Phosphoglucomutase (P36938)

Identification
Name:Phosphoglucomutase
Synonyms:
  • PGM
  • Glucose phosphomutase
Gene Name:pgm
Enzyme Class:
Biological Properties
General Function:Involved in intramolecular transferase activity, phosphotransferases
Specific Function:This enzyme participates in both the breakdown and synthesis of glucose
Cellular Location:Not Available
SMPDB Pathways:
KEGG Pathways:
KEGG Reactions:
1.0Thumb ↔ 1.0Thumb
1.0Glucose 1-phosphate ↔ 1.0Glucose 6-phosphate
ReactionCard
1.0alpha-D-Ribose 1-phosphate+1.0Thumb ↔ 1.0Thumb
1.0alpha-D-Ribose 1-phosphate + 1.0Ribose-1-phosphate ↔ 1.0D-Ribose-5-phosphate
ReactionCard
EcoCyc Reactions:
1.0Thumb ↔ 1.0α-D-glucose 6-phosphate
1.0Glucose 1-phosphate ↔ 1.0α-D-glucose 6-phosphate
ReactionCard
Metabolites:
ECMDB IDNameView
ECMDB23064Alpha-D-glucose 6-phosphateMetaboCard
ECMDB02033D-Ribose-5-phosphateMetaboCard
ECMDB01586Glucose 1-phosphateMetaboCard
ECMDB01401Glucose 6-phosphateMetaboCard
ECMDB11688Ribose 1,5-bisphosphateMetaboCard
ECMDB04147Ribose-1-phosphateMetaboCard
GO Classification:
Function
binding
catalytic activity
cation binding
intramolecular transferase activity
intramolecular transferase activity, phosphotransferases
ion binding
isomerase activity
magnesium ion binding
metal ion binding
phosphoglucomutase activity
Process
carbohydrate metabolic process
metabolic process
primary metabolic process
Gene Properties
Blattner:b0688
Gene OrientationClockwise
Centisome Percentage:15.36
Left Sequence End712781
Right Sequence End714421
Gene Sequence:
>1641 bp
ATGGCAATCCACAATCGTGCAGGCCAACCTGCACAACAGAGTGATTTGATTAACGTCGCC
CAACTGACGGCGCAATATTATGTACTGAAACCAGAAGCAGGGAATGCGGAGCACGCGGTG
AAATTCGGTACTTCCGGTCACCGTGGCAGTGCAGCGCGCCACAGCTTTAACGAGCCGCAC
ATTCTGGCGATCGCTCAGGCAATTGCTGAAGAACGTGCGAAAAACGGCATCACTGGCCCT
TGCTATGTGGGTAAAGATACTCACGCCCTGTCCGAACCTGCATTCATTTCCGTTCTGGAA
GTGCTGGCAGCGAACGGCGTTGATGTCATTGTGCAGGAAAACAATGGCTTCACCCCGACG
CCTGCCGTTTCCAATGCCATCCTGGTTCACAATAAAAAAGGTGGCCCGCTGGCAGACGGT
ATCGTGATTACACCGTCCCATAACCCGCCGGAAGATGGTGGAATCAAATACAATCCGCCA
AATGGTGGCCCGGCTGATACCAACGTCACTAAAGTGGTGGAAGACAGGGCCAACGCACTG
CTGGCCGATGGCCTGAAAGGCGTGAAGCGTATCTCCCTCGACGAAGCGATGGCATCCGGT
CATGTGAAAGAGCAGGATCTGGTGCAGCCGTTCGTGGAAGGTCTGGCCGATATCGTTGAT
ATGGCCGCGATTCAGAAAGCGGGCCTGACGCTGGGCGTTGATCCGCTGGGCGGTTCCGGT
ATCGAATACTGGAAGCGTATTGGCGAGTATTACAACCTCAACCTGACTATCGTTAACGAT
CAGGTCGATCAAACCTTCCGCTTTATGCACCTTGATAAAGACGGCGCGATCCGTATGGAC
TGCTCCTCCGAGTGTGCGATGGCGGGCCTGCTGGCACTGCGTGATAAGTTCGATCTGGCG
TTTGCTAACGACCCGGATTATGACCGTCACGGTATCGTCACTCCGGCAGGTTTGATGAAT
CCGAACCACTACCTGGCGGTGGCAATCAATTACCTGTTCCAGCATCGTCCGCAGTGGGGC
AAAGATGTTGCCGTCGGTAAAACGCTGGTTTCATCTGCGATGATCGACCGTGTGGTCAAC
GACTTGGGCCGTAAACTGGTAGAAGTCCCGGTAGGTTTCAAATGGTTTGTCGATGGTCTG
TTCGACGGCAGCTTCGGCTTTGGCGGCGAAGAGAGTGCAGGGGCTTCCTTCCTGCGTTTC
GACGGCACGCCGTGGTCCACCGACAAAGACGGCATCATCATGTGTCTGCTGGCGGCGGAA
ATCACCGCTGTCACCGGTAAGAACCCGCAGGAACACTACAACGAACTGGCAAAACGCTTT
GGTGCGCCGAGCTACAACCGTTTGCAGGCAGCTGCGACTTCCGCACAAAAAGCGGCGCTG
TCTAAGCTGTCTCCGGAAATGGTGAGCGCCAGCACCCTGGCAGGTGACCCGATCACCGCG
CGCCTGACTGCTGCTCCGGGCAACGGTGCTTCTATTGGCGGTCTGAAAGTGATGACTGAC
AACGGCTGGTTCGCCGCGCGTCCGTCAGGCACGGAAGACGCATATAAGATCTACTGCGAA
AGCTTCCTCGGTGAAGAACATCGCAAGCAGATTGAGAAAGAAGCGGTTGAGATTGTTAGC
GAAGTTCTGAAAAACGCGTAA
Protein Properties
Pfam Domain Function:
Protein Residues:546
Protein Molecular Weight:58361
Protein Theoretical pI:5
Signaling Regions:
  • None
Transmembrane Regions:
  • None
Protein Sequence:
>Phosphoglucomutase
MAIHNRAGQPAQQSDLINVAQLTAQYYVLKPEAGNAEHAVKFGTSGHRGSAARHSFNEPH
ILAIAQAIAEERAKNGITGPCYVGKDTHALSEPAFISVLEVLAANGVDVIVQENNGFTPT
PAVSNAILVHNKKGGPLADGIVITPSHNPPEDGGIKYNPPNGGPADTNVTKVVEDRANAL
LADGLKGVKRISLDEAMASGHVKEQDLVQPFVEGLADIVDMAAIQKAGLTLGVDPLGGSG
IEYWKRIGEYYNLNLTIVNDQVDQTFRFMHLDKDGAIRMDCSSECAMAGLLALRDKFDLA
FANDPDYDRHGIVTPAGLMNPNHYLAVAINYLFQHRPQWGKDVAVGKTLVSSAMIDRVVN
DLGRKLVEVPVGFKWFVDGLFDGSFGFGGEESAGASFLRFDGTPWSTDKDGIIMCLLAAE
ITAVTGKNPQEHYNELAKRFGAPSYNRLQAAATSAQKAALSKLSPEMVSASTLAGDPITA
RLTAAPGNGASIGGLKVMTDNGWFAARPSGTEDAYKIYCESFLGEEHRKQIEKEAVEIVS
EVLKNA
References
External Links:
ResourceLink
Uniprot ID:P36938
Uniprot Name:PGM_ECOLI
GenBank Gene ID:AP009048
Genebank Protein ID:1651293
Ecogene ID:EG12144
Ecocyc:EG12144
ColiBase:b0688
Kegg Gene:b0688
EchoBASE ID:EB2065
CCDB:PGM_ECOLI
BacMap:16128664
General Reference:
  • Blattner, F. R., Plunkett, G. 3rd, Bloch, C. A., Perna, N. T., Burland, V., Riley, M., Collado-Vides, J., Glasner, J. D., Rode, C. K., Mayhew, G. F., Gregor, J., Davis, N. W., Kirkpatrick, H. A., Goeden, M. A., Rose, D. J., Mau, B., Shao, Y. (1997). "The complete genome sequence of Escherichia coli K-12." Science 277:1453-1462. Pubmed: 9278503
  • Hayashi, K., Morooka, N., Yamamoto, Y., Fujita, K., Isono, K., Choi, S., Ohtsubo, E., Baba, T., Wanner, B. L., Mori, H., Horiuchi, T. (2006). "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Mol Syst Biol 2:2006.0007. Pubmed: 16738553
  • JOSHI, J. G., HANDLER, P. (1964). "PHOSPHOGLUCOMUTASE. I. PURIFICATION AND PROPERTIES OF PHOSPHOGLUCOMUTASE FROM ESCHERICHIA COLI." J Biol Chem 239:2741-2751. Pubmed: 14216423
  • Lu, M., Campbell, J. L., Boye, E., Kleckner, N. (1994). "SeqA: a negative modulator of replication initiation in E. coli." Cell 77:413-426. Pubmed: 8011018
  • Lu, M., Kleckner, N. (1994). "Molecular cloning and characterization of the pgm gene encoding phosphoglucomutase of Escherichia coli." J Bacteriol 176:5847-5851. Pubmed: 8083177
  • Oshima, T., Aiba, H., Baba, T., Fujita, K., Hayashi, K., Honjo, A., Ikemoto, K., Inada, T., Itoh, T., Kajihara, M., Kanai, K., Kashimoto, K., Kimura, S., Kitagawa, M., Makino, K., Masuda, S., Miki, T., Mizobuchi, K., Mori, H., Motomura, K., Nakamura, Y., Nashimoto, H., Nishio, Y., Saito, N., Horiuchi, T., et, a. l. .. (1996). "A 718-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 12.7-28.0 min region on the linkage map." DNA Res 3:137-155. Pubmed: 8905232