| Identification |
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| Name: | Fructose-bisphosphate aldolase class 1 |
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| Synonyms: | - Fructose-biphosphate aldolase class I
- FBP aldolase
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| Gene Name: | fbaB |
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| Enzyme Class: | |
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| Biological Properties |
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| General Function: | Involved in catalytic activity |
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| Specific Function: | D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate |
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| Cellular Location: | Cytoplasm (Probable) |
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| SMPDB Pathways: | - Gluconeogenesis from L-malic acid PW000819
- fructose metabolism PW000913
- glycerol metabolism PW000914
- glycerol metabolism II PW000915
- glycerol metabolism III (sn-glycero-3-phosphoethanolamine) PW000916
- glycerol metabolism IV (glycerophosphoglycerol) PW000917
- glycerol metabolism V (glycerophosphoserine) PW000918
- glycolysis and pyruvate dehydrogenase PW000785
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| KEGG Pathways: | - Carbon fixation in photosynthetic organisms ec00710
- Fructose and mannose metabolism ec00051
- Glycolysis / Gluconeogenesis ec00010
- Metabolic pathways eco01100
- Methane metabolism ec00680
- Microbial metabolism in diverse environments ec01120
- Pentose phosphate pathway ec00030
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| KEGG Reactions: | | | | | | | |
1.0 | ↔ | 1.0 | + | 1.0D-Glyceraldehyde |
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| SMPDB Reactions: | |
1.0Fructose 1,6-bisphosphate | + | 1.0 | ↔ | 1.0D-Glyceraldehyde 3-phosphate | + | 1.0 | + | 1.0 |
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1.0D-Glyceraldehyde 3-phosphate | + | 1.0 | + | 1.0 | → | 1.0Fructose 1,6-bisphosphate | + | 1.0 |
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1.0Fructose 1,6-bisphosphate | + | 1.0 | → | 1.0 | + | 1.0D-Glyceraldehyde 3-phosphate | + | 1.0 |
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| EcoCyc Reactions: | |
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| Complex Reactions: | |
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| Metabolites: | |
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| GO Classification: | | Function |
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| catalytic activity | | lyase activity | | Process |
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| metabolic process |
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| Gene Properties |
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| Blattner: | b2097 |
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| Gene Orientation | Counterclockwise |
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| Centisome Percentage: | 46.89 |
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| Left Sequence End | 2175534 |
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| Right Sequence End | 2176586 |
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| Gene Sequence: | >1053 bp
ATGAATTATCAGAACGACGATTTACGCATCAAAGAAATCAAAGAGTTACTTCCTCCTGTC
GCATTGCTGGAAAAATTCCCCGCTACTGAAAATGCCGCGAATACGGTTGCCCATGCCCGA
AAAGCGATCCATAAGATCCTGAAAGGTAATGATGATCGCCTGTTGGTTGTGATTGGCCCA
TGCTCAATTCATGATCCTGTCGCGGCAAAAGAGTATGCCACTCGCTTGCTGGCGCTGCGT
GAAGAGCTGAAAGATGAGCTGGAAATCGTAATGCGCGTCTATTTTGAAAAGCCGCGTACC
ACGGTGGGCTGGAAAGGGCTGATTAACGATCCGCATATGGATAATAGCTTCCAGATCAAC
GACGGTCTGCGTATAGCCCGTAAATTGCTGCTTGATATTAACGACAGCGGTCTGCCAGCG
GCAGGTGAGTTTCTCGATATGATCACCCCACAATATCTCGCTGACCTGATGAGCTGGGGC
GCAATTGGCGCACGTACCACCGAATCGCAGGTGCACCGCGAACTGGCATCAGGGCTTTCT
TGTCCGGTCGGCTTCAAAAATGGCACCGACGGTACGATTAAAGTGGCTATCGATGCCATT
AATGCCGCCGGTGCGCCGCACTGCTTCCTGTCCGTAACGAAATGGGGGCATTCGGCGATT
GTGAATACCAGCGGTAACGGCGATTGCCATATCATTCTGCGCGGCGGTAAAGAGCCTAAC
TACAGCGCGAAGCACGTTGCTGAAGTGAAAGAAGGGCTGAACAAAGCAGGCCTGCCAGCA
CAGGTGATGATCGATTTCAGCCATGCTAACTCGTCCAAACAATTCAAAAAGCAGATGGAT
GTTTGTGCTGACGTTTGCCAGCAGATTGCCGGTGGCGAAAAGGCCATTATTGGCGTGATG
GTGGAAAGCCATCTGGTGGAAGGCAATCAGAGCCTCGAGAGCGGGGAGCCGCTGGCCTAC
GGTAAGAGCATCACCGATGCCTGCATCGGCTGGGAAGATACCGATGCTCTGTTACGTCAA
CTGGCGAATGCAGTAAAAGCGCGTCGCGGGTAA |
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| Protein Properties |
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| Pfam Domain Function: | |
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| Protein Residues: | 350 |
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| Protein Molecular Weight: | 38109 |
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| Protein Theoretical pI: | 7 |
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| Signaling Regions: | |
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| Transmembrane Regions: | |
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| Protein Sequence: | >Fructose-bisphosphate aldolase class 1
MTDIAQLLGKDADNLLQHRCMTIPSDQLYLPGHDYVDRVMIDNNRPPAVLRNMQTLYNTG
RLAGTGYLSILPVDQGVEHSAGASFAANPLYFDPKNIVELAIEAGCNCVASTYGVLASVS
RRYAHRIPFLVKLNHNETLSYPNTYDQTLYASVEQAFNMGAVAVGATIYFGSEESRRQIE
EISAAFERAHELGMVTVLWAYLRNSAFKKDGVDYHVSADLTGQANHLAATIGADIVKQKM
AENNGGYKAINYGYTDDRVYSKLTSENPIDLVRYQLANCYMGRAGLINSGGAAGGETDLS
DAVRTAVINKRAGGMGLILGRKAFKKSMADGVKLINAVQDVYLDSKITIA |
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| References |
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| External Links: | |
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| General Reference: | - Blattner, F. R., Plunkett, G. 3rd, Bloch, C. A., Perna, N. T., Burland, V., Riley, M., Collado-Vides, J., Glasner, J. D., Rode, C. K., Mayhew, G. F., Gregor, J., Davis, N. W., Kirkpatrick, H. A., Goeden, M. A., Rose, D. J., Mau, B., Shao, Y. (1997). "The complete genome sequence of Escherichia coli K-12." Science 277:1453-1462. Pubmed: 9278503
- Hayashi, K., Morooka, N., Yamamoto, Y., Fujita, K., Isono, K., Choi, S., Ohtsubo, E., Baba, T., Wanner, B. L., Mori, H., Horiuchi, T. (2006). "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Mol Syst Biol 2:2006.0007. Pubmed: 16738553
- Thomson, G. J., Howlett, G. J., Ashcroft, A. E., Berry, A. (1998). "The dhnA gene of Escherichia coli encodes a class I fructose bisphosphate aldolase." Biochem J 331 ( Pt 2):437-445. Pubmed: 9531482
- Zhang, J., Sprung, R., Pei, J., Tan, X., Kim, S., Zhu, H., Liu, C. F., Grishin, N. V., Zhao, Y. (2009). "Lysine acetylation is a highly abundant and evolutionarily conserved modification in Escherichia coli." Mol Cell Proteomics 8:215-225. Pubmed: 18723842
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