ECMDB

Identification

Name:

Alcohol dehydrogenase, propanol-preferring

Synonyms:

Not Available

Gene Name:

adhP

Enzyme Class:

1.1.1.1

Biological Properties

General Function:

Involved in zinc ion binding

Specific Function:

Preferred specificity is towards 1-propanol

Cellular Location:

Not Available

SMPDB Pathways:

Collection of Reactions without pathways PW001891
Fatty acid metabolism PW000796

KEGG Pathways:

1- and 2-Methylnaphthalene degradation ec00624
3-Chloroacrylic acid degradation ec00641
Chloroalkane and chloroalkene degradation ec00625
Drug metabolism - cytochrome P450 ec00982
Fatty acid metabolism ec00071
Glycine, serine and threonine metabolism ec00260
Glycolysis / Gluconeogenesis ec00010
Metabolic pathways eco01100
Metabolism of xenobiotics by cytochrome P450 ec00980
Microbial metabolism in diverse environments ec01120
Naphthalene degradation ec00626
Retinol metabolism ec00830
Tyrosine metabolism ec00350
alpha-Linolenic acid metabolism ec00592

KEGG Reactions:

1.0

↔

1.0

1.0Ethanol + 1.0NAD ↔ 1.0Acetaldehyde + 1.0Hydrogen ion + 1.0NADH
ReactionCard

1.0Primary alcohol

1.0

↔

1.0Aldehyde

1.0

1.0Primary alcohol + 1.0NAD ↔ 1.0Aldehyde + 1.0NADH + 1.0Hydrogen ion
ReactionCard

1.0

↔

1.0

1.0Retinol + 1.0NAD ↔ 1.0Retinal + 1.0NADH + 1.0Hydrogen ion
ReactionCard

1.0trans-3-Chloro-2-propene-1-ol

1.0

↔

1.0trans-3-Chloroallyl aldehyde

1.0

1.0trans-3-Chloro-2-propene-1-ol + 1.0NAD ↔ 1.0trans-3-Chloroallyl aldehyde + 1.0NADH + 1.0Hydrogen ion
ReactionCard

1.0cis-3-Chloro-2-propene-1-ol

1.0

↔

1.0cis-3-Chloroallyl aldehyde

1.0

1.0cis-3-Chloro-2-propene-1-ol + 1.0NAD ↔ 1.0cis-3-Chloroallyl aldehyde + 1.0NADH + 1.0Hydrogen ion
ReactionCard

1.0

↔

1.0

1.0(2-Naphthyl)methanol + 1.0NAD ↔ 1.02-Naphthaldehyde + 1.0NADH + 1.0Hydrogen ion
ReactionCard

1.0Chloral hydrate

1.0

↔

1.0Trichloroethanol

1.0

1.0Chloral hydrate + 1.0NADH + 1.0Hydrogen ion ↔ 1.0Trichloroethanol + 1.0NAD + 1.0Water
ReactionCard

1.0

↔

1.0

1.02-Phenyl-1,3-propanediol monocarbamate + 1.0NAD ↔ 1.03-Carbamoyl-2-phenylpropionaldehyde + 1.0NADH + 1.0Hydrogen ion
ReactionCard

1.0

↔

1.0

1.04-Hydroxy-5-phenyltetrahydro-1,3-oxazin-2-one + 1.0NAD ↔ 1.05-Phenyl-1,3-oxazinane-2,4-dione + 1.0NADH + 1.0Hydrogen ion
ReactionCard

1.0Primary alcohol

1.0

↔

1.0

1.0Primary alcohol + 1.0NAD + 1.0Secondary alcohol ↔ 1.0Aldehyde + 1.0NADH + 1.0Hydrogen ion + 1.0Ketone
ReactionCard

SMPDB Reactions:

1.0

→

1.0

1.0(2-Naphthyl)methanol + 1.0NAD → 1.02-Naphthaldehyde + 1.0Hydrogen ion + 1.0NADH
ReactionCard

