ECMDB: beta-D-Fructose 1,6-bisphosphate (ECMDB20123) (M2MDB000971)

Identification Taxonomy Physical Properties Biological Properties Spectra Concentrations Links References Enzymes (7)XML

Proteins (1820)

Record Information

Version

2.0

Creation Date

2012-05-31 14:28:42 -0600

Update Date

2015-06-03 17:19:21 -0600

Secondary Accession Numbers

ECMDB20123

Identification

Name:

beta-D-Fructose 1,6-bisphosphate

Description

Beta-D-fructose 1,6-bisphosphate is a member of the chemical class known as Pentoses. These are monosaccharides in which the carbohydrate moiety contains five carbon atoms. The hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate is a key reaction of carbohydrate metabolism. (PMID 3008716) Fructose-1,6-bisphosphate (F-1,6-P2) is an allosteric activator of two key enzymes of glycolysis: phosphofructokinase and pyruvate kinase. (PMID 18025560) In gluconeogenesis, fructose 6-phosphate is formed from fructose 1,6-bisphosphate, and if fructose 1,6-bisphosphate were reformed by the phosphofructokinase reaction there would be a "gluconeogenic futile cycle". (PMID 6217196) Fructose-1,6-bisphosphate (FBP) aldolase is an essential glycolytic enzyme that reversibly cleaves its ketohexose substrate into triose phosphates. (PMID 14699122) Fructose 1-phosphate is a metabolite that plays a regulatory role in metabolism and is best measured using an assay based on its conversion to fructose 1,6-bisphosphate by a bacterial fructose-1-phosphate kinase (Fru1PK). (PMID 10833389) For growth, the assimilated fructose is sequentially phosphorylated by ATP and (i) manno(fructo)kinase, to form fructose 6-phosphate, and (ii) phosphofructokinase, to form fructose 1,6-bisphosphate, which is a member of central routes of glycolysis and gluconeogenesis. (PMID 17159144)

Structure

MOL SDF PDB SMILES InChI

Synonyms:

β-D-fructose-1,6-diphosphate
β-D-fructose-1,6-diphosphoric acid
1,6-Di-O-phosphono-b-D-fructofuranose
1,6-Di-O-phosphono-beta-D-fructofuranose
1,6-Di-O-phosphono-β-D-fructofuranose
6055-82-9 (Calcium[1:2] salt)
b Fructose 1,6-diphosphate
b Fructose 1,6-diphosphoric acid
b-D-Fructofuranose 1,6-bis(dihydrogen phosphate)
b-D-Fructofuranose 1,6-bis(dihydrogen phosphoric acid)
b-D-Fructofuranose 1,6-bisphosphate
b-D-Fructofuranose 1,6-bisphosphoric acid
b-D-Fructofuranose, 1,6-bis(dihydrogen phosphate)
b-D-Fructofuranose, 1,6-bis(dihydrogen phosphoric acid)
b-D-Fructose 1,6-bisphosphate
b-D-Fructose 1,6-bisphosphoric acid
b-D-Fructose-1,6-diphosphate
b-D-Fructose-1,6-diphosphoric acid
Beta Fructose 1,6-diphosphate
beta Fructose 1,6-diphosphoric acid
Beta-D-Fructofuranose 1,6-bis(dihydrogen phosphate)
beta-D-Fructofuranose 1,6-bis(dihydrogen phosphoric acid)
Beta-D-Fructofuranose 1,6-bisphosphate
beta-D-Fructofuranose 1,6-bisphosphoric acid
Beta-D-Fructofuranose, 1,6-bis(dihydrogen phosphate)
beta-D-Fructofuranose, 1,6-bis(dihydrogen phosphoric acid)
beta-D-Fructose 1,6-bisphosphoric acid
Beta-D-Fructose-1,6-diphosphate
beta-D-Fructose-1,6-diphosphoric acid
BFP
D-Arabino-2-Hexulose-1,6-bis(dihydrogenphosphat)
D-Fructofuranose, 1,6-bis(dihydrogen phosphate)
D-Fructofuranose, 1,6-bis(dihydrogen phosphoric acid)
D-Fructose 1,6-bis(dihydrogen phosphate)
D-Fructose 1,6-bis(dihydrogen phosphoric acid)
D-Fructose, 1,6-bis(dihydrogen phosphate)
D-Fructose, 1,6-bis(dihydrogen phosphoric acid)
D-Fructose-1,6-bis(dihydrogenphosphat)
D-Fructose-1,6-bisphosphate
D-Fructose-1,6-bisphosphoric acid
D-Fructose-1,6-diphosphate
D-Fructose-1,6-diphosphoric acid
FBP
Fructose 1,6-bisphosphate
Fructose 1,6-bisphosphoric acid
Fructose 1,6-diphosphate
Fructose 1,6-diphosphoric acid
Fructose-1,6-biphosphate
Fructose-1,6-biphosphoric acid
Fructose-1,6-bisphosphate
Fructose-1,6-bisphosphoric acid
Fructose-1,6-diphosphate
Fructose-1,6-diphosphoric acid
Harden-young-ester
β Fructose 1,6-diphosphate
β Fructose 1,6-diphosphoric acid
β-D-Fructofuranose 1,6-bis(dihydrogen phosphate)
β-D-Fructofuranose 1,6-bis(dihydrogen phosphoric acid)
β-D-Fructofuranose 1,6-bisphosphate
β-D-Fructofuranose 1,6-bisphosphoric acid
β-D-Fructofuranose, 1,6-bis(dihydrogen phosphate)
β-D-Fructofuranose, 1,6-bis(dihydrogen phosphoric acid)
β-D-Fructose 1,6-bisphosphate
β-D-Fructose 1,6-bisphosphoric acid
β-D-Fructose-1,6-diphosphate
β-D-Fructose-1,6-diphosphoric acid

