L-Methionine (ECMDB00696) (M2MDB000175)

General function:

Involved in nucleotide binding

Specific function:

Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation

Gene Name:

metG

Uniprot ID:

P00959

Molecular weight:

76254

Reactions

General function:

Involved in transferase activity

Specific function:

An aromatic amino acid + 2-oxoglutarate = an aromatic oxo acid + L-glutamate

Gene Name:

tyrB

Uniprot ID:

P04693

Molecular weight:

43537

Reactions

General function:

Involved in oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor

Specific function:

Could have an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine

Gene Name:

msrA

Uniprot ID:

P0A744

Molecular weight:

23315

Reactions

General function:

Involved in peptide-methionine-(S)-S-oxide reductase activity

Specific function:

Peptide-L-methionine + thioredoxin disulfide + H(2)O = peptide-L-methionine (R)-S-oxide + thioredoxin

Gene Name:

msrB

Uniprot ID:

P0A746

Molecular weight:

15451

Reactions

General function:

Involved in methionine adenosyltransferase activity

Specific function:

Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. Is essential for growth

Gene Name:

metK

Uniprot ID:

P0A817

Molecular weight:

41951

Reactions

General function:

Involved in catalytic activity

Specific function:

Activation of pyruvate formate-lyase 1 under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine

Gene Name:

pflA

Uniprot ID:

P0A9N4

Molecular weight:

28204

Reactions

General function:

Involved in [formate-C-acetyltransferase]-activating enzyme activity

Specific function:

Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine

Gene Name:

nrdG

Uniprot ID:

P0A9N8

Molecular weight:

17446

General function:

Involved in electron carrier activity

Specific function:

Efficient electron donor for the essential enzyme ribonucleotide reductase. Is also able to reduce the interchain disulfide bridges of insulin

Gene Name:

trxC

Uniprot ID:

P0AGG4

Molecular weight:

15555

Reactions

General function:

Involved in catalytic activity

Specific function:

Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism

Gene Name:

bioB

Uniprot ID:

P12996

Molecular weight:

38648

Reactions

General function:

Involved in methionine synthase activity

Specific function:

Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate

Gene Name:

metH

Uniprot ID:

P13009

Molecular weight:

135996

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

This enzyme may serve as a scavenger, allowing the cell to utilize biotin sulfoxide as a biotin source. It reduces a spontaneous oxidation product of biotin, D-biotin D-sulfoxide (BSO or BDS), back to biotin

Gene Name:

bisC

Uniprot ID:

P20099

Molecular weight:

85850

General function:

Involved in 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity

Specific function:

Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation

Gene Name:

metE

Uniprot ID:

P25665

Molecular weight:

84673

Reactions

General function:

Involved in transporter activity

Specific function:

Part of the binding-protein-dependent transport system for D-methionine and the toxic methionine analog alpha-methyl- methionine. Probably responsible for the translocation of the substrate across the membrane

Gene Name:

metI

Uniprot ID:

P31547

Molecular weight:

23256

General function:

Involved in catalytic activity

Specific function:

Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes. Is also able to catalyze very poorly the transfer of lipoyl and octanoyl moiety from their acyl carrier protein

Gene Name:

lplA

Uniprot ID:

P32099

Molecular weight:

37926

Reactions

General function:

Involved in coproporphyrinogen oxidase activity

Specific function:

Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX

Gene Name:

hemN

Uniprot ID:

P32131

Molecular weight:

52729

Reactions

General function:

Involved in iron-sulfur cluster binding

Specific function:

Activation of pyruvate formate-lyase 2 under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine

Gene Name:

pflC

Uniprot ID:

P32675

Molecular weight:

32429

Reactions

General function:

Involved in coproporphyrinogen oxidase activity

Specific function:

Not Available

Gene Name:

yggW

Uniprot ID:

P52062

Molecular weight:

42584

General function:

Involved in catalytic activity

Specific function:

Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. Free octanoate is not a substrate for lipA

Gene Name:

lipA

Uniprot ID:

P60716

Molecular weight:

36071

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

Activation of pyruvate formate-lyase 2 under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine

Gene Name:

ybiY

Uniprot ID:

P75794

Molecular weight:

33038

Reactions

General function:

Involved in homocysteine S-methyltransferase activity

Specific function:

Catalyzes methyl transfer from S-methylmethionine or S- adenosylmethionine (less efficient) to homocysteine, selenohomocysteine and less efficiently selenocysteine

Gene Name:

mmuM

Uniprot ID:

Q47690

Molecular weight:

33422

Reactions

General function:

Involved in nucleotide binding

Specific function:

Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (Probable). It has also been shown to be involved in formyl-L-methionine transport

Gene Name:

metN

Uniprot ID:

P30750

Molecular weight:

37788

General function:

Involved in catalytic activity

Specific function:

Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S

Gene Name:

thiG

Uniprot ID:

P30139

Molecular weight:

26896

Reactions

General function:

Involved in catalytic activity

Specific function:

Catalyzes the radical-mediated cleavage of tyrosine to dehydroglycine and p-cresol

Gene Name:

thiH

Uniprot ID:

P30140

Molecular weight:

43320

Reactions

General function:

Inorganic ion transport and metabolism

Specific function:

This protein is a component of a D-methionine permease, a binding protein-dependent, ATP-driven transport system

Gene Name:

metQ

Uniprot ID:

P28635

Molecular weight:

29432

General function:

Involved in thiamine biosynthetic process

Specific function:

Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction

Gene Name:

thiC

Uniprot ID:

P30136

Molecular weight:

70850

Reactions

General function:

Involved in electron carrier activity

Specific function:

Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions

Gene Name:

trxA

Uniprot ID:

P0AA25

Molecular weight:

11807

General function:

Not Available

Specific function:

Not Available

Gene Name:

yncA

Uniprot ID:

P76112

Molecular weight:

Not Available

General function:

Translation, ribosomal structure and biogenesis

Specific function:

Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)

Gene Name:

queA

Uniprot ID:

P0A7F9

Molecular weight:

39430

Reactions

General function:

Involved in 4 iron, 4 sulfur cluster binding

Specific function:

Specifically methylates position 2 of adenine 2503 in 23S rRNA

Gene Name:

rlmN

Uniprot ID:

P36979

Molecular weight:

43085

Reactions

General function:

tRNA methylthiolation

Specific function:

Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.

Gene Name:

miaB

Uniprot ID:

P0AEI1

Molecular weight:

53662

Reactions

General function:

RNA modification

Specific function:

Catalyzes the methylthiolation of the residue Asp-89 of ribosomal protein S12.

Gene Name:

rimO

Uniprot ID:

P0AEI4

Molecular weight:

49581

Reactions