Mannose permease IIC component (P69801)

Identification
Name:Mannose permease IIC component
Synonyms:
  • EII-P-Man
  • EIIC-Man
  • PTS system mannose-specific EIIC component
Gene Name:manY
Enzyme Class:Not Available
Biological Properties
General Function:Involved in phosphoenolpyruvate-dependent sugar phosphotransferase system
Specific Function:The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. This system is involved in mannose transport
Cellular Location:Cell inner membrane; Multi-pass membrane protein
SMPDB Pathways:
KEGG Pathways:
Transports:
Transport References:
  • Uniprot Consortium (2012). "Reorganizing the protein space at the Universal Protein Resource (UniProt)." Nucleic Acids Res 40:D71-D75. Pubmed: 22102590
KEGG Reactions:
1.0Protein N(pi)-phospho-L-histidine+1.0Thumb ↔ 1.0Protein histidine+1.0Thumb
1.0Protein N(pi)-phospho-L-histidine + 1.0D-Mannose ↔ 1.0Protein histidine + 1.0Mannose 6-phosphate
ReactionCard
SMPDB Reactions:
1.0Thumb+1.0HPr - phosphorylated → 1.0α-D-mannose 6-phosphate+1.0HPr
1.0D-allopyranose + 1.0HPr - phosphorylated → 1.0α-D-mannose 6-phosphate + 1.0HPr
ReactionCard
1.0β-D-fructofuranose+1.0HPr - phosphorylated+1.0Thumb → 1.0Thumb+1.0HPr
1.0β-D-fructofuranose + 1.0HPr - phosphorylated + 1.0D-Fructose → 1.0D-tagatofuranose 6-phosphate + 1.0HPr
ReactionCard
1.0D-Fructose+1.0HPr - phosphorylated+1.0Thumb → 1.0HPr+1.0Fructose 6-phosphate+1.0Thumb
1.0D-Fructose + 1.0HPr - phosphorylated + 1.0D-Fructose → 1.0HPr + 1.0Fructose 6-phosphate + 1.0Fructose 6-phosphate
ReactionCard
1.0Thumb+1.0HPr - phosphorylated → 1.0Thumb+1.0HPr
1.02-Deoxyglucose + 1.0HPr - phosphorylated → 1.02-Deoxy-D-glucose 6-phosphate + 1.0HPr
ReactionCard
1.0Thumb+1.0HPr - phosphorylated → 1.0HPr
1.0Sorbitol-6-phosphate + 1.0HPr - phosphorylated → 1.0HPr
ReactionCard
EcoCyc Reactions:
1.0Thumb+1.0Thumb → 1.0Thumb+1.0Thumb
1.0Phosphoenolpyruvic acid + 1.0D-Mannose → 1.0Mannose 6-phosphate + 1.0Pyruvic acid
ReactionCard
1.0Thumb+1.0Thumb → 1.0Thumb+1.0Thumb
1.0Phosphoenolpyruvic acid + 1.0N-Acetylmannosamine → 1.0N-Acetyl-D-mannosamine 6-phosphate + 1.0Pyruvic acid
ReactionCard
1.0Thumb+1.0Thumb → 1.0Thumb+1.0Thumb
1.0Phosphoenolpyruvic acid + 1.0Glucosamine → 1.0Glucosamine 6-phosphate + 1.0Pyruvic acid
ReactionCard
Complex Reactions:
1.0Thumb+1.0Thumb → 1.0Thumb+1.0Thumb
1.0Phosphoenolpyruvic acid + 1.0D-Glucose → 1.0Glucose 6-phosphate + 1.0Pyruvic acid
ReactionCard
1.0Thumb+1.0Thumb → 1.0Thumb+1.0Thumb
1.0Phosphoenolpyruvic acid + 1.0D-Fructose → 1.0Fructose 6-phosphate + 1.0Pyruvic acid
ReactionCard
Metabolites:
ECMDB IDNameView
ECMDB202252-Deoxy-D-glucose 6-phosphateMetaboCard
ECMDB031742-DeoxyglucoseMetaboCard
ECMDB24208D-allopyranoseMetaboCard
ECMDB00660D-FructoseMetaboCard
ECMDB00122D-GlucoseMetaboCard
ECMDB00169D-MannoseMetaboCard
ECMDB24205D-tagatofuranose 6-phosphateMetaboCard
ECMDB00124Fructose 6-phosphateMetaboCard
ECMDB01514GlucosamineMetaboCard
ECMDB01254Glucosamine 6-phosphateMetaboCard
ECMDB01401Glucose 6-phosphateMetaboCard
ECMDB01078Mannose 6-phosphateMetaboCard
ECMDB01121N-Acetyl-D-mannosamine 6-phosphateMetaboCard
ECMDB01129N-AcetylmannosamineMetaboCard
ECMDB00263Phosphoenolpyruvic acidMetaboCard
ECMDB00243Pyruvic acidMetaboCard
ECMDB01400Sorbitol-6-phosphateMetaboCard
GO Classification:
Component
cell part
integral to membrane
intrinsic to membrane
membrane part
Process
carbohydrate transport
establishment of localization
phosphoenolpyruvate-dependent sugar phosphotransferase system
transport
Gene Properties
Blattner:b1818
Gene OrientationClockwise
Centisome Percentage:40.97
Left Sequence End1901106