Chemical Formula:

C₆H₁₄O₁₂P₂

Weight:

Average: 340.1157
Monoisotopic: 339.996048936

InChI Key:

RNBGYGVWRKECFJ-ARQDHWQXSA-N

InChI:

InChI=1S/C6H14O12P2/c7-4-3(1-16-19(10,11)12)18-6(9,5(4)8)2-17-20(13,14)15/h3-5,7-9H,1-2H2,(H2,10,11,12)(H2,13,14,15)/t3-,4-,5+,6-/m1/s1

CAS number:

125740-83-2

IUPAC Name:

{[(2R,3S,4S,5R)-3,4,5-trihydroxy-5-[(phosphonooxy)methyl]oxolan-2-yl]methoxy}phosphonic acid

Traditional IUPAC Name:

[(2R,3S,4S,5R)-3,4,5-trihydroxy-5-[(phosphonooxy)methyl]oxolan-2-yl]methoxyphosphonic acid

SMILES:

O[C@H]1[C@H](O)[C@@](O)(COP(O)(O)=O)O[C@@H]1COP(O)(O)=O

Chemical Taxonomy

Description

belongs to the class of organic compounds known as hexose phosphates. These are carbohydrate derivatives containing a hexose substituted by one or more phosphate groups.

Kingdom

Organic compounds

Super Class

Organic oxygen compounds

Class

Organooxygen compounds

Sub Class

Carbohydrates and carbohydrate conjugates

Direct Parent

Hexose phosphates

Alternative Parents

Substituents

Hexose phosphate
Pentose phosphate
Pentose-5-phosphate
C-glycosyl compound
Glycosyl compound
Monosaccharide phosphate
Pentose monosaccharide
Monoalkyl phosphate
Organic phosphoric acid derivative
Alkyl phosphate
Phosphoric acid ester
Tetrahydrofuran
1,2-diol
Hemiacetal
Secondary alcohol
Organoheterocyclic compound
Oxacycle
Polyol
Alcohol
Hydrocarbon derivative
Organic oxide
Aliphatic heteromonocyclic compound

Molecular Framework

Aliphatic heteromonocyclic compounds

External Descriptors

D-fructofuranose 1,6-bisphosphate (CHEBI:28013 )

Physical Properties

State:

Not Available

Charge:

-4

Melting point:

Not Available

Experimental Properties:

Property	Value	Source

Predicted Properties

Property	Value	Source
Water Solubility	16.1 g/L	ALOGPS
logP	-1.5	ALOGPS
logP	-3	ChemAxon
logS	-1.3	ALOGPS
pKa (Strongest Acidic)	0.89	ChemAxon
pKa (Strongest Basic)	-3.7	ChemAxon
Physiological Charge	-4	ChemAxon
Hydrogen Acceptor Count	10	ChemAxon
Hydrogen Donor Count	7	ChemAxon
Polar Surface Area	203.44 Å²	ChemAxon
Rotatable Bond Count	6	ChemAxon
Refractivity	58.11 m³·mol⁻¹	ChemAxon
Polarizability	25.7 Å³	ChemAxon
Number of Rings	1	ChemAxon
Bioavailability	0	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	Yes	ChemAxon
Veber's Rule	Yes	ChemAxon
MDDR-like Rule	Yes	ChemAxon