EcoCyc Reactions:

1.0

↔

1.0

1.0Ethanol + 1.0NAD ↔ 1.0Acetaldehyde + 1.0Hydrogen ion + 1.0NADH
ReactionCard

1.0a primary alcohol

1.0

↔

1.0an aldehyde

1.0

1.0a primary alcohol + 1.0NAD ↔ 1.0an aldehyde + 1.0NADH + 1.0Hydrogen ion
ReactionCard

Metabolites:

ECMDB ID	Name	View
ECMDB20007	(2-Naphthyl)methanol	MetaboCard
ECMDB20021	1-Hydroxymethylnaphthalene	MetaboCard
ECMDB20047	2-Naphthaldehyde	MetaboCard
ECMDB20048	2-Phenyl-1,3-propanediol monocarbamate	MetaboCard
ECMDB00318	3,4-Dihydroxyphenylglycol	MetaboCard
ECMDB20065	3-Carbamoyl-2-phenylpropionaldehyde	MetaboCard
ECMDB20091	4-Hydroxy-5-phenyltetrahydro-1,3-oxazin-2-one	MetaboCard
ECMDB20107	5-Phenyl-1,3-oxazinane-2,4-dione	MetaboCard
ECMDB00990	Acetaldehyde	MetaboCard
ECMDB21646	Aldehyde	MetaboCard
ECMDB00108	Ethanol	MetaboCard
ECMDB21225	Hydrogen ion	MetaboCard
ECMDB00902	NAD	MetaboCard
ECMDB01487	NADH	MetaboCard
ECMDB21659	Retinal	MetaboCard
ECMDB21660	Retinol	MetaboCard
ECMDB00494	Water	MetaboCard

GO Classification:

Function
binding
catalytic activity
cation binding
ion binding
metal ion binding
oxidoreductase activity
transition metal ion binding
zinc ion binding
Process
metabolic process
oxidation reduction

Gene Properties

Blattner:

b1478

Gene Orientation

Counterclockwise

Centisome Percentage:

33.43

Left Sequence End

1550852

Right Sequence End

1551862

Gene Sequence:

>1011 bp
ATGTACTACCCCTTCGTTCGTAAAGCCCTTTTCCAGCTCGATCCAGAGCGCGCTCATGAG
TTTACTTTTCAGCAATTACGCCGTATTACAGGAACGCCGTTTGAAGCACTGGTGCGGCAG
AAAGTGCCTGCGAAACCTGTTAACTGCATGGGCCTGACGTTTAAAAATCCGCTTGGTCTG
GCAGCCGGTCTTGATAAAGACGGGGAGTGCATTGACGCGTTAGGCGCGATGGGATTTGGA
TCGATCGAGATCGGTACCGTCACGCCACGTCCACAGCCAGGTAATGACAAGCCGCGTCTC
TTTCGTCTGGTAGATGCCGAAGGTTTGATCAACCGTATGGGCTTTAATAATCTTGGCGTT
GATAACCTCGTAGAGAACGTAAAAAAGGCCCATTATGACGGCGTCCTGGGTATTAACATC
GGCAAAAATAAAGATACGCCAGTGGAGCAGGGCAAAGATGACTATCTGATTTGTATGGAA
AAAATCTATGCCTATGCGGGATATATCGCCATCAATATTTCATCGCCGAATACCCCAGGA
TTACGCACGCTGCAATATGGTGAAGCGCTGGATGATCTCTTAACCGCGATTAAAAATAAG
CAAAATGATTTGCAAGCGATGCACCATAAATATGTGCCGATCGCAGTGAAGATCGCGCCG
GATCTTTCTGAAGAAGAATTGATCCAGGTTGCCGATAGTTTAGTTCGCCATAATATTGAT
GGCGTTATTGCAACCAATACCACACTCGATCGTTCTCTTGTTCAGGGAATGAAAAATTGC
GATCAAACCGGTGGCTTAAGTGGTCGTCCGCTTCAGTTAAAAAGCACCGAAATTATTCGC
CGCTTGTCACTGGAATTAAACGGTCGCTTACCGATCATCGGTGTTGGCGGCATCGACTCG
GTTATCGCTGCGCGTGAAAAGATTGCTGCGGGTGCCTCACTGGTGCAAATTTATTCTGGT
TTTATTTTTAAAGGTCCGCCGCTGATTAAAGAAATCGTTACCCATATCTAA

