D-mannonate oxidoreductase (P39160)

Identification
Name:D-mannonate oxidoreductase
Synonyms:
  • Fructuronate reductase
Gene Name:uxuB
Enzyme Class:
Biological Properties
General Function:Involved in oxidation-reduction process
Specific Function:D-mannonate + NAD(+) = D-fructuronate + NADH
Cellular Location:Not Available
SMPDB Pathways:
  • hexuronide and hexuronate degradation PW000834
KEGG Pathways:
KEGG Reactions:
1.0Thumb+1.0Thumb ↔ 1.0Thumb+1.0Thumb+1.0Thumb
1.0D-Mannonate + 1.0NAD ↔ 1.0D-Fructuronate + 1.0Hydrogen ion + 1.0NADH
ReactionCard
SMPDB Reactions:
1.0Thumb+1.0Thumb+1.0Thumb → 1.0Thumb+1.0Thumb
1.0D-Fructuronate + 1.0NADH + 1.0Hydrogen ion → 1.0NAD + 1.0 D-altronate
ReactionCard
EcoCyc Reactions:
1.0Thumb+1.0Thumb ↔ 1.0Thumb+1.0Thumb+1.0Thumb
1.0D-Mannonate + 1.0NAD ↔ 1.0D-Fructuronate + 1.0Hydrogen ion + 1.0NADH
ReactionCard
Complex Reactions:
1.0Thumb+1.0Thumb → 1.0Thumb+1.0Thumb
1.0D-Mannonate + 1.0NAD → 1.0D-Fructuronate + 1.0NADH
ReactionCard
Metabolites:
ECMDB IDNameView
ECMDB24229 D-altronateMetaboCard
ECMDB20138D-FructuronateMetaboCard
ECMDB04101D-MannonateMetaboCard
ECMDB21225Hydrogen ionMetaboCard
ECMDB00902NADMetaboCard
ECMDB01487NADHMetaboCard
GO Classification:
Function
binding
catalytic activity
coenzyme binding
cofactor binding
oxidoreductase activity
Process
metabolic process
oxidation reduction
Gene Properties
Blattner:b4323
Gene OrientationClockwise
Centisome Percentage:98.09
Left Sequence End4550924
Right Sequence End4552384
Gene Sequence:
>1461 bp
ATGCACTCCTGGAAAAAGAAACTTGTAGTATCACAATTAGCATTGGCTTGCACTCTGGCT
ATCACCTCTCAGGCTAATGCAGCAAACTATGATACCTGGACTTATATCGATAATCCCGTT
ACAGCACTTGATTGGGATCATATGGATAAGGCAGGCACTGTAGATGGCAACTATGTAAAC
TATAGTGGTTTTGTCTATTACAACAACACCAATGGTGATTTCGATCAGTCCTTTAACGGC
GATACCGTTAACGGCACGATCTCAACCTATTATTTGAACCATGATTATGCAGACAGTACT
GCTAATCAGCTTGATATCAGTAATTCAGTGATTCACGGTTCGATTACTTCTATGCTGCCT
GGCGGTTATTATGATCGTTTTGATGCAGATGGTAATAATCTGGGTGGATATGATTTTTAC
ACTGATGCGGTTGTTGATACACACTGGCGTGATGGTGATGTTTTCACTTTGAACATTGCT
AACACTACTATTGATGATGATTATGAAGCTCTTTACTTCACTGATTCTTATAAAGATGGT
GATGTAACCAAGCACACAAATGAGACATTTGATACAAGTGAAGGCGTTGCTGTTAATCTT
GATGTAGAAAGTAACATCAATATTTCCAATAACTCCCGCGTTGCAGGTATTGCATTATCT
CAAGGTAATACTTACAACGAAACCTACACTACCGAATCTCATACTTGGGATAACAATATC
TCTGTAAAAGATTCCACAGTGACTTCGGGTTCAAATTATATCCTGGATAGCAATACTTAT
GGCAAAACTGGTCACTTTGGCAATTCTGATGAACCGAGTGATTATGCTGGCCCGGGTGAT
GTTGCAATGTCCTTTACTGCTTCAGGTTCCGACTATGCGATGAAGAACAATGTATTCCTC