Biological Properties

Cellular Locations:

Cytoplasm

Reactions:

beta-D-Fructose 1,6-bisphosphate <> Dihydroxyacetone phosphate + D-Glyceraldehyde 3-phosphate
Adenosine triphosphate + Fructose 1-phosphate <> ADP + beta-D-Fructose 1,6-bisphosphate
Adenosine triphosphate + beta-D-Fructose 6-phosphate <> ADP + beta-D-Fructose 1,6-bisphosphate
beta-D-Fructose 1,6-bisphosphate + Water <> beta-D-Fructose 6-phosphate + Phosphate
Adenosine triphosphate + Fructose 1-phosphate <> ADP + beta-D-Fructose 1,6-bisphosphate

SMPDB Pathways:

Not Available

KEGG Pathways:

Fructose and mannose metabolism ec00051
Glycolysis / Gluconeogenesis ec00010
Microbial metabolism in diverse environments ec01120
Pentose phosphate pathway ec00030

EcoCyc Pathways:

fructose degradation PWY0-1314
gluconeogenesis I GLUCONEO-PWY
glycolysis I GLYCOLYSIS

Concentrations

Concentration	Strain	Media	Growth Status	Growth System	Temperature	Details
85± 0 uM	W3110	4.0 g/L Na2SO4; 5.36 g/L (NH4)2SO4; 1.0 g/L NH4Cl; 7.3 g/L K2HPO4; 1.8 g/L NaH2PO4 H2O; 12.0 g/L (NH4)2-H-citrate; 4.0 mL/L MgSO4 (1 M); 6.0 mL/L trace element solution; 0.02 g/L thiamine, 20 g/L glucose	Mid Log Phase	Bioreactor, pH controlled, aerated, dilution rate=0.125 L/h	37 oC	Park, C., Park, C., Lee, Y., Lee, S.Y., Oh, H.B., Lee, J. (2011) Determination of the Intracellular Concentration of Metabolites in Escherichia coli Collected during the Exponential and Stationary Growth Phases using Liquid Chromatography-Mass Spectrometry. Bull Korean Chem. Soc. 32: 524-530.
5± 0 uM	W3110	4.0 g/L Na2SO4; 5.36 g/L (NH4)2SO4; 1.0 g/L NH4Cl; 7.3 g/L K2HPO4; 1.8 g/L NaH2PO4 H2O; 12.0 g/L (NH4)2-H-citrate; 4.0 mL/L MgSO4 (1 M); 6.0 mL/L trace element solution; 0.02 g/L thiamine, 20 g/L glucose	Stationary Phase	Bioreactor, pH controlled, aerated	37 oC	Park, C., Park, C., Lee, Y., Lee, S.Y., Oh, H.B., Lee, J. (2011) Determination of the Intracellular Concentration of Metabolites in Escherichia coli Collected during the Exponential and Stationary Growth Phases using Liquid Chromatography-Mass Spectrometry. Bull Korean Chem. Soc. 32: 524-530.
3290± 179 uM	K12	0.2 g/L NH4Cl, 2.0 g/L (NH4)2SO4, 3.25 g/L KH2PO4, 2.5 g/L K2HPO4, 1.5 g/L NaH2PO4, 0.5 g/L MgSO4; trace substances: 10 mg/L CaCl2, 0.5 mg/L ZnSO4, 0.25 mg/L CuCl2, 0.25 mg/L MnSO4, 0.175 mg/L CoCl2, 0.125 mg/L H3BO3, 2.5 mg/L AlCl3, 0.5 mg/L Na2MoO4, 10	Stationary Phase, glucose limited	Bioreactor, pH controlled, aerated, dilution rate=0.125 L/h	37 oC	PMID: 11488613
1010± 100 uM	BW25113	M9 Minimal Media, 4 g/L Glucose	Mid-Log Phase	Bioreactor, pH controlled, O2 controlled, dilution rate: 0.2/h	37 oC	PMID: 15158257
15200± 0 uM	K12 NCM3722	Gutnick minimal complete medium (4.7 g/L KH2PO4; 13.5 g/L K2HPO4; 1 g/L K2SO4; 0.1 g/L MgSO4-7H2O; 10 mM NH4Cl) with 4 g/L glucose	Mid-Log Phase	Shake flask and filter culture	37 oC	PMID: 19561621
5850± 0 uM	K12 NCM3722	Gutnick minimal complete medium (4.7 g/L KH2PO4; 13.5 g/L K2HPO4; 1 g/L K2SO4; 0.1 g/L MgSO4-7H2O; 10 mM NH4Cl) with 4 g/L glycerol	Mid-Log Phase	Shake flask and filter culture	37 oC	PMID: 19561621
152± 0 uM	K12 NCM3722	Gutnick minimal complete medium (4.7 g/L KH2PO4; 13.5 g/L K2HPO4; 1 g/L K2SO4; 0.1 g/L MgSO4-7H2O; 10 mM NH4Cl) with 4 g/L acetate	Mid-Log Phase	Shake flask and filter culture	37 oC	PMID: 19561621