Protein Properties

Pfam Domain Function:

ADH_N (PF08240 )
ADH_zinc_N (PF00107 )

Protein Residues:

336

Protein Molecular Weight:

35379

Protein Theoretical pI:

Signaling Regions:

None

Transmembrane Regions:

None

Protein Sequence:

>Alcohol dehydrogenase, propanol-preferring
MKAAVVTKDHHVDVTYKTLRSLKHGEALLKMECCGVCHTDLHVKNGDFGDKTGVILGHEG
IGVVAEVGPGVTSLKPGDRASVAWFYEGCGHCEYCNSGNETLCRSVKNAGYSVDGGMAEE
CIVVADYAVKVPDGLDSAAASSITCAGVTTYKAVKLSKIRPGQWIAIYGLGGLGNLALQY
AKNVFNAKVIAIDVNDEQLKLATEMGADLAINSHTEDAAKIVQEKTGGAHAAVVTAVAKA
AFNSAVDAVRAGGRVVAVGLPPESMSLDIPRLVLDGIEVVGSLVGTRQDLTEAFQFAAEG
KVVPKVALRPLADINTIFTEMEEGKIRGRMVIDFRH

References

External Links:

Resource	Link
Uniprot ID:	P39451
Uniprot Name:	ADHP_ECOLI
GenBank Gene ID:	AP009048
Genebank Protein ID:	1651460
Ecogene ID:	EG12622
Ecocyc:	EG12622
ColiBase:	b1478
Kegg Gene:	b1478
EchoBASE ID:	EB2506
CCDB:	ADHP_ECOLI
BacMap:	90111280

General Reference:

Aiba, H., Baba, T., Hayashi, K., Inada, T., Isono, K., Itoh, T., Kasai, H., Kashimoto, K., Kimura, S., Kitakawa, M., Kitagawa, M., Makino, K., Miki, T., Mizobuchi, K., Mori, H., Mori, T., Motomura, K., Nakade, S., Nakamura, Y., Nashimoto, H., Nishio, Y., Oshima, T., Saito, N., Sampei, G., Horiuchi, T., et, a. l. .. (1996). "A 570-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 28.0-40.1 min region on the linkage map." DNA Res 3:363-377. Pubmed: 9097039
Blattner, F. R., Plunkett, G. 3rd, Bloch, C. A., Perna, N. T., Burland, V., Riley, M., Collado-Vides, J., Glasner, J. D., Rode, C. K., Mayhew, G. F., Gregor, J., Davis, N. W., Kirkpatrick, H. A., Goeden, M. A., Rose, D. J., Mau, B., Shao, Y. (1997). "The complete genome sequence of Escherichia coli K-12." Science 277:1453-1462. Pubmed: 9278503
Hayashi, K., Morooka, N., Yamamoto, Y., Fujita, K., Isono, K., Choi, S., Ohtsubo, E., Baba, T., Wanner, B. L., Mori, H., Horiuchi, T. (2006). "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Mol Syst Biol 2:2006.0007. Pubmed: 16738553
Kubo, K. M., Craig, N. L. (1990). "Bacterial transposon Tn7 utilizes two different classes of target sites." J Bacteriol 172:2774-2778. Pubmed: 2158980

Alcohol dehydrogenase, propanol-preferring (P39451)