Phosphoenolpyruvic acid (ECMDB00263) (M2MDB000111)

General function:

Involved in transporter activity

Specific function:

The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in mannitol transport

Gene Name:

mtlA

Uniprot ID:

P00550

Molecular weight:

67972

Reactions

General function:

Involved in phosphoenolpyruvate carboxylase activity

Specific function:

Through the carboxylation of phosphoenolpyruvate (PEP) it forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle

Gene Name:

ppc

Uniprot ID:

P00864

Molecular weight:

99062

Reactions

General function:

Involved in catalytic activity

Specific function:

Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)

Gene Name:

aroH

Uniprot ID:

P00887

Molecular weight:

38735

Reactions

General function:

Involved in catalytic activity

Specific function:

Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)

Gene Name:

aroF

Uniprot ID:

P00888

Molecular weight:

38804

Reactions

General function:

Involved in protein-N(PI)-phosphohistidine-sugar phosphotransferase activity

Specific function:

The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in glucitol/sorbitol transport

Gene Name:

srlB

Uniprot ID:

P05706

Molecular weight:

13304

Reactions

General function:

Involved in protein-N(PI)-phosphohistidine-sugar phosphotransferase activity

Specific function:

Acts as both a kinase and a phosphatase on BglG

Gene Name:

bglF

Uniprot ID:

P08722

Molecular weight:

66482

Reactions

General function:

Involved in transferase activity, transferring phosphorus-containing groups

Specific function:

General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)

Gene Name:

ptsI

Uniprot ID:

P08839

Molecular weight:

63561

Reactions

General function:

Involved in protein-N(PI)-phosphohistidine-sugar phosphotransferase activity

Specific function:

The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in N-acetylglucosamine transport

Gene Name:

nagE

Uniprot ID:

P09323

Molecular weight:

68346

Reactions

General function:

Involved in transferase activity, transferring alkyl or aryl (other than methyl) groups

Specific function:

Phosphoenolpyruvate + 3-phosphoshikimate = phosphate + 5-O-(1-carboxyvinyl)-3-phosphoshikimate

Gene Name:

aroA

Uniprot ID:

P0A6D3

Molecular weight:

46095

Reactions

General function:

Involved in magnesium ion binding

Specific function:

Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis. It is also a component of the RNA degradosome, a multi-enzyme complex involved in RNA processing and messenger RNA degradation. Its interaction with RNase E is important for the turnover of mRNA, in particular on transcripts encoding enzymes of energy-generating metabolic routes. Its presence in the degradosome is required for the response to excess phosphosugar. May play a regulatory role in the degradation of specific RNAs, such as ptsG mRNA, therefore linking cellular metabolic status with post-translational gene regulation

Gene Name:

eno

Uniprot ID:

P0A6P9

Molecular weight:

45655

Reactions

General function:

Involved in catalytic activity

Specific function:

Synthesis of KDO 8-P which is required for lipid A maturation and cellular growth

Gene Name:

kdsA

Uniprot ID:

P0A715

Molecular weight:

30833

Reactions

General function:

Involved in transferase activity, transferring alkyl or aryl (other than methyl) groups

Specific function:

Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine. Target for the antibiotic phosphomycin

Gene Name:

murA

Uniprot ID:

P0A749

Molecular weight:

44817

Reactions

General function:

Involved in catalytic activity

Specific function:

Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)

Gene Name:

aroG

Uniprot ID:

P0AB91

Molecular weight:

38009

Reactions

General function:

Involved in magnesium ion binding

Specific function:

ATP + pyruvate = ADP + phosphoenolpyruvate

Gene Name:

pykF

Uniprot ID:

P0AD61

Molecular weight:

50729

Reactions

General function:

Involved in protein-N(PI)-phosphohistidine-sugar phosphotransferase activity

Specific function:

MalX encodes a phosphotransferase system enzyme II that can recognize glucose and maltose as substrates even though these sugars may not represent the natural substrates of the system

Gene Name:

malX

Uniprot ID:

P19642

Molecular weight:

56627

Reactions

General function:

Involved in sugar:hydrogen symporter activity

Specific function:

The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in fructose transport

Gene Name:

fruA

Uniprot ID:

P20966

Molecular weight:

57519

Reactions

General function:

Involved in magnesium ion binding

Specific function:

ATP + pyruvate = ADP + phosphoenolpyruvate

Gene Name:

pykA

Uniprot ID:

P21599

Molecular weight:

51357

Reactions

General function:

Involved in phosphoenolpyruvate carboxykinase (ATP) activity

Specific function:

ATP + oxaloacetate = ADP + phosphoenolpyruvate + CO(2)

Gene Name:

pckA

Uniprot ID:

P22259

Molecular weight:

59643

Reactions

General function:

Involved in catalytic activity

Specific function:

Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate

Gene Name:

ppsA

Uniprot ID:

P23538

Molecular weight:

87434

Reactions

General function:

Involved in protein-N(PI)-phosphohistidine-sugar phosphotransferase activity

Specific function:

The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in arbutin, cellobiose, and salicin transport

Gene Name:

ascF

Uniprot ID:

P24241

Molecular weight:

51025

Reactions

General function:

Involved in transferase activity, transferring phosphorus-containing groups

Specific function:

The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane

Gene Name:

ptsA

Uniprot ID:

P32670

Molecular weight:

91773

Reactions

General function:

Involved in protein-N(PI)-phosphohistidine-sugar phosphotransferase activity

Specific function:

The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in trehalose transport

Gene Name:

treB

Uniprot ID:

P36672

Molecular weight:

51080

Reactions

General function:

Involved in protein binding

Specific function:

Component of the phosphoenolpyruvate-dependent nitrogen- metabolic phosphotransferase system (nitrogen-metabolic PTS), that seems to be involved in regulating nitrogen metabolism. Enzyme I- Ntr transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (NPr). Could function in the transcriptional regulation of sigma-54 dependent operons in conjunction with the NPr (ptsO) and EIIA-Ntr (ptsN) proteins

Gene Name:

ptsP

Uniprot ID:

P37177

Molecular weight:

83715

Reactions

General function:

Involved in sugar:hydrogen symporter activity

Specific function:

The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. This system is involved in galactitol transport

Gene Name:

gatB

Uniprot ID:

P37188

Molecular weight:

10222

Reactions

General function:

Involved in transporter activity

Specific function:

The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane

Gene Name:

hrsA

Uniprot ID:

P54745

Molecular weight:

69667

Reactions

General function:

Involved in protein-N(PI)-phosphohistidine-sugar phosphotransferase activity

Specific function:

The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in glucitol/sorbitol transport

Gene Name:

srlE

Uniprot ID:

P56580

Molecular weight:

33332

Reactions

General function:

Involved in sugar:hydrogen symporter activity

Specific function:

The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in glucose transport

Gene Name:

crr

Uniprot ID:

P69783

Molecular weight:

18251

Reactions

General function:

Involved in protein-N(PI)-phosphohistidine-sugar phosphotransferase activity

Specific function:

The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in glucose transport. This enzyme is also a chemoreceptor monitoring the environment for changes in sugar concentration

Gene Name:

ptsG

Uniprot ID:

P69786

Molecular weight:

50676

Reactions

General function:

Involved in phosphoenolpyruvate-dependent sugar phosphotransferase system

Specific function:

The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in mannose transport

Gene Name:

manX

Uniprot ID:

P69797

Molecular weight:

35047

Reactions

General function:

Involved in transporter activity

Specific function:

The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in fructose transport

Gene Name:

fruB

Uniprot ID:

P69811

Molecular weight:

39647

Reactions

General function:

Involved in transporter activity

Specific function:

The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in ascorbate transport

Gene Name:

ulaC

Uniprot ID:

P69820

Molecular weight:

17237

Reactions

General function:

Involved in sugar:hydrogen symporter activity

Specific function:

The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in ascorbate transport

Gene Name:

ulaB

Uniprot ID:

P69822

Molecular weight:

10896

Reactions

General function:

Involved in transporter activity

Specific function:

The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in galactitol transport

Gene Name:

gatA

Uniprot ID:

P69828

Molecular weight:

16907

Reactions

General function:

Involved in protein-N(PI)-phosphohistidine-sugar phosphotransferase activity

Specific function:

The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in N-acetylmuramic acid (MurNAc) transport, yielding cytoplasmic MurNAc-6-P. Is responsible for growth on MurNAc as the sole source of carbon and energy. Is also able to take up anhydro-N-acetylmuramic acid (anhMurNAc), but cannot phosphorylate the carbon 6, probably because of the 1,6- anhydro ring

Gene Name:

murP

Uniprot ID:

P77272

Molecular weight:

49801

Reactions

General function:

Involved in transferase activity, transferring phosphorus-containing groups

Specific function:

Multifunctional protein that includes general (non sugar-specific) and sugar-specific components of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr). HPr transfers the phosphoryl group to the phosphoryl carrier EIIA, which then transfers it to EIIB

Gene Name:

fryA

Uniprot ID:

P77439

Molecular weight:

92129

Reactions

General function:

Involved in phosphoenolpyruvate-dependent sugar phosphotransferase system

Specific function:

The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active- transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. This system is involved in ascorbate transport

Gene Name:

ulaA

Uniprot ID:

P39301

Molecular weight:

50737

General function:

Involved in phosphoenolpyruvate-dependent sugar phosphotransferase system

Specific function:

The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. This system is involved in glucitol/sorbitol transport

Gene Name:

srlA

Uniprot ID:

P56579

Molecular weight:

20580

General function:

Involved in phosphoenolpyruvate-dependent sugar phosphotransferase system

Specific function:

The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. This system is involved in mannose transport

Gene Name:

manY

Uniprot ID:

P69801

Molecular weight:

27636

General function:

Involved in phosphoenolpyruvate-dependent sugar phosphotransferase system

Specific function:

The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. This system is involved in mannose transport

Gene Name:

manZ

Uniprot ID:

P69805

Molecular weight:

31303

General function:

Involved in phosphoenolpyruvate-dependent sugar phosphotransferase system

Specific function:

The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. This system is involved in galactitol transport

Gene Name:

gatC

Uniprot ID:

P69831

Molecular weight:

48365

General function:

Involved in glycerone kinase activity

Specific function:

Dihydroxyacetone binding subunit of the dihydroxyacetone kinase, which is responsible for phosphorylating dihydroxyacetone. Binds covalently dihydroxyacetone in hemiaminal linkage. Acts also as a corepressor of dhaR by binding to its sensor domain, in the absence of dihydroxyacetone

Gene Name:

dhaK

Uniprot ID:

P76015

Molecular weight:

38215

General function:

Involved in glycerone kinase activity

Specific function:

ADP-binding subunit of the dihydroxyacetone kinase, which is responsible for phosphorylating dihydroxyacetone. DhaL- ADP receives a phosphoryl group from dhaM and transmits it to dihydroxyacetone. DhaL-ADP acts also as a coactivator by binding to the sensor domain of dhaR. DhaL-ATP is inactive

Gene Name:

dhaL

Uniprot ID:

P76014

Molecular weight:

22632

General function:

Involved in transferase activity, transferring phosphorus-containing groups

Specific function:

Phosphotransferase subunit of the dihydroxyacetone kinase, which is responsible for phosphorylating dihydroxyacetone. DhaM serves as the phosphoryl donor. It is phosphorylated by HPr, then it donates its phosphoryl group to dhaL-ADP, which eventually transmits it to dihydroxyacetone

Gene Name:

dhaM

Uniprot ID:

P37349

Molecular weight:

51448

Reactions

General function:

Involved in sugar:hydrogen symporter activity

Specific function:

General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The phosphoryl group from phosphoenolpyruvate (PEP) is transferred to the phosphoryl carrier protein HPr by enzyme I. Phospho-HPr then transfers it to the permease (enzymes II/III)

Gene Name:

ptsH

Uniprot ID:

P0AA04

Molecular weight:

9119

Reactions