Find out more about how we convert literature concentrations.

Spectra

Spectra:

Spectrum Type	Description	Splash Key
GC-MS	GC-MS Spectrum - GC-MS (7 TMS)	splash10-014i-0497100000-d0c0dfadfe65ee3cc4e5	View in MoNA
GC-MS	GC-MS Spectrum - GC-MS (1 MEOX; 7 TMS)	splash10-014r-1779100000-ba60994aacef73cf8691	View in MoNA
GC-MS	GC-MS Spectrum - GC-MS (1 MEOX; 7 TMS)	splash10-014r-0779100000-b52ccd042ce4169961ed	View in MoNA
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (Non-derivatized) - 70eV, Positive	splash10-01xt-9532000000-c3c4929a4987e34c0dc0	View in MoNA
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (3 TMS) - 70eV, Positive	splash10-03fs-9412510000-0a0a9e96cc6bea61e3c7	View in MoNA
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (Non-derivatized) - 70eV, Positive	Not Available	View in JSpectraViewer
LC-MS/MS	LC-MS/MS Spectrum - n/a 23V, negative	splash10-0006-0190000000-95a4b5217606c0b9d1fb	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - n/a 23V, negative	splash10-0002-0900000000-74a1700e0fae0f6aa64e	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - Orbitrap 6V, negative	splash10-000i-0009000000-631b4fa683b46f4c89cb	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - Orbitrap 8V, negative	splash10-000i-1009000000-9df66c58adba653741e0	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - Orbitrap 10V, negative	splash10-000j-7129000000-f1414a0a896a7c132d2d	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - Orbitrap 14V, negative	splash10-0002-9111000000-0fc51e8f6b123f0a5982	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - Orbitrap 18V, negative	splash10-0002-9100000000-762070874ad885772dc4	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - Orbitrap 21V, negative	splash10-0002-9100000000-d705002b3a24c5b5ac0f	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - Orbitrap 25V, negative	splash10-002b-9000000000-caf9814ab914b2093561	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - Orbitrap 29V, negative	splash10-004j-9000000000-3b04f1a6a67ed239b001	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - Orbitrap 33V, negative	splash10-004i-9000000000-388ef99a8af7f88e6447	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - Orbitrap 41V, negative	splash10-004i-9000000000-bc85bd9d38f2c4bf3c58	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - n/a 23V, negative	splash10-0006-0190000000-ba22a78fbbfc1a90ace3	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - n/a 23V, negative	splash10-0a4i-0900000000-b559d4679fc0eaa79be7	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - n/a 23V, negative	splash10-004i-9000000000-5ef060d5ec4b80c35c1a	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - n/a 23V, negative	splash10-0002-9530000000-8e5076b641ebc42fb2ef	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - n/a 23V, negative	splash10-004i-9000000000-5ef060d5ec4b80c35c1a	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - n/a 23V, negative	splash10-0fdk-9870000000-6332e12e884d56a6c22b	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - n/a 23V, negative	splash10-004i-9000000000-5ef060d5ec4b80c35c1a	View in MoNA
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 10V, Positive	splash10-0007-6469000000-934f8ed1edcbd28bc667	View in MoNA
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 20V, Positive	splash10-006y-7295000000-a5ca0806e65ba8c99e88	View in MoNA
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 40V, Positive	splash10-0005-9700000000-02fcc2f4b95b801c5949	View in MoNA
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 10V, Negative	splash10-002r-8509000000-2992f67772e061c3ffe5	View in MoNA
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 20V, Negative	splash10-004i-9000000000-9ac5383c77bff5f6cb96	View in MoNA
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 40V, Negative	splash10-004i-9000000000-9d902dae0eabfe2165da	View in MoNA
1D NMR	1H NMR Spectrum	Not Available	View in JSpectraViewer
1D NMR	13C NMR Spectrum	Not Available	View in JSpectraViewer
1D NMR	1H NMR Spectrum	Not Available	View in JSpectraViewer
1D NMR	13C NMR Spectrum	Not Available	View in JSpectraViewer
1D NMR	1H NMR Spectrum	Not Available	View in JSpectraViewer
1D NMR	13C NMR Spectrum	Not Available	View in JSpectraViewer
1D NMR	1H NMR Spectrum	Not Available	View in JSpectraViewer
1D NMR	13C NMR Spectrum	Not Available	View in JSpectraViewer
1D NMR	1H NMR Spectrum	Not Available	View in JSpectraViewer
1D NMR	13C NMR Spectrum	Not Available	View in JSpectraViewer
1D NMR	1H NMR Spectrum	Not Available	View in JSpectraViewer
1D NMR	13C NMR Spectrum	Not Available	View in JSpectraViewer
1D NMR	1H NMR Spectrum	Not Available	View in JSpectraViewer
1D NMR	13C NMR Spectrum	Not Available	View in JSpectraViewer
1D NMR	1H NMR Spectrum	Not Available	View in JSpectraViewer
1D NMR	13C NMR Spectrum	Not Available	View in JSpectraViewer
1D NMR	1H NMR Spectrum	Not Available	View in JSpectraViewer
1D NMR	13C NMR Spectrum	Not Available	View in JSpectraViewer
1D NMR	1H NMR Spectrum	Not Available	View in JSpectraViewer
1D NMR	13C NMR Spectrum	Not Available	View in JSpectraViewer

