K., Mayhew, G. F., Gregor, J., Davis, N. W., Kirkpatrick, H. A., Goeden, M. A., Rose, D. J., Mau, B., Shao, Y. (1997). "The complete genome sequence of Escherichia coli K-12." Science 277:1453-1462. Pubmed: 9278503
  • Hayashi, K., Morooka, N., Yamamoto, Y., Fujita, K., Isono, K., Choi, S., Ohtsubo, E., Baba, T., Wanner, B. L., Mori, H., Horiuchi, T. (2006). "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Mol Syst Biol 2:2006.0007. Pubmed: 16738553
  • Thomson, G. J., Howlett, G. J., Ashcroft, A. E., Berry, A. (1998). "The dhnA gene of Escherichia coli encodes a class I fructose bisphosphate aldolase." Biochem J 331 ( Pt 2):437-445. Pubmed: 9531482
  • Zhang, J., Sprung, R., Pei, J., Tan, X., Kim, S., Zhu, H., Liu, C. F., Grishin, N. V., Zhao, Y. (2009). "Lysine acetylation is a highly abundant and evolutionarily conserved modification in Escherichia coli." Mol Cell Proteomics 8:215-225. Pubmed: 18723842