Right Sequence End1901906
Gene Sequence:
>801 bp
GTGCGAAAAAACACCTATGCCATGCGCTATGTTGCCGGACAACCTGCGGAAAGGATCTTA
CCGCCGGGGTCTTTTGCGAGCATCGGCCAGGCATTACCACCTGGGGAACCGTTAAGTACC
GAAGAGCGTATTCGGATCCTGGTGTGGAACATATACAAACAGCAACGCGCTGAATGGTTG
TCGGTATTAAAGAACTACGGCAAAGATGCACATCTGGTGTTATTGCAGGAAGCGCAGACA
ACGCCAGAGTTAGTACAGTTTGCGACCGCTAACTATCTTGCCGCCGATCAGGTACCCGCT
TTCGTGCTGCCACAACATCCTTCTGGCGTAATGACCCTTTCGGCGGCACATCCAGTGTAT
TGCTGCCCGTTACGTGAACGAGAACCCATTTTGCGTCTGGCGAAGTCGGCACTGGTGACG
GTCTATCCATTACCTGACACCCGCCTGTTGATGGTGGTTAATATACACGCCGTCAACTTC
AGTCTGGGCGTGGATGTCTATAGTAAGCAGTTACTTCCTATTGGCGATCAGATAGCTCAC
CACAGCGGCCCGGTCATTATGGCGGGAGATTTCAATGCCTGGAGCCGTAGAAGGATGAAC
GCGTTATATCGCTTTGCGCGGGAAATGTCGCTGCGCCAGGTGCGTTTTACCGATGATCAG
CGCCGTCGGGCGTTTGGTCGCCCGCTCGATTTTGTTTTCTACCGTGGTCTGAACGTCAGT
GAAGCTTCTGTACTGGTTACGCGCGCTTCCGATCACAATCCGCTACTCGTTGAATTCAGT
CCCGGCAAGCCTGATAAATAA
Protein Properties
Pfam Domain Function:
Protein Residues:266
Protein Molecular Weight:27636
Protein Theoretical pI:5
Signaling Regions:
  • None
Transmembrane Regions:
  • 5-24
  • 50-69
  • 84-102
  • 106-124
  • 151-170
  • 182-201
Protein Sequence:
>Mannose permease IIC component
MEITTLQIVLVFIVACIAGMGSILDEFQFHRPLIACTLVGIVLGDMKTGIIIGGTLEMIA
LGWMNIGAAVAPDAALASIISTILVIAGHQSIGAGIALAIPLAAAGQVLTIIVRTITVAF
QHAADKAADNGNLTAISWIHVSSLFLQAMRVAIPAVIVALSVGTSEVQNMLNAIPEVVTN
GLNIAGGMIVVVGYAMVINMMRAGYLMPFFYLGFVTAAFTNFNLVALGVIGTVMAVLYIQ
LSPKYNRVAGAPAQAAGNNDLDNELD
References
External Links:
ResourceLink
Uniprot ID:P69801
Uniprot Name:PTNC_ECOLI
GenBank Gene ID:AP009048
Genebank Protein ID:85674383
Ecogene ID:EG10568
Ecocyc:EG10568
ColiBase:b1818
Kegg Gene:b1818
EchoBASE ID:EB0563
CCDB:PTNC_ECOLI
BacMap:16129772
General Reference:
  • Blattner, F. R., Plunkett, G. 3rd, Bloch, C. A., Perna, N. T., Burland, V., Riley, M., Collado-Vides, J., Glasner, J. D., Rode, C. K., Mayhew, G. F., Gregor, J., Davis, N. W., Kirkpatrick, H. A., Goeden, M. A., Rose, D. J., Mau, B., Shao, Y. (1997). "The complete genome sequence of Escherichia coli K-12." Science 277:1453-1462. Pubmed: 9278503
  • Daley, D. O., Rapp, M., Granseth, E., Melen, K., Drew, D., von Heijne, G. (2005). "Global topology analysis of the Escherichia coli inner membrane proteome." Science 308:1321-1323. Pubmed: 15919996
  • Erni, B., Zanolari, B., Kocher, H. P. (1987). "The mannose permease of Escherichia coli consists of three different proteins. Amino acid sequence and function in sugar transport, sugar phosphorylation, and penetration of phage lambda DNA." J Biol Chem 262:5238-5247. Pubmed: 2951378
  • Hayashi, K., Morooka, N., Yamamoto, Y., Fujita, K., Isono, K., Choi, S., Ohtsubo, E., Baba, T., Wanner, B. L., Mori, H., Horiuchi, T. (2006). "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Mol Syst Biol 2:2006.0007. Pubmed: 16738553
  • Huber, F., Erni, B. (1996). "Membrane topology of the mannose transporter of Escherichia coli K12." Eur J Biochem 239:810-817. Pubmed: 8774730
  • Itoh, T., Aiba, H., Baba, T., Hayashi, K., Inada, T., Isono, K., Kasai, H., Kimura, S., Kitakawa, M., Kitagawa, M., Makino, K., Miki, T., Mizobuchi, K., Mori, H., Mori, T., Motomura, K., Nakade, S., Nakamura, Y., Nashimoto, H., Nishio, Y., Oshima, T., Saito, N., Sampei, G., Seki, Y., Horiuchi, T., et, a. l. .. (1996). "A 460-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 40.1-50.0 min region on the linkage map." DNA Res 3:379-392. Pubmed: 9097040
  • Rhiel, E., Flukiger, K., Wehrli, C., Erni, B. (1994). "The mannose transporter of Escherichia coli K12: oligomeric structure, and function of two conserved cysteines." Biol Chem Hoppe Seyler 375:551-559. Pubmed: 7811395