References

References:

Bennett, B. D., Kimball, E. H., Gao, M., Osterhout, R., Van Dien, S. J., Rabinowitz, J. D. (2009). "Absolute metabolite concentrations and implied enzyme active site occupancy in Escherichia coli." Nat Chem Biol 5:593-599. Pubmed: 19561621
Buchholz, A., Takors, R., Wandrey, C. (2001). "Quantification of intracellular metabolites in Escherichia coli K12 using liquid chromatographic-electrospray ionization tandem mass spectrometric techniques." Anal Biochem 295:129-137. Pubmed: 11488613
Daldal, F., Fraenkel, D. G. (1983). "Assessment of a futile cycle involving reconversion of fructose 6-phosphate to fructose 1,6-bisphosphate during gluconeogenic growth of Escherichia coli." J Bacteriol 153:390-394. Pubmed: 6217196
Izard, T., Sygusch, J. (2004). "Induced fit movements and metal cofactor selectivity of class II aldolases: structure of Thermus aquaticus fructose-1,6-bisphosphate aldolase." J Biol Chem 279:11825-11833. Pubmed: 14699122
Kanehisa, M., Goto, S., Sato, Y., Furumichi, M., Tanabe, M. (2012). "KEGG for integration and interpretation of large-scale molecular data sets." Nucleic Acids Res 40:D109-D114. Pubmed: 22080510
Keseler, I. M., Collado-Vides, J., Santos-Zavaleta, A., Peralta-Gil, M., Gama-Castro, S., Muniz-Rascado, L., Bonavides-Martinez, C., Paley, S., Krummenacker, M., Altman, T., Kaipa, P., Spaulding, A., Pacheco, J., Latendresse, M., Fulcher, C., Sarker, M., Shearer, A. G., Mackie, A., Paulsen, I., Gunsalus, R. P., Karp, P. D. (2011). "EcoCyc: a comprehensive database of Escherichia coli biology." Nucleic Acids Res 39:D583-D590. Pubmed: 21097882
Kornberg, H., Lourenco, C. (2006). "A route for fructose utilization by Escherichia coli involving the fucose regulon." Proc Natl Acad Sci U S A 103:19496-19499. Pubmed: 17159144
Nghiem, N. P., Cofer, T. M. (2007). "Effect of a nonmetabolizable analog of fructose-1,6-bisphosphate on glycolysis and ethanol production in strains of Saccharomyces cerevisiae and Escherichia coli." Appl Biochem Biotechnol 141:335-347. Pubmed: 18025560
Park, C., Park, C., Lee, Y., Lee, S.Y., Oh, H.B., Lee, J. (2011) Determination of the Intracellular Concentration of Metabolites in Escherichia coli Collected during the Exponential and Stationary Growth Phases using Liquid Chromatography-Mass Spectrometry. Bull Korean Chem. Soc. 32: 524-530.
Peng, L., Arauzo-Bravo, M. J., Shimizu, K. (2004). "Metabolic flux analysis for a ppc mutant Escherichia coli based on 13C-labelling experiments together with enzyme activity assays and intracellular metabolite measurements." FEMS Microbiol Lett 235:17-23. Pubmed: 15158257
Veiga-da-Cunha, M., Hoyoux, A., Van Schaftingen, E. (2000). "Overexpression and purification of fructose-1-phosphate kinase from Escherichia coli: application to the assay of fructose 1-phosphate." Protein Expr Purif 19:48-52. Pubmed: 10833389

