Anaerobic dimethyl sulfoxide reductase chain C (P18777)

Identification
Name:Anaerobic dimethyl sulfoxide reductase chain C
Synonyms:
  • DMSO reductase anchor subunit
Gene Name:dmsC
Enzyme Class:Not Available
Biological Properties
General Function:Involved in anaerobic electron transport chain
Specific Function:Terminal reductase during anaerobic growth on various sulfoxide and N-oxide compounds. DmsC anchors the dmsAB dimer to the membrane and stabilizes it
Cellular Location:Cell inner membrane; Multi-pass membrane protein
SMPDB Pathways:
KEGG Pathways:
SMPDB Reactions:
1.0Thumb+1.0Thumb+2.0Thumb+2.0Electron → 1.0menaquinone-8+1.0Thumb+1.0Thumb+2.0Thumb
1.0Menaquinol 8 + 1.0Dimethyl sulfoxide + 2.0Hydrogen ion + 2.0Electron → 1.0menaquinone-8 + 1.0Dimethyl sulfide + 1.0Water + 2.0Hydrogen ion
ReactionCard
Complex Reactions:
1.0Thumb+1.0Thumb+1.0Thumb → 1.0Thumb+1.0Menaquinone 8+1.0Thumb
1.0Hydrogen ion + 1.0Menaquinol 8 + 1.0Trimethylamine N-Oxide → 1.0Water + 1.0Menaquinone 8 + 1.0Trimethylamine
ReactionCard
1.0Thumb+1.0Thumb+1.0Thumb → 1.0Thumb+1.0Thumb+1.0Thumb
1.02-Demethylmenaquinol 8 + 1.0Hydrogen ion + 1.0Trimethylamine N-Oxide → 1.02-Demethylmenaquinone 8 + 1.0Water + 1.0Trimethylamine
ReactionCard
1.0Thumb+1.0Thumb → 1.0Thumb+1.0Thumb+1.0Menaquinone 8
1.0Dimethyl sulfoxide + 1.0Menaquinol 8 → 1.0Dimethyl sulfide + 1.0Water + 1.0Menaquinone 8
ReactionCard
1.0Thumb+1.0Thumb → 1.0Thumb+1.0Thumb+1.0Thumb
1.02-Demethylmenaquinol 8 + 1.0Dimethyl sulfoxide → 1.02-Demethylmenaquinone 8 + 1.0Dimethyl sulfide + 1.0Water
ReactionCard
Metabolites:
ECMDB IDNameView
ECMDB211542-Demethylmenaquinol 8MetaboCard
ECMDB211552-Demethylmenaquinone 8MetaboCard
ECMDB21207Dimethyl sulfideMetaboCard
ECMDB21208Dimethyl sulfoxideMetaboCard
ECMDB21225Hydrogen ionMetaboCard
ECMDB21551Menaquinol 6MetaboCard
ECMDB21245Menaquinol 8MetaboCard
ECMDB04102MenaquinoneMetaboCard
ECMDB00906TrimethylamineMetaboCard
ECMDB04161Trimethylamine N-OxideMetaboCard
ECMDB00494WaterMetaboCard
GO Classification:
Component
cell part
integral to membrane
intrinsic to membrane
membrane part
Process
anaerobic electron transport chain
cellular metabolic process
electron transport chain
generation of precursor metabolites and energy
metabolic process
respiratory electron transport chain
Gene Properties
Blattner:b0896
Gene OrientationClockwise
Centisome Percentage:20.33
Left Sequence End943256
Right Sequence End944119
Gene Sequence:
>864 bp
GTGTGGGCGCTAACTGCGGATGCGGATTTTCTGGCGCAGCGGGGGCAAGGACAGGTTGAA
CAGGTCTTTGCCAGAGCGGTAAATATCGCACTCCCGGCTCGCCAGCAGTTGCTGACGCTG
CTTTGTGAAGAGTACGACAATGCGCCAAACAGTTGTCGGTTGGCACTCACTCACTTTGAT
GATCTGTTCCGGCATGGTGATAAGGTTCAGTTTGACGATCAAGGTATTACGGTTGGTCAA
CATCTTCATATAGAGATGAGTCGTTGTCGGCGTTGGCTGTCCCCAACCTTGCAAATGACC
GCTGTGAATTTTCACCTTATCGCCTGGCTACAGTGGCACGACATTATTCATCAGCACCTG
GGGGAAAATGAAACCCTGTTTAATTATCGCGGCGATAATCCGTTTTATCAGGCGTTAAAT
AAAGAATTACATATTAAACGACGGGCAGTTATTCAGGCCGTAAACGATAAACAAAATATC
GCCTCAGCGGTCGCCAGTATGATGGGGTTAGGGATTGGCCTTACGCCATCAGCCGACGAT
TATTTAACAGGTCTGGCGCTTATTTTATTTATTCCCGGGCATCCGGCGGAAAAATACAAA
GAGGAATTTTATCTCGGTCTGCAACGCGGCAAAAATAATACCACATTATTAAGTGCCATA
ACGCTGGAAGCCGCATTACAACAACGCTGCCGGGAAAATATTCATCGTTTTATTCACAAC
ATTATTTATGACATCCCTGGGAACGCAACTCAGGCAATAGAAAAAATTAAACATATTGGC
TCCAGTTCCGGCTGCGACATGCTGTATGGCATGGCCGATGGTTGTGCGCTGAGCCAAACC
TACGGAGGGAATTATGTCAGTTAA
Protein Properties
Pfam Domain Function:
Protein Residues:287
Protein Molecular Weight:30826
Protein Theoretical pI:9
Signaling Regions:
  • None
Transmembrane Regions:
  • 10-32
  • 44-66
  • 90-107
  • 115-134
  • 157-174
  • 183-201
  • 225-242
  • 255-280
Protein Sequence:
>Anaerobic dimethyl sulfoxide reductase chain C
MGSGWHEWPLMIFTVFGQCVAGGFIVLALALLKGDLRAEAQQRVIACMFGLWVLMGIGFI
ASMLHLGSPMRAFNSLNRVGASALSNEIASGSIFFAVGGIGWLLAMLKKLSPALRTLWLI
VTMVLGVIFVWMMVRVYNSIDTVPTWYSIWTPMGFFLTMFMGGPLLGYLLLSLAGVDGWA
MRLLPAISVLALVVSGVVSVMQGAELATIHSSVQQAAALVPDYGALMSWRIVLLAVALCL
WIAPQLKGYQPAVPLLSVSFILLLAGELIGRGVFYGLHMTVGMAVAS
References
External Links:
ResourceLink
Uniprot ID:P18777
Uniprot Name:DMSC_ECOLI
GenBank Gene ID:AP009048
Genebank Protein ID:85674462
Ecogene ID:EG10234
Ecocyc:EG10234
ColiBase:b0896
Kegg Gene:b0896
EchoBASE ID:EB0230
CCDB:DMSC_ECOLI
BacMap:16128863
General Reference:
  • Bilous, P. T., Cole, S. T., Anderson, W. F., Weiner, J. H. (1988). "Nucleotide sequence of the dmsABC operon encoding the anaerobic dimethylsulphoxide reductase of Escherichia coli." Mol Microbiol 2:785-795. Pubmed: 3062312
  • Blattner, F. R., Plunkett, G. 3rd, Bloch, C. A., Perna, N. T., Burland, V., Riley, M., Collado-Vides, J., Glasner, J. D., Rode, C. K., Mayhew, G. F., Gregor, J., Davis, N. W., Kirkpatrick, H. A., Goeden, M. A., Rose, D. J., Mau, B., Shao, Y. (1997). "The complete genome sequence of Escherichia coli K-12." Science 277:1453-1462. Pubmed: 9278503
  • Daley, D. O., Rapp, M., Granseth, E., Melen, K., Drew, D., von Heijne, G. (2005). "Global topology analysis of the Escherichia coli inner membrane proteome." Science 308:1321-1323. Pubmed: 15919996
  • Hayashi, K., Morooka, N., Yamamoto, Y., Fujita, K., Isono, K., Choi, S., Ohtsubo, E., Baba, T., Wanner, B. L., Mori, H., Horiuchi, T. (2006). "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Mol Syst Biol 2:2006.0007. Pubmed: 16738553
  • Oshima, T., Aiba, H., Baba, T., Fujita, K., Hayashi, K., Honjo, A., Ikemoto, K., Inada, T., Itoh, T., Kajihara, M., Kanai, K., Kashimoto, K., Kimura, S., Kitagawa, M., Makino, K., Masuda, S., Miki, T., Mizobuchi, K., Mori, H., Motomura, K., Nakamura, Y., Nashimoto, H., Nishio, Y., Saito, N., Horiuchi, T., et, a. l. .. (1996). "A 718-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 12.7-28.0 min region on the linkage map." DNA Res 3:137-155. Pubmed: 8905232
  • Sambasivarao, D., Scraba, D. G., Trieber, C., Weiner, J. H. (1990). "Organization of dimethyl sulfoxide reductase in the plasma membrane of Escherichia coli." J Bacteriol 172:5938-5948. Pubmed: 2170332
  • Weiner, J. H., Shaw, G., Turner, R. J., Trieber, C. A. (1993). "The topology of the anchor subunit of dimethyl sulfoxide reductase of Escherichia coli." J Biol Chem 268:3238-3244. Pubmed: 8429002