L-Cysteine (ECMDB00574) (M2MDB000152)

General function:

Involved in transferase activity

Specific function:

L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate

Gene Name:

aspC

Uniprot ID:

P00509

Molecular weight:

43573

Reactions

General function:

Involved in pyridoxal phosphate binding

Specific function:

O(4)-succinyl-L-homoserine + L-cysteine = L- cystathionine + succinate

Gene Name:

metB

Uniprot ID:

P00935

Molecular weight:

41550

Reactions

General function:

Involved in proteolysis

Specific function:

Aminopeptidase N is involved in the degradation of intracellular peptides generated by protein breakdown during normal growth as well as in response to nutrient starvation

Gene Name:

pepN

Uniprot ID:

P04825

Molecular weight:

98918

Reactions

General function:

Involved in pyridoxal phosphate binding

Specific function:

L-cystathionine + H(2)O = L-homocysteine + NH(3) + pyruvate

Gene Name:

metC

Uniprot ID:

P06721

Molecular weight:

43212

Reactions

General function:

Involved in metabolic process

Specific function:

Catalyzes the removal of elemental sulfur and selenium atoms from cysteine and selenocysteine to produce alanine. Functions as a sulfur delivery protein for NAD, biotin and Fe-S cluster synthesis. Transfers sulfur on 'Cys-456' of thiI in a transpersulfidation reaction. Transfers sulfur on 'Cys-19' of tusA in a transpersulfidation reaction. Functions also as a selenium delivery protein in the pathway for the biosynthesis of selenophosphate

Gene Name:

iscS

Uniprot ID:

P0A6B7

Molecular weight:

45089

Reactions

General function:

Involved in glutamate-cysteine ligase activity

Specific function:

ATP + L-glutamate + L-cysteine = ADP + phosphate + gamma-L-glutamyl-L-cysteine

Gene Name:

gshA

Uniprot ID:

P0A6W9

Molecular weight:

58269

Reactions

General function:

Involved in lyase activity

Specific function:

L-tryptophan + H(2)O = indole + pyruvate + NH(3)

Gene Name:

tnaA

Uniprot ID:

P0A853

Molecular weight:

52773

Reactions

General function:

Involved in cysteine biosynthetic process from serine

Specific function:

O(3)-acetyl-L-serine + H(2)S = L-cysteine + acetate

Gene Name:

cysK

Uniprot ID:

P0ABK5

Molecular weight:

34489

Reactions

General function:

Involved in phosphopantothenate--cysteine ligase activity

Specific function:

Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine

Gene Name:

coaBC

Uniprot ID:

P0ABQ0

Molecular weight:

43438

Reactions

General function:

Involved in hydrolase activity

Specific function:

Dipeptidase with broad substrate specificity. Requires dipeptide substrates with an unblocked N-terminus and the amino group in the alpha or beta position. Non-protein amino acids and proline are not accepted in the C-terminal position, whereas some dipeptide amides and formyl amino acids are hydrolyzed. Also shows cysteinylglycinase activity, which is sufficient for E.coli to utilize cysteinylglycine as a cysteine source

Gene Name:

pepD

Uniprot ID:

P15288

Molecular weight:

52915

Reactions

General function:

Involved in cysteine biosynthetic process from serine

Specific function:

Two cysteine synthase enzymes are found. Both catalyze the same reaction. Cysteine synthase B can also use thiosulfate in place of sulfide to give cysteine thiosulfonate as a product

Gene Name:

cysM

Uniprot ID:

P16703

Molecular weight:

32664

Reactions

General function:

Involved in cysteine-tRNA ligase activity

Specific function:

ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys)

Gene Name:

cysS

Uniprot ID:

P21888

Molecular weight:

52202

Reactions

General function:

Involved in transferase activity

Specific function:

Acts as a beta-cystathionase and as a repressor of the maltose regulon

Gene Name:

malY

Uniprot ID:

P23256

Molecular weight:

43641

Reactions

General function:

Involved in aminopeptidase activity

Specific function:

Probably plays an important role in intracellular peptide degradation

Gene Name:

pepB

Uniprot ID:

P37095

Molecular weight:

46180

Reactions

General function:

Involved in aminopeptidase activity

Specific function:

Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides. Required for plasmid ColE1 site-specific recombination but not in its aminopeptidase activity. Could act as a structural component of the putative nucleoprotein complex in which the Xer recombination reaction takes place

Gene Name:

pepA

Uniprot ID:

P68767

Molecular weight:

54879

Reactions

General function:

Involved in metabolic process

Specific function:

Cysteine desulfurases mobilize the sulfur from L- cysteine to yield L-alanine, an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Component of the suf operon, which is activated and required under specific conditions such as oxidative stress and iron limitation. Acts as a potent selenocysteine lyase in vitro, that mobilizes selenium from L-selenocysteine. Selenocysteine lyase activity is however unsure in vivo

Gene Name:

sufS

Uniprot ID:

P77444

Molecular weight:

44433

Reactions

General function:

Involved in nucleotide binding

Specific function:

Somehow involved in the cytochrome D branch of aerobic respiration. Seems to be a component of a transport system

Gene Name:

cydC

Uniprot ID:

P23886

Molecular weight:

62920

General function:

Involved in nucleotide binding

Specific function:

Somehow involved in the cytochrome D branch of aerobic respiration. Seems to be a component of a transport system

Gene Name:

cydD

Uniprot ID:

P29018

Molecular weight:

65055

General function:

Involved in RNA binding

Specific function:

Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by iscS

Gene Name:

thiI

Uniprot ID:

P77718

Molecular weight:

54973

Reactions

General function:

Not Available

Specific function:

Participates in cysteine desulfuration mediated by sufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for sufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of sufS, an intermediate product of cysteine desulfuration process. Together with the sufBCD complex, it thereby enhances up to 50- fold, the cysteine desulfurase activity of sufS. Component of the suf operon, which is activated and required under specific conditions such as oxidative stress and iron limitation. Does not affect the selenocysteine lyase activity of sufS

Gene Name:

sufE

Uniprot ID:

P76194

Molecular weight:

15800