Synthesis Reference:

Not Available

Material Safety Data Sheet (MSDS)

Not Available

Links

External Links:

Resource	Link
CHEBI ID	28013
HMDB ID	HMDB0001058
Pubchem Compound ID	10267
Kegg ID	C05378
ChemSpider ID	9848
Wikipedia ID	Fructose 1,6-bisphosphate
BioCyc ID	FRUCTOSE-16-DIPHOSPHATE
EcoCyc ID	FRUCTOSE-16-DIPHOSPHATE
Ligand Expo	FBP

Enzymes

Protein Details

1. 6-phosphofructokinase isozyme 2

General function:: Involved in phosphotransferase activity, alcohol group as acceptor
Specific function:: ATP + D-fructose 6-phosphate = ADP + D- fructose 1,6-bisphosphate
Gene Name:: pfkB
Uniprot ID:: P06999
Molecular weight:: 32456

Reactions

ATP + D-fructose 6-phosphate = ADP + D-fructose 1,6-bisphosphate.

Protein Details

2. 6-phosphofructokinase isozyme 1

General function:: Involved in ATP binding
Specific function:: ATP + D-fructose 6-phosphate = ADP + D- fructose 1,6-bisphosphate
Gene Name:: pfkA
Uniprot ID:: P0A796
Molecular weight:: 34842

Reactions

ATP + D-fructose 6-phosphate = ADP + D-fructose 1,6-bisphosphate.

Protein Details

3. Fructose-bisphosphate aldolase class 1

General function:: Involved in catalytic activity
Specific function:: D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate
Gene Name:: fbaB
Uniprot ID:: P0A991
Molecular weight:: 38109

Reactions

D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.

Protein Details

4. Fructose-1,6-bisphosphatase class 1

General function:: Involved in phosphoric ester hydrolase activity
Specific function:: D-fructose 1,6-bisphosphate + H(2)O = D- fructose 6-phosphate + phosphate
Gene Name:: fbp
Uniprot ID:: P0A993
Molecular weight:: 36834

Reactions

D-fructose 1,6-bisphosphate + H(2)O = D-fructose 6-phosphate + phosphate.

Protein Details

5. Fructose-1,6-bisphosphatase class 2

General function:: Involved in glycerol metabolic process
Specific function:: D-fructose 1,6-bisphosphate + H(2)O = D- fructose 6-phosphate + phosphate
Gene Name:: glpX
Uniprot ID:: P0A9C9
Molecular weight:: 35852

Reactions

D-fructose 1,6-bisphosphate + H(2)O = D-fructose 6-phosphate + phosphate.

Protein Details

6. Fructose-bisphosphate aldolase class 2

General function:: Involved in catalytic activity
Specific function:: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3- phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis
Gene Name:: fbaA
Uniprot ID:: P0AB71
Molecular weight:: 39147

Reactions

D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.

Protein Details

7. 1-phosphofructokinase

General function:: Involved in 1-phosphofructokinase activity
Specific function:: ATP + D-fructose 1-phosphate = ADP + D- fructose 1,6-bisphosphate
Gene Name:: fruK
Uniprot ID:: P0AEW9
Molecular weight:: 33755

Reactions

ATP + D-fructose 1-phosphate = ADP + D-fructose 1,6-bisphosphate.

beta-D-Fructose 1,6-bisphosphate (ECMDB20123) (M2MDB000971)

Structure for #<Compound:0x97c37854>

Enzymes

Reactions

Reactions

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Reactions

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Reactions