Identification
Name:Ferric iron reductase protein fhuF
Synonyms:Not Available
Gene Name:fhuF
Enzyme Class:Not Available
Biological Properties
General Function:Involved in 2 iron, 2 sulfur cluster binding
Specific Function:Involved in the reduction of ferric iron in cytoplasmic ferrioxamine B
Cellular Location:Cytoplasm. Cell membrane; Peripheral membrane protein
SMPDB Pathways:Not Available
KEGG Pathways:Not Available
Complex Reactions:
1.0Thumb+2.0Thumb1.0Thumb+2.0Thumb+2.0Thumb+2.0Thumb
2.0Thumb+1.0Thumb2.0Thumb+2.0Thumb+1.0Thumb+2.0Thumb
2.0Thumb+1.0Thumb2.0Thumb+2.0Thumb+2.0Thumb+1.0Thumb
Metabolites:
ECMDB IDNameView
ECMDB01248FADMetaboCard
ECMDB01197FADH2MetaboCard
ECMDB21333FerroxamineMetaboCard
ECMDB21332ferroxamine minus Fe(3)MetaboCard
ECMDB01520Flavin MononucleotideMetaboCard
ECMDB01142FMNHMetaboCard
ECMDB21225Hydrogen ionMetaboCard
ECMDB00692IronMetaboCard
ECMDB21279Reduced riboflavinMetaboCard
ECMDB00244RiboflavinMetaboCard
GO Classification:Not Available
Gene Properties
Blattner:b4367
Gene OrientationCounterclockwise
Centisome Percentage:99.21
Left Sequence End4602898
Right Sequence End4603686
Gene Sequence:
>789 bp
GTGATTGATAAATCCGCCTTTGTGCATCCAACCGCCATTGTGGAAGAGGGCGCGTCAATT
GGCGCGAACGCACACATTGGTCCTTTTTGTATCGTTGGACCCCATGTCGAAATTGGTGAG
GGTACCGTACTGAAATCTCACGTTGTCGTGAATGGTCATACTAAAATTGGCCGCGATAAT
GAGATTTATCAGTTCGCCTCCATCGGCGAAGTTAACCAGGATCTGAAATATGCTGGCGAA
CCGACCCGTGTGGAAATCGGCGATCGTAACCGCATTCGCGAAAGCGTCACCATTCATCGT
GGCACAGTCCAGGGCGGTGGATTGACGAAGGTGGGCAGCGACAACTTACTGATGATCAAC
GCGCACATTGCGCACGATTGTACGGTAGGTAACCGCTGTATTCTCGCCAACAACGCAACG
CTGGCGGGTCACGTATCGGTTGACGACTTCGCGATCATCGGCGGCATGACCGCAGTCCAT
CAGTTCTGCATCATTGGTGCGCACGTGATGGTTGGCGGCTGCTCCGGTGTGGCGCAGGAC
GTCCCTCCTTATGTCATTGCGCAGGGTAACCACGCAACGCCGTTCGGTGTCAATATCGAA
GGGCTGAAGCGCCGCGGATTCAGCCGTGAGGCGATTACCGCTATCCGCAATGCGTATAAG
CTGATTTATCGTAGCGGTAAAACGCTCGATGAAGTGAAACCGGAAATTGCTGAACTGGCG
GAAACATATCCGGAAGTGAAAGCCTTTACCGATTTCTTTGCACGCTCAACGCGCGGTCTG
ATTCGTTAA
Protein Properties
Pfam Domain Function:
Protein Residues:262
Protein Molecular Weight:30113
Protein Theoretical pI:7
Signaling Regions:
  • None
Transmembrane Regions:
  • None
Protein Sequence:
>Ferric iron reductase protein fhuF
MAYRSAPLYEDVIWRTHLQPQDPTLAQAVRATIAKHREHLLEFIRLDEPAPLNAMTLAQW
SSPNVLSSLLAVYSDHIYRNQPMMIRENKPLISLWAQWYIGLMVPPLMLALLTQEKALDV
SPEHFHAEFHETGRVACFWVDVCEDKNATPHSPQHRMETLISQALVPVVQALEATGEING
KLIWSNTGYLINWYLTEMKQLLGEATVESLRHALFFEKTLTNGEDNPLWRTVVLRDGLLV
RRTCCQRYRLPDVQQCGDCTLK
References
External Links:
ResourceLink
Uniprot ID:P39405
Uniprot Name:FHUF_ECOLI
GenBank Gene ID:AP009048
Genebank Protein ID:85674370
Ecogene ID:EG12595
Ecocyc:EG12595
ColiBase:b4367
Kegg Gene:b4367
EchoBASE ID:EB2480
CCDB:FHUF_ECOLI
BacMap:16132188
General Reference:
  • Blattner, F. R., Plunkett, G. 3rd, Bloch, C. A., Perna, N. T., Burland, V., Riley, M., Collado-Vides, J., Glasner, J. D., Rode, C. K., Mayhew, G. F., Gregor, J., Davis, N. W., Kirkpatrick, H. A., Goeden, M. A., Rose, D. J., Mau, B., Shao, Y. (1997). "The complete genome sequence of Escherichia coli K-12." Science 277:1453-1462. Pubmed: 9278503
  • Burland, V., Plunkett, G. 3rd, Sofia, H. J., Daniels, D. L., Blattner, F. R. (1995). "Analysis of the Escherichia coli genome VI: DNA sequence of the region from 92.8 through 100 minutes." Nucleic Acids Res 23:2105-2119. Pubmed: 7610040
  • Hayashi, K., Morooka, N., Yamamoto, Y., Fujita, K., Isono, K., Choi, S., Ohtsubo, E., Baba, T., Wanner, B. L., Mori, H., Horiuchi, T. (2006). "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Mol Syst Biol 2:2006.0007. Pubmed: 16738553
  • Muller, K., Matzanke, B. F., Schunemann, V., Trautwein, A. X., Hantke, K. (1998). "FhuF, an iron-regulated protein of Escherichia coli with a new type of [2Fe-2S] center." Eur J Biochem 258:1001-1008. Pubmed: 9990318