UDP-glucose 6-dehydrogenase (P76373)

Identification
Name:UDP-glucose 6-dehydrogenase
Synonyms:
  • UDP-Glc dehydrogenase
  • UDP-GlcDH
  • UDPGDH
Gene Name:ugd
Enzyme Class:
Biological Properties
General Function:Involved in oxidation-reduction process
Specific Function:UDP-glucose + 2 NAD(+) + H(2)O = UDP- glucuronate + 2 NADH
Cellular Location:Not Available
SMPDB Pathways:
  • Amino sugar and nucleotide sugar metabolism III PW000895
  • Starch and sucrose metabolism PW000941
  • colanic acid building blocks biosynthesis PW000951
KEGG Pathways:
  • Amino sugar and nucleotide sugar metabolism ec00520
  • Ascorbate and aldarate metabolism ec00053
  • Metabolic pathways eco01100
  • Pentose and glucuronate interconversions ec00040
  • Starch and sucrose metabolism ec00500
KEGG Reactions:
1.0Thumb+2.0Thumb+1.0Thumb ↔ 3.0Thumb+2.0Thumb+1.0Thumb+1.0Thumb
1.0Water + 2.0NAD + 1.0UDP-Glucose ↔ 3.0Hydrogen ion + 2.0NADH + 1.0Uridine diphosphate glucuronic acid + 1.0UDP-Glucuronic acid
ReactionCard
1.0Thumb+1.0Thumb+2.0Thumb ↔ 1.0Thumb+2.0Thumb+2.0Thumb
1.0UDP-Glucose + 1.0Water + 2.0NAD ↔ 1.0Uridine diphosphate glucuronic acid + 2.0NADH + 2.0Hydrogen ion
ReactionCard
SMPDB Reactions:
1.0Thumb+2.0Thumb+1.0Thumb → 1.0Thumb+2.0Thumb+3.0Thumb
1.0UDP-Glucose + 2.0NAD + 1.0Water → 1.0UDP-Glucuronic acid + 2.0NADH + 3.0Hydrogen ion
ReactionCard
EcoCyc Reactions:
1.0Thumb+2.0Thumb+1.0Thumb ↔ 3.0Thumb+2.0Thumb+1.0Thumb+1.0Thumb
1.0Water + 2.0NAD + 1.0UDP-Glucose ↔ 3.0Hydrogen ion + 2.0NADH + 1.0Uridine diphosphate glucuronic acid + 1.0UDP-Glucuronic acid
ReactionCard
1.0Thumb+1.0Thumb+1.0Thumb → 1.0Thumb+1.0Thumb+1.0Thumb
1.0UDP-Glucose + 1.0Water + 1.0NAD → 1.0Hydrogen ion + 1.0NADH + 1.0Uridine diphosphate glucuronic acid
ReactionCard
Complex Reactions:
1.0Thumb+2.0Thumb+1.0Thumb → 1.0Thumb+2.0Thumb
1.0UDP-Glucose + 2.0NAD + 1.0Water → 1.0UDP-Glucuronic acid + 2.0NADH
ReactionCard
Metabolites:
ECMDB IDNameView
ECMDB21225Hydrogen ionMetaboCard
ECMDB00902NADMetaboCard
ECMDB01487NADHMetaboCard
ECMDB04171UDP-GlucoseMetaboCard
ECMDB01384UDP-Glucuronic acidMetaboCard
ECMDB04166Uridine diphosphate glucuronic acidMetaboCard
ECMDB00494WaterMetaboCard
GO Classification:
Function
binding
catalytic activity
NAD or NADH binding
nucleotide binding
oxidoreductase activity
oxidoreductase activity, acting on CH-OH group of donors
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
Process
metabolic process
oxidation reduction
Gene Properties
Blattner:b2028
Gene OrientationCounterclockwise
Centisome Percentage:45.19
Left Sequence End2096471
Right Sequence End2097637
Gene Sequence:
>1167 bp
GTGAAACATCTGCATCGATTCTTTAGCAGTGATGCCTCGGGAGGCATTATTCTTATCATT
GCCGCTATCCTGGCGATGATTATGGCCAACAGCGGCGCAACCAGTGGATGGTATCACGAC
TTTCTGGAGACGCCGGTTCAGCTCCGGGTTGGTTCACTCGAAATCAACAAAAACATGCTG
TTATGGATAAATGACGCGCTGATGGCGGTATTTTTCCTGTTAGTCGGTCTGGAAGTTAAA
CGTGAACTGATGCAAGGATCGCTAGCCAGCTTACGCCAGGCCGCATTTCCAGTTATCGCC
GCTATTGGTGGGATGATTGTGCCGGCATTACTCTATCTGGCTTTTAACTATGCCGATCCG
ATTACCCGCGAAGGGTGGGCGATCCCGGCGGCTACTGACATTGCTTTTGCACTTGGTGTA
CTGGCGCTGTTGGGAAGTCGTGTTCCGTTAGCGCTGAAGATCTTTTTGATGGCTCTGGCT
ATTATCGACGATCTTGGGGCCATCATTATCATCGCATTGTTCTACACTAATGACTTATCG
ATGGCCTCTCTTGGCGTCGCGGCTGTAGCAATTGCGGTACTCGCGGTATTGAATCTGTGT
GGTGCACGCCGCACGGGCGTCTATATTCTTGTTGGCGTGGTGTTGTGGACTGCGGTGTTG
AAATCGGGGGTTCACGCAACTCTGGCGGGGGTAATTGTCGGCTTCTTTATTCCTTTGAAA
GAGAAGCATGGGCGTTCTCCAGCGAAGCGACTGGAGCATGTGTTGCACCCGTGGGTGGCG
TATCTGATTTTGCCGCTGTTTGCATTTGCTAATGCTGGCGTTTCACTGCAAGGCGTCACG
CTGGATGGCTTGACCTCCATTCTGCCATTGGGGATCATCGCTGGCTTGCTGATTGGCAAA
CCGCTGGGGATTAGTCTGTTCTGCTGGTTGGCGCTGCGTTTGAAACTGGCGCATCTGCCT
GAGGGAACGACTTATCAGCAAATTATGGTGGTGGGGATCCTGTGCGGTATCGGTTTTACT
ATGTCTATCTTTATTGCCAGCCTGGCCTTTGGTAGCGTAGATCCAGAACTGATTAACTGG
GCGAAACTCGGTATCCTGGTCGGTTCTATCTCTTCGGCGGTAATTGGATACAGCTGGTTA
CGCGTTCGTTTGCGTCCATCAGTTTGA
Protein Properties
Pfam Domain Function:
Protein Residues:388
Protein Molecular Weight:43656
Protein Theoretical pI:6
Signaling Regions:
  • None
Transmembrane Regions:
  • None
Protein Sequence:
>UDP-glucose 6-dehydrogenase
MKITISGTGYVGLSNGLLIAQNHEVVALDILPSRVAMLNDRISPIVDKEIQQFLQSDKIH
FNATLDKNEAYRDADYVIIATPTDYDPKTNYFNTSSVESVIKDVVEINPYAVMVIKSTVP
VGFTAAMHKKYRTENIIFSPEFLREGKALYDNLHPSRIVIGERSERAERFAALLQEGAIK
QNIPMLFTDSTEAEAIKLFANTYLAMRVAYFNELDSYAESLGLNSRQIIEGVCLDPRIGN
HYNNPSFGYGGYCLPKDTKQLLANYQSVPNNLISAIVDANRTRKDFIADAILSRKPQVVG
IYRLIMKSGSDNFRASSIQGIMKRIKAKGVEVIIYEPVMKEDSFFNSRLERDLATFKQQA
DVIISNRMAEELKDVADKVYTRDLFGSD
References
External Links:
ResourceLink
Uniprot ID:P76373
Uniprot Name:UDG_ECOLI
GenBank Gene ID:AP009048
Genebank Protein ID:21321905
Ecogene ID:EG13407
Ecocyc:EG13407
ColiBase:b2028
Kegg Gene:b2028
EchoBASE ID:EB3183
CCDB:UDG_ECOLI
BacMap:16129969
General Reference:
  • Blattner, F. R., Plunkett, G. 3rd, Bloch, C. A., Perna, N. T., Burland, V., Riley, M., Collado-Vides, J., Glasner, J. D., Rode, C. K., Mayhew, G. F., Gregor, J., Davis, N. W., Kirkpatrick, H. A., Goeden, M. A., Rose, D. J., Mau, B., Shao, Y. (1997). "The complete genome sequence of Escherichia coli K-12." Science 277:1453-1462. Pubmed: 9278503
  • Grangeasse, C., Obadia, B., Mijakovic, I., Deutscher, J., Cozzone, A. J., Doublet, P. (2003). "Autophosphorylation of the Escherichia coli protein kinase Wzc regulates tyrosine phosphorylation of Ugd, a UDP-glucose dehydrogenase." J Biol Chem 278:39323-39329. Pubmed: 12851388
  • Hayashi, K., Morooka, N., Yamamoto, Y., Fujita, K., Isono, K., Choi, S., Ohtsubo, E., Baba, T., Wanner, B. L., Mori, H., Horiuchi, T. (2006). "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Mol Syst Biol 2:2006.0007. Pubmed: 16738553
  • Itoh, T., Aiba, H., Baba, T., Hayashi, K., Inada, T., Isono, K., Kasai, H., Kimura, S., Kitakawa, M., Kitagawa, M., Makino, K., Miki, T., Mizobuchi, K., Mori, H., Mori, T., Motomura, K., Nakade, S., Nakamura, Y., Nashimoto, H., Nishio, Y., Oshima, T., Saito, N., Sampei, G., Seki, Y., Horiuchi, T., et, a. l. .. (1996). "A 460-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 40.1-50.0 min region on the linkage map." DNA Res 3:379-392. Pubmed: 9097040