T-protein (P07023)

Identification
Name:T-protein
Synonyms:
  • Chorismate mutase
  • CM
  • Prephenate dehydrogenase
  • PDH
Gene Name:tyrA
Enzyme Class:
Biological Properties
General Function:Involved in oxidation-reduction process
Specific Function:Chorismate = prephenate
Cellular Location:Cytoplasm
SMPDB Pathways:
KEGG Pathways:
  • Metabolic pathways eco01100
  • Phenylalanine, tyrosine and tryptophan biosynthesis ec00400
KEGG Reactions:
1.0Thumb ↔ 1.0Thumb
1.0Chorismate ↔ 1.0Prephenate
ReactionCard
1.0Thumb+1.0Thumb → 1.0Thumb+1.0Thumb+1.0Thumb
1.0NAD + 1.0Prephenate → 1.04-Hydroxyphenylpyruvic acid + 1.0Carbon dioxide + 1.0NADH
ReactionCard
1.0Thumb+1.0Thumb ↔ 1.0Thumb+1.0Thumb+1.0Thumb+1.0Thumb
1.0Prephenate + 1.0NAD ↔ 1.04-Hydroxyphenylpyruvic acid + 1.0Carbon dioxide + 1.0NADH + 1.0Hydrogen ion
ReactionCard
EcoCyc Reactions:
1.0Thumb ↔ 1.0Thumb
1.0Chorismate ↔ 1.0Prephenate
ReactionCard
1.0Thumb+1.0Thumb → 1.0Thumb+1.0Thumb+1.0Thumb
1.0NAD + 1.0Prephenate → 1.04-Hydroxyphenylpyruvic acid + 1.0Carbon dioxide + 1.0NADH
ReactionCard
Metabolites:
ECMDB IDNameView
ECMDB007074-Hydroxyphenylpyruvic acidMetaboCard
ECMDB04030Carbon dioxideMetaboCard
ECMDB12199ChorismateMetaboCard
ECMDB21225Hydrogen ionMetaboCard
ECMDB00902NADMetaboCard
ECMDB01487NADHMetaboCard
ECMDB12283PrephenateMetaboCard
GO Classification:
Component
cell part
cytoplasm
intracellular part
Function
catalytic activity
chorismate mutase activity
intramolecular transferase activity
isomerase activity
oxidoreductase activity
oxidoreductase activity, acting on the CH-CH group of donors
oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor
prephenate dehydrogenase (NADP+) activity
prephenate dehydrogenase activity
Process
aromatic amino acid family metabolic process
carboxylic acid metabolic process
cellular amino acid and derivative metabolic process
cellular amino acid metabolic process
cellular metabolic process
chorismate metabolic process
dicarboxylic acid metabolic process
metabolic process
organic acid metabolic process
oxidation reduction
oxoacid metabolic process
tyrosine biosynthetic process
tyrosine metabolic process
Gene Properties
Blattner:b2600
Gene OrientationCounterclockwise
Centisome Percentage:58.99
Left Sequence End2736970
Right Sequence End2738091
Gene Sequence:
>1122 bp
ATGGTTGCTGAATTGACCGCATTACGCGATCAAATTGATGAAGTCGATAAAGCGCTGCTG
AATTTATTAGCGAAGCGTCTGGAACTGGTTGCTGAAGTGGGCGAGGTGAAAAGCCGCTTT
GGACTGCCTATTTATGTTCCGGAGCGCGAGGCATCTATGTTGGCCTCGCGTCGTGCAGAG
GCGGAAGCTCTGGGTGTACCGCCAGATCTGATTGAGGATGTTTTGCGTCGGGTGATGCGT
GAATCTTACTCCAGTGAAAACGACAAAGGATTTAAAACACTTTGTCCGTCACTGCGTCCG
GTGGTTATCGTCGGCGGTGGCGGTCAGATGGGACGCCTGTTCGAGAAGATGCTGACCCTC
TCGGGTTATCAGGTGCGGATTCTGGAGCAACATGACTGGGATCGAGCGGCTGATATTGTT
GCCGATGCCGGAATGGTGATTGTTAGTGTGCCAATCCACGTTACTGAGCAAGTTATTGGC
AAATTACCGCCTTTACCGAAAGATTGTATTCTGGTCGATCTGGCATCAGTGAAAAATGGG
CCATTACAGGCCATGCTGGTGGCGCATGATGGTCCGGTGCTGGGGCTACACCCGATGTTC
GGTCCGGACAGCGGTAGCCTGGCAAAGCAAGTTGTGGTCTGGTGTGATGGACGTAAACCG
GAAGCATACCAATGGTTTCTGGAGCAAATTCAGGTCTGGGGCGCTCGGCTGCATCGTATT
AGCGCCGTCGAGCACGATCAGAATATGGCGTTTATTCAGGCACTGCGCCACTTTGCTACT
TTTGCTTACGGGCTGCACCTGGCAGAAGAAAATGTTCAGCTTGAGCAACTTCTGGCGCTC
TCTTCGCCGATTTACCGCCTTGAGCTGGCGATGGTCGGGCGACTGTTTGCTCAGGATCCG
CAGCTTTATGCCGACATCATTATGTCGTCAGAGCGTAATCTGGCGTTAATCAAACGTTAC
TATAAGCGTTTCGGCGAGGCGATTGAGTTGCTGGAGCAGGGCGATAAGCAGGCGTTTATT
GACAGTTTCCGCAAGGTGGAGCACTGGTTCGGCGATTACGCACAGCGTTTTCAGAGTGAA
AGCCGCGTGTTATTGCGTCAGGCGAATGACAATCGCCAGTAA
Protein Properties
Pfam Domain Function:
Protein Residues:373
Protein Molecular Weight:42042
Protein Theoretical pI:6
Signaling Regions:
  • None
Transmembrane Regions:
  • None
Protein Sequence:
>T-protein
MVAELTALRDQIDEVDKALLNLLAKRLELVAEVGEVKSRFGLPIYVPEREASMLASRRAE
AEALGVPPDLIEDVLRRVMRESYSSENDKGFKTLCPSLRPVVIVGGGGQMGRLFEKMLTL
SGYQVRILEQHDWDRAADIVADAGMVIVSVPIHVTEQVIGKLPPLPKDCILVDLASVKNG
PLQAMLVAHDGPVLGLHPMFGPDSGSLAKQVVVWCDGRKPEAYQWFLEQIQVWGARLHRI
SAVEHDQNMAFIQALRHFATFAYGLHLAEENVQLEQLLALSSPIYRLELAMVGRLFAQDP
QLYADIIMSSERNLALIKRYYKRFGEAIELLEQGDKQAFIDSFRKVEHWFGDYAQRFQSE
SRVLLRQANDNRQ
References
External Links:
ResourceLink
Uniprot ID:P07023
Uniprot Name:TYRA_ECOLI
GenBank Gene ID:AP009048
Genebank Protein ID:85675476
Ecogene ID:EG11039
Ecocyc:EG11039
ColiBase:b2600
Kegg Gene:b2600
EchoBASE ID:EB1032
CCDB:TYRA_ECOLI
BacMap:16130521
General Reference:
  • Blattner, F. R., Plunkett, G. 3rd, Bloch, C. A., Perna, N. T., Burland, V., Riley, M., Collado-Vides, J., Glasner, J. D., Rode, C. K., Mayhew, G. F., Gregor, J., Davis, N. W., Kirkpatrick, H. A., Goeden, M. A., Rose, D. J., Mau, B., Shao, Y. (1997). "The complete genome sequence of Escherichia coli K-12." Science 277:1453-1462. Pubmed: 9278503
  • Hayashi, K., Morooka, N., Yamamoto, Y., Fujita, K., Isono, K., Choi, S., Ohtsubo, E., Baba, T., Wanner, B. L., Mori, H., Horiuchi, T. (2006). "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Mol Syst Biol 2:2006.0007. Pubmed: 16738553
  • Hudson, G. S., Davidson, B. E. (1984). "Nucleotide sequence and transcription of the phenylalanine and tyrosine operons of Escherichia coli K12." J Mol Biol 180:1023-1051. Pubmed: 6396419
  • Yamamoto, Y., Aiba, H., Baba, T., Hayashi, K., Inada, T., Isono, K., Itoh, T., Kimura, S., Kitagawa, M., Makino, K., Miki, T., Mitsuhashi, N., Mizobuchi, K., Mori, H., Nakade, S., Nakamura, Y., Nashimoto, H., Oshima, T., Oyama, S., Saito, N., Sampei, G., Satoh, Y., Sivasundaram, S., Tagami, H., Horiuchi, T., et, a. l. .. (1997). "Construction of a contiguous 874-kb sequence of the Escherichia coli -K12 genome corresponding to 50.0-68.8 min on the linkage map and analysis of its sequence features." DNA Res 4:91-113. Pubmed: 9205837