Identification |
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Name: | 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase |
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Synonyms: | Not Available |
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Gene Name: | entA |
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Enzyme Class: | |
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Biological Properties |
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General Function: | Involved in oxidoreductase activity |
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Specific Function: | 2,3-dihydro-2,3-dihydroxybenzoate + NAD(+) = 2,3-dihydroxybenzoate + NADH |
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Cellular Location: | Not Available |
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SMPDB Pathways: | - 2,3-dihydroxybenzoate biosynthesis PW000751
- Biosynthesis of siderophore group nonribosomal peptides PW000760
- Enterobactin Biosynthesis PW002048
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KEGG Pathways: | - Biosynthesis of siderophore group nonribosomal peptides ec01053
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KEGG Reactions: | |
1.0 | + | 1.0 | + | 1.0 | ↔ | 1.0 | + | 1.0 | + | 1.0 |
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SMPDB Reactions: | |
1.02,3-dihydroxy-2,3-dihydrobenzoate | + | 1.0 | → | 1.0 | + | 1.0 | + | 1.0 |
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1.02,3-dihydroxy-2,3-dihydrobenzoate | + | 1.0 | → | 1.0 | + | 1.0 | + | 1.0 |
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EcoCyc Reactions: | |
1.0 | + | 1.0 | + | 1.0 | ↔ | 1.0 | + | 1.0 | + | 1.0 |
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Metabolites: | |
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GO Classification: | Function |
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2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity | binding | catalytic activity | oxidoreductase activity | oxidoreductase activity, acting on the CH-CH group of donors | oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor | Process |
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cellular aromatic compound metabolic process | cellular metabolic process | enterobactin biosynthetic process | enterobactin metabolic process | metabolic process | oxidation reduction |
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Gene Properties |
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Blattner: | b0596 |
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Gene Orientation | Clockwise |
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Centisome Percentage: | 13.53 |
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Left Sequence End | 627774 |
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Right Sequence End | 628520 |
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Gene Sequence: | >747 bp
ATGGATTTCAGCGGTAAAAATGTCTGGGTAACCGGCGCAGGTAAAGGTATCGGCTACGCC
ACGGCGCTGGCGTTTGTTGAGGCGGGAGCGAAAGTTACAGGTTTTGATCAAGCGTTCACT
CAGGAGCAATATCCCTTTGCGACCGAAGTGATGGATGTTGCCGACGCTGCGCAGGTCGCG
CAAGTGTGTCAGCGACTGTTAGCTGAAACGGAGCGACTGGACGCGCTGGTCAATGCGGCG
GGAATTTTACGCATGGGCGCGACCGATCAGCTCAGTAAAGAGGACTGGCAGCAGACTTTT
GCGGTTAACGTCGGCGGTGCGTTTAACCTGTTCCAGCAAACCATGAACCAGTTTCGCCGT
CAGCGGGGCGGGGCGATTGTCACTGTGGCGTCCGACGCCGCGCACACGCCGCGTATTGGC
ATGAGTGCTTATGGCGCATCGAAAGCGGCGCTGAAAAGCCTGGCGTTGAGCGTCGGGCTG
GAACTGGCGGGTAGCGGCGTGCGCTGTAATGTGGTTTCGCCTGGCTCCACCGACACCGAT
ATGCAACGCACGCTGTGGGTGAGCGATGACGCCGAAGAACAGCGTATTCGCGGCTTTGGC
GAGCAGTTTAAACTCGGCATTCCGCTGGGGAAAATCGCCCGTCCACAAGAGATCGCCAAC
ACGATTTTGTTCCTCGCCTCTGACCTCGCCAGCCATATTACCCTACAGGATATTGTGGTC
GATGGCGGCTCAACGCTGGGGGCATAA |
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Protein Properties |
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Pfam Domain Function: | |
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Protein Residues: | 248 |
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Protein Molecular Weight: | 26250 |
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Protein Theoretical pI: | 5 |
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Signaling Regions: | |
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Transmembrane Regions: | |
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Protein Sequence: | >2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase
MDFSGKNVWVTGAGKGIGYATALAFVEAGAKVTGFDQAFTQEQYPFATEVMDVADAAQVA
QVCQRLLAETERLDALVNAAGILRMGATDQLSKEDWQQTFAVNVGGAFNLFQQTMNQFRR
QRGGAIVTVASDAAHTPRIGMSAYGASKAALKSLALSVGLELAGSGVRCNVVSPGSTDTD
MQRTLWVSDDAEEQRIRGFGEQFKLGIPLGKIARPQEIANTILFLASDLASHITLQDIVV
DGGSTLGA |
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References |
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External Links: | |
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General Reference: | - Blattner, F. R., Plunkett, G. 3rd, Bloch, C. A., Perna, N. T., Burland, V., Riley, M., Collado-Vides, J., Glasner, J. D., Rode, C. K., Mayhew, G. F., Gregor, J., Davis, N. W., Kirkpatrick, H. A., Goeden, M. A., Rose, D. J., Mau, B., Shao, Y. (1997). "The complete genome sequence of Escherichia coli K-12." Science 277:1453-1462. Pubmed: 9278503
- Hayashi, K., Morooka, N., Yamamoto, Y., Fujita, K., Isono, K., Choi, S., Ohtsubo, E., Baba, T., Wanner, B. L., Mori, H., Horiuchi, T. (2006). "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Mol Syst Biol 2:2006.0007. Pubmed: 16738553
- Liu, J., Duncan, K., Walsh, C. T. (1989). "Nucleotide sequence of a cluster of Escherichia coli enterobactin biosynthesis genes: identification of entA and purification of its product 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase." J Bacteriol 171:791-798. Pubmed: 2521622
- Nahlik, M. S., Brickman, T. J., Ozenberger, B. A., McIntosh, M. A. (1989). "Nucleotide sequence and transcriptional organization of the Escherichia coli enterobactin biosynthesis cistrons entB and entA." J Bacteriol 171:784-790. Pubmed: 2521621
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