Riboflavin (ECMDB00244) (M2MDB000103)

General function:

Involved in acid phosphatase activity

Specific function:

A phosphate monoester + H(2)O = an alcohol + phosphate

Gene Name:

appA

Uniprot ID:

P07102

Molecular weight:

47056

Reactions

General function:

Involved in acid phosphatase activity

Specific function:

Dephosphorylates several organic phosphomonoesters and catalyzes the transfer of low-energy phosphate groups from phosphomonoesters to hydroxyl groups of various organic compounds. Preferentially acts on aryl phosphoesters. Might function as a broad-spectrum dephosphorylating enzyme able to scavenge both 3'- and 5'-nucleotides and also additional organic phosphomonoesters

Gene Name:

aphA

Uniprot ID:

P0AE22

Molecular weight:

26103

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

Catalyzes the reduction of soluble flavins by reduced pyridine nucleotides. Seems to reduces the complexed Fe(3+) iron of siderophores to Fe(2+), thus releasing it from the chelator

Gene Name:

fre

Uniprot ID:

P0AEN1

Molecular weight:

26242

Reactions

General function:

Involved in riboflavin synthase activity

Specific function:

Riboflavin synthase is a bifunctional enzyme complex catalyzing the formation of riboflavin from 5-amino-6-(1'-D)- ribityl-amino-2,4(1H,3H)-pyrimidinedione and L-3,4-dihydrohy-2- butanone-4-phosphate via 6,7-dimethyl-8-lumazine. The alpha subunit catalyzes the dismutation of 6,7-dimethyl-8-lumazine to riboflavin and 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)- pyrimidinedione

Gene Name:

ribE

Uniprot ID:

P0AFU8

Molecular weight:

23445

Reactions

General function:

Involved in FMN adenylyltransferase activity

Specific function:

ATP + riboflavin = ADP + FMN

Gene Name:

ribF

Uniprot ID:

P0AG40

Molecular weight:

34734

Reactions

General function:

Involved in sulfite reductase (NADPH) activity

Specific function:

Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate

Gene Name:

cysI

Uniprot ID:

P17846

Molecular weight:

63998

Reactions

General function:

Involved in sulfite reductase (NADPH) activity

Specific function:

Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH -> FAD -> FMN to the hemoprotein component

Gene Name:

cysJ

Uniprot ID:

P38038

Molecular weight:

66269

Reactions

General function:

Involved in 2 iron, 2 sulfur cluster binding

Specific function:

Involved in the reduction of ferric iron in cytoplasmic ferrioxamine B

Gene Name:

fhuF

Uniprot ID:

P39405

Molecular weight:

30113

General function:

Involved in riboflavin biosynthetic process

Specific function:

Riboflavin synthase is a bifunctional enzyme complex catalyzing the formation of riboflavin from 5-amino-6-(1'-D)- ribityl-amino-2,4(1H,3H)-pyrimidinedione and L-3,4-dihydrohy-2- butanone-4-phosphate via 6,7-dimethyl-8-lumazine. The beta subunit catalyzes the condensation of 5-amino-6-(1'-D)-ribityl-amino- 2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4- phosphate yielding 6,7-dimethyl-8-lumazine

Gene Name:

ribH

Uniprot ID:

P61714

Molecular weight:

16156

Reactions

General function:

Involved in catalytic activity

Specific function:

Catalyzes the dephosphorylation of the artificial chromogenic substrate p-nitrophenyl phosphate (pNPP) and of the natural substrates FMN and beta-glucose 1-phosphate

Gene Name:

ybjI

Uniprot ID:

P75809

Molecular weight:

30196