Succinate-semialdehyde dehydrogenase [NADP+] (P25526)

Identification
Name:Succinate-semialdehyde dehydrogenase [NADP+]
Synonyms:
  • SSDH
Gene Name:gabD
Enzyme Class:
Biological Properties
General Function:Involved in oxidoreductase activity
Specific Function:Succinate semialdehyde + NAD(P)(+) + H(2)O = succinate + NAD(P)H
Cellular Location:Not Available
SMPDB Pathways:
KEGG Pathways:
KEGG Reactions:
1.0Thumb+1.0Thumb+1.0Thumb → 2.0Thumb+1.0Thumb+1.0Thumb
1.0Water + 1.0NADP + 1.0Succinic acid semialdehyde → 2.0Hydrogen ion + 1.0NADPH + 1.0Succinic acid
ReactionCard
1.0Thumb+1.0Thumb+1.0Thumb → 2.0Thumb+1.0Thumb+1.0Thumb
1.0Water + 1.0NAD + 1.0Succinic acid semialdehyde → 2.0Hydrogen ion + 1.0NADH + 1.0Succinic acid
ReactionCard
1.0Thumb+1.0Thumb+1.0Thumb ↔ 1.0Thumb+1.0Thumb+1.0Thumb
1.0Succinic acid semialdehyde + 1.0NAD + 1.0Water ↔ 1.0Succinic acid + 1.0NADH + 1.0Hydrogen ion
ReactionCard
1.0Thumb+1.0Thumb+1.0Thumb ↔ 1.0Thumb+1.0Thumb+1.0Thumb
1.0Succinic acid semialdehyde + 1.0NADP + 1.0Water ↔ 1.0Succinic acid + 1.0NADPH + 1.0Hydrogen ion
ReactionCard
1.0Thumb+1.0Thumb+1.0Thumb+1.0Thumb ↔ 1.0Thumb+1.0Thumb+1.0Thumb+2.0Thumb
1.0Succinic acid semialdehyde + 1.0NAD + 1.0NADP + 1.0Water ↔ 1.0Succinic acid + 1.0NADH + 1.0NADPH + 2.0Hydrogen ion
ReactionCard
SMPDB Reactions:
1.0Thumb+1.0Thumb+1.0Thumb → 1.0NADPH+2.0Thumb+1.0Thumb+1.0Thumb
1.0Succinic acid semialdehyde + 1.0Water + 1.0NADP → 1.0NADPH + 2.0Hydrogen ion + 1.0Succinic acid + 1.0NADPH
ReactionCard
EcoCyc Reactions:
1.0Thumb+1.0Thumb+1.0Thumb → 2.0Thumb+1.0Thumb+1.0Thumb
1.0Water + 1.0NADP + 1.0Succinic acid semialdehyde → 2.0Hydrogen ion + 1.0NADPH + 1.0Succinic acid
ReactionCard
1.0Thumb+1.0Thumb+1.0Thumb → 2.0Thumb+1.0Thumb+1.0Thumb
1.0Water + 1.0NAD + 1.0Succinic acid semialdehyde → 2.0Hydrogen ion + 1.0NADH + 1.0Succinic acid
ReactionCard
Complex Reactions:
1.0Thumb+1.0Thumb+1.0Thumb → 1.0Thumb+1.0Thumb
1.0Succinic acid semialdehyde + 1.0NADP + 1.0Water → 1.0Succinic acid + 1.0NADPH
ReactionCard
Metabolites:
ECMDB IDNameView
ECMDB21425Glutaric acidMetaboCard
ECMDB21225Hydrogen ionMetaboCard
ECMDB00902NADMetaboCard
ECMDB01487NADHMetaboCard
ECMDB00217NADPMetaboCard
ECMDB04111NADPHMetaboCard
ECMDB00254Succinic acidMetaboCard
ECMDB01259Succinic acid semialdehydeMetaboCard
ECMDB00494WaterMetaboCard
GO Classification:
Function
catalytic activity
oxidoreductase activity
oxidoreductase activity, acting on the aldehyde or oxo group of donors
oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
Process
metabolic process
oxidation reduction
Gene Properties
Blattner:b2661
Gene OrientationClockwise
Centisome Percentage:60.12
Left Sequence End2789295
Right Sequence End2790743
Gene Sequence:
>1449 bp
ATGAAGTTTATCATTAAATTGTTCCCGGAAATCACCATCAAAAGCCAATCTGTGCGCTTG
CGCTTTATAAAAATCCTTACCGGGAACATTCGTAACGTTTTAAAGCACTATGATGAGACG
CTCGCTGTCGTCCGCCACTGGGATAACATCGAAGTTCGCGCAAAAGATGAAAACCAGCGT
CTGGCTATTCGCGACGCTCTGACCCGTATTCCGGGTATCCACCATATTCTCGAAGTCGAA
GACGTGCCGTTTACCGACATGCACGATATTTTCGAGAAAGCGTTGGTTCAGTATCGCGAT
CAGCTGGAAGGCAAAACCTTCTGCGTACGCGTGAAGCGCCGTGGCAAACATGATTTTAGC
TCGATTGATGTGGAACGTTACGTCGGCGGCGGTTTAAATCAGCATATTGAATCCGCGCGC
GTGAAGCTGACCAATCCGGATGTGACTGTCCATCTGGAAGTGGAAGACGATCGTCTCCTG
CTGATTAAAGGCCGCTACGAAGGTATTGGCGGTTTCCCGATCGGCACCCAGGAAGATGTG
CTGTCGCTCATTTCCGGTGGTTTCGACTCCGGTGTTTCCAGTTATATGTTGATGCGTCGC
GGCTGCCGCGTGCATTACTGCTTCTTTAACCTCGGCGGCGCGGCGCATGAAATTGGCGTG
CGTCAGGTGGCGCATTATCTGTGGAACCGCTTTGGCAGCTCCCACCGCGTGCGTTTTGTC
GCTATTAATTTCGAACCGGTCGTCGGGGAAATTCTCGAGAAAATCGACGACGGTCAGATG
GGCGTTATCCTCAAACGTATGATGGTGCGTGCCGCATCTAAAGTGGCTGAACGTTACGGC
GTACAGGCGCTGGTCACCGGCGAAGCGCTCGGCCAGGTGTCCAGCCAGACGCTGACCAAC
CTGCGCCTGATTGATAACGTCTCCGACACGCTGATCCTGCGTCCGCTGATCTCTTACGAC
AAAGAGCACATCATCAACCTGGCCCGCCAGATTGGCACCGAAGACTTTGCTCGCACGATG
CCGGAATATTGTGGTGTGATCTCCAAAAGCCCGACGGTGAAAGCAGTTAAATCGAAGATT
GAAGCGGAAGAAGAGAAGTTCGACTTCAGCATTCTCGATAAAGTGGTTGAGGAAGCGAAT
AACGTTGATATCCGCGAAATCGCCCAGCAGACCGAGCAGGAAGTGGTGGAAGTGGAAACC
GTCAATGGCTTCGGCCCGAACGACGTGATCCTCGATATCCGTTCTATCGATGAACAGGAA
GATAAGCCACTGAAAGTCGAAGGGATTGATGTGGTTTCTCTGCCGTTCTATAAACTGAGC
ACCAAATTTGGCGATCTCGACCAGAACAAAACCTGGCTGCTGTGGTGTGAGCGCGGGGTG
ATGAGCCGTCTGCAGGCGCTCTATCTGCGCGAGCAGGGCTTTAACAATGTGAAGGTATAT
CGCCCGTAA
Protein Properties
Pfam Domain Function:
Protein Residues:482
Protein Molecular Weight:51720
Protein Theoretical pI:5
Signaling Regions:
  • None
Transmembrane Regions:
  • None
Protein Sequence:
>Succinate-semialdehyde dehydrogenase [NADP+]
MKLNDSNLFRQQALINGEWLDANNGEAIDVTNPANGDKLGSVPKMGADETRAAIDAANRA
LPAWRALTAKERATILRNWFNLMMEHQDDLARLMTLEQGKPLAEAKGEISYAASFIEWFA
EEGKRIYGDTIPGHQADKRLIVIKQPIGVTAAITPWNFPAAMITRKAGPALAAGCTMVLK
PASQTPFSALALAELAIRAGVPAGVFNVVTGSAGAVGNELTSNPLVRKLSFTGSTEIGRQ
LMEQCAKDIKKVSLELGGNAPFIVFDDADLDKAVEGALASKFRNAGQTCVCANRLYVQDG
VYDRFAEKLQQAVSKLHIGDGLDNGVTIGPLIDEKAVAKVEEHIADALEKGARVVCGGKA
HERGGNFFQPTILVDVPANAKVSKEETFGPLAPLFRFKDEADVIAQANDTEFGLAAYFYA
RDLSRVFRVGEALEYGIVGINTGIISNEVAPFGGIKASGLGREGSKYGIEDYLEIKYMCI
GL
References
External Links:
ResourceLink
Uniprot ID:P25526
Uniprot Name:GABD_ECOLI
GenBank Gene ID:AP009048
Genebank Protein ID:85674563
Ecogene ID:EG11329
Ecocyc:EG11329
ColiBase:b2661
Kegg Gene:b2661
EchoBASE ID:EB1305
CCDB:GABD_ECOLI
BacMap:16130575
General Reference:
  • Blattner, F. R., Plunkett, G. 3rd, Bloch, C. A., Perna, N. T., Burland, V., Riley, M., Collado-Vides, J., Glasner, J. D., Rode, C. K., Mayhew, G. F., Gregor, J., Davis, N. W., Kirkpatrick, H. A., Goeden, M. A., Rose, D. J., Mau, B., Shao, Y. (1997). "The complete genome sequence of Escherichia coli K-12." Science 277:1453-1462. Pubmed: 9278503
  • Hayashi, K., Morooka, N., Yamamoto, Y., Fujita, K., Isono, K., Choi, S., Ohtsubo, E., Baba, T., Wanner, B. L., Mori, H., Horiuchi, T. (2006). "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Mol Syst Biol 2:2006.0007. Pubmed: 16738553
  • Niegemann, E., Schulz, A., Bartsch, K. (1993). "Molecular organization of the Escherichia coli gab cluster: nucleotide sequence of the structural genes gabD and gabP and expression of the GABA permease gene." Arch Microbiol 160:454-460. Pubmed: 8297211
  • Yamamoto, Y., Aiba, H., Baba, T., Hayashi, K., Inada, T., Isono, K., Itoh, T., Kimura, S., Kitagawa, M., Makino, K., Miki, T., Mitsuhashi, N., Mizobuchi, K., Mori, H., Nakade, S., Nakamura, Y., Nashimoto, H., Oshima, T., Oyama, S., Saito, N., Sampei, G., Satoh, Y., Sivasundaram, S., Tagami, H., Horiuchi, T., et, a. l. .. (1997). "Construction of a contiguous 874-kb sequence of the Escherichia coli -K12 genome corresponding to 50.0-68.8 min on the linkage map and analysis of its sequence features." DNA Res 4:91-113. Pubmed: 9205837