AGCAATTCAACGCTGATGGGTGATGTTGCCTTTACCAGCACCTGGAATAGTAATTTTGAT
CCGAATGGTCATGATTCCAACGGTGACGGGGTGAAAGATACCAACGGGGGTTGGACTGAT
GATAGCCTCAACGTTGATGAACTAAATCTCACTCTCGATAACGGAAGCAAGTGGGTTGGT
CAGGCAATTTATAACGTTGCTGAAACGTCAGCAATGTATGATGTTGCTACAAACAGCCTT
ACTCCTGATGCAACATATGAAAACAATGACTGGAAACGTGTTGTTGATGACAAGGTCTTC
CAGAGCGGTGTATTTAACGTAGCGTTGAATAACGGTTCTGAATGGGATACTACAGGTCGT
TCCATCGTTGATACCTTGACAGTTAATAATGGTTCTCAGGTTAATGTTTCGGAATCTAAA
TTAACTTCAGATACTATCGATTTAACTAACGGTTCTTCGCTGAACATTGGTGAAGATGGC
TACGTTGATACCGATCATCTGACTATTAACTCCTACAGTACTGTTGCGTTGACCGAATCT
ACTGGGTGGGGGGCTGATTGA
Protein Properties
Pfam Domain Function:
Protein Residues:486
Protein Molecular Weight:53580
Protein Theoretical pI:5
Signaling Regions:
  • None
Transmembrane Regions:
  • None
Protein Sequence:
>D-mannonate oxidoreductase
MTTIVDSNLPVARPSWDHSRLESRIVHLGCGAFHRAHQALYTHHLLESTDSDWGICEVNL
MPGNDRVLIENLKKQQLLYTVAEKGAESTELKIIGSMKEALHPEIDGCEGILNAMARPQT
AIVSLTVTEKGYCADAASGQLDLNNPLIKHDLENPTAPKSAIGYIVEALRLRREKGLKAF
TVMSCDNVRENGHVAKVAVLGLAQARDPQLAAWIEENVTFPCTMVDRIVPAATPETLQEI
ADQLGVYDPCAIACEPFRQWVIEDNFVNGRPDWDKVGAQFVADVVPFEMMKLRMLNGSHS
FLAYLGYLGGYETIADTVTNPAYRKAAFALMMQEQAPTLSMPEGTDLNAYATLLIERFSN
PSLRHRTWQIAMDGSQKLPQRLLDPVRLHLQNGGSWRHLALGVAGWMRYTQGVDEQGNAI
DVVDPMLAEFQKINAQYQGADRVKALLGLSGIFADDLPQNADFVGAVTAAYQQLCERGAR
ECVAAL
References
External Links:
ResourceLink
Uniprot ID:P39160
Uniprot Name:UXUB_ECOLI
GenBank Gene ID:AP009048
Genebank Protein ID:85674512
Ecogene ID:EG20248
Ecocyc:EG20248
ColiBase:b4323
Kegg Gene:b4323
EchoBASE ID:EB4150
CCDB:UXUB_ECOLI
BacMap:16132144
General Reference:
  • Blattner, F. R., Plunkett, G. 3rd, Bloch, C. A., Perna, N. T., Burland, V., Riley, M., Collado-Vides, J., Glasner, J. D., Rode, C. K., Mayhew, G. F., Gregor, J., Davis, N. W., Kirkpatrick, H. A., Goeden, M. A., Rose, D. J., Mau, B., Shao, Y. (1997). "The complete genome sequence of Escherichia coli K-12." Science 277:1453-1462. Pubmed: 9278503
  • Burland, V., Plunkett, G. 3rd, Sofia, H. J., Daniels, D. L., Blattner, F. R. (1995). "Analysis of the Escherichia coli genome VI: DNA sequence of the region from 92.8 through 100 minutes." Nucleic Acids Res 23:2105-2119. Pubmed: 7610040
  • Hayashi, K., Morooka, N., Yamamoto, Y., Fujita, K., Isono, K., Choi, S., Ohtsubo, E., Baba, T., Wanner, B. L., Mori, H., Horiuchi, T. (2006). "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Mol Syst Biol 2:2006.0007. Pubmed